The DOI matches its Crossref record; 39 of the 39 references it cites were found in a registry or an index.
Cadherin-related family member 3, a childhood asthma susceptibility gene product, mediates rhinovirus C binding and replication
Open accessAbstract
Significance: The rhinovirus C (RV-C) species was first identified in 2006 and is a major cause of acute respiratory illnesses in children and hospitalizations for exacerbations of asthma. In this study, we discovered that expression of human cadherin-related family member 3 (CDHR3), a transmembrane protein with yet unknown biological function, enables RV-C binding and replication in normally unsusceptible host cells. Intriguingly, we found that a coding SNP (rs6967330, C 529 Y) in CDHR3, previously linked to wheezing illnesses and hospitalizations for childhood asthma by genetic analysis, also mediates enhanced RV-C binding and increased progeny yields in vitro. Finally, using structural modeling, we identified potential binding sites in CDHR3 domains 1 and 2 interacting with viral capsid surface regions that are highly conserved among RV-C types.
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Metadata
- Authors
- Bochkov, Y. A., Watters, K., Ashraf, S., Griggs, T. F., Devries, M. K., Jackson, D. J., Palmenberg, A. C., & Gern, J. E.
- Venue
- Proceedings of the National Academy of Sciences
- Published
- 2015-04-06
- Volume
- 112
- Issue
- 17
- Pages
- 5485-5490
- ISSN
- 0027-8424 (ISSN-L)
- 1091-6490
- OpenAlex
- W1992974787
- Cited by
- 422
- References
- 39
- FWCI
- 30.96
- Type
- journal article
- Language
- en
- Open access
- green
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- Bochkov, Y. A., Watters, K., Ashraf, S., Griggs, T. F., Devries, M. K., Jackson, D. J., Palmenberg, A. C., & Gern, J. E. (2015). Cadherin-related family member 3, a childhood asthma susceptibility gene product, mediates rhinovirus C binding and replication. Proceedings of the National Academy of Sciences. https://doi.org/10.1073/pnas.1421178112
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