The gut microbiota in IBD
Open accessAbstract
IBD-ulcerative colitis and Crohn's disease-is emerging as a worldwide epidemic. An association between the increased incidence of IBD and environmental factors linked to socioeconomic development has been persistently detected in different parts of the world. The lifestyle in developed countries might impair the natural patterns of microbial colonization of the human gut. The interaction of microbes with mucosal immune compartments in the gut seems to have a major role in priming and regulating immunity. In IBD, mucosal lesions are generated by an excessive or dysregulated immune response against commensal microbes in the gut. In individuals with a genetic susceptibility to IBD, abnormal microbial colonization of the gastrointestinal tract might be the origin of such dysregulation. Developments in gene-sequencing technologies, as well as increased availability of powerful bioinformatic tools, have enabled novel insights into the microbial composition of the human gut microbiota and the effect of microbial communities on human physiology and disease. Studies that used these technologies indicate that dysbiosis (that is, abnormal microbiota composition) and decreased complexity of the gut microbial ecosystem are common features in patients with Crohn's disease or ulcerative colitis. Whether such changes are a cause or a consequence of the disease remains to be elucidated.
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There is increasing evidence of the pathogenic implication of the host microbiota in inflammatory bowel disease (IBD), as several taxonomic and functional changes, as well as imbalances in the host-microbiota cross-talk, have been described.
“There is increasing evidence of the pathogenic implication of the host microbiota in inflammatory bowel disease (IBD), as several taxonomic and functional changes, as well as imbalances in the host-microbiota cross-talk, have been described [29] .”
From Intestinal microbiota in health and disease: Role of bifidobacteria in gut homeostasis (2014) · cites this paper as [29]
Clinical and basic evidence suggests that dysbiosis has a key role in the initiation and progression of chronic inflammation in the pouch reservoir.
“Clinical and basic evidence suggests that dysbiosis has a key role in the initiation and progression of chronic inflammation in the pouch reservoir [29] .”
From Intestinal microbiota in health and disease: Role of bifidobacteria in gut homeostasis (2014) · cites this paper as [29]
Low abundance of Faecalibacterium prausnitzii is associated with a higher risk of postoperative recurrence of ileal disease.
“UC and Crohn´s disease (CD) present a low abundance of F. prausnitzii, which has known anti-inflammatory properties [38] , and this is associated with a higher risk of postoperative recurrence of ileal disease [29] , and with a concomitant increase in the abundance of Escherichia coli (E.coli) [39] .”
From Intestinal microbiota in health and disease: Role of bifidobacteria in gut homeostasis (2014) · cites this paper as [29]
Advanced molecular techniques have demonstrated fundamental differences in microbial composition and function in IBD patients.
“Advanced molecular techniques have demonstrated fundamental differences in both microbial composition and function in patients with IBD.56–58”
From Update on Fecal Microbiota Transplantation 2015: Indications, Methodologies, Mechanisms, and Outlook (2015) · cites this paper as [57]
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- Authors
- Manichanh, C., Borruel, N., Casellas, F., & Guarner, F.
- Affiliations
- Vall d'Hebron Hospital Universitari (ES)
- Corresponding author
- Guarner, Francisco
- Venue
- Nature Reviews Gastroenterology & Hepatology
- Published
- 2012-08-21
- Volume
- 9
- Issue
- 10
- Pages
- 599-608
- ISSN
- 1759-5045 (ISSN-L)
- 1759-5053
- OpenAlex
- W2090711753
- Cited by
- 1,160
- References
- 78
- Citations by year
- 2026: 35 · 2025: 53 · 2024: 80 · 2023: 89 · 2022: 92 · 2021: 112 · 2020: 86 · 2019: 102 · 2018: 86 · 2017: 85 · 2016: 95 · 2015: 97 · 2014: 86 · 2013: 57 · 2012: 5
- FWCI
- 7.15
- Type
- journal article
- Language
- en
- Open access
- green
- zenodo.org
- Licence
- other-oa
- www.springer.com/tdm (tdm)
- Locations
- Nature Reviews Gastroenterology & Hepatology (publishedVersion)
- PubMed (publishedVersion)
- Zenodo (CERN European Organization for Nuclear Research) (submittedVersion, other-oa)
- Funders
- European Commission
- Topics
- Life Sciences › Biochemistry, Genetics and Molecular Biology › Molecular Biology › Gut microbiota and health
- Life Sciences › Biochemistry, Genetics and Molecular Biology › Genetics › Inflammatory Bowel Disease
- Health Sciences › Medicine › Epidemiology › Microscopic Colitis
- Keywords
- gut microbiota, inflammatory bowel disease, Crohn's disease, ulcerative colitis, dysbiosis, microbial colonization, mucosal immunity, commensal microorganisms, genetic susceptibility, environmental risk factors, microbial diversity, pathogenesis
- MeSH terms
- Humans, Immune Tolerance, Immunity, Innate, Intestinal Mucosa, Life Style, Risk Factors, Symbiosis, Inflammatory Bowel Diseases, Incidence, Gastrointestinal Tract, Metagenome
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