A Microbial Drugstore for Motility

Serotonin, tryptophan metabolism and the brain-gut-microbiome axis

O’Mahony, S. M., Clarke, G., Borre, Y. E., Dinan, T. G., & Cryan, J. F. (2015) · Behavioural Brain Research · doi:10.1016/j.bbr.2014.07.027 · Cited by 2,012 · see citing works

G Protein-Coupled Receptors as Targets for Approved Drugs: How Many Targets and How Many Drugs?

Sriram, K., & Insel, P. A. (2018) · Molecular Pharmacology · doi:10.1124/mol.117.111062 · Cited by 1,258 · see citing works

The neuropharmacology of butyrate: the bread and butter of the microbiota-gut-brain axis

Stilling, R. M., van de Wouw, M., Clarke, G., Stanton, C., Dinan, T. G., & Cryan, J. F. (2016) · Neurochemistry International · doi:10.1016/j.neuint.2016.06.011 · Cited by 891 · see citing works

Small molecules from the human microbiota

Donia, M. S., & Fischbach, M. A. (2015) · Science · doi:10.1126/science.1254766 · Cited by 760 · see citing works

Commensal bacteria make GPCR ligands that mimic human signalling molecules

Cohen, L. J., Esterhazy, D., Kim, S.-H., Lemetre, C., Aguilar, R. R., Gordon, E. A., Pickard, A. J., Cross, J. R., Emiliano, A. B., Han, S. M., et al. (2017) · Nature · doi:10.1038/nature23874 · Cited by 500 · see citing works

Feeding the microbiota–gut–brain axis: Diet, microbiome, and neuropsychiatry

Sandhu, K. V., Sherwin, E., Schellekens, H., Stanton, C., Dinan, T. G., & Cryan, J. F. (2017) · Translational Research · doi:10.1016/j.trsl.2016.10.002 · Cited by 491 · see citing works

Microbiota-gut-brain axis: Modulator of host metabolism and appetite

van de Wouw, M., Schellekens, H., Dinan, T. G., & Cryan, J. F. (2017) · The Journal of Nutrition · doi:10.3945/jn.116.240481 · Cited by 461 · see citing works

Gut Microbiota-Produced Tryptamine Activates an Epithelial G-Protein-Coupled Receptor to Increase Colonic Secretion

Bhattarai, Y., Williams, B. B., Battaglioli, E. J., Whitaker, W. R., Till, L., Grover, M., Linden, D. R., Akiba, Y., Kandimalla, K. K., Zachos, N. C., et al. (2018) · Cell Host & Microbe · doi:10.1016/j.chom.2018.05.004 · Cited by 436 · see citing works

Bacterial Neuroactive Compounds Produced by Psychobiotics

Wall, R., Cryan, J. F., Ross, R. P., Fitzgerald, G. F., Dinan, T. G., & Stanton, C. (2014) · Advances in experimental medicine and biology · doi:10.1007/978-1-4939-0897-4_10 · Cited by 362 · see citing works

Recent developments in understanding the role of the gut microbiota in brain health and disease

Sherwin, E., Dinan, T. G., & Cryan, J. F. (2018) · Annals of the New York Academy of Sciences · doi:10.1111/nyas.13416 · Cited by 338 · see citing works

Microbial Metabolism in the Mammalian Gut

Hall, A., & Versalovic, J. A. (2018) · Journal of Pediatric Gastroenterology and Nutrition · doi:10.1097/mpg.0000000000001857 · Cited by 20 · see citing works

The Microbiota-Gut-Brain Axis

Cryan, J. F., O'Riordan, K. J., Cowan, C. S. M., Sandhu, K. V., Bastiaanssen, T. F. S., Boehme, M., Codagnone, M. G., Cussotto, S., Fulling, C., Golubeva, A. V., et al. (2019) · Physiological Reviews · doi:10.1152/physrev.00018.2018 · Cited by 5,286 · see citing works

Menstruation: science and society

Critchley, H., Babayev, E., Bulun, S. E., Clark, S., Garcia-Grau, I., Gregersen, P. K., Kilcoyne, A., Kim, J.-Y. J., Lavender, M. D., Marsh, E. E., et al. (2020) · American Journal of Obstetrics and Gynecology · doi:10.1016/j.ajog.2020.06.004 · Cited by 484 · see citing works

Microbiota-Gut-Brain Axis: New Therapeutic Opportunities

Long-Smith, C., O'Riordan, K. J., Clarke, G., Stanton, C., Dinan, T. G., & Cryan, J. F. (2020) · Annual Review of Pharmacology and Toxicology · doi:10.1146/annurev-pharmtox-010919-023628 · Cited by 419 · see citing works

Gut Microbial Metabolites of Aromatic Amino Acids as Signals in Host–Microbe Interplay

Liu, Y., Hou, Y., Wang, G., Zheng, X., & Hao, H. (2020) · Trends in Endocrinology and Metabolism · doi:10.1016/j.tem.2020.02.012 · Cited by 357 · see citing works

Demystifying the manipulation of host immunity, metabolism, and extraintestinal tumors by the gut microbiome

Zhang, Z., Tang, H., Chen, P., Xie, H., & Tao, Y. (2019) · Signal Transduction and Targeted Therapy · doi:10.1038/s41392-019-0074-5 · Cited by 251 · see citing works

Short-chain fatty acids and microbiota metabolites attenuate ghrelin receptor signaling

Torres‐Fuentes, C., Golubeva, A. V., Zhdanov, A. V., Wallace, S., Arboleya, S., Papkovsky, D. B., Aidy, S. E., Ross, P., Roy, B. L., Stanton, C., et al. (2019) · The FASEB Journal · doi:10.1096/fj.201901433r · Cited by 154 · see citing works

Gut peptides and the microbiome: focus on ghrelin

Leeuwendaal, N. K., Cryan, J. F., & Schellekens, H. (2021) · Current Opinion in Endocrinology Diabetes and Obesity · doi:10.1097/med.0000000000000616 · Cited by 103 · see citing works

Dietary phospholipids: Role in cognitive processes across the lifespan

Schverer, M., O’Mahony, S. M., O’Riordan, K. J., Donoso, F., Roy, B. L., Stanton, C., Dinan, T. G., Schellekens, H., & Cryan, J. F. (2020) · Neuroscience & Biobehavioral Reviews · doi:10.1016/j.neubiorev.2020.01.012 · Cited by 91 · see citing works

Microbiota and body weight control: Weight watchers within?

Boscaini, S., Leigh, S., Lavelle, A., García‐Cabrerizo, R., Lipuma, T., Clarke, G. A., Schellekens, H., & Cryan, J. F. (2021) · Molecular Metabolism · doi:10.1016/j.molmet.2021.101427 · Cited by 66 · see citing works

Precision Psychobiotics for Gut–Brain Axis Health: Advancing the Discovery Pipelines to Deliver Mechanistic Pathways and Proven Health Efficacy

Slykerman, R. F., Davies, N., Vlčková, K., O’Riordan, K. J., Bassett, S. A., Dekker, J., Schellekens, H., Hyland, N. P., Clarke, G. A., & Patterson, E. (2025) · Microbial Biotechnology · doi:10.1111/1751-7915.70079 · Cited by 43 · see citing works

The International Scientific Association for Probiotics and Prebiotics (ISAPP) consensus statement on the definition and scope of gut health

Marco, M. L., Cunningham, M., Bischoff, S. C., Clarke, G. A., Delzenne, N. M., Lewis, J., Meisel, M., Merenstein, D. J., O’Toole, P. W., Staudacher, H. M., et al. (2026) · Nature Reviews Gastroenterology & Hepatology · doi:10.1038/s41575-026-01176-x · Cited by 44 · see citing works

Processing Method Altered Mouse Intestinal Morphology and Microbial Composition by Affecting Digestion of Meat Proteins

Xie, Y., Wang, C., Zhao, D., Zhou, G., & Li, C. (2020) · Frontiers in Microbiology · doi:10.3389/fmicb.2020.00511 · Cited by 37 · see citing works

Seeking the Psilocybiome: Psychedelics meet the microbiota-gut-brain axis

Kelly, J. R., Clarke, G. A., Harkin, A., Corr, S. C., Galvin, S. D., Pradeep, V., Cryan, J. F., O’Keane, V., & Dinan, T. G. (2022) · International Journal of Clinical and Health Psychology · doi:10.1016/j.ijchp.2022.100349 · Cited by 38 · see citing works

Bifidobacterium animalis F1-7 in combination with konjac glucomannan improves constipation in mice via humoral transport

Lü, Y., Yu, Z., Zhang, Z., Liang, X., Gong, P., Yi, H., Yang, L., Liu, T., Shi, H., & Zhang, L. (2020) · Food & Function · doi:10.1039/d0fo02227f · Cited by 33 · see citing works

Microbial Therapeutics in Neurocognitive and Psychiatric Disorders

Alagiakrishnan, K., & Halverson, T. (2021) · Journal of Clinical Medicine Research · doi:10.14740/jocmr4575 · Cited by 29 · see citing works

The human periconceptional maternal-embryonic space in health and disease

Moreno, I., Capalbo, A., Mas, A., Garrido‐Gómez, T., Rosón, B., Poli, M., Dimitriadis, E., Santamaría, X., Vilella, F., & Simón, C. (2023) · Physiological Reviews · doi:10.1152/physrev.00050.2021 · Cited by 27 · see citing works

The gut microbiome and pharmacology: a prescription for therapeutic targeting of the gut–brain axis

Leprun, P. M. B., & Clarke, G. A. (2019) · Current Opinion in Pharmacology · doi:10.1016/j.coph.2019.04.007 · Cited by 23 · see citing works

Investigation of Host–Microbe–Parasite Interactions in an In Vitro 3D Model of the Vertebrate Gut

Moysidou, C., Withers, A. M., Nisbet, A. J., Price, D. R. G., Bryant, C. E., Cantacessi, C., & Owens, R. M. (2022) · Advanced Biology · doi:10.1002/adbi.202200015 · Cited by 15 · see citing works

The Gut Microbiome and Colonic Motility Disorders: A Practical Framework for the Gastroenterologist

Ma, W., Drew, D. A., & Staller, K. D. (2022) · Current Gastroenterology Reports · doi:10.1007/s11894-022-00847-4 · Cited by 15 · see citing works

Modelling Human Gut‐Microbiome Interactions in a 3D Bioelectronic Platform

Moysidou, C., van Niekerk, D. C., Stoeger, V., Pitsalidis, C., Draper, L. A., Withers, A. M., Hughes, K., McCoy, R. S. A., Acharya, R., Hill, C., et al. (2024) · Small Science · doi:10.1002/smsc.202300349 · Cited by 10 · see citing works

Insights into host-microbe interaction: What can we do for the swine industry?

Fan, L., Liu, B., Han, Z., & Ren, W. (2020) · Animal nutrition · doi:10.1016/j.aninu.2020.10.003 · Cited by 8 · see citing works

Tryptophan Metabolism and the Microbiome-Gut-Brain Axis

Clarke, G. A., Villalobos-Manríquez, F., & Marin, D. C. (2021) · Oxford University Press eBooks · doi:10.1093/oxfordhb/9780190931544.013.13 · Cited by 7 · see citing works

When pharmacology meets the microbiome: new targets for therapeutics?

Hyland, N. P., & Cryan, J. F. (2018) · British Journal of Pharmacology · doi:10.1111/bph.14502 · Cited by 5 · see citing works

Human gut microbiota, nutrition and health

Bi, Y., & Yang, R. (2018) · Chinese Science Bulletin (Chinese Version) · doi:10.1360/n972018-00641 · Cited by 3 · see citing works

The Function of Tryptophan Metabolism in the Gut

Tang, X., Wan, L., Gao, J., Jiang, Q., Hu, S., Xiao, H., Wang, J., Qi, M., Wang, L., Huang, L., et al. (2024) · Springer eBooks · doi:10.1007/978-981-97-4719-1_2 · Cited by 3 · see citing works

From human to superhuman: the impact of the microbiome on physiology

Keely, S. J., Cotter, P. D., Wahlstrom, A. M., Schellekens, H., Weinkove, D., & Barrett, K. E. (2025) · The Journal of Physiology · doi:10.1113/jp287883 · Cited by 2 · see citing works

Oral supplementation of heat-killed Enterococcus faecalis strain EC-12 relieves gastrointestinal discomfort and alters the gut microecology in academically stressed students

Li, J., Terajima, T., Liu, H., Miyata, S., Kambe, J., Makioka‐Itaya, Y., Inoüe, R., Yamamoto, Y., & Nagaoka, K. (2024) · Beneficial Microbes · doi:10.1163/18762891-bja00046 · Cited by 2 · see citing works

The Impact of the Human Microbiome on Mental Health: A Systemic Review

-, K. N. V. (2023) · International Journal For Multidisciplinary Research · doi:10.36948/ijfmr.2023.v05i02.1832 · Cited by 1 · see citing works

Mining for the Next-Generation Microbiota Across the Gut–Brain Axis

Schellekens, H. (2024) · Elsevier eBooks · doi:10.1016/b978-0-323-99971-7.00008-4 · Cited by 1 · see citing works

Human clostridia improve visceral hypersensitivity in stressed mice through upregulation of 5-hydroxytryptamine 4Preprint

Xiao, Y., Miao, B., Li, B., Li, L., Fei, S., & Zhao, Y. (2023) · Research Square · doi:10.21203/rs.3.rs-2746941/v1

Human clostridia improve visceral hypersensitivity in stressed mice through upregulation of 5-HT4Preprint

Xiao, Y., Miao, B., Li, B., Li, L., Zhao, Y., Zhang, C., & Fei, S. (2023) · Research Square · doi:10.21203/rs.3.rs-2820955/v1

Perspectives on Manipulating the Microbiome to Modulate the Gut-Brain Axis

Clarke, G. A., & Cryan, J. F. (2024) · Elsevier eBooks · doi:10.1016/b978-0-323-99971-7.00016-3

Microbiota to brain communication

Foster, J. A., & Clarke, G. A. (2024) · Elsevier eBooks · doi:10.1016/b978-0-12-814800-6.00007-8

LC–MS/MS Profiling and Evaluation of Antibacterial, Antivirulence, Antioxidant, and Anti‐Inflammatory Activities of Pinus halepensis Mill. Bark Extracts: In Vitro and In Silico Analysis

Rahal, S., DJENDI, M. L., Boufafa, M., Kaki, S. A., Menaa, B., Yılmaz, M. A., Çakır, O., Tarhan, A., Abderrahim, A., & Benzaid, C. (2026) · Chemistry & Biodiversity · doi:10.1002/cbdv.202503772

The Effect Of Tryptamine Producing Bacteria On Gut Motility In Mice

Norberg, E. S. (2023) · ScholarWorks -A service of University of Vermont Libraries (University of Vermont)

Tryptophan metabolites get the gut moving

Benech, N., Rolhion, N., & Sokol, H. (2021) · Cell Host & Microbe · doi:10.1016/j.chom.2021.01.009 · Cited by 49 · see citing works

Bacterially Derived Tryptamine Increases Mucus Release by Activating a Host Receptor in a Mouse Model of Inflammatory Bowel Disease

Bhattarai, Y., Jie, S., Linden, D. R., Ghatak, S., Mars, R. A. T., Williams, B. B., Pu, M., Sonnenburg, J. L., Fischbach, M. A., Farrugia, G., et al. (2020) · iScience · doi:10.1016/j.isci.2020.101798 · Cited by 73 · see citing works

Gut Microbiota-Produced Tryptamine Activates an Epithelial G-Protein-Coupled Receptor to Increase Colonic Secretion

Bhattarai, Y., Williams, B. B., Battaglioli, E. J., Whitaker, W. R., Till, L., Grover, M., Linden, D. R., Akiba, Y., Kandimalla, K. K., Zachos, N. C., et al. (2018) · Cell Host & Microbe · doi:10.1016/j.chom.2018.05.004 · Cited by 436 · see citing works

Role of gut microbiota-derived signals in the regulation of gastrointestinal motility

Zheng, Z., Tang, J., Hu, Y., & Zhang, W. (2022) · Frontiers in Medicine · doi:10.3389/fmed.2022.961703 · Cited by 91 · see citing works