The DOI matches its Crossref record; 8 of the 8 references it cites were found in a registry or an index.
A Host-Produced Autoinducer-2 Mimic Activates Bacterial Quorum Sensing
Open accessAbstract
Summary Host-microbial symbioses are vital to health; nonetheless, little is known about the role cross-kingdom signaling plays in these relationships. In a process called quorum sensing, bacteria communicate with one another using extracellular signal molecules called autoinducers. One autoinducer, AI-2, is proposed to promote inter-species bacterial communication, including in the mammalian gut. We show that mammalian epithelia produce an AI-2 mimic activity in response to bacteria or tight-junction disruption. This AI-2 mimic is detected by the bacterial AI-2 receptor, LuxP/LsrB, and can activate quorum-sensing-controlled gene expression, including in the enteric pathogen Salmonella typhimurium. AI-2 mimic activity is induced when epithelia are directly or indirectly exposed to bacteria, suggesting that a secreted bacterial component(s) stimulates its production. Mutagenesis revealed genes required for bacteria to both detect and stimulate production of the AI-2 mimic. These findings uncover a potential role for the mammalian AI-2 mimic in fostering cross-kingdom signaling and host-bacterial symbioses.
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Cites
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Outer Membrane Vesicles of a Human Commensal Mediate Immune Regulation and Disease Protection
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Cited by
Quorum sensing signal-response systems in Gram-negative bacteria
Papenfort, K., & Bassler, B. L. (2016) · Nature Reviews Microbiology · doi:10.1038/nrmicro.2016.89 · Cited by 2,256
Self-citationBacterial quorum sensing in complex and dynamically changing environments
Mukherjee, S., & Bassler, B. L. (2019) · Nature Reviews Microbiology · doi:10.1038/s41579-019-0186-5 · Cited by 1,374
Self-citationDeciphering the quorum-sensing lexicon of the gut microbiota
Oliveira, R. A., Cabral, V., Torcato, I., & Xavier, K. B. (2023) · Cell Host & Microbe · doi:10.1016/j.chom.2023.03.015 · Cited by 74
Metadata
- Authors
- Ismail, A. S., Valastyan, J. S., & Bassler, B. L.
- Venue
- Cell Host & Microbe
- Publisher
- Elsevier BV
- Published
- 2016-04
- Volume
- 19
- Issue
- 4
- Pages
- 470-480
- ISSN
- 1931-3128 (ISSN-L)
- OpenAlex
- W2301415099
- Cited by
- 162
- References
- 8
- FWCI
- 6.47
- Type
- journal article
- Language
- en
- Open access
- bronze
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- Ismail, A. S., Valastyan, J. S., & Bassler, B. L. (2016). A Host-Produced Autoinducer-2 Mimic Activates Bacterial Quorum Sensing. Cell Host & Microbe. https://doi.org/10.1016/j.chom.2016.02.020
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