Microbiota-Gut-Brain Axis: New Therapeutic Opportunities
Abstract
The traditional fields of pharmacology and toxicology are beginning to consider the substantial impact our gut microbiota has on host physiology. The microbiota-gut-brain axis is emerging as a particular area of interest and a potential new therapeutic target for effective treatment of central nervous system disorders, in addition to being a potential cause of drug side effects. Microbiota-gut-brain axis signaling can occur via several pathways, including via the immune system, recruitment of host neurochemical signaling, direct enteric nervous system routes and the vagus nerve, and the production of bacterial metabolites. Altered gut microbial profiles have been described in several psychiatric and neurological disorders. Psychobiotics, live biotherapeutics or substances whose beneficial effects on the brain are bacterially mediated, are currently being investigated as direct and/or adjunctive therapies for psychiatric and neurodevelopmental disorders and possibly for neurodegenerative disease, and they may emerge as new therapeutic options in the clinical management of brain disorders.
Integrity signals
Registry
Cites
Statistics
Claims the paper makes
Claims other papers make about this one
Each is checked against this paper’s own text: does it say what the citing paper says it does?
The microbiota may play a causal role in the pathophysiology of depression.
“suggesting the possibility of a causal role for the microbiota in the pathophysiology of depression [63, 65].”
From Role of diet and its effects on the gut microbiome in the pathophysiology of mental disorders (2022) · cites this paper as [65]
Transferring the microbiome of a depressed individual into a healthy rodent can induce depressive-like behaviors in the murine recipient.
“Several studies have also shown that transferring the microbiome of a depressed individual into a healthy rodent (without or with suppressed gut microbiota) can induce depressive-like behaviors in the murine recipient”
From Role of diet and its effects on the gut microbiome in the pathophysiology of mental disorders (2022) · cites this paper as [65]
While effects of probiotics and prebiotics on the microbiota and mood or cognition have been more widely studied, investigations into whole-food and diet approaches are scarce.
“While the effects of probiotics and prebiotics on the microbiota and mood or cognition have been more widely studied (12), investigations into whole-food and diet approaches are scarce.”
From Diet and the Microbiota–Gut–Brain Axis: Sowing the Seeds of Good Mental Health (2021) · cites this paper as [12]
Cites
1 retracted
Mohammadi, A. A., Jazayeri, S., Khosravi‐Darani, K., Solati, Z., Mohammadpour, N., Asemi, Z., Adab, Z., Djalali, M., Tehrani‐Doost, M., Hosseini, M., et al. (2015) · Nutritional Neuroscience · doi:10.1179/1476830515y.0000000023 · Cited by 239 · see citing works
RetractedStructure, function and diversity of the healthy human microbiome
The Human Microbiome Project Consortium (2012) · Nature · doi:10.1038/nature11234 · Cited by 11,726 · see citing works
Diet rapidly and reproducibly alters the human gut microbiome
David, L. A., Maurice, C. F., Carmody, R. N., Gootenberg, D. B., Button, J. E., Wolfe, B. E., Ling, A. V., Devlin, A. S., Varma, Y., Fischbach, M. A., et al. (2014) · Nature · doi:10.1038/nature12820 · Cited by 10,100 · see citing works
Hill (2014) · doi:10.1038/nrgastro.2014.66 · Cited by 9,592 · see citing works
Gibson, G. R., Hutkins, R., Sanders, M. E., Prescott, S. L., Reimer, R. A., Salminen, S. J., Scott, K., Stanton, C., Swanson, K. S., Cani, P. D., et al. (2017) · Nature Reviews Gastroenterology & Hepatology · doi:10.1038/nrgastro.2017.75 · Cited by 5,634 · see citing works
Self-citationDe Filippo, C., Cavalieri, D., Di Paola, M., Ramazzotti, M., Poullet, J. B., Massart, S., Collini, S., Pieraccini, G., & Lionetti, P. (2010) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.1005963107 · Cited by 5,579 · see citing works
Dominguez-Bello, M. G., Costello, E. K., Contreras, M., Magris, M., Hidalgo, G., Fierer, N., & Knight, R. (2010) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.1002601107 · Cited by 4,774 · see citing works
Bravo, J. A., Forsythe, P., Chew, M. V., Escaravage, E., Savignac, H. M., Dinan, T. G., Bienenstock, J., & Cryan, J. F. (2011) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.1102999108 · Cited by 3,888 · see citing works
Self-citationGut microbiota regulate motor deficits and neuroinflammation in a model of Parkinson's disease
Sampson, T. R., Debelius, J. W., Thron, T., Janssen, S., Shastri, G. G., Ilhan, Z. E., Challis, C., Schretter, C. E., Rocha, S., Gradinaru, V., et al. (2016) · Cell · doi:10.1016/j.cell.2016.11.018 · Cited by 3,622 · see citing works
Sudo, N., Chida, Y., Aiba, Y., Sonoda, J., Oyama, N., Yu, X., Kubo, C., & Koga, Y. (2004) · The Journal of Physiology · doi:10.1113/jphysiol.2004.063388 · Cited by 2,735 · see citing works
Population-level analysis of gut microbiome variation
Falony, G., Joossens, M., Vieira-Silva, S., Wang, J., Darzi, Y., Faust, K., Kurilshikov, A., Bonder, M. J., Valles-Colomer, M., Vandeputte, D., et al. (2016) · Science · doi:10.1126/science.aad3503 · Cited by 2,400 · see citing works
Altered fecal microbiota composition in patients with major depressive disorder
Jiang, H., Ling, Z., Zhang, Y., Mao, H., Ma, Z., Yin, Y., Wang, W., Tang, W., Tan, Z., Shi, J., et al. (2015) · Brain, Behavior, and Immunity · doi:10.1016/j.bbi.2015.03.016 · Cited by 2,275 · see citing works
Diet–microbiota interactions as moderators of human metabolism
Sonnenburg, J. L., & Bäckhed, F. (2016) · Nature · doi:10.1038/nature18846 · Cited by 2,257 · see citing works
Gut microbiome alterations in Alzheimer’s disease
Vogt, N. M., Kerby, R. L., Dill-McFarland, K. A., Harding, S. J., Merluzzi, A. P., Johnson, S. C., Carlsson, C. M., Asthana, S., Zetterberg, H., Blennow, K., et al. (2017) · Scientific Reports · doi:10.1038/s41598-017-13601-y · Cited by 2,137 · see citing works
Disentangling type 2 diabetes and metformin treatment signatures in the human gut microbiota
MetaHIT consortium, Forslund, K., Hildebrand, F., Nielsen, T., Falony, G., Le Chatelier, E., Sunagawa, S., Prifti, E., Vieira-Silva, S., Gudmundsdottir, V., et al. (2015) · Nature · doi:10.1038/nature15766 · Cited by 2,116 · see citing works
Are We Really Vastly Outnumbered? Revisiting the Ratio of Bacterial to Host Cells in Humans
Sender, R., Fuchs, S., & Milo, R. (2016) · Cell · doi:10.1016/j.cell.2016.01.013 · Cited by 2,050 · see citing works
Zheng, P., Zeng, B., Zhou, C., Liu, M., Fang, Z., Xu, X., Zeng, L., Chen, J., Fan, S., Du, X., et al. (2016) · Molecular Psychiatry · doi:10.1038/mp.2016.44 · Cited by 2,023 · see citing works
Gut microbiota are related to Parkinson's disease and clinical phenotype
Scheperjans, F., Aho, V., Pereira, P. A. B., Koskinen, K., Paulin, L., Pekkonen, E., Haapaniemi, E., Kaakkola, S., Eerola‐Rautio, J., Pohja, M., et al. (2015) · Movement Disorders · doi:10.1002/mds.26069 · Cited by 1,968 · see citing works
The neuroactive potential of the human gut microbiota in quality of life and depression
Valles-Colomer, M., Falony, G., Darzi, Y., Tigchelaar, E. F., Wang, J., Tito, R. Y., Schiweck, C., Kurilshikov, A., Joossens, M., Wijmenga, C., et al. (2019) · Nature Microbiology · doi:10.1038/s41564-018-0337-x · Cited by 1,963 · see citing works
Population-based metagenomics analysis reveals markers for gut microbiome composition and diversity
Zhernakova, A., Kurilshikov, A., Bonder, M. J., Tigchelaar, E. F., Schirmer, M., Vatanen, T., Mujagic, Z., Vila, A. V., Falony, G., Vieira-Silva, S., et al. (2016) · Science · doi:10.1126/science.aad3369 · Cited by 1,914 · see citing works
Extensive impact of non-antibiotic drugs on human gut bacteria
Maier, L., Pruteanu, M., Kuhn, M., Zeller, G., Telzerow, A., Anderson, E. E., Brochado, A. R., Fernandez, K. C., Dose, H., Mori, H., et al. (2018) · Nature · doi:10.1038/nature25979 · Cited by 1,905 · see citing works
Clarke, G., Grenham, S., Scully, P., Fitzgerald, P., Moloney, R. D., Shanahan, F., Dinan, T. G., & Cryan, J. F. (2013) · Molecular Psychiatry · doi:10.1038/mp.2012.77 · Cited by 1,893 · see citing works
Self-citationKelly, J. R., Borre, Y., O' Brien, C., Patterson, E., El Aidy, S., Deane, J., Kennedy, P. J., Beers, S., Scott, K., Moloney, G., et al. (2016) · Journal of Psychiatric Research · doi:10.1016/j.jpsychires.2016.07.019 · Cited by 1,683 · see citing works
Self-citationBrain insulin resistance in type 2 diabetes and Alzheimer disease: concepts and conundrums
Arnold, S. E., Arvanitakis, Z., Macauley-Rambach, S. L., Koenig, A. M., Wang, H.-Y., Ahima, R. S., Craft, S., Gandy, S., Buettner, C., Stoeckel, L. E., et al. (2018) · Nature Reviews Neurology · doi:10.1038/nrneurol.2017.185 · Cited by 1,597 · see citing works
Causal relationships among the gut microbiome, short-chain fatty acids and metabolic diseases
Sanna, S., van Zuydam, N. R., Mahajan, A., Kurilshikov, A., Vich Vila, A., Võsa, U., Mujagic, Z., Masclee, A. A. M., Jonkers, D. M. A. E., Oosting, M., et al. (2019) · Nature Genetics · doi:10.1038/s41588-019-0350-x · Cited by 1,539 · see citing works
Exercise and associated dietary extremes impact on gut microbial diversity
Clarke, S. F., Murphy, E. F., O'Sullivan, O., Lucey, A. J., Humphreys, M., Hogan, A., Hayes, P., O'Reilly, M., Jeffery, I. B., Wood-Martin, R., et al. (2014) · Gut · doi:10.1136/gutjnl-2013-306541 · Cited by 1,439 · see citing works
Kang, D.-W., Adams, J. B., Gregory, A. C., Borody, T., Chittick, L., Fasano, A., Khoruts, A., Geis, E., Maldonado, J., McDonough-Means, S., et al. (2017) · Microbiome · doi:10.1186/s40168-016-0225-7 · Cited by 1,391 · see citing works
Cattaneo, A., Cattane, N., Galluzzi, S., Provasi, S., Lopizzo, N., Festari, C., Ferrari, C., Guerra, U. P., Paghera, B., Muscio, C., et al. (2017) · Neurobiology of Aging · doi:10.1016/j.neurobiolaging.2016.08.019 · Cited by 1,382 · see citing works
Proton pump inhibitors affect the gut microbiome
Imhann, F., Bonder, M. J., Vich Vila, A., Fu, J., Mujagic, Z., Vork, L., Tigchelaar, E. F., Jankipersadsing, S. A., Cenit, M. C., Harmsen, H. J. M., et al. (2016) · Gut · doi:10.1136/gutjnl-2015-310376 · Cited by 1,371 · see citing works
Braak, H., de Vos, R. A. I., Bohl, J., & Del Tredici, K. (2006) · Neuroscience Letters · doi:10.1016/j.neulet.2005.11.012 · Cited by 1,354 · see citing works
Psychobiotics: A novel class of psychotropic
Dinan, T. G., Stanton, C., & Cryan, J. F. (2013) · Biological Psychiatry · doi:10.1016/j.biopsych.2013.05.001 · Cited by 1,287 · see citing works
Self-citationColonic bacterial composition in Parkinson's disease
Keshavarzian, A., Green, S. J., Engen, P. A., Voigt, R. M., Naqib, A., Forsyth, C. B., Mutlu, E., & Shannon, K. M. (2015) · Movement Disorders · doi:10.1002/mds.26307 · Cited by 1,281 · see citing works
The microbiome in early life: Implications for health outcomes
Tamburini, S., Shen, N., Wu, H. C., & Clemente, J. C. (2016) · Nature Medicine · doi:10.1038/nm.4142 · Cited by 1,213 · see citing works
Minireview: Gut microbiota: The neglected endocrine organ
Clarke, G., Stilling, R. M., Kennedy, P. J., Stanton, C., Cryan, J. F., & Dinan, T. G. (2014) · Molecular Endocrinology · doi:10.1210/me.2014-1108 · Cited by 1,192 · see citing works
Self-citationConsumption of fermented milk product with probiotic modulates brain activity
Tillisch, K., Labus, J., Kilpatrick, L., Jiang, Z., Stains, J., Ebrat, B., Guyonnet, D., Legrain–Raspaud, S., Trotin, B., Naliboff, B., et al. (2013) · Gastroenterology · doi:10.1053/j.gastro.2013.02.043 · Cited by 1,192 · see citing works
Vagus Nerve as Modulator of the Brain–Gut Axis in Psychiatric and Inflammatory Disorders
Breit, S., Kupferberg, A., Rogler, G., & Hasler, G. (2018) · Frontiers in Psychiatry · doi:10.3389/fpsyt.2018.00044 · Cited by 1,189 · see citing works
Unger, M. M., Spiegel, J., Dillmann, K.-U., Grundmann, D., Philippeit, H., Bürmann, J., Faßbender, K., Schwiertz, A., & Schäfer, K.-H. (2016) · Parkinsonism & Related Disorders · doi:10.1016/j.parkreldis.2016.08.019 · Cited by 1,159 · see citing works
Stress & the gut-brain axis: Regulation by the microbiome
Foster, J. A., Rinaman, L., & Cryan, J. F. (2017) · Neurobiology of Stress · doi:10.1016/j.ynstr.2017.03.001 · Cited by 1,150 · see citing works
Self-citationJacka, F. N., O’Neil, A., Opie, R., Itsiopoulos, C., Cotton, S., Mohebbi, M., Castle, D., Dash, S., Mihalopoulos, C., Chatterton, M. L., et al. (2017) · BMC Medicine · doi:10.1186/s12916-017-0791-y · Cited by 1,093 · see citing works
Psychobiotics and the manipulation of bacteria–gut–brain signals
Sarkar, A., Lehto, S. M., Harty, S., Dinan, T. G., Cryan, J. F., & Burnet, P. W. J. (2016) · Trends in Neurosciences · doi:10.1016/j.tins.2016.09.002 · Cited by 1,068 · see citing works
Self-citationCorrelation between the human fecal microbiota and depression
Naseribafrouei, A., Hestad, K., Avershina, E., Sekelja, M., Linløkken, A., Wilson, R., & Rudi, K. (2014) · Neurogastroenterology & Motility · doi:10.1111/nmo.12378 · Cited by 1,044 · see citing works
New evidences on the altered gut microbiota in autism spectrum disorders
Strati, F., Cavalieri, D., Albanese, D., De Felice, C., Donati, C., Hayek, J., Jousson, O., Leoncini, S., Renzi, D., Calabrò, A., et al. (2017) · Microbiome · doi:10.1186/s40168-017-0242-1 · Cited by 1,040 · see citing works
Next-generation probiotics: the spectrum from probiotics to live biotherapeutics
O’Toole, P. W., Marchesi, J. R., & Hill, C. (2017) · Nature Microbiology · doi:10.1038/nmicrobiol.2017.57 · Cited by 971 · see citing works
Akbari, E., Asemi, Z., Daneshvar Kakhaki, R., Bahmani, F., Kouchaki, E., Tamtaji, O. R., Hamidi, G. A., & Salami, M. (2016) · Frontiers in Aging Neuroscience · doi:10.3389/fnagi.2016.00256 · Cited by 946 · see citing works
A gut-brain neural circuit for nutrient sensory transduction
Kaelberer, M. M., Buchanan, K. L., Klein, M. E., Barth, B. B., Montoya, M. M., Shen, X., & Bohórquez, D. V. (2018) · Science · doi:10.1126/science.aat5236 · Cited by 932 · see citing works
Lassale, C., Batty, G. D., Baghdadli, A., Jacka, F., Sánchez-Villegas, A., Kivimäki, M., & Akbaraly, T. (2019) · Molecular Psychiatry · doi:10.1038/s41380-018-0237-8 · Cited by 931 · see citing works
Enterochromaffin cells are gut chemosensors that couple to sensory neural pathways
Bellono, N. W., Bayrer, J. R., Leitch, D. B., Castro, J., Zhang, C., O’Donnell, T. A., Brierley, S. M., Ingraham, H. A., & Julius, D. (2017) · Cell · doi:10.1016/j.cell.2017.05.034 · Cited by 910 · see citing works
Proton pump inhibitors alter the composition of the gut microbiota
Jackson, M. A., Goodrich, J. K., Maxan, M.-E., Freedberg, D. E., Abrams, J. A., Poole, A. C., Sutter, J. L., Welter, D., Ley, R. E., Bell, J. T., et al. (2016) · Gut · doi:10.1136/gutjnl-2015-310861 · Cited by 895 · see citing works
Gut Microbiota is Altered in Patients with Alzheimer’s Disease
Zhuang, Z.-Q., Shen, L.-L., Li, W.-W., Fu, X., Zeng, F., Gui, L., Lü, Y., Cai, M., Zhu, C., Tan, Y.-L., et al. (2018) · Journal of Alzheimer's Disease · doi:10.3233/jad-180176 · Cited by 885 · see citing works
Hill‐Burns, E. M., Debelius, J. W., Morton, J. T., Wissemann, W. T., Lewis, M. R., Wallen, Z. D., Peddada, S. D., Factor, S. A., Molho, E., Zabetian, C. P., et al. (2017) · Movement Disorders · doi:10.1002/mds.26942 · Cited by 874 · see citing works
Pinto-Sanchez, M. I., Hall, G. B., Ghajar, K., Nardelli, A., Bolino, C., Lau, J. T., Martin, F.-P., Cominetti, O., Welsh, C., Rieder, A., et al. (2017) · Gastroenterology · doi:10.1053/j.gastro.2017.05.003 · Cited by 821 · see citing works
Safety assessment of probiotics for human use
Sanders, M. E., Akkermans, L. M. A., Haller, D., Hammerman, C., Heimbach, J. T., Hörmannsperger, G., & Huys, G. (2010) · Gut Microbes · doi:10.4161/gmic.1.3.12127 · Cited by 816 · see citing works
Association of Western and Traditional Diets With Depression and Anxiety in Women
Jacka, F. N., Pasco, J. A., Mykletun, A., Williams, L. J., Hodge, A. M., O'Reilly, S. L., Nicholson, G. C., Kotowicz, M. A., & Berk, M. (2010) · American Journal of Psychiatry · doi:10.1176/appi.ajp.2009.09060881 · Cited by 812 · see citing works
Vagotomy and subsequent risk of <scp>P</scp> arkinson's disease
Svensson, E., Horváth‐Puhó, E., Thomsen, R. W., Djurhuus, J. C., Pedersen, L., Borghammer, P., & Sørensen, H. T. (2015) · Annals of Neurology · doi:10.1002/ana.24448 · Cited by 806 · see citing works
Mediterranean diet, stroke, cognitive impairment, and depression: A meta‐analysis
Psaltopoulou, T., Sergentanis, T. N., Panagiotakos, D. B., Sergentanis, I. N., Kosti, R., & Scarmeas, N. (2013) · Annals of Neurology · doi:10.1002/ana.23944 · Cited by 793 · see citing works
van de Wouw, M., Boehme, M., Lyte, J. M., Wiley, N., Strain, C., O'Sullivan, O., Clarke, G., Stanton, C., Dinan, T. G., & Cryan, J. F. (2018) · The Journal of Physiology · doi:10.1113/jp276431 · Cited by 789 · see citing works
Self-citationAkkasheh, G., Kashani-Poor, Z., Tajabadi-Ebrahimi, M., Jafari, P., Akbari, H., Taghizadeh, M., Memarzadeh, M. R., Asemi, Z., & Esmaillzadeh, A. (2016) · Nutrition · doi:10.1016/j.nut.2015.09.003 · Cited by 767 · see citing works
Bacteriophages of the Human Gut: The “Known Unknown” of the Microbiome
Shkoporov, A. N., & Hill, C. (2019) · Cell Host & Microbe · doi:10.1016/j.chom.2019.01.017 · Cited by 760 · see citing works
A Neural Circuit for Gut-Induced Reward
Han, W., Téllez, L. A., Perkins, M. H., Pérez-Martínez, I. O., Qu, T., Ferreira, J. G. P., Ferreira, T. L., Quinn, D., Liu, Z.-W., Gao, X., et al. (2018) · Cell · doi:10.1016/j.cell.2018.08.049 · Cited by 739 · see citing works
Kynurenine pathway metabolism and the microbiota-gut-brain axis
Kennedy, P. J., Cryan, J. F., Dinan, T. G., & Clarke, G. (2017) · Neuropharmacology · doi:10.1016/j.neuropharm.2016.07.002 · Cited by 724 · see citing works
Self-citationZheng, P., Zeng, B., Liu, M., Chen, J., Pan, J., Han, Y., Liu, Y., Cheng, K., Zhou, C., Wang, H., et al. (2019) · Science Advances · doi:10.1126/sciadv.aau8317 · Cited by 704 · see citing works
Steenbergen, L., Sellaro, R., van Hemert, S., Bosch, J. A., & Colzato, L. S. (2015) · Brain, Behavior, and Immunity · doi:10.1016/j.bbi.2015.04.003 · Cited by 671 · see citing works
Bedarf, J. R., Hildebrand, F., Coelho, L. P., Sunagawa, S., Bahram, M., Goeser, F., Bork, P., & Wüllner, U. (2017) · Genome Medicine · doi:10.1186/s13073-017-0428-y · Cited by 642 · see citing works
Parletta, N., Zarnowiecki, D., Cho, J., Wilson, A., Bogomolova, S., Villani, A., Itsiopoulos, C., Niyonsenga, T., Blunden, S., Meyer, B., et al. (2019) · Nutritional Neuroscience · doi:10.1080/1028415x.2017.1411320 · Cited by 629 · see citing works
Vanuytsel, T., van Wanrooy, S., Vanheel, H., Vanormelingen, C., Verschueren, S., Houben, E., Salim Rasoel, S., Tόth, J., Holvoet, L., Farré, R., et al. (2014) · Gut · doi:10.1136/gutjnl-2013-305690 · Cited by 615 · see citing works
Short-Term Benefit From Oral Vancomycin Treatment of Regressive-Onset Autism
Sandler, R. H., Finegold, S. M., Bolte, E. R., Buchanan, C. P., Maxwell, A. P., Väisänen, M.-L., Nelson, M. N., & Wexler, H. M. (2000) · Journal of Child Neurology · doi:10.1177/088307380001500701 · Cited by 614 · see citing works
Dietary patterns and depression risk: a meta-analysis
Li, Y., Lv, M.-R., Wei, Y.-J., Sun, L., Zhang, J.-X., Zhang, H.-G., & Li, B. (2017) · Psychiatry Research · doi:10.1016/j.psychres.2017.04.020 · Cited by 599 · see citing works
Rao, A. V., Bested, A. C., Beaulne, T. M., Katzman, M. A., Iorio, C., Berardi, J. M., & Logan, A. C. (2009) · Gut Pathogens · doi:10.1186/1757-4749-1-6 · Cited by 577 · see citing works
Aizawa, E., Tsuji, H., Asahara, T., Takahashi, T., Teraishi, T., Yoshida, S., Ota, M., Koga, N., Hattori, K., & Kunugi, H. (2016) · Journal of Affective Disorders · doi:10.1016/j.jad.2016.05.038 · Cited by 576 · see citing works
Messaoudi, M., Violle, N., Bisson, J.-F., Desor, D., Javelot, H., & Rougeot, C. (2011) · Gut Microbes · doi:10.4161/gmic.2.4.16108 · Cited by 574 · see citing works
Anxiety, depression, and the microbiome: A role for gut peptides
Lach, G., Schellekens, H., Dinan, T. G., & Cryan, J. F. (2018) · Neurotherapeutics · doi:10.1007/s13311-017-0585-0 · Cited by 573 · see citing works
Self-citationFirth, J., Marx, W., Dash, S., Carney, R., Teasdale, S. B., Solmi, M., Stubbs, B., Schuch, F. B., Carvalho, A. F., Jacka, F., et al. (2019) · Psychosomatic Medicine · doi:10.1097/psy.0000000000000673 · Cited by 566 · see citing works
Impact of consuming a milk drink containing a probiotic on mood and cognition
Benton, D., Williams, C., & Brown, A. (2007) · European Journal of Clinical Nutrition · doi:10.1038/sj.ejcn.1602546 · Cited by 554 · see citing works
SILK, D. B. A., DAVIS, A., VULEVIC, J., TZORTZIS, G., & GIBSON, G. R. (2009) · Alimentary Pharmacology & Therapeutics · doi:10.1111/j.1365-2036.2008.03911.x · Cited by 551 · see citing works
Molendijk, M., Molero, P., Ortuño Sánchez-Pedreño, F., Van der Does, W., & Angel Martínez-González, M. (2018) · Journal of Affective Disorders · doi:10.1016/j.jad.2017.09.022 · Cited by 550 · see citing works
Kazemi, A., Noorbala, A. A., Azam, K., Eskandari, M. H., & Djafarian, K. (2019) · Clinical Nutrition · doi:10.1016/j.clnu.2018.04.010 · Cited by 534 · see citing works
Intestinal dysbiosis and lowered serum lipopolysaccharide-binding protein in Parkinson's disease
Hasegawa, S., Goto, S., Tsuji, H., Okuno, T., Asahara, T., Nomoto, K., Shibata, A., Fujisawa, Y., Minato, T., Okamoto, A., et al. (2015) · PLOS ONE · doi:10.1371/journal.pone.0142164 · Cited by 523 · see citing works
Schmidt, K., Cowen, P. J., Harmer, C. J., Tzortzis, G., Errington, S., & Burnet, P. W. J. (2015) · Psychopharmacology · doi:10.1007/s00213-014-3810-0 · Cited by 522 · see citing works
van Kessel, S. P., Frye, A. K., El-Gendy, A. O., Castejon, M., Keshavarzian, A., van Dijk, G., & El Aidy, S. (2019) · Nature Communications · doi:10.1038/s41467-019-08294-y · Cited by 521 · see citing works
Allen, A. P., Hutch, W., Borre, Y. E., Kennedy, P. J., Temko, A., Boylan, G., Murphy, E., Cryan, J. F., Dinan, T. G., & Clarke, G. (2016) · Translational Psychiatry · doi:10.1038/tp.2016.191 · Cited by 513 · see citing works
The microbiome: a key regulator of stress and neuroinflammation
Rea, K., Dinan, T. G., & Cryan, J. F. (2016) · Neurobiology of Stress · doi:10.1016/j.ynstr.2016.03.001 · Cited by 508 · see citing works
Self-citationHuang, R., Wang, K., & Hu, J. (2016) · Nutrients · doi:10.3390/nu8080483 · Cited by 505 · see citing works
Rudzki, L., Ostrowska, L., Pawlak, D., Małus, A., Pawlak, K., Waszkiewicz, N., & Szulc, A. (2019) · Psychoneuroendocrinology · doi:10.1016/j.psyneuen.2018.10.010 · Cited by 499 · see citing works
Feeding the microbiota–gut–brain axis: Diet, microbiome, and neuropsychiatry
Sandhu, K. V., Sherwin, E., Schellekens, H., Stanton, C., Dinan, T. G., & Cryan, J. F. (2017) · Translational Research · doi:10.1016/j.trsl.2016.10.002 · Cited by 491 · see citing works
Self-citationPrenatal exposure to antibiotics, cesarean section and risk of childhood obesity
Mueller, N. T., Whyatt, R. M., Hoepner, L., Oberfield, S. E., Domínguez-Bello, M. G., Widen, E. M., Hassoun, A. A., Perera, F. P., & Rundle, A. (2014) · International Journal of Obesity · doi:10.1038/ijo.2014.180 · Cited by 487 · see citing works
Gareau, M. G., Jury, J., MacQueen, G., Sherman, P. M., & Perdue, M. H. (2007) · Gut · doi:10.1136/gut.2006.117176 · Cited by 472 · see citing works
The effects of probiotics on depressive symptoms in humans: a systematic review
Wallace, C. J. K., & Milev, R. (2017) · Annals of General Psychiatry · doi:10.1186/s12991-017-0138-2 · Cited by 471 · see citing works
Vagotomy and Parkinson disease: A Swedish register–based matched-cohort study
Liu, B., Fang, F., Pedersen, N. L., Tillander, A., Ludvigsson, J. F., Ekbom, A., Svenningsson, P., Chen, H., & Wirdefeldt, K. (2017) · Neurology · doi:10.1212/wnl.0000000000003961 · Cited by 447 · see citing works
Maternal prenatal stress is associated with the infant intestinal microbiota
Zijlmans, M. A. C., Korpela, K., Riksen-Walraven, J. M., de Vos, W. M., & de Weerth, C. (2015) · Psychoneuroendocrinology · doi:10.1016/j.psyneuen.2015.01.006 · Cited by 438 · see citing works
de Almada, C. N., de Almada, C. N., Martinez, R. C. R., & Sant’Ana, A. S. (2016) · Trends in Food Science & Technology · doi:10.1016/j.tifs.2016.09.011 · Cited by 425 · see citing works
Slykerman, R. F., Hood, F., Wickens, K., Thompson, J. M. D., Barthow, C., Murphy, R., Kang, J., Rowden, J., Stone, P., Crane, J., et al. (2017) · EBioMedicine · doi:10.1016/j.ebiom.2017.09.013 · Cited by 422 · see citing works
Maternal separation as a model of brain-gut axis dysfunction
O’Mahony, S. M., Hyland, N. P., Dinan, T. G., & Cryan, J. F. (2011) · Psychopharmacology · doi:10.1007/s00213-010-2010-9 · Cited by 415 · see citing works
Probiotics and prebiotic fiber for constipation associated with Parkinson disease: An RCT
Barichella, M., Pacchetti, C., Bolliri, C., Cassani, E., Iorio, L., Pusani, C., Pinelli, G., Privitera, G., Cesari, I., Faierman, S. A., et al. (2016) · Neurology · doi:10.1212/wnl.0000000000003127 · Cited by 390 · see citing works
The role of probiotics in children with autism spectrum disorder: A prospective, open-label study
Shaaban, S. Y., El Gendy, Y. G., Mehanna, N. S., El-Senousy, W. M., El-Feki, H. S. A., Saad, K., & El-Asheer, O. M. (2018) · Nutritional Neuroscience · doi:10.1080/1028415x.2017.1347746 · Cited by 374 · see citing works
A prebiotic intervention study in children with autism spectrum disorders (ASDs)
Grimaldi, R., Gibson, G. R., Vulevic, J., Giallourou, N., Castro-Mejía, J. L., Hansen, L. H., Leigh Gibson, E., Nielsen, D. S., & Costabile, A. (2018) · Microbiome · doi:10.1186/s40168-018-0523-3 · Cited by 369 · see citing works
A meta-analysis of the use of probiotics to alleviate depressive symptoms
Ng, Q. X., Peters, C., Ho, C. Y. X., Lim, D. Y., & Yeo, W.-S. (2018) · Journal of Affective Disorders · doi:10.1016/j.jad.2017.11.063 · Cited by 357 · see citing works
Kelly, J. R., Allen, A. P., Temko, A., Hutch, W., Kennedy, P. J., Farid, N., Murphy, E., Boylan, G., Bienenstock, J., Cryan, J. F., et al. (2017) · Brain, Behavior, and Immunity · doi:10.1016/j.bbi.2016.11.018 · Cited by 355 · see citing works
Self-citationNho, K., Kueider‐Paisley, A., MahmoudianDehkordi, S., Arnold, M., Risacher, S. L., Louie, G., Blach, C., Baillie, R., Han, X., Kastenmüller, G., et al. (2019) · Alzheimer's & Dementia · doi:10.1016/j.jalz.2018.08.012 · Cited by 343 · see citing works
Prenatal Stress Alters Bacterial Colonization of the Gut in Infant Monkeys
Bailey, M. T., Lubach, G. R., & Coe, C. L. (2004) · Journal of Pediatric Gastroenterology and Nutrition · doi:10.1097/00005176-200404000-00009 · Cited by 339 · see citing works
Irritable bowel syndrome: A microbiome-gut-brain axis disorder?
Kennedy, P. J. (2014) · World Journal of Gastroenterology · doi:10.3748/wjg.v20.i39.14105 · Cited by 335 · see citing works
Mitsou, E. K., Kakali, A., Antonopoulou, S., Mountzouris, K. C., Yannakoulia, M., Panagiotakos, D. B., & Kyriacou, A. (2017) · British Journal of Nutrition · doi:10.1017/s0007114517001593 · Cited by 325 · see citing works
Romijn, A. R., Rucklidge, J. J., Kuijer, R. G., & Frampton, C. (2017) · Australian & New Zealand Journal of Psychiatry · doi:10.1177/0004867416686694 · Cited by 323 · see citing works
Freedberg, D. E., Toussaint, N. C., Chen, S. P., Ratner, A. J., Whittier, S., Wang, T. C., Wang, H. H., & Abrams, J. A. (2015) · Gastroenterology · doi:10.1053/j.gastro.2015.06.043 · Cited by 322 · see citing works
Possible association of Firmicutes in the gut microbiota of patients with major depressive disorder
Huang, Y., Shi, X., Li, Z., Shen, Y., Shi, X., Wang, L., Li, G., Yuan, Y., Wang, J., Zhang, Y., et al. (2018) · Neuropsychiatric Disease and Treatment · doi:10.2147/ndt.s188340 · Cited by 311 · see citing works
Altered brain-gut axis in autism: comorbidity or causative mechanisms
Mayer, E. A., Padua, D., & Tillisch, K. (2014) · BioEssays · doi:10.1002/bies.201400075 · Cited by 304 · see citing works
Structural & functional consequences of chronic psychosocial stress on the microbiome & host
Bharwani, A., Mian, M. F., Foster, J. A., Surette, M. G., Bienenstock, J., & Forsythe, P. (2016) · Psychoneuroendocrinology · doi:10.1016/j.psyneuen.2015.10.001 · Cited by 293 · see citing works
Labus, J. S., Hollister, E. B., Jacobs, J., Kirbach, K., Oezguen, N., Gupta, A., Acosta, J., Luna, R. A., Aagaard, K., Versalovic, J., et al. (2017) · Microbiome · doi:10.1186/s40168-017-0260-z · Cited by 284 · see citing works
Golubeva, A. V., Crampton, S., Desbonnet, L., Edge, D., O'Sullivan, O., Lomasney, K. W., Zhdanov, A. V., Crispie, F., Moloney, R. D., Borre, Y. E., et al. (2015) · Psychoneuroendocrinology · doi:10.1016/j.psyneuen.2015.06.002 · Cited by 283 · see citing works
Self-citationDavey, K. J., O’Mahony, S. M., Schellekens, H., O’Sullivan, O., Bienenstock, J., Cotter, P. D., Dinan, T. G., & Cryan, J. F. (2012) · Psychopharmacology · doi:10.1007/s00213-011-2555-2 · Cited by 275 · see citing works
Self-citationEffect of Antibiotic Treatment on the Intestinal Metabolome
Antunes, L. C. M., Han, J., Ferreira, R. B. R., Lolić, P., Borchers, C. H., & Finlay, B. B. (2011) · Antimicrobial Agents and Chemotherapy · doi:10.1128/aac.01664-10 · Cited by 271 · see citing works
Pirbaglou, M., Katz, J., de Souza, R. J., Stearns, J. C., Motamed, M., & Ritvo, P. (2016) · Nutrition Research · doi:10.1016/j.nutres.2016.06.009 · Cited by 270 · see citing works
Liu, W.-H., Chuang, H.-L., Huang, Y.-T., Wu, C.-C., Chou, G.-T., Wang, S., & Tsai, Y.-C. (2016) · Behavioural Brain Research · doi:10.1016/j.bbr.2015.10.046 · Cited by 269 · see citing works
Differential effects of psychotropic drugs on microbiome composition and gastrointestinal function
Cussotto, S., Strain, C. R., Fouhy, F., Strain, R. G., Peterson, V. L., Clarke, G., Stanton, C., Dinan, T. G., & Cryan, J. F. (2019) · Psychopharmacology · doi:10.1007/s00213-018-5006-5 · Cited by 266 · see citing works
Self-citationGut Microbiota Features in Young Children With Autism Spectrum Disorders
Coretti, L., Paparo, L., Riccio, M. P., Amato, F., Cuomo, M., Natale, A., Borrelli, L., Corrado, G., De Caro, C., Comegna, M., et al. (2018) · Frontiers in Microbiology · doi:10.3389/fmicb.2018.03146 · Cited by 266 · see citing works
Gastrointestinal Conditions in Children With Autism Spectrum Disorder: Developing a Research Agenda
Coury, D. L., Ashwood, P., Fasano, A., Fuchs, G., Geraghty, M., Kaul, A., Mawe, G., Patterson, P., & Jones, N. E. (2012) · Pediatrics · doi:10.1542/peds.2012-0900n · Cited by 264 · see citing works
Sanctuary, M. R., Kain, J. N., Chen, S. Y., Kalanetra, K., Lemay, D. G., Rose, D. R., Yang, H. T., Tancredi, D. J., German, J. B., Slupsky, C. M., et al. (2019) · PLOS ONE · doi:10.1371/journal.pone.0210064 · Cited by 255 · see citing works
Agahi, A., Hamidi, G. A., Kakhaki, R. D., Hamdieh, M., Soheili, M., Alinaghipour, A., Taba, S. M. E., & Salami, M. (2018) · Frontiers in Neurology · doi:10.3389/fneur.2018.00662 · Cited by 248 · see citing works
Takada, M., Nishida, K., Kataoka‐Kato, A., Gondo, Y., Ishikawa, H., Suda, K., Kawai, M., Hoshi, R., Watanabe, O., Igarashi, T., et al. (2016) · Neurogastroenterology & Motility · doi:10.1111/nmo.12804 · Cited by 243 · see citing works
Davey, K. J., Cotter, P. D., O'Sullivan, O., Crispie, F., Dinan, T. G., Cryan, J. F., & O'Mahony, S. M. (2013) · Translational Psychiatry · doi:10.1038/tp.2013.83 · Cited by 236 · see citing works
Self-citationPrenatal and post‐natal exposure to antibiotics and risk of asthma in childhood
Metsälä, J., Lundqvist, A., Virta, L. J., Kaila, M., Gissler, M., & Virtanen, S. M. (2014) · Clinical & Experimental Allergy · doi:10.1111/cea.12356 · Cited by 219 · see citing works
Shultz, S. R., MacFabe, D. F., Ossenkopp, K.-P., Scratch, S., Whelan, J., Taylor, R., & Cain, D. P. (2008) · Neuropharmacology · doi:10.1016/j.neuropharm.2008.01.013 · Cited by 217 · see citing works
Vatanen, T., Plichta, D. R., Somani, J., Münch, P. C., Arthur, T. D., Hall, A. B., Rudolf, S., Oakeley, E. J., Ke, X., Young, R. A., et al. (2018) · Nature Microbiology · doi:10.1038/s41564-018-0321-5 · Cited by 216 · see citing works
The microbiome in posttraumatic stress disorder and trauma-exposed controls: an exploratory study
Hemmings, S. M. J., Malan-Müller, S., van den Heuvel, L. L., Demmitt, B. A., Stanislawski, M. A., Smith, D. G., Bohr, A. D., Stamper, C. E., Hyde, E. R., Morton, J. T., et al. (2017) · Psychosomatic Medicine · doi:10.1097/psy.0000000000000512 · Cited by 208 · see citing works
Chong, H.-X., Yusoff, N., Hor, Y.-Y., Lew, L.-C., Jaafar, M. H., Choi, S. B., Yusoff, M. S. B., Wahid, N. A., Abdullah, M. F. I. L. B., Zakaria, N., et al. (2019) · Beneficial Microbes · doi:10.3920/bm2018.0135 · Cited by 207 · see citing works
Gastroenterology Issues in Schizophrenia: Why the Gut Matters
Severance, E. G., Prandovszky, E., Castiglione, J., & Yolken, R. H. (2015) · Current Psychiatry Reports · doi:10.1007/s11920-015-0574-0 · Cited by 196 · see citing works
Miyaoka, T., Kanayama, M., Wake, R., Hashioka, S., Hayashida, M., Nagahama, M., Okazaki, S., Yamashita, S., Miura, S., Miki, H., et al. (2018) · Clinical Neuropharmacology · doi:10.1097/wnf.0000000000000299 · Cited by 190 · see citing works
Aslam, H., Green, J., Jacka, F. N., Collier, F., Berk, M., Pasco, J., & Dawson, S. L. (2020) · Nutritional Neuroscience · doi:10.1080/1028415x.2018.1544332 · Cited by 179 · see citing works
Severance, E. G., Gressitt, K. L., Stallings, C. R., Katsafanas, E., Schweinfurth, L. A. B., Savage, C. L. G., Adamos, M. B., Sweeney, K., Origoni, A. E., Khushalani, S., et al. (2016) · Brain Behavior and Immunity · doi:10.1016/j.bbi.2016.11.019 · Cited by 178 · see citing works
A psychology of the human brain-gut-microbiome axis
Allen, A. P., Dinan, T. G., Clarke, G., & Cryan, J. F. (2017) · Social and Personality Psychology Compass · doi:10.1111/spc3.12309 · Cited by 174 · see citing works
Self-citationChung, Y.-C., Jin, H.-M., Cui, Y., Kim, D. S., Jung, J. M., Park, J.-I., Jung, E.-S., Choi, E.-K., & Chae, S.-W. (2014) · Journal of Functional Foods · doi:10.1016/j.jff.2014.07.007 · Cited by 173 · see citing works
Psychotropics and the Microbiome: a Chamber of Secrets…
Cussotto, S., Clarke, G. A., Dinan, T. G., & Cryan, J. F. (2019) · Psychopharmacology · doi:10.1007/s00213-019-5185-8 · Cited by 169 · see citing works
Self-citationO’Sullivan, Ó., Cronin, O., Clarke, S. F., Murphy, E. F., Molloy, M., Shanahan, F., & Cotter, P. D. (2015) · Gut Microbes · doi:10.1080/19490976.2015.1011875 · Cited by 168 · see citing works
Kato-Kataoka, A., Nishida, K., Takada, M., Suda, K., Kawai, M., Shimizu, K., Kushiro, A., Hoshi, R., Watanabe, O., Igarashi, T., et al. (2016) · Beneficial Microbes · doi:10.3920/bm2015.0100 · Cited by 166 · see citing works
Novel probiotics and prebiotics: road to the market
Kumar, H., Salminen, S., Verhagen, H., Rowland, I. R., Heimbach, J., Bañares, S., Young, T., Nomoto, K., & Lalonde, M. (2014) · Current Opinion in Biotechnology · doi:10.1016/j.copbio.2014.11.021 · Cited by 165 · see citing works
Daban, C., Martinez-Aran, A., Cruz, N., & Vieta, E. (2008) · Journal of Affective Disorders · doi:10.1016/j.jad.2008.02.012 · Cited by 163 · see citing works
Diop, L., Guillou, S., & Durand, H. (2008) · Nutrition Research · doi:10.1016/j.nutres.2007.10.001 · Cited by 162 · see citing works
Tomasik, J., Yolken, R. H., Bahn, S., & Dickerson, F. (2015) · Biomarker Insights · doi:10.4137/bmi.s22007 · Cited by 152 · see citing works
Wei, C.-L., Wang, S., Yen, J.-T., Cheng, Y.-F., Liao, C.-L., Hsu, C.-C., Wu, C.-C., & Tsai, Y.-C. (2019) · Brain Research · doi:10.1016/j.brainres.2019.01.025 · Cited by 150 · see citing works
Okubo, R., Koga, M., Katsumata, N., Odamaki, T., Matsuyama, S., Oka, M., Narita, H., Hashimoto, N., Kusumi, I., Xiao, J., et al. (2019) · Journal of Affective Disorders · doi:10.1016/j.jad.2018.11.011 · Cited by 149 · see citing works
Shafiei, F., Salari-Moghaddam, A., Larijani, B., & Esmaillzadeh, A. (2019) · Nutrition Reviews · doi:10.1093/nutrit/nuy070 · Cited by 147 · see citing works
Cristancho, P., Cristancho, M. A., Baltuch, G. H., Thase, M. E., & O’Reardon, J. P. (2011) · The Journal of Clinical Psychiatry · doi:10.4088/jcp.09m05888blu · Cited by 142 · see citing works
The Role of Nutrition and the Gut-Brain Axis in Psychiatry: A Review of the Literature
Mörkl, S., Wagner‐Skacel, J., Lahousen, T., Lackner, S., Holasek, S. J., Bengesser, S., Painold, A., Holl, A. K., & Reininghaus, E. Z. (2018) · Neuropsychobiology · doi:10.1159/000492834 · Cited by 129 · see citing works
Kao, A. C.-C., Spitzer, S., Anthony, D. C., Lennox, B., & Burnet, P. W. J. (2018) · Translational Psychiatry · doi:10.1038/s41398-018-0116-8 · Cited by 128 · see citing works
Manderino, L., Carroll, I., Azcarate-Peril, M. A., Rochette, A., Heinberg, L., Peat, C., Steffen, K., Mitchell, J., & Gunstad, J. (2017) · Journal of the International Neuropsychological Society · doi:10.1017/s1355617717000492 · Cited by 125 · see citing works
Takagi, T., Naito, Y., Inoue, R., Kashiwagi, S., Uchiyama, K., Mizushima, K., Tsuchiya, S., Okayama, T., Dohi, O., Yoshida, N., et al. (2018) · Journal of Clinical Biochemistry and Nutrition · doi:10.3164/jcbn.17-78 · Cited by 121 · see citing works
A Fungal World: Could the Gut Mycobiome Be Involved in Neurological Disease?
Forbes, J. D., Bernstein, C. N., Tremlett, H. L., Domselaar, G. V., & Knox, N. (2019) · Frontiers in Microbiology · doi:10.3389/fmicb.2018.03249 · Cited by 117 · see citing works
H. pylori and Parkinson’s disease: Meta-analyses including clinical severity
Dardiotis, E., Tsouris, Z., Mentis, A. A., Siokas, V., Michalopoulou, A., Sokratous, M., Dastamani, M., Bogdanos, D. P., Deretzi, G., & Kountouras, J. (2018) · Clinical Neurology and Neurosurgery · doi:10.1016/j.clineuro.2018.09.039 · Cited by 115 · see citing works
Meta‐analysis: Association of <i>Helicobacter pylori</i> infection with Parkinson's diseases
Shen, X., Yang, H., Wu, Y., Zhang, D., & Jiang, H. (2017) · Helicobacter · doi:10.1111/hel.12398 · Cited by 114 · see citing works
Aizawa, E., Tsuji, H., Asahara, T., Takahashi, T., Teraishi, T., Yoshida, S., Koga, N., Hattori, K., Ota, M., & Kunugi, H. (2019) · Frontiers in Psychiatry · doi:10.3389/fpsyt.2018.00730 · Cited by 110 · see citing works
Finding the needle in the haystack: systematic identification of psychobiotics
Bambury, A., Sandhu, K., Cryan, J. F., & Dinan, T. G. (2017) · British Journal of Pharmacology · doi:10.1111/bph.14127 · Cited by 107 · see citing works
Self-citationWang, X., Yang, J., Zhang, H., Yu, J., & Yao, Z. (2019) · Autism Research · doi:10.1002/aur.2079 · Cited by 107 · see citing works
The fetal and neonatal hypothalamic–pituitary–adrenal axis
Ng, P. C. (2000) · Archives of Disease in Childhood Fetal & Neonatal · doi:10.1136/fn.82.3.f250 · Cited by 105 · see citing works
Nishida, K., Sawada, D., Kuwano, Y., Tanaka, H., Sugawara, T., Aoki, Y., Fujiwara, S., & Rokutan, K. (2017) · Journal of Functional Foods · doi:10.1016/j.jff.2017.06.031 · Cited by 104 · see citing works
Flowers, S. A., Baxter, N. T., Ward, K. M., Kraal, A. Z., McInnis, M. G., Schmidt, T. M., & Ellingrod, V. L. (2019) · Pharmacotherapy The Journal of Human Pharmacology and Drug Therapy · doi:10.1002/phar.2214 · Cited by 100 · see citing works
Lyte, M., Daniels, K. M., & Schmitz‐Esser, S. (2019) · PeerJ · doi:10.7717/peerj.6199 · Cited by 91 · see citing works
Acute and repeated exposure to social stress reduces gut microbiota diversity in Syrian hamsters
Partrick, K. A., Chassaing, B., Beach, L. Q., McCann, K. E., Gewirtz, A. T., & Huhman, K. L. (2018) · Behavioural Brain Research · doi:10.1016/j.bbr.2018.02.005 · Cited by 83 · see citing works
Economic evaluation of a dietary intervention for adults with major depression (the “SMILES” trial)
Chatterton, M. L., Mihalopoulos, C., O’Neil, A., Itsiopoulos, C., Opie, R., Castle, D., Dash, S., Brazionis, L., Berk, M., & Jacka, F. (2018) · BMC Public Health · doi:10.1186/s12889-018-5504-8 · Cited by 81 · see citing works
The qualified presumption of safety assessment and its role in EFSA risk evaluations: 15 years past
Herman, L., Chemaly, M., Cocconcelli, P. S., et al. (2018) · FEMS Microbiology Letters · doi:10.1093/femsle/fny260 · Cited by 81 · see citing works
El-Ansary, A. K., Bacha, A. G. B., Bjørklund, G., Al-Orf, N., Bhat, R. S., Moubayed, N., & Aabed, K. (2018) · Metabolic Brain Disease · doi:10.1007/s11011-018-0212-8 · Cited by 79 · see citing works
Dobbs, S. M., Dobbs, R. J., Weller, C., Charlett, A., Bjarnason, I., Lawson, A., Letley, D. P., Harbin, L. J., Price, A. B., Ibrahim, M. A. A., et al. (2010) · Helicobacter · doi:10.1111/j.1523-5378.2010.00768.x · Cited by 75 · see citing works
Patusco, R., & Ziegler, J. (2018) · Advances in Nutrition · doi:10.1093/advances/nmy031 · Cited by 75 · see citing works
Forsyth, A., Deane, F. P., & Williams, P. (2015) · Psychiatry Research · doi:10.1016/j.psychres.2015.10.001 · Cited by 74 · see citing works
Andersson, H., Tullberg, C., Ahrné, S., Hamberg, K., Lazou Ahrén, I., Molin, G., Sonesson, M., & Håkansson, Å. (2016) · International Journal of Microbiology · doi:10.1155/2016/8469018 · Cited by 73 · see citing works
Alonso, C., Guilarte, M., Vicario, M., Ramos, L., Rezzi, S., Martínez, C., Lobo, B., Martin, F., Pigrau, M., González-Castro, A. M., et al. (2012) · Neurogastroenterology & Motility · doi:10.1111/j.1365-2982.2012.01928.x · Cited by 72 · see citing works
Tingö, L., Kihlgren, A. L., Repsilber, D., Björkstén, B., Brummer, R. J., & Schoultz, I. (2015) · Nutrition Journal · doi:10.1186/s12937-016-0198-1 · Cited by 68 · see citing works
Shaping the Infant Microbiome With Non-digestible Carbohydrates
Verkhnyatskaya, S. A., Ferrari, M. D. L., de Vos, P., & Walvoort, M. T. C. (2019) · Frontiers in Microbiology · doi:10.3389/fmicb.2019.00343 · Cited by 64 · see citing works
Evidences of a new psychobiotic formulation on body composition and anxiety
Colica, C., Avolio, E., Bollero, P., Costa de Miranda, R., Ferraro, S., Sinibaldi Salimei, P., De Lorenzo, A., & Di Renzo, L. (2017) · Mediators of Inflammation · doi:10.1155/2017/5650627 · Cited by 63 · see citing works
Nishihira, J., Kagami‐Katsuyama, H., Tanaka, A., Nishimura, M., Kobayashi, T., & Kawasaki, Y. (2014) · Journal of Functional Foods · doi:10.1016/j.jff.2014.09.002 · Cited by 53 · see citing works
Ceccarelli, G., Brenchley, J. M., Cavallari, E. N., Scheri, G. C., Fratino, M., Pinacchio, C., Schietroma, I., Fard, S. N., Scagnolari, C., Mezzaroma, I., et al. (2017) · Nutrients · doi:10.3390/nu9111269 · Cited by 51 · see citing works
Liśkiewicz, P., Pełka-Wysiecka, J., Kaczmarczyk, M., Łoniewski, I., Wroński, M., Bąba-Kubiś, A., Skonieczna‐Żydecka, K., Marlicz, W. M., Misiak, B., & Samochowiec, J. (2019) · Journal of Clinical Medicine · doi:10.3390/jcm8020164 · Cited by 42 · see citing works
A Microbial Drugstore for Motility
Cryan, J. F., Clarke, G., Dinan, T. G., & Schellekens, H. (2018) · Cell Host & Microbe · doi:10.1016/j.chom.2018.05.020 · Cited by 34 · see citing works
Self-citationGut microbes and depression: Still waiting for Godot
Dinan, T. G., & Cryan, J. F. (2019) · Brain Behavior and Immunity · doi:10.1016/j.bbi.2019.02.007 · Cited by 33 · see citing works
Self-citationFrom isoniazid to psychobiotics: the gut microbiome as a new antidepressant target
Butler, M., Sandhu, K., Cryan, J. F., & Dinan, T. G. (2019) · British Journal of Hospital Medicine · doi:10.12968/hmed.2019.80.3.139 · Cited by 33 · see citing works
Self-citationDinan, T. G., & Cryan, J. F. (2018) · The World Journal of Biological Psychiatry · doi:10.1080/15622975.2018.1540793 · Cited by 32 · see citing works
Self-citationGocan, A. G., Bachg, D., Schindler, A. E., et al. (2012) · Hormone Molecular Biology and Clinical Investigation · doi:10.1515/hmbci-2011-0135 · Cited by 30 · see citing works
Gut Microbes and Brain Development Have Black Box Connectivity
Dinan, T. G., Cryan, J. F., & Stanton, C. (2017) · Biological Psychiatry · doi:10.1016/j.biopsych.2017.11.005 · Cited by 28 · see citing works
Self-citationProbiotics in irritable bowel syndrome: underachievers or underpowered? authors’ reply
Simrén, M., Öhman, L., Olsson, J., Svensson, U., Ohlson, K., Posserud, I., & Strid, H. (2010) · Alimentary Pharmacology & Therapeutics · doi:10.1111/j.1365-2036.2010.04239.x · Cited by 23 · see citing works
(2014) · CU Scholar (University of Colorado Boulder) · Cited by 15 · see citing works
Bailey (1999) · doi:10.1002/(sici)1098-2302(199909)35:2
Flagged first, then by citations
Cited by
Sorted by citations
The microbiota-gut-brain axis: from motility to mood
Margolis, K. G., Cryan, J. F., & Mayer, E. A. (2021) · Gastroenterology · doi:10.1053/j.gastro.2020.10.066 · Cited by 999 · see citing works
Diet and depression: Exploring the biological mechanisms of action
Marx, W., Lane, M., Hockey, M., Aslam, H., Berk, M., Walder, K., Borsini, A., Firth, J., Pariante, C. M., Berding, K., et al. (2021) · Molecular Psychiatry · doi:10.1038/s41380-020-00925-x · Cited by 685 · see citing works
Self-citationGut microbiota and dysbiosis in Alzheimer's disease: Implications for pathogenesis and treatment
Liu, S., Gao, J., Zhu, M., Liu, K., & Zhang, H.-L. (2020) · Molecular Neurobiology · doi:10.1007/s12035-020-02073-3 · Cited by 516 · see citing works
Diet and the Microbiota–Gut–Brain Axis: Sowing the Seeds of Good Mental Health
Berding, K., Vlckova, K., Marx, W., Schellekens, H., Stanton, C., Clarke, G., Jacka, F., Dinan, T. G., & Cryan, J. F. (2021) · Advances in Nutrition · doi:10.1093/advances/nmaa181 · Cited by 451 · see citing works
Self-citationMicrobiota and the gut-brain-axis: Implications for new therapeutic design in the CNS
Liu, L., Huh, J. R., & Shah, K. (2022) · eBioMedicine · doi:10.1016/j.ebiom.2022.103908 · Cited by 344 · see citing works
The Potential Role of Gut Microbiota in Alzheimer’s Disease: From Diagnosis to Treatment
Varesi, A., Pierella, E., Romeo, M., Piccini, G. B., Alfano, C., Bjørklund, G., Oppong, A., Ricevuti, G., Esposito, C., Chirumbolo, S., et al. (2022) · Nutrients · doi:10.3390/nu14030668 · Cited by 225 · see citing works
Role of diet and its effects on the gut microbiome in the pathophysiology of mental disorders
Horn, J., Mayer, D. E., Chen, S., & Mayer, E. A. (2022) · Translational Psychiatry · doi:10.1038/s41398-022-01922-0 · Cited by 193 · see citing works
Gut Microbiota: A Novel Therapeutic Target for Parkinson’s Disease
Zhu, M., Liu, X., Ye, Y., Yan, X., Cheng, Y., Zhao, L., Chen, F., & Ling, Z. (2022) · Frontiers in Immunology · doi:10.3389/fimmu.2022.937555 · Cited by 177 · see citing works
van de Wouw, M., Walsh, A. M., Crispie, F., van Leuven, L., Lyte, J. M., Boehme, M., Clarke, G., Dinan, T. G., Cotter, P. D., & Cryan, J. F. (2020) · Microbiome · doi:10.1186/s40168-020-00846-5 · Cited by 123 · see citing works
Self-citationGoing with the grain: Fiber, cognition, and the microbiota-gut-brain-axis
Berding, K., Carbia, C., & Cryan, J. F. (2021) · Experimental Biology and Medicine · doi:10.1177/1535370221995785 · Cited by 100 · see citing works
Self-citationMarx, W., Scholey, A., Firth, J., D’Cunha, N. M., Lane, M., Hockey, M., Ashton, M. M., Cryan, J. F., O’Neil, A., Naumovski, N., et al. (2020) · Neuroscience & Biobehavioral Reviews · doi:10.1016/j.neubiorev.2020.07.036 · Cited by 87 · see citing works
Self-citationLiu, J., Jin, Y., Li, H., Yu, J., Gong, T., Gao, X., & Sun, J. (2020) · Journal of Agricultural and Food Chemistry · doi:10.1021/acs.jafc.0c06332 · Cited by 37 · see citing works
Xie, S., Wang, C., Song, J., Zhang, Y., Wang, H., Chen, X., & Suo, H. (2024) · Journal of Agricultural and Food Chemistry · doi:10.1021/acs.jafc.4c03870 · Cited by 27 · see citing works
Lewis, N., Villani, A., & Lagopoulos, J. (2025) · Neuroscience · doi:10.1016/j.neuroscience.2025.01.031 · Cited by 25 · see citing works
Palacios‐García, I., Mhuireach, G. A., Grasso‐Cladera, A., Cryan, J. F., & Parada, F. J. (2022) · BioEssays · doi:10.1002/bies.202100249 · Cited by 14 · see citing works
Self-citationChehadi, A. C., Pereira de Lima, E., Detregiachi, C. R. P., Santos de Argollo Haber, R., Catharin, V. M. C. S., Fornari Laurindo, L., Engracia Valenti, V., Machado Galhardi, C., Tanaka, M., & Maria Barbalho, S. (2026) · International Journal of Molecular Sciences · doi:10.3390/ijms27010465 · Cited by 8 · see citing works
- Authors
- Long-Smith, C., O'Riordan, K. J., Clarke, G., Stanton, C., Dinan, T. G., & Cryan, J. F.
- Affiliations
- University College Cork (IE)
- APC Microbiome Ireland, University College Cork, Cork, Ireland;
- Teagasc - The Irish Agriculture and Food Development Authority (IE)
- Venue
- Annual Review of Pharmacology and Toxicology
- Publisher
- Annual Reviews
- Published
- 2020-01-06
- Volume
- 60
- Issue
- 1
- Pages
- 477-502
- ISSN
- 0362-1642 (ISSN-L)
- 1545-4304
- OpenAlex
- W2972987364
- Cited by
- 419
- References
- 179
- Citations by year
- 2026: 35 · 2025: 70 · 2024: 79 · 2023: 73 · 2022: 56 · 2021: 59 · 2020: 42 · 2019: 3
- FWCI
- 3.52
- Type
- journal article
- Language
- en
- Open access
- closed
- Locations
- The Annual Review of Pharmacology and Toxicology (publishedVersion)
- PubMed (publishedVersion)
- Topics
- Life Sciences › Biochemistry, Genetics and Molecular Biology › Molecular Biology › Gut microbiota and health
- Health Sciences › Medicine › Gastroenterology › Gastrointestinal motility and disorders
- Life Sciences › Neuroscience › Biological Psychiatry › Tryptophan and brain disorders
- Keywords
- microbiota-gut-brain axis, gut microbiota, psychobiotics, live biotherapeutic products, mental illness, neurodevelopmental disorders, neurodegenerative diseases, vagus nerve signaling, enteric nervous system, bacterial metabolites, adverse drug reactions, neuroimmune signaling
- MeSH terms
- Gastrointestinal Microbiome, Animals, Mental Disorders, Brain, Central Nervous System Diseases, Humans, Neurodegenerative Diseases, Drug-Related Side Effects and Adverse Reactions
About these checks
Registry, retraction, Cites and statistics results are computed, not judged, with one exception: a printed reference that no index lists is read once by a model before it counts as a citation error. Claims are extracted by a model and kept only when their quote appears verbatim in the text; each cited source is then checked, with a model’s help, for whether it says what the claim relies on. Those verdicts can be wrong — read the claim’s quote and the cited source before relying on one.
Statistics and arithmetic are recomputed, not judged.
Confidence bands are shown only for fields calibrated on our annotated test set. None is calibrated yet, so no band is shown.
What counts as a claim ›How we measure confidence ›How we check this ›
Are you an author, or do you see a problem with this page? Request a review