Cited by 274Inflammasome and immune disordersImmune Response and InflammationStreptococcal Infections and Treatments

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Staphylococcus aureus Evades Lysozyme-Based Peptidoglycan Digestion that Links Phagocytosis, Inflammasome Activation, and IL-1β Secretion

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Shimada, Takahiro, Park, Bong Goo, Wolf, Andrea J., Brikos, Constantinos, Goodridge, Helen S., Becker, Courtney A., Reyes, Christopher N., Miao, Edward A., Aderem, Alan, Götz, Friedrich, Liu, George Y., Underhill, David M.·2010·Cell Host & Microbe

DOI 10.1016/j.chom.2009.12.008PMC PMC2818986

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Abstract

IL-1beta produced by phagocytes is important for protection against the mucosal pathogen Staphylococcus aureus. Processing and maturation of this cytokine requires activation of the multiprotein inflammasome complex. We observed that the bacterial cell wall component peptidoglycan (PGN) must be particulate and internalized via phagocytosis to activate NLRP3 inflammasomes and IL-1beta secretion. In the context of S. aureus infection of macrophages, we find that phagocytosis and lysozyme-based bacterial cell wall degradation are necessary to induce IL-1beta secretion. Further, an S. aureus enzyme, PGN O-acetyltransferase A, previously demonstrated to make cell wall PGN resistant to lysozyme, strongly suppresses inflammasome activation and inflammation in vitro and in vivo. These observations demonstrate that phagocytosis and lysozyme-based cell wall degradation of S. aureus are functionally coupled to inflammasome activation and IL-1beta secretion and illustrate a case whereby a bacterium specifically subverts IL-1beta secretion through chemical modification of its cell wall PGN.

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Authors: Shimada, T., Park, B. G., Wolf, A. J., Brikos, C., Goodridge, H. S., Becker, C. A., Reyes, C. N., Miao, E. A., Aderem, A., Götz, F., Liu, G. Y., & Underhill, D. M.
Affiliations: Cedars-Sinai Medical Center (US)
Institute for Systems Biology (US)
University of Tübingen (DE)
Corresponding author: Underhill, David M.
ORCID: Wolf, Andrea J.
Goodridge, Helen S.
Becker, Courtney A.
Miao, Edward A.
Aderem, Alan
Götz, Friedrich
Liu, George Y.
Underhill, David M.
Venue: Cell Host & Microbe
Publisher: Elsevier BV
Published: 2010-01
Volume: 7
Issue: 1
Pages: 38-49
ISSN: 1931-3128 (ISSN-L)
DOI: 10.1016/j.chom.2009.12.008
PMC: PMC2818986
OpenAlex: W2064358027
Cited by: 274
References: 65
Citations by year: 2026: 9 · 2025: 12 · 2024: 13 · 2023: 12 · 2022: 17 · 2021: 17 · 2020: 11 · 2019: 18 · 2018: 21 · 2017: 13 · 2016: 20 · 2015: 20 · 2014: 13 · 2013: 17 · 2012: 26
FWCI: 10.16
Type: journal article
Language: en
Open access: bronze
doi.org
Licence: www.elsevier.com/tdm/userlicense/1.0/ (tdm)
www.elsevier.com/open-access/userlicense/1.0/ (vor, 1293 d)
Locations: Cell Host & Microbe (publishedVersion)
PubMed (publishedVersion)
PubMed Central (acceptedVersion)
Funders: Genentech
National Institute of General Medical Sciences (GM-085796, R01GM085796)
National Institute of Allergy and Infectious Diseases (R01AI025032)
Topics: Life Sciences › Biochemistry, Genetics and Molecular Biology › Molecular Biology › Inflammasome and immune disorders
Life Sciences › Immunology and Microbiology › Immunology › Immune Response and Inflammation
Health Sciences › Medicine › Infectious Diseases › Streptococcal Infections and Treatments
Keywords: Staphylococcus aureus, peptidoglycan, lysozyme, phagocytosis, NLRP3 inflammasome, IL-1β secretion, macrophages, inflammation, bacterial evasion of host defense
MeSH terms: NLR Family, Pyrin Domain-Containing 3 Protein, Animals, Bacterial Proteins, Carrier Proteins, Macrophages, Models, Biological, Muramidase, Peptidoglycan, Phagosomes, Staphylococcus aureus, Interleukin-1beta

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Staphylococcus aureus Evades Lysozyme-Based Peptidoglycan Digestion that Links Phagocytosis, Inflammasome Activation, and IL-1β Secretion

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