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Depletion of Butyrate-Producing Clostridia from the Gut Microbiota Drives an Aerobic Luminal Expansion of Salmonella
Open accessAbstract
The mammalian intestine is host to a microbial community that prevents pathogen expansion through unknown mechanisms, while antibiotic treatment can increase susceptibility to enteric pathogens. Here we show that streptomycin treatment depleted commensal, butyrate-producing Clostridia from the mouse intestinal lumen, leading to decreased butyrate levels, increased epithelial oxygenation, and aerobic expansion of Salmonella enterica serovar Typhimurium. Epithelial hypoxia and Salmonella restriction could be restored by tributyrin treatment. Clostridia depletion and aerobic Salmonella expansion were also observed in the absence of streptomycin treatment in genetically resistant mice but proceeded with slower kinetics and required the presence of functional Salmonella type III secretion systems. The Salmonella cytochrome bd-II oxidase synergized with nitrate reductases to drive luminal expansion, and both were required for fecal-oral transmission. We conclude that Salmonella virulence factors and antibiotic treatment promote pathogen expansion through the same mechanism: depletion of butyrate-producing Clostridia to elevate epithelial oxygenation, allowing aerobic Salmonella growth.
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“When butyrate is reduced with antibiotic treatment oxygen availability increases, which promotes the growth of facultatively anaerobic pathogens [50].”
From Role of the gut microbiota in nutrient competition and protection against intestinal pathogen colonization (2023) · cites this paper as [50]
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Cites
Induction of Colonic Regulatory T Cells by Indigenous Clostridium Species
Atarashi, K., Tanoue, T., Shima, T., Imaoka, A., Kuwahara, T., Momose, Y., Cheng, G., Yamasaki, S., Saito, T., Ohba, Y., et al. (2011) · Science · doi:10.1126/science.1198469 · Cited by 3,752
Treg induction by a rationally selected mixture of Clostridia strains from the human microbiota
Atarashi, K., Tanoue, T., Oshima, K., Suda, W., Nagano, Y., Nishikawa, H., Fukuda, S., Saito, T., Narushima, S., Hase, K., et al. (2013) · Nature · doi:10.1038/nature12331 · Cited by 2,872
The Global Burden of Nontyphoidal Salmonella Gastroenteritis
Majowicz, S. E., Musto, J., Scallan, E., Angulo, F. J., Kirk, M., O’Brien, S. J., Jones, T. F., Fazil, A., & Hoekstra, R. M. (2010) · Clinical Infectious Diseases · doi:10.1086/650733 · Cited by 2,465
Louis, P., & Flint, H. J. (2009) · FEMS Microbiology Letters · doi:10.1111/j.1574-6968.2009.01514.x · Cited by 2,179
Complete genome sequence of Salmonella enterica serovar Typhimurium LT2
McClelland, M., Sanderson, K. E., Spieth, J., Clifton, S. W., Latreille, P., Courtney, L., Porwollik, S., Ali, J., Dante, M., Du, F., et al. (2001) · Nature · doi:10.1038/35101614 · Cited by 1,838
Kelly, C. J., Zheng, L., Campbell, E. L., Saeedi, B., Scholz, C. C., Bayless, A. J., Wilson, K. E., Glover, L. E., Kominsky, D. J., Magnuson, A., et al. (2015) · Cell Host & Microbe · doi:10.1016/j.chom.2015.03.005 · Cited by 1,716
Gut inflammation provides a respiratory electron acceptor for Salmonella
Winter, S., Thiennimitr, P., Winter, M. G., Butler, B. P., Huseby, D. L., Crawford, R. W., Russell, J. M., Bevins, C. L., Adams, L. G., Tsolis, R. M., et al. (2010) · Nature · doi:10.1038/nature09415 · Cited by 1,271
Self-citationWhy is the partial oxygen pressure of human tissues a crucial parameter? Small molecules and hypoxia
Carreau, A., Hafny‐Rahbi, B. E., Matejuk, A., Grillon, C., & Kieda, C. (2011) · Journal of Cellular and Molecular Medicine · doi:10.1111/j.1582-4934.2011.01258.x · Cited by 1,246
Simultaneous Identification of Bacterial Virulence Genes by Negative Selection
Hensel, M., Shea, J. E., Gleeson, C., Jones, M. D., Dalton, E. C., & Holden, D. W. (1995) · Science · doi:10.1126/science.7618105 · Cited by 1,200
Revealing the Bacterial Butyrate Synthesis Pathways by Analyzing (Meta)genomic Data
Vital, M., Howe, A. C., & Tiedje, J. M. (2014) · mBio · doi:10.1128/mbio.00889-14 · Cited by 1,189
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Self-citationYang, J., Pei, G., Sun, X., Xiao, Y., Miao, C., Zhou, L., Wang, B., Yang, L., Yu, M., Zhang, Z.-S., et al. (2022) · Figshare · doi:10.6084/m9.figshare.21151210
Panah, F. M., Lauridsen, C., Højberg, O., Jensen, H. E., & Nielsen, T. S. (2024) · Figshare · doi:10.6084/m9.figshare.26590649
Das, O., Masid, A., Chakraborty, M., Gope, A., Dutta, S., & Bhaumik, M. (2024) · Figshare · doi:10.6084/m9.figshare.26584221
Yang, J., Pei, G., Sun, X., Xiao, Y., Miao, C., Zhou, L., Wang, B., Yang, L., Yu, M., Zhang, Z.-S., et al. (2022) · Figshare · doi:10.6084/m9.figshare.21151222
Sun, P., Wang, M., Liu, Y.-X., Li, L., Chai, X., Zheng, W., Chen, S., Zhu, X., & Zhao, S. (2023) · Figshare · doi:10.6084/m9.figshare.23714236
Yang, J., Pei, G., Sun, X., Xiao, Y., Miao, C., Zhou, L., Wang, B., Yang, L., Yu, M., Zhang, Z.-S., et al. (2022) · Figshare · doi:10.6084/m9.figshare.21151219
Yang, J., Pei, G., Sun, X., Xiao, Y., Miao, C., Zhou, L., Wang, B., Yang, L., Yu, M., Zhang, Z.-S., et al. (2022) · Figshare · doi:10.6084/m9.figshare.21151216
Yang, J., Pei, G., Sun, X., Xiao, Y., Miao, C., Zhou, L., Wang, B., Yang, L., Yu, M., Zhang, Z.-S., et al. (2022) · Figshare · doi:10.6084/m9.figshare.21151213
Yang, J., Pei, G., Sun, X., Xiao, Y., Miao, C., Zhou, L., Wang, B., Yang, L., Yu, M., Zhang, Z.-S., et al. (2022) · Figshare · doi:10.6084/m9.figshare.21151234
Hu, J., Zou, H., Qiao, X., Wang, Y., Lv, M., Zhang, K., & Wang, F. (2024) · Figshare · doi:10.6084/m9.figshare.25876139
Yang, J., Pei, G., Sun, X., Xiao, Y., Miao, C., Zhou, L., Wang, B., Yang, L., Yu, M., Zhang, Z.-S., et al. (2022) · Figshare · doi:10.6084/m9.figshare.21151228
Lay, C., Chu, C. W., Purbojati, R. W., Acerbi, E., Drautz‐Moses, D. I., de Sessions, P. F., Jie, S., Ho, E. X. P., Kok, Y. J., Bi, X., et al. (2021) · Figshare · doi:10.6084/m9.figshare.14850770
Du, C., Zhou, X., Zhang, K., Huang, S., Wang, X., Zhou, S., & Chen, Y. (2022) · Figshare · doi:10.6084/m9.figshare.21546640
Yang, J., Pei, G., Sun, X., Xiao, Y., Miao, C., Zhou, L., Wang, B., Yang, L., Yu, M., Zhang, Z.-S., et al. (2022) · Figshare · doi:10.6084/m9.figshare.21151231
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Liang, Z., Zhang, X., Chen, S., Wang, M., Men, D., Liu, W., & Lv, X. (2025) · Foods · doi:10.3390/foods14244209
Mellouk, A., Maresca, M., Canaple, L., Michel, V., Lemâle, O., Goossens, T., & Consuegra, J. (2026) · Veterinary Research Communications · doi:10.1007/s11259-026-11108-4
Probiotics in poultry production: combating Salmonella spp. and enhancing food safety
Hoepers, P. G., Sousa, A. C. P., Costa, M. S., Sommerfeld, S., Huillet, E., & Fonseca, B. B. (2026) · World s Poultry Science Journal · doi:10.1080/00439339.2026.2635500
Role of macrophages in colon homeostasis
Chikina, A. S. (2020) · theses.fr (ABES) · doi:10.70675/914bf102zc92ez4351zb4dbz1945d4116eea
Martin‐Gallausiaux, C. (2018) · theses.fr (ABES) · doi:10.70675/c6162413z61d4z4a51z889bze8ca8724b717
Les cellules MAIT et la riboflavine dans les interactions hôte-microbiote
Morr, Y. E. (2021) · theses.fr (ABES) · doi:10.70675/c6a9fb38zefecz4f2ez8e2fz84c7e5f828dc
Cherrak, Y. (2020) · theses.fr (ABES) · doi:10.70675/50fe6f7bz2852z46e8z8c69z34c04bfce736
The role of non-coding RNAs (ncRNA) in the pathogenesis of Clostridioides difficile
Piattelli, E. (2023) · theses.fr (ABES) · doi:10.70675/430fbe25ze30az4c99z8defz8d76a374d4c5
Study of human perinatal B cells in the context of intestinal microbial colonization
Gu, Q. (2024) · theses.fr (ABES) · doi:10.70675/fdf94bf2z3bd1z42bezb8f0z3bb3a42a8771
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Lécuyer, E., Guendel, F., Cording, S., Nigro, G., Medvedovic, J., Dulauroy, S., Moguel-Houssin, H., Rincel, M., Chassaing, B., Vives, F. L., et al. (2026) · bioRxiv (Cold Spring Harbor Laboratory) · doi:10.64898/2026.04.20.719606
Scheidweiler, D., Bornet, E., Ochner, H., Blasche, S., Thiriet-Rupert, S., Dorison, L., Beloin, C., Davit, Y., Gobaa, S., Bharat, T. A. M., et al. (2026) · bioRxiv (Cold Spring Harbor Laboratory) · doi:10.64898/2026.05.02.721930
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Biasi, J. D., Giménez‐Bastida, J. A., & Krupa‐Kozak, U. (2026) · Nutrition Reviews · doi:10.1093/nutrit/nuaf252
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Gut microbiota associate with disease severity and survival in idiopathic pulmonary fibrosis
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Tabish, R. W., Lin, Y., Rochell, S. J., Pacheco, W. J., Bailey, M. A., Dozier, W. A., Robinson, K., & Hauck, R. (2026) · Poultry Science · doi:10.1016/j.psj.2026.107151
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Larabi, A. B., & Bäumler, A. J. (2026) · Molecular Cell · doi:10.1016/j.molcel.2026.05.021
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La-ongkham, O. (2026) · วารสารวิจัยและพัฒนาผลิตภัณฑ์อาหาร · doi:10.56825/jfrpd.2026.5616398
Lee, J., Kim, H., Kim, I., Yu, J., Park, I., Kim, J., Lee, G. S., Lee, S. H., Kim, W., Lee, W., et al. (2026) · JACS Au · doi:10.1021/jacsau.6c00763
El-Kafrawy, S. A., Abbas, A. T., El-Kafrawy, A. S., El-Daly, M. M., & Azhar, E. I. (2026) · Frontiers in Immunology · doi:10.3389/fimmu.2026.1903103
Persistence of non-typhoidal Salmonella across hosts and environments: a One Health perspective
Abdelgany, A., Wong, A., & Guan, J. (2026) · Frontiers in Microbiology · doi:10.3389/fmicb.2026.1830232
Birabaharan, M., Kaelber, D. C., Nizet, V., & Zarrinpar, A. (2026) · Open Forum Infectious Diseases · doi:10.1093/ofid/ofag457
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Vázquez‐Torres, A. (2026) · Nature Reviews Microbiology · doi:10.1038/s41579-026-01348-1
do Nascimento, C. S., Fonteles, T. V., de Oliveira, F. A., & Rodrigues, S. (2026) · Food Bioscience · doi:10.1016/j.fbio.2026.109607
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Miki, T., Haneda, T., Ito, M., Okada, N., & Kim, Y. (2026) · Microbiology and Immunology · doi:10.1111/1348-0421.70084
Biemond, J. J., Kullberg, R. F. J., Bénard, M. V., Savage, H. P., Bays, D. J., van Dam, A. P., Bart, A., Haaften, P. E. B.-V., Wentink-Bonnema, E. M., Ponsioen, C. Y., et al. (2026) · The Lancet Microbe · doi:10.1016/j.lanmic.2026.101432
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Benson, S., Chin, P., Rogatti, S., Scopelliti, A., Zechini, L., Heron, R., Dawson, C., Davey, A. E., Simpson, M. S., Wong, A. O., et al. (2026) · bioRxiv (Cold Spring Harbor Laboratory) · doi:10.64898/2026.08.11.744130
Sierra-Bakhshi, C. G., Farr, L. A., Smith, M. E., Kalaskey, T. A., Perkins, K. G., Winter, M. G., Sigdel, S., Winter, S., & Bogomolnaya, L. M. (2026) · bioRxiv (Cold Spring Harbor Laboratory) · doi:10.64898/2026.08.14.744872
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Oka, A., Bongers, G., Mishima, Y., Baltus, A. E., Gray, S. M., Liu, B., Herzog, J., Benedetto, J. R., Fan, T.-J., Jang, J., et al. (2026) · Cell Host & Microbe · doi:10.1016/j.chom.2026.08.003 · Cited by 1
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Morua, E., Criado‐Mesas, L., Chumaceiro, G., Palma, M. L., Malinverni, R., Sanseverino, W., Cigliano, R. A., Cuyas, L., & Matías‐Hernández, L. (2026) · Veterinary Sciences · doi:10.3390/vetsci13090877
Pang, T., Zhou, X., & Ge, Z. (2026) · Metabolites · doi:10.3390/metabo16090638
Liu, T., Zhang, X., Xu, H., Wu, X., Fan, Y., Jiang, H., Pan, X., Ma, R., Liu, C., & Tian, Y. (2026) · Food Hydrocolloids · doi:10.1016/j.foodhyd.2026.113354
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Gerner, R. R., Almási, É. D. H., & Stecher, B. (2026) · Springer eBooks · doi:10.1007/978-3-032-26410-7_14
Shen, Y., Chadwick, B. J., Peng, X., Gao, Y., & Ding, C. (2026) · Gut Microbes · doi:10.1080/19490976.2026.2734644
Mridha, S., Alam, M. Z., Denny, J. E., Hulit, E. N., Maslanka, J. R., Mdluli, N. V., Tran-Ha, M., Mears, K. S., Brown, D. D., Alameh, M., et al. (2026) · bioRxiv (Cold Spring Harbor Laboratory) · doi:10.64898/2026.09.17.752434
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Ji, Y., Wang, C., Wang, K., Ye, H., Deng, X., & Shen, X. (2026) · One Health Advances · doi:10.1186/s44280-026-00148-9
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Qin, J., Li, T., Li, X., Han, P., Jin, M., & Qiao, L. (2026) · Animals · doi:10.3390/ani16193075
Chen, S., Yin, Y., Yin, J., & Zhou, X. (2026) · Antioxidants · doi:10.3390/antiox15101255
Zhang, H., Liu, A., Xu, J., Che, J., Cai, Z., Si, X., Ding, J., Chang, Y., & Wang, L. (2026) · Aquaculture Reports · doi:10.1016/j.aqrep.2026.103868
Wheeler, M., & Bakkeren, E. (2026) · Microbial Genomics · doi:10.1099/mgen.0.001856
Gut microbial metabolism of amino acids and its impact on enteric infections
Jaswal, K., & Behnsen, J. (2026) · Infection and Immunity · doi:10.1128/iai.00298-26
Mitchell, M. K., Carty, M. A., Snow, N. L., Archambault, M. T., Budsberg, A. E., Carrillo, E. V., Vignieri, E. E., Older, E. A., Rometo, O. L., van de Wal, L. E., et al. (2026) · bioRxiv (Cold Spring Harbor Laboratory) · doi:10.64898/2026.10.10.758071
Wu, Y., Lu, J., Mo, Y., Xu, Y., Yan, X., Yan, C., & Wang, Y. (2026) · Frontiers in Immunology · doi:10.3389/fimmu.2026.1998563
Gao, Z., Li, Z., Cui, J., Zhang, Q., Jia, Y., Ding, K., Shang, K., & Chen, S. (2026) · Virulence · doi:10.1080/21505594.2026.2745323
Xie, M., Shang, H., Wang, F., Yang, J., Geer, N., Zhang, Q., Xu, X., & Baolige, D. (2026) · Microorganisms · doi:10.3390/microorganisms14102370
BindingDB (2019) · UC San Diego · doi:10.7270/q2jd507r
Hockenberry, A. M. (2024) · Zenodo (CERN European Organization for Nuclear Research) · doi:10.5281/zenodo.13863027
Metadata
- Authors
- Rivera-Chávez, F., Zhang, L. F., Faber, F., Lopez, C. A., Byndloss, M. X., Olsan, E. E., Xu, G., Velazquez, E. M., Lebrilla, C. B., Winter, S. E., & Bäumler, A. J.
- Affiliations
- University of California, Davis (US)
- The University of Texas Southwestern Medical Center (US)
- Corresponding author
- Bäumler, Andreas J.
- ORCID
- Venue
- Cell Host & Microbe
- Publisher
- Elsevier BV
- Published
- 2016-04
- Volume
- 19
- Issue
- 4
- Pages
- 443-454
- ISSN
- 1931-3128 (ISSN-L)
- PMC
- PMC4832419
- OpenAlex
- W2338773685
- Cited by
- 864
- References
- 50
- Citations by year
- 2026: 75 · 2025: 93 · 2024: 93 · 2023: 90 · 2022: 115 · 2021: 127 · 2020: 74 · 2019: 70 · 2018: 60 · 2017: 46 · 2016: 18
- FWCI
- 33.77
- Type
- journal article
- Language
- en
- Open access
- bronze
- doi.org
- Licence
- Locations
- Cell Host & Microbe (publishedVersion)
- PubMed (publishedVersion)
- PubMed Central (acceptedVersion)
- eScholarship (California Digital Library) (submittedVersion)
- Funders
- National Institutes of Health (T32OD010931, T35OD010956)
- National Institute of General Medical Sciences (R25GM056765)
- National Institute of Allergy and Infectious Diseases (R01AI044170, AI112949, AI103248, R01AI076278, R21AI103248, AI060555, R01AI076246, F31AI112241, AI096528, AI112241, R56AI112949, R21AI117303, R37AI044170, T32AI060555, R01AI112949, R01AI096528)
- Topics
- Life Sciences › Biochemistry, Genetics and Molecular Biology › Molecular Biology › Gut microbiota and health
- Life Sciences › Agricultural and Biological Sciences › Food Science › Salmonella and Campylobacter epidemiology
- Life Sciences › Immunology and Microbiology › Microbiology › Escherichia coli research studies
- Keywords
- gut microbiota depletion, Salmonella typhimurium, streptomycin, antibiotic-induced dysbiosis, tributyrin, type III secretion system, nitrate reductase, fecal-oral transmission, host-pathogen interaction, commensal bacteria
- MeSH terms
- Gastrointestinal Microbiome, Aerobiosis, Animals, Anti-Bacterial Agents, Bacterial Proteins, Clostridium, Female, Intestines, Mice, Inbred CBA, Mice, Inbred C57BL, Oxygen, Salmonella typhimurium, Streptomycin, Butyric Acid, Virulence Factors, Mice
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