The DOI matches its Crossref record; 38 of the 38 references it cites were found in a registry or an index.
Bacterial Lipopolysaccharide Binding Enhances Virion Stability and Promotes Environmental Fitness of an Enteric Virus
Open accessAbstract
Summary Enteric viruses, including poliovirus and reovirus, encounter a vast microbial community in the mammalian gastrointestinal tract, which has been shown to promote virus replication and pathogenesis. Investigating the underlying mechanisms, we find that poliovirus binds bacterial surface polysaccharides, which enhances virion stability and cell attachment by increasing binding to the viral receptor. Additionally, we identified a poliovirus mutant, VP1-T99K, with reduced lipopolysaccharide (LPS) binding. Although T99K and WT poliovirus cell attachment, replication and pathogenesis in mice are equivalent, following peroral inoculation of mice, VP1-T99K poliovirus was unstable in feces. Consequently, the ratio of mutant virus in feces is reduced following additional cycles of infection in mice. Thus, the mutant virus incurs a fitness cost when environmental stability is a factor. These data suggest that poliovirus binds bacterial surface polysaccharides, enhancing cell attachment and environmental stability, potentially promoting transmission to a new host.
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Modulation of immune development and function by intestinal microbiota
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The Commensal Microbiota and Viral Infection: A Comprehensive Review
Li, N., Ma, W.-T., Pang, M., Fan, Q.-L., & Hua, J.-L. (2019) · Frontiers in Immunology · doi:10.3389/fimmu.2019.01551 · Cited by 283
Metadata
- Authors
- Robinson, C. M., Jesudhasan, P. R., & Pfeiffer, J. K.
- Venue
- Cell Host & Microbe
- Publisher
- Elsevier BV
- Published
- 2014-01
- Volume
- 15
- Issue
- 1
- Pages
- 36-46
- ISSN
- 1931-3128 (ISSN-L)
- OpenAlex
- W2058530259
- Cited by
- 317
- References
- 38
- FWCI
- 13.90
- Type
- journal article
- Language
- en
- Open access
- bronze
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- Robinson, C. M., Jesudhasan, P. R., & Pfeiffer, J. K. (2014). Bacterial Lipopolysaccharide Binding Enhances Virion Stability and Promotes Environmental Fitness of an Enteric Virus. Cell Host & Microbe. https://doi.org/10.1016/j.chom.2013.12.004
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Contains information from the Semantic Scholar Academic Graph Datasets, made available under the ODC Attribution License (ODC-BY 1.0).
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