Stimulation of bacterial growth by heat-stable, norepinephrine-induced autoinducers
Abstract
The ability of norepinephrine to increase the growth of Escherichia coli in a serum-based medium has previously been shown to be due to the production of an autoinducer of growth during early log phase. Seventeen Gram-negative and 6 Gram-positive clinical isolates were examined for a similar ability to respond to norepinephrine, and to synthesise autoinducer. The majority of Gram-negative strains both produced and responded to heat-stable norepinephrine-induced autoinducers of growth. Most of these autoinducers showed a high degree of cross-species activity, suggesting the existence of a novel family of Gram-negative bacterial signalling molecules. In contrast, although a number of Gram-positive strains were able to respond to norepinephrine, the majority failed to produce autoinducers in the presence of norepinephrine.
Integrity signals
Registry
Cites
Statistics
Claims the paper makes
Claims other papers make about this one
Each is checked against this paper’s own text: does it say what the citing paper says it does?
Bacterial growth promotion by host stress molecules is not unique to P aeruginosa and is also seen with Streptococcus pneumoniae, S aureus, and Klebsiella pneumoniae.
“Bacterial growth promotion by host stress molecules is not unique to P aeruginosa, and is also seen with Streptococcus pneumoniae,121 S aureus,122 and Klebsiella pneumoniae.”
From The microbiome and critical illness (2016) · cites this paper as [123]
Cites
Catecholamine induced growth of gram negative bacteria
Lyte, M., & Ernst, S. (1992) · Life Sciences · doi:10.1016/0024-3205(92)90273-r · Cited by 396 · see citing works
Self-citationMarshall, J. C. (1988) · Archives of Surgery · doi:10.1001/archsurg.1988.01400270043006 · Cited by 328 · see citing works
The adrenergic innervation of the gastrointestinal tract
Furness, J. B., & Costa, M. (1974) · Springer eBooks · doi:10.1007/3-540-06498-2_1 · Cited by 282 · see citing works
Deitch, E. A., MAEJIMA, K., & Berg, R. D. (1985) · The Journal of Trauma: Injury, Infection, and Critical Care · doi:10.1097/00005373-198505000-00002 · Cited by 259 · see citing works
Neuroendocrine–Bacterial Interactions in a Neurotoxin-Induced Model of Trauma
Lyte, M., & Bailey, M. T. (1997) · Journal of Surgical Research · doi:10.1006/jsre.1997.5130 · Cited by 168 · see citing works
Self-citationThe role of microbial endocrinology in infectious disease
Lyte, M. (1993) · Journal of Endocrinology · doi:10.1677/joe.0.1370343 · Cited by 168 · see citing works
Self-citationLyte, M., Arulanandam, B. P., & Frank, C. D. (1996) · Journal of Laboratory and Clinical Medicine · doi:10.1016/s0022-2143(96)80011-4 · Cited by 142 · see citing works
Self-citationNorepinephrine-Induced Expression of the K99 Pilus Adhesin of EnterotoxigenicEscherichia coli
Lyte, M., Erickson, A. K., Arulanandam, B. P., Frank, C. D., Crawford, M., & Francis, D. H. (1997) · Biochemical and Biophysical Research Communications · doi:10.1006/bbrc.1997.6356 · Cited by 114 · see citing works
Self-citationProduction of an autoinducer of growth by norepinephrine culturedEscherichia coliO157:H7
Lyte, M., Frank, C. D., & Green, B. T. (1996) · FEMS Microbiology Letters · doi:10.1111/j.1574-6968.1996.tb08196.x · Cited by 111 · see citing works
Self-citationLyte, M., & Ernst, S. (1993) · Biochemical and Biophysical Research Communications · doi:10.1006/bbrc.1993.1068 · Cited by 100 · see citing works
Self-citationMammalian hormones in microbial cells
Lenard, J. (1992) · Trends in Biochemical Sciences · doi:10.1016/0968-0004(92)90323-2 · Cited by 98 · see citing works
Infection, the gut and the development of the multiple organ dysfunction syndrome.
Nieuwenhuijzen, G. A. P., Deitch, E. A., & Goris, R. J. A. (1996) · PubMed · Cited by 87 · see citing works
The Catecholamine Response to Multisystem Trauma
Woolf, P. D. (1992) · Archives of Surgery · doi:10.1001/archsurg.1992.01420080033005 · Cited by 84 · see citing works
Coulanges, V, Andre, P., Ziegler, O., Buchheit, L., & Vidon, D. J. (1997) · Infection and Immunity · doi:10.1128/iai.65.7.2778-2785.1997 · Cited by 75 · see citing works
Costa, M., Brookes, S. J., Waterman, S. A., Song, Z.-M., & Mayo, C. R. (1993) · Journal of the Autonomic Nervous System · doi:10.1016/0165-1838(93)90134-g · Cited by 53 · see citing works
Lyte, M. (2006) · FEMS Microbiology Letters · doi:10.1111/j.1574-6968.1997.tb12651.x · Cited by 26 · see citing works
Self-citationLocal release of monoamines in the gastrointestinal tract: An in vivo study in rabbits
Meirieu, O., Pairet, M., Sutra, J. F., et al. (1986) · Life Sciences · doi:10.1016/0024-3205(86)90599-0 · Cited by 23 · see citing works
CHANGES IN TISSUE CONTENT OF CATECHOL AMINES IN TRAUMATIC SHOCK.
Be, Z., Palmerio, C., & Fine, J. (1964) · PubMed · Cited by 16 · see citing works
Constantinescu, M. (2016) · Advances in Experimental Medicine and Biology · doi:10.1007/978-3-319-27592-5 · Cited by 1 · see citing works
Flagged first, then by citations
Cited by
Sorted by citations
Bacteria–host communication: the language of hormones
Sperandio, V., Torres, A. G., Jarvis, B., Nataro, J. P., & Kaper, J. B. (2003) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.1537100100 · Cited by 902 · see citing works
The microbiome and critical illness
Dickson, R. P. (2016) · The Lancet Respiratory Medicine · doi:10.1016/s2213-2600(15)00427-0 · Cited by 460 · see citing works
Microbial endocrinology: how stress influences susceptibility to infection
Freestone, P. P. E., Sandrini, S. M., Haigh, R. D., & Lyte, M. (2008) · Trends in Microbiology · doi:10.1016/j.tim.2007.11.005 · Cited by 299 · see citing works
Self-citationAlverdy, J., Holbrook, C., Rocha, F., Seiden, L., Licheng, R., Wu, Musch, M., Chang, E., Ohman, D., & Suh, S. (2000) · Annals of Surgery · doi:10.1097/00000658-200010000-00003 · Cited by 207 · see citing works
Norepinephrine increases the pathogenic potential of <i>Campylobacter jejuni</i>
Cogan, T. A., Thomas, A. O., Rees, L. E. N., Taylor, A. H., Jepson, M. A., Williams, P. H., Ketley, J., & Humphrey, T. J. (2007) · Gut · doi:10.1136/gut.2006.114926 · Cited by 203 · see citing works
Self-citationAlverdy, J. C., Laughlin, R. S., & Wu, L. (2003) · Critical Care Medicine · doi:10.1097/01.ccm.0000045576.55937.67 · Cited by 200 · see citing works
Sandrini, S. M., Shergill, R., Woodward, J., Muralikuttan, R., Haigh, R. D., Lyte, M., & Freestone, P. P. (2010) · Journal of Bacteriology · doi:10.1128/jb.01028-09 · Cited by 143 · see citing works
Self-citationMicrobial endocrinology: Host-bacteria communication within the gut microbiome
Sandrini, S., Aldriwesh, M., Alruways, M., & Freestone, P. (2015) · Journal of Endocrinology · doi:10.1530/joe-14-0615 · Cited by 130 · see citing works
Self-citationBailey, M. T., Engler, H., & Sheridan, J. F. (2006) · Journal of Neuroimmunology · doi:10.1016/j.jneuroim.2005.09.008 · Cited by 133 · see citing works
Freestone, P. P. E., Haigh, R. D., & Lyte, M. (2007) · FEMS Microbiology Letters · doi:10.1111/j.1574-6968.2006.00619.x · Cited by 110 · see citing works
Self-citationPseudomonas aeruginosa -Catecholamine Inotrope Interactions
Freestone, P. P., Hirst, R. A., Sandrini, S. M., Sharaff, F., Fry, H., Hyman, S., & O'Callaghan, C. (2012) · Chest · doi:10.1378/chest.11-2614 · Cited by 107 · see citing works
Self-citationVisschers, R. G. J., Luyer, M. D., Schaap, F. G., Olde Damink, S. W. M., & Soeters, P. B. (2013) · Current Opinion in Clinical Nutrition and Metabolic Care · doi:10.1097/mco.0b013e32836410a4 · Cited by 60 · see citing works
Ünsal, H., Balkaya, M., Ünsal, C., Bıyık, H., Başbülbül, G., & Poyrazoğlu, E. (2008) · Digestive Diseases and Sciences · doi:10.1007/s10620-007-0089-6 · Cited by 31 · see citing works
Identification and Characterisation of an Iron-Responsive Candidate Probiotic
Bailey, J. R., Probert, C. S. J., & Cogan, T. A. (2011) · PLoS ONE · doi:10.1371/journal.pone.0026507 · Cited by 25 · see citing works
- Authors
- Freestone, P. P. E., Haigh, R. D., Williams, P. H., & Lyte, M.
- Affiliations
- University of Leicester (GB)
- Minnesota State University, Mankato (US)
- Corresponding author
- Freestone, Primrose P.E
- Venue
- FEMS Microbiology Letters
- Publisher
- Oxford University Press (OUP)
- Published
- 1999-03
- Volume
- 172
- Issue
- 1
- Pages
- 53-60
- ISSN
- 0378-1097 (ISSN-L)
- 1574-6968
- OpenAlex
- W2134412511
- Cited by
- 199
- References
- 19
- Citations by year
- 2026: 4 · 2025: 7 · 2024: 4 · 2023: 9 · 2022: 5 · 2021: 18 · 2020: 11 · 2019: 6 · 2018: 9 · 2017: 4 · 2016: 16 · 2015: 5 · 2014: 6 · 2013: 8 · 2012: 11
- FWCI
- 1.38
- Type
- journal article
- Language
- en
- Open access
- closed
- Locations
- FEMS Microbiology Letters (publishedVersion)
- PubMed (publishedVersion)
- Leicester Research Archive (University of Leicester) (submittedVersion)
- Funders
- Wellcome Trust
- National Institutes of Health (5k02mh001371-02)
- State Key Laboratory of Synthetical Automation for Process Industries
- National Institute of Mental Health (MH-50431, MH01371, R01MH050431)
- Topics
- Life Sciences › Biochemistry, Genetics and Molecular Biology › Molecular Biology › Bacterial biofilms and quorum sensing
- Life Sciences › Biochemistry, Genetics and Molecular Biology › Genetics › Bacterial Genetics and Biotechnology
- Life Sciences › Biochemistry, Genetics and Molecular Biology › Endocrinology › Escherichia coli research studies
- Keywords
- norepinephrine, autoinducers, bacterial growth stimulation, Escherichia coli, bacterial quorum sensing, Gram-negative bacteria, Gram-positive bacteria, clinical bacterial isolates
- MeSH terms
- Gram-Negative Bacteria, Gram-Positive Bacteria, Humans, Norepinephrine, Gram-Negative Bacterial Infections, Gram-Positive Bacterial Infections, Culture Media, Conditioned
About these checks
Registry, retraction, Cites and statistics results are computed, not judged, with one exception: a printed reference that no index lists is read once by a model before it counts as a citation error. Claims are extracted by a model and kept only when their quote appears verbatim in the text; each cited source is then checked, with a model’s help, for whether it says what the claim relies on. Those verdicts can be wrong — read the claim’s quote and the cited source before relying on one.
Statistics and arithmetic are recomputed, not judged.
Confidence bands are shown only for fields calibrated on our annotated test set. None is calibrated yet, so no band is shown.
What counts as a claim ›How we measure confidence ›How we check this ›
Are you an author, or do you see a problem with this page? Request a review
