The DOI matches its Crossref record; 52 of the 52 references it cites were found in a registry or an index.
Selective Subversion of Autophagy Complexes Facilitates Completion of the Brucella Intracellular Cycle
Open accessAbstract
Summary Autophagy is a cellular degradation process that can capture and eliminate intracellular microbes by delivering them to lysosomes for destruction. However, pathogens have evolved mechanisms to subvert this process. The intracellular bacteria Brucella abortus ensures its survival by forming the Brucella-containing vacuole (BCV) that traffics from the endocytic compartment to the endoplasmic reticulum (ER), where the bacterium proliferates. We show that Brucella replication in the ER is followed by BCV conversion into a compartment with autophagic features (aBCV). While Brucella trafficking to the ER was unaffected in autophagy-deficient cells, aBCV formation required the autophagy initiation proteins ULK1, Beclin 1 and ATG14L, and PI3-kinase activity. However, aBCV formation was independent of the autophagy elongation proteins ATG5, ATG16L1, ATG4B, ATG7 and LC3B. Furthermore, aBCVs were required to complete the intracellular Brucella lifecycle and for cell-to-cell spreading, demonstrating that Brucella selectively co-opts autophagy initiation complexes to subvert host clearance and promote infection.
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Cites
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Cited by
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Klionsky, D. J., Abdelmohsen, K., Abe, A., Abedin, M. J., Abeliovich, H., Acevedo Arozena, A., Adachi, H., Adams, C. M., Adams, P. D., Adeli, K., et al. (2016) · Autophagy · doi:10.1080/15548627.2015.1100356 · Cited by 5,894
Self-citationBiological Functions of Autophagy Genes: A Disease Perspective
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Metadata
- Authors
- Starr, T., Child, R., Wehrly, T. D., Hansen, B., Hwang, S., López-Otin, C., Virgin, H. W., & Celli, J.
- Venue
- Cell Host & Microbe
- Publisher
- Elsevier BV
- Published
- 2012-01
- Volume
- 11
- Issue
- 1
- Pages
- 33-45
- ISSN
- 1931-3128 (ISSN-L)
- OpenAlex
- W2056133106
- Cited by
- 340
- References
- 52
- FWCI
- 23.48
- Type
- journal article
- Language
- en
- Open access
- bronze
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- Starr, T., Child, R., Wehrly, T. D., Hansen, B., Hwang, S., López-Otin, C., Virgin, H. W., & Celli, J. (2012). Selective Subversion of Autophagy Complexes Facilitates Completion of the Brucella Intracellular Cycle. Cell Host & Microbe. https://doi.org/10.1016/j.chom.2011.12.002
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