Cited by 419Gut microbiota and healthGastrointestinal motility and disordersTryptophan and brain disorders

Microbiota-Gut-Brain Axis: New Therapeutic Opportunities

Long-Smith, Caitríona, O'Riordan, Kenneth J., Clarke, Gerard, Stanton, Catherine, Dinan, Timothy G., Cryan, John F.·2020·Annual Review of Pharmacology and Toxicology

Abstract

The traditional fields of pharmacology and toxicology are beginning to consider the substantial impact our gut microbiota has on host physiology. The microbiota-gut-brain axis is emerging as a particular area of interest and a potential new therapeutic target for effective treatment of central nervous system disorders, in addition to being a potential cause of drug side effects. Microbiota-gut-brain axis signaling can occur via several pathways, including via the immune system, recruitment of host neurochemical signaling, direct enteric nervous system routes and the vagus nerve, and the production of bacterial metabolites. Altered gut microbial profiles have been described in several psychiatric and neurological disorders. Psychobiotics, live biotherapeutics or substances whose beneficial effects on the brain are bacterially mediated, are currently being investigated as direct and/or adjunctive therapies for psychiatric and neurodevelopmental disorders and possibly for neurodegenerative disease, and they may emerge as new therapeutic options in the clinical management of brain disorders.

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Registry

Crossref · 10.1146/annurev-pharmtox-010919-023628

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179 of 179 references verified0 citation errors · 0 not checkable

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Authors
Long-Smith, C., O'Riordan, K. J., Clarke, G., Stanton, C., Dinan, T. G., & Cryan, J. F.
Affiliations
  • University College Cork (IE)
  • APC Microbiome Ireland, University College Cork, Cork, Ireland;
  • Teagasc - The Irish Agriculture and Food Development Authority (IE)
Venue
Annual Review of Pharmacology and Toxicology
Published
2020-01-06
Volume
60
Issue
1
Pages
477-502
ISSN
  • 0362-1642 (ISSN-L)
  • 1545-4304
OpenAlex
W2972987364
Cited by
419
References
179
Citations by year
2026: 35 · 2025: 70 · 2024: 79 · 2023: 73 · 2022: 56 · 2021: 59 · 2020: 42 · 2019: 3
FWCI
3.52
Type
journal article
Language
en
Open access
closed
Locations
  • The Annual Review of Pharmacology and Toxicology (publishedVersion)
  • PubMed (publishedVersion)
Topics
  • Life Sciences › Biochemistry, Genetics and Molecular Biology › Molecular Biology › Gut microbiota and health
  • Health Sciences › Medicine › Gastroenterology › Gastrointestinal motility and disorders
  • Life Sciences › Neuroscience › Biological Psychiatry › Tryptophan and brain disorders
Keywords
microbiota-gut-brain axis, gut microbiota, psychobiotics, live biotherapeutic products, mental illness, neurodevelopmental disorders, neurodegenerative diseases, vagus nerve signaling, enteric nervous system, bacterial metabolites, adverse drug reactions, neuroimmune signaling
MeSH terms
Gastrointestinal Microbiome, Animals, Mental Disorders, Brain, Central Nervous System Diseases, Humans, Neurodegenerative Diseases, Drug-Related Side Effects and Adverse Reactions

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