Cited by 866Gut microbiota and healthSalmonella and Campylobacter epidemiologyEscherichia coli research studies

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Depletion of Butyrate-Producing Clostridia from the Gut Microbiota Drives an Aerobic Luminal Expansion of Salmonella

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Rivera-Chávez, Fabian, Zhang, Lillian F., Faber, Franziska, Lopez, Christopher A., Byndloss, Mariana X., Olsan, Erin E., Xu, Gege, Velazquez, Eric M., Lebrilla, Carlito B., Winter, Sebastian E., Bäumler, Andreas J.·2016·Cell Host & Microbe

DOI 10.1016/j.chom.2016.03.004PMC PMC4832419

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Abstract

The mammalian intestine is host to a microbial community that prevents pathogen expansion through unknown mechanisms, while antibiotic treatment can increase susceptibility to enteric pathogens. Here we show that streptomycin treatment depleted commensal, butyrate-producing Clostridia from the mouse intestinal lumen, leading to decreased butyrate levels, increased epithelial oxygenation, and aerobic expansion of Salmonella enterica serovar Typhimurium. Epithelial hypoxia and Salmonella restriction could be restored by tributyrin treatment. Clostridia depletion and aerobic Salmonella expansion were also observed in the absence of streptomycin treatment in genetically resistant mice but proceeded with slower kinetics and required the presence of functional Salmonella type III secretion systems. The Salmonella cytochrome bd-II oxidase synergized with nitrate reductases to drive luminal expansion, and both were required for fecal-oral transmission. We conclude that Salmonella virulence factors and antibiotic treatment promote pathogen expansion through the same mechanism: depletion of butyrate-producing Clostridia to elevate epithelial oxygenation, allowing aerobic Salmonella growth.

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Atarashi, K., Tanoue, T., Shima, T., Imaoka, A., Kuwahara, T., Momose, Y., Cheng, G., Yamasaki, S., Saito, T., Ohba, Y., et al. (2011) · Science · doi:10.1126/science.1198469 · Cited by 3,752
Treg induction by a rationally selected mixture of Clostridia strains from the human microbiota
Atarashi, K., Tanoue, T., Oshima, K., Suda, W., Nagano, Y., Nishikawa, H., Fukuda, S., Saito, T., Narushima, S., Hase, K., et al. (2013) · Nature · doi:10.1038/nature12331 · Cited by 2,872
The Global Burden of Nontyphoidal Salmonella Gastroenteritis
Majowicz, S. E., Musto, J., Scallan, E., Angulo, F. J., Kirk, M., O’Brien, S. J., Jones, T. F., Fazil, A., & Hoekstra, R. M. (2010) · Clinical Infectious Diseases · doi:10.1086/650733 · Cited by 2,465
Diversity, metabolism and microbial ecology of butyrate-producing bacteria from the human large intestine
Louis, P., & Flint, H. J. (2009) · FEMS Microbiology Letters · doi:10.1111/j.1574-6968.2009.01514.x · Cited by 2,179
Complete genome sequence of Salmonella enterica serovar Typhimurium LT2
McClelland, M., Sanderson, K. E., Spieth, J., Clifton, S. W., Latreille, P., Courtney, L., Porwollik, S., Ali, J., Dante, M., Du, F., et al. (2001) · Nature · doi:10.1038/35101614 · Cited by 1,838
Crosstalk between microbiota-derived short-chain fatty acids and intestinal epithelial HIF augments tissue barrier function
Kelly, C. J., Zheng, L., Campbell, E. L., Saeedi, B., Scholz, C. C., Bayless, A. J., Wilson, K. E., Glover, L. E., Kominsky, D. J., Magnuson, A., et al. (2015) · Cell Host & Microbe · doi:10.1016/j.chom.2015.03.005 · Cited by 1,716
Gut inflammation provides a respiratory electron acceptor for Salmonella
Winter, S., Thiennimitr, P., Winter, M. G., Butler, B. P., Huseby, D. L., Crawford, R. W., Russell, J. M., Bevins, C. L., Adams, L. G., Tsolis, R. M., et al. (2010) · Nature · doi:10.1038/nature09415 · Cited by 1,271
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Carreau, A., Hafny‐Rahbi, B. E., Matejuk, A., Grillon, C., & Kieda, C. (2011) · Journal of Cellular and Molecular Medicine · doi:10.1111/j.1582-4934.2011.01258.x · Cited by 1,246
Simultaneous Identification of Bacterial Virulence Genes by Negative Selection
Hensel, M., Shea, J. E., Gleeson, C., Jones, M. D., Dalton, E. C., & Holden, D. W. (1995) · Science · doi:10.1126/science.7618105 · Cited by 1,200
Revealing the Bacterial Butyrate Synthesis Pathways by Analyzing (Meta)genomic Data
Vital, M., Howe, A. C., & Tiedje, J. M. (2014) · mBio · doi:10.1128/mbio.00889-14 · Cited by 1,189

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Kim, J.-S., Uppalapati, S. R., Margolis, A., McClelland, M., Elajaili, H. B., Nozik, E., Liu, L., & Vázquez‐Torres, A. (2026) · Nature Microbiology · doi:10.1038/s41564-026-02443-y · Cited by 1
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Xu, Y., Bolvig, A. K., McCarthy-Sinclair, B., Marco, M. L., Knudsen, K. E. B., Hedemann, M. S., & Lærke, H. N. (2021) · Food & Function · doi:10.1039/d1fo00213a · Cited by 1
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王, 全., 郭, 小., Zhang, Z., 周, 志., 李, 舒., 冉, 超., & 何, 夙. (2017) · Scientia Sinica Vitae · doi:10.1360/n052017-00131 · Cited by 1
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Maceda, M. T. G. (1991) · A distancia
[The therapeutic use of potassium chloride in arrhythmia].
Tp, C. (1967) · PubMed
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Additional file 2 of Inactivation of the MSTN gene expression changes the composition and function of the gut microbiome in sheep
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Additional file 8 of Exposing new taxonomic variation with inflammation — a murine model-specific genome database for gut microbiome researchers
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Additional file 9 of RhoB affects colitis through modulating cell signaling and intestinal microbiome
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Additional file 11 of RhoB affects colitis through modulating cell signaling and intestinal microbiome
Yang, J., Pei, G., Sun, X., Xiao, Y., Miao, C., Zhou, L., Wang, B., Yang, L., Yu, M., Zhang, Z.-S., et al. (2022) · Figshare · doi:10.6084/m9.figshare.21151201
Additional file 4 of Inactivation of the MSTN gene expression changes the composition and function of the gut microbiome in sheep
Du, C., Zhou, X., Zhang, K., Huang, S., Wang, X., Zhou, S., & Chen, Y. (2022) · Figshare · doi:10.6084/m9.figshare.21546643
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Additional file 1 of Composition of mucus- and digesta-associated bacteria in growing pigs with and without diarrhea differed according to the presence of colonic inflammation
Panah, F. M., Lauridsen, C., Højberg, O., Jensen, H. E., & Nielsen, T. S. (2024) · Figshare · doi:10.6084/m9.figshare.26590646
Additional file 13 of RhoB affects colitis through modulating cell signaling and intestinal microbiome
Yang, J., Pei, G., Sun, X., Xiao, Y., Miao, C., Zhou, L., Wang, B., Yang, L., Yu, M., Zhang, Z.-S., et al. (2022) · Figshare · doi:10.6084/m9.figshare.21151207
Additional file 10 of RhoB affects colitis through modulating cell signaling and intestinal microbiome
Yang, J., Pei, G., Sun, X., Xiao, Y., Miao, C., Zhou, L., Wang, B., Yang, L., Yu, M., Zhang, Z.-S., et al. (2022) · Figshare · doi:10.6084/m9.figshare.21151195
Additional file 3 of Composition of mucus- and digesta-associated bacteria in growing pigs with and without diarrhea differed according to the presence of colonic inflammation
Panah, F. M., Lauridsen, C., Højberg, O., Jensen, H. E., & Nielsen, T. S. (2024) · Figshare · doi:10.6084/m9.figshare.26590652
Additional file 12 of RhoB affects colitis through modulating cell signaling and intestinal microbiome
Yang, J., Pei, G., Sun, X., Xiao, Y., Miao, C., Zhou, L., Wang, B., Yang, L., Yu, M., Zhang, Z.-S., et al. (2022) · Figshare · doi:10.6084/m9.figshare.21151204
Additional file 1 of Closely related Salmonella Derby strains triggered distinct gut microbiota alteration
Yuan, X., Xue, H., Xu, X., Jiao, X., Pan, Z., & Zhang, Y. (2022) · Figshare · doi:10.6084/m9.figshare.19068744

Authors: Rivera-Chávez, F., Zhang, L. F., Faber, F., Lopez, C. A., Byndloss, M. X., Olsan, E. E., Xu, G., Velazquez, E. M., Lebrilla, C. B., Winter, S. E., & Bäumler, A. J.
Affiliations: University of California, Davis (US)
The University of Texas Southwestern Medical Center (US)
Corresponding author: Bäumler, Andreas J.
ORCID: Rivera-Chávez, Fabian
Faber, Franziska
Lopez, Christopher A.
Byndloss, Mariana X.
Olsan, Erin E.
Xu, Gege
Velazquez, Eric M.
Lebrilla, Carlito B.
Winter, Sebastian E.
Bäumler, Andreas J.
Venue: Cell Host & Microbe
Publisher: Elsevier BV
Published: 2016-04
Volume: 19
Issue: 4
Pages: 443-454
ISSN: 1931-3128 (ISSN-L)
DOI: 10.1016/j.chom.2016.03.004
PMC: PMC4832419
OpenAlex: W2338773685
Cited by: 864
References: 50
Citations by year: 2026: 75 · 2025: 93 · 2024: 93 · 2023: 90 · 2022: 115 · 2021: 127 · 2020: 74 · 2019: 70 · 2018: 60 · 2017: 46 · 2016: 18
FWCI: 33.77
Type: journal article
Language: en
Open access: bronze
doi.org
Licence: www.elsevier.com/tdm/userlicense/1.0/ (tdm)
www.elsevier.com/open-access/userlicense/1.0/ (vor, 377 d)
Locations: Cell Host & Microbe (publishedVersion)
PubMed (publishedVersion)
PubMed Central (acceptedVersion)
eScholarship (California Digital Library) (submittedVersion)
Funders: National Institutes of Health (T32OD010931, T35OD010956)
National Institute of General Medical Sciences (R25GM056765)
National Institute of Allergy and Infectious Diseases (R01AI044170, AI112949, AI103248, R01AI076278, R21AI103248, AI060555, R01AI076246, F31AI112241, AI096528, AI112241, R56AI112949, R21AI117303, R37AI044170, T32AI060555, R01AI112949, R01AI096528)
Topics: Life Sciences › Biochemistry, Genetics and Molecular Biology › Molecular Biology › Gut microbiota and health
Life Sciences › Agricultural and Biological Sciences › Food Science › Salmonella and Campylobacter epidemiology
Life Sciences › Immunology and Microbiology › Microbiology › Escherichia coli research studies
Keywords: gut microbiota depletion, Salmonella typhimurium, streptomycin, antibiotic-induced dysbiosis, tributyrin, type III secretion system, nitrate reductase, fecal-oral transmission, host-pathogen interaction, commensal bacteria
MeSH terms: Gastrointestinal Microbiome, Aerobiosis, Animals, Anti-Bacterial Agents, Bacterial Proteins, Clostridium, Female, Intestines, Mice, Inbred CBA, Mice, Inbred C57BL, Oxygen, Salmonella typhimurium, Streptomycin, Butyric Acid, Virulence Factors, Mice

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Depletion of Butyrate-Producing Clostridia from the Gut Microbiota Drives an Aerobic Luminal Expansion of Salmonella

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