The DOI matches its Crossref record; 14 of the 14 references it cites were found in a registry or an index.
Salmonella Require the Fatty Acid Regulator PPARδ for the Establishment of a Metabolic Environment Essential for Long-Term Persistence
Open accessAbstract
Summary Host adapted Salmonella strains are responsible for a number of disease manifestations in mammals, including an asymptomatic chronic infection where bacteria survive within macrophages located in systemic sites. However, the host cell physiology and metabolic requirements supporting bacterial persistence are poorly understood. In a mouse model of long-term infection, we found that S. typhimurium preferentially associates with anti-inflammatory/M2 macrophages at later stages of infection. Further, PPARδ, a eukaryotic transcription factor involved in sustaining fatty acid metabolism, is up-regulated in Salmonella-infected macrophages. PPARδ deficiency dramatically inhibits Salmonella replication, which is linked to the metabolic state of macrophages and the level of intracellular glucose available to bacteria. Pharmacological activation of PPARδ increases glucose availability and enhances bacterial replication in macrophages and mice, while Salmonella fail to persist in Pparδ-null mice. These data suggest that M2 macrophages represent a unique niche for the long-term intracellular bacterial survival and link the PPARδ-regulated metabolic state of the host cell to persistent bacterial infection.
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Cites
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BackgroundInfluentialSelf-citationMolecular recognition of fatty acids by peroxisome proliferator-activated receptors
Xu, H. E., Lambert, M. H., Montana, V. G., Parks, D. J., Blanchard, S. G., Brown, P. J., Sternbach, D. D., Lehmann, J. M., Wisely, G. B., Willson, T. M., et al. (1999) · Molecular Cell · doi:10.1016/s1097-2765(00)80467-0 · Cited by 1,169
Mycobacterial persistence requires the utilization of host cholesterol
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Alternatively activated macrophages produce catecholamines to sustain adaptive thermogenesis
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Cited by
Czyż, D. M., Willett, J. W., & Crosson, S. (2017) · Journal of Bacteriology · doi:10.1128/jb.00227-17 · Cited by 87
Salmonella enterica Infection Stimulates Macrophages to Hemophagocytose
Pilonieta, M. C., Moreland, S. M., English, C. N., & Detweiler, C. S. (2014) · mBio · doi:10.1128/mbio.02211-14 · Cited by 35
Salmonella acquires ferrous iron from haemophagocytic macrophages
Nagy, T. A., Moreland, S. M., & Detweiler, C. S. (2014) · Molecular Microbiology · doi:10.1111/mmi.12739 · Cited by 33
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Janiszewski, L. N., Minson, M., Allen, M. A., Dowell, R. D., & Palmer, A. E. (2021) · Infection and Immunity · doi:10.1128/iai.00273-21 · Cited by 6
Metadata
- Authors
- Eisele, N. A., Ruby, T., Jacobson, A., Manzanillo, P. S., Cox, J. S., Lam, L., Mukundan, L., Chawla, A., & Monack, D. M.
- Venue
- Cell Host & Microbe
- Publisher
- Elsevier BV
- Published
- 2013-08
- Volume
- 14
- Issue
- 2
- Pages
- 171-182
- ISSN
- 1931-3128 (ISSN-L)
- OpenAlex
- W1992149604
- Cited by
- 224
- References
- 14
- FWCI
- 22.67
- Type
- journal article
- Language
- en
- Open access
- bronze
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- CoChat. (2026). Citation check: Salmonella Require the Fatty Acid Regulator PPARδ for the Establishment of a Metabolic Environment Essential for Long-Term Persistence. https://app.cochat.ai/papers/10.1016/j.chom.2013.07.010
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- Eisele, N. A., Ruby, T., Jacobson, A., Manzanillo, P. S., Cox, J. S., Lam, L., Mukundan, L., Chawla, A., & Monack, D. M. (2013). Salmonella Require the Fatty Acid Regulator PPARδ for the Establishment of a Metabolic Environment Essential for Long-Term Persistence. Cell Host & Microbe. https://doi.org/10.1016/j.chom.2013.07.010
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