The DOI matches its Crossref record; 11 of the 11 references it cites were found in a registry or an index.
Dengue Virus Perturbs Mitochondrial Morphodynamics to Dampen Innate Immune Responses
Open accessAbstract
Summary With no antiviral drugs or widely available vaccines, Dengue virus (DENV) constitutes a public health concern. DENV replicates at ER-derived cytoplasmic structures that include substructures called convoluted membranes (CMs); however, the purpose of these membrane alterations remains unclear. We determine that DENV nonstructural protein (NS)4B, a promising drug target with unknown function, associates with mitochondrial proteins and alters mitochondria morphology to promote infection. During infection, NS4B induces elongation of mitochondria, which physically contact CMs. This restructuring compromises the integrity of mitochondria-associated membranes, sites of ER-mitochondria interface critical for innate immune signaling. The spatio-temporal parameters of CM biogenesis and mitochondria elongation are linked to loss of activation of the fission factor Dynamin-Related Protein-1. Mitochondria elongation promotes DENV replication and alleviates RIG-I-dependent activation of interferon responses. As Zika virus infection induces similar mitochondria elongation, this perturbation may protect DENV and related viruses from innate immunity and create a favorable replicative environment.
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Cites
The global distribution and burden of dengue
Bhatt, S., Gething, P. W., Brady, O. J., Messina, J. P., Farlow, A. W., Moyes, C. L., Drake, J. M., Brownstein, J. S., Hoen, A. G., Sankoh, O., et al. (2013) · Nature · doi:10.1038/nature12060 · Cited by 10,037
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Fusion and fission: interlinked processes critical for mitochondrial health
Chan, D. C. (2012) · Annual Review of Genetics · doi:10.1146/annurev-genet-110410-132529 · Cited by 1,196 · cited 4×
“Ser616 of DRP1 was previously reported to be phosphorylated by several kinases, namely CDK1, CDK5, and ERK1/2 (Lee and Yoon, 2014; Chan, 2012).”
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“, DRP1 and mitochondrial fission factor [MFF]) (Smirnova et al., 2001; Smirnova et al., 1998; Otera et al., 2010; Chen et al., 2003; Olichon et al., 2003).”
An Actin-Dependent Step in Mitochondrial Fission Mediated by the ER-Associated Formin INF2
Korobova, F., Ramabhadran, V., & Higgs, H. N. (2013) · Science · doi:10.1126/science.1228360 · Cited by 817
New functions of mitochondria associated membranes in cellular signaling
van Vliet, A. R., Verfaillie, T., & Agostinis, P. (2014) · Biochimica et Biophysica Acta (BBA) - Molecular Cell Research · doi:10.1016/j.bbamcr.2014.03.009 · Cited by 353
Mitochondrial dynamics regulate the RIG-I-like receptor antiviral pathway
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Mitofusin 2 Inhibits Mitochondrial Antiviral Signaling
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Cited by
Decoding type I and III interferon signalling during viral infection
Mesev, E. V., LeDesma, R. A., & Ploss, A. (2019) · Nature Microbiology · doi:10.1038/s41564-019-0421-x · Cited by 538
Ten Strategies of Interferon Evasion by Viruses
García-Sastre, A. (2017) · Cell Host & Microbe · doi:10.1016/j.chom.2017.07.012 · Cited by 423
Rewiring cellular networks by members of the Flaviviridae family
Neufeldt, C. J., Cortese, M., Acosta, E. G., & Bartenschlager, R. (2018) · Nature Reviews Microbiology · doi:10.1038/nrmicro.2017.170 · Cited by 409
Self-citationUltrastructural Characterization of Zika Virus Replication Factories
Cortese, M., Goellner, S., Acosta, E. G., Neufeldt, C. J., Oleksiuk, O., Lampe, M., Haselmann, U., Funaya, C., Schieber, N., Ronchi, P., et al. (2017) · Cell Reports · doi:10.1016/j.celrep.2017.02.014 · Cited by 359
Self-citationMitochondria as a Cellular Hub in Infection and Inflammation
Andrieux, P., Chevillard, C., Cunha-Neto, E., & Nunes, J. P. S. (2021) · International Journal of Molecular Sciences · doi:10.3390/ijms222111338 · Cited by 346
Metadata
- Authors
- Chatel-Chaix, L., Cortese, M., Romero-Brey, I., Bender, S., Neufeldt, C. J., Fischl, W., Scaturro, P., Schieber, N., Schwab, Y., Fischer, B., Ruggieri, A., & Bartenschlager, R.
- Venue
- Cell Host & Microbe
- Publisher
- Elsevier BV
- Published
- 2016-09
- Volume
- 20
- Issue
- 3
- Pages
- 342-356
- ISSN
- 1931-3128 (ISSN-L)
- OpenAlex
- W2510523315
- Cited by
- 280
- References
- 11
- FWCI
- 24.18
- Type
- journal article
- Language
- en
- Open access
- bronze
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- Chatel-Chaix, L., Cortese, M., Romero-Brey, I., Bender, S., Neufeldt, C. J., Fischl, W., Scaturro, P., Schieber, N., Schwab, Y., Fischer, B., Ruggieri, A., & Bartenschlager, R. (2016). Dengue Virus Perturbs Mitochondrial Morphodynamics to Dampen Innate Immune Responses. Cell Host & Microbe. https://doi.org/10.1016/j.chom.2016.07.008
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Contains information from the Semantic Scholar Academic Graph Datasets, made available under the ODC Attribution License (ODC-BY 1.0).
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