Gut Microbiota-Produced Tryptamine Activates an Epithelial G-Protein-Coupled Receptor to Increase Colonic Secretion
Open accessAbstract
Tryptamine, a tryptophan-derived monoamine similar to 5-hydroxytryptamine (5-HT), is produced by gut bacteria and is abundant in human and rodent feces. However, the physiologic effect of tryptamine in the gastrointestinal (GI) tract remains unknown. Here, we show that the biological effects of tryptamine are mediated through the 5-HT 4 receptor (5-HT 4 R), a G-protein-coupled receptor (GPCR) uniquely expressed in the colonic epithelium. Tryptamine increases both ionic flux across the colonic epithelium and fluid secretion in colonoids from germ-free (GF) and humanized (ex-GF colonized with human stool) mice, consistent with increased intestinal secretion. The secretory effect of tryptamine is dependent on 5-HT 4 R activation and is blocked by 5-HT 4 R antagonist and absent in 5-HT 4 R-/- mice. GF mice colonized by Bacteroides thetaiotaomicron engineered to produce tryptamine exhibit accelerated GI transit. Our study demonstrates an aspect of host physiology under control of a bacterial metabolite that can be exploited as a therapeutic modality. VIDEO ABSTRACT.
The claims and statistics of this paper haven’t been checked yet.
Run the check — free, no account needed. It reads the open-access text and checks the sources it cites.
Integrity signals
Registry
Cites
Statistics
Claims the paper makes
The claims and statistics of this paper haven’t been checked yet.
Run the check — free, no account needed. It reads the open-access text and checks the sources it cites.
Claims other papers make about this one
Each is checked against this paper’s own text: does it say what the citing paper says it does?
Tryptamine activates the 5-HT4 receptor expressed in the colonic epithelium to control colonic transit.
“Much attention has been directed towards the GI tract, in which tryptamine activates the 5-HT 4 receptor expressed in the colonic epithelium to control colonic transit (Bhattarai et al., 2018;Cryan et al., 2018).”
From The Microbiota-Gut-Brain Axis (2019) · cites this paper as Bhattarai et al., 2018
The Results section on epithelial 5-HT4Rs shows that tryptamine acts through receptors in the colonic epithelium to increase secretion. The Discussion reports accelerated whole-gut transit with microbial tryptamine production, but the Methods specify that transit was measured across the whole gut, not the colon separately. The paper does not directly establish that epithelial 5-HT4R activation controls colonic transit. (LLM, conf=0.88)
Experimental — accuracy not yet measured
Self-check
Percentages, sums and reported differences re-computed from the paper’s own numbers.
The self-check needs the paper’s full text.
Cites
Zelante, T., Iannitti, R. G., Cunha, C., De Luca, A., Giovannini, G., Pieraccini, G., Zecchi, R., D’Angelo, C., Massi-Benedetti, C., Fallarino, F., et al. (2013) · Immunity · doi:10.1016/j.immuni.2013.08.003 · Cited by 2,614 · see citing works
Principles and clinical implications of the brain-gut-enteric microbiota axis
Rhee, S. H., Pothoulakis, C., & Mayer, E. A. (2009) · Nature Reviews Gastroenterology & Hepatology · doi:10.1038/nrgastro.2009.35 · Cited by 1,342 · see citing works
Bacterial metabolite indole modulates incretin secretion from intestinal enteroendocrine L cells
Chimerel, C., Emery, E., Summers, D. K., Keyser, U., Gribble, F. M., & Reimann, F. (2014) · Cell Reports · doi:10.1016/j.celrep.2014.10.032 · Cited by 548 · see citing works
Commensal bacteria make GPCR ligands that mimic human signalling molecules
Cohen, L. J., Esterhazy, D., Kim, S.-H., Lemetre, C., Aguilar, R. R., Gordon, E. A., Pickard, A. J., Cross, J. R., Emiliano, A. B., Han, S. M., et al. (2017) · Nature · doi:10.1038/nature23874 · Cited by 500 · see citing works
Irritable bowel syndrome: a gut microbiota-related disorder?
Bhattarai, Y., Muniz Pedrogo, D. A., & Kashyap, P. C. (2017) · American Journal of Physiology-Gastrointestinal and Liver Physiology · doi:10.1152/ajpgi.00338.2016 · Cited by 294 · see citing works
Self-citationBhattarai, Y., Schmidt, B. A., Linden, D. R., Larson, E. D., Grover, M., Beyder, A., Farrugia, G., & Kashyap, P. C. (2017) · American Journal of Physiology-Gastrointestinal and Liver Physiology · doi:10.1152/ajpgi.00448.2016 · Cited by 102 · see citing works
Self-citationAo, M., Sarathy, J., Domingue, J., Alrefai, W. A., & Rao, M. C. (2013) · American Journal of Physiology-Cell Physiology · doi:10.1152/ajpcell.00416.2012 · Cited by 62 · see citing works
Flagged first, then by citations
Research works printed but not linked: 68
- Anderson GM 1975 Quantitation of tryptophan metabolites in rat feces by thin-layer chromatography J Chromatogr 105 2 323 8 1150778
- Anitha M Reichardt F Tabatabavakili S Nezami BG Chassaing B Mwangi S Vijay-Kumar M Gewirtz A Srinivasan S 2016 Intestinal dysbiosis contributes to the delayed gastrointestinal transit in high-fat diet fed mice Cell Mol Gastroenterol Hepatol 2 3 328 339 27446985 PMC4945127
- Bender DA 1983 Biochemistry of tryptophan in health and disease Mol Aspects Med 6 2 101 97 6371429
- Bhattarai Y Kashyap PC 2016 Germ-Free Mice Model for Studying Host-Microbial Interactions Methods Mol Biol 1438 123 35 27150088
- Borman RA Burleigh DE 1997 Heterogeneity of 5-HT receptors mediating secretion in the human intestine Ann N Y Acad Sci 812 224 5 9186751
- Brooks JB Nunez-Montiel OL Basta MT Hierholzer JC 1984 Studies of stools from pseudomembranous colitis, rotaviral, and other diarrheal syndromes by frequency-pulsed electron capture gas-liquid chromatography J Clin Microbiol 20 3 549 60 6490836 PMC271369
- Cil O Phuan PW Lee S Tan J Haggie PM Levin MH Sun L Thiagarajah JR Ma T Verkman AS 2016 CFTR activator increases intestinal fluid secretion and normalizes stool output in a mouse model of constipation Cell Mol Gastroenterol Hepatol 2 3 317 327 27127798 PMC4844355
- Clarke G Stilling RM Kennedy PJ Stanton C Cryan JF Dinan TG 2014 Minireview: Gut microbiota: the neglected endocrine organ Mol Endocrinol 28 8 1221 38 24892638 PMC5414803
- Cole P Rabasseda X 2004 Tegaserod: a serotonin 5-HT4 receptor agonist for treatment of constipation-predominant irritable bowel syndrome Drugs Today (Barc) 40 12 1013 30 15645012
- Compan V Zhou M Grailhe R Gazzara RA Martin R Gingrich J Dumuis A Brunner D Bockaert J Hen R 2004 Attenuated response to stress and novelty and hypersensitivity to seizures in 5-HT4 receptor knock-out mice J Neurosci 24 2 412 9 14724239 PMC6729986
- Davies DG Parsek MR Pearson JP Iglewski BH Costerton JW Greenberg EP 1998 The involvement of cell-to-cell signals in the development of a bacterial biofilm Science 280 5361 295 8 9535661
- Dekkers JF Wiegerinck CL de Jonge HR Bronsveld I Janssens HM de Winter-de Groot KM Brandsma AM de Jong NW Bijvelds MJ Scholte BJ Nieuwenhuis EE van den Brink S Clevers H van der Ent CK Middendorp S Beekman JM 2013 A functional CFTR assay using primary cystic fibrosis intestinal organoids Nat Med 19 7 939 45 23727931
- Dey N Wagner VE Blanton LV Cheng J Fontana L Haque R Ahmed T Gordon JI 2015 Regulators of Gut Motility Revealed by a Gnotobiotic Model of Diet-Microbiome Interactions Related to Travel Cell 163 1 95 107 26406373 PMC4583712
- Dodd D Spitzer MH Van Treuren W Merrill BD Hryckowian AJ Higginbottom SK Le A Cowan TM Nolan GP Fischbach MA Sonnenburg JL 2017 A gut bacterial pathway metabolizes aromatic amino acids into nine circulating metabolites Nature 551 7682 648 652 29168502 PMC5850949
- Domingue JC Ao M Sarathy J George A Alrefai WA Nelson DJ Rao MC 2014 HEK-293 cells expressing the cystic fibrosis transmembrane conductance regulator (CFTR): a model for studying regulation of Cl− transport Physiol Rep 2 9 PMC4270233 25263207
- Drolet B Khalifa M Daleau P Hamelin BA Turgeon J 1998 Block of the rapid component of the delayed rectifier potassium current by the prokinetic agent cisapride underlies drug-related lengthening of the QT interval Circulation 97 2 204 10 9445174
- Esser C Rannug A 2015 The aryl hydrocarbon receptor in barrier organ physiology, immunology, and toxicology Pharmacol Rev 67 2 259 79 25657351
- Facchini PJ Huber-Allanach KL Tari LW 2000 Plant aromatic L-amino acid decarboxylases: evolution, biochemistry, regulation, and metabolic engineering applications Phytochemistry 54 2 121 38 10872203
- Frizzell RA Hanrahan JW 2012 Physiology of epithelial chloride and fluid secretion Cold Spring Harb Perspect Med 2 6 a009563 22675668 PMC3367533
- Gargaro M Pirro M Romani R Zelante T Fallarino F 2016 Aryl Hydrocarbon Receptor-Dependent Pathways in Immune Regulation Am J Transplant 16 8 2270 6 26751261
- Gevi F Zolla L Gabriele S Persico AM 2016 Urinary metabolomics of young Italian autistic children supports abnormal tryptophan and purine metabolism Mol Autism 7 47 27904735 PMC5121959
- Grider JR Foxx-Orenstein AE Jin JG 1998 5-Hydroxytryptamine4 receptor agonists initiate the peristaltic reflex in human, rat, and guinea pig intestine Gastroenterology 115 2 370 80 9679042
- Han B Sheng B Zhang Z Pu A Yin J Wang Q Yang K Sun L Yu M Qiu Y Xiao W Yang H 2016 Aryl Hydrocarbon Receptor Activation in Intestinal Obstruction Ameliorates Intestinal Barrier Dysfunction Via Suppression of MLCK-MLC Phosphorylation Pathway Shock 46 3 319 28 26939041
- Heath-Pagliuso S Rogers WJ Tullis K Seidel SD Cenijn PH Brouwer A Denison MS 1998 Activation of the Ah receptor by tryptophan and tryptophan metabolites Biochemistry 37 33 11508 15 9708986
- Hoffman JM Tyler K MacEachern SJ Balemba OB Johnson AC Brooks EM Zhao H Swain GM Moses PL Galligan JJ Sharkey KA Greenwood-Van Meerveld B Mawe GM 2012 Activation of colonic mucosal 5-HT(4) receptors accelerates propulsive motility and inhibits visceral hypersensitivity Gastroenterology 142 4 844 854 e4 22226658 PMC3477545
- Holmes E Li JV Marchesi JR Nicholson JK 2012 Gut microbiota composition and activity in relation to host metabolic phenotype and disease risk Cell Metab 16 5 559 64 23140640
- Hurst NR Kendig DM Murthy KS Grider JR 2014 The short chain fatty acids, butyrate and propionate, have differential effects on the motility of the guinea pig colon Neurogastroenterol Motil 26 11 1586 96 25223619 PMC4438679
- In JG Foulke-Abel J Estes MK Zachos NC Kovbasnjuk O Donowitz M 2016 Human mini-guts: new insights into intestinal physiology and host-pathogen interactions Nat Rev Gastroenterol Hepatol 13 11 633 642 27677718 PMC5079760
- Jin JG Foxx-Orenstein AE Grider JR 1999 Propulsion in guinea pig colon induced by 5-hydroxytryptamine (HT) via 5-HT4 and 5-HT3 receptors J Pharmacol Exp Ther 288 1 93 7 9862758
- Jin UH Lee SO Sridharan G Lee K Davidson LA Jayaraman A Chapkin RS Alaniz R Safe S 2014 Microbiome-derived tryptophan metabolites and their aryl hydrocarbon receptor-dependent agonist and antagonist activities Mol Pharmacol 85 5 777 88 24563545 PMC3990014
- Jones RM 2016 The Influence of the Gut Microbiota on Host Physiology: In Pursuit of Mechanisms Yale J Biol Med 89 3 285 297 27698613 PMC5045138
- Jones RS 1982 Tryptamine: a neuromodulator or neurotransmitter in mammalian brain? Prog Neurobiol 19 1–2 117 39 6131482
- Kabouridis PS Lasrado R McCallum S Chng SH Snippert HJ Clevers H Pettersson S Pachnis V 2015 Microbiota controls the homeostasis of glial cells in the gut lamina propria Neuron 85 2 289 95 25578362 PMC4306542
- Kagnoff MF Eckmann L 1997 Epithelial cells as sensors for microbial infection J Clin Invest 100 1 6 10 9202050 PMC508158
- Kaji I Akiba Y Said H Narimatsu K Kaunitz JD 2015 Luminal 5-HT stimulates colonic bicarbonate secretion in rats Br J Pharmacol 172 19 4655 70 26061462 PMC4594270
- Kelly JR Kennedy PJ Cryan JF Dinan TG Clarke G Hyland NP 2015 Breaking down the barriers: the gut microbiome, intestinal permeability and stress-related psychiatric disorders Front Cell Neurosci 9 392 26528128 PMC4604320
- Marcobal A Kashyap PC Nelson TA Aronov PA Donia MS Spormann A Fischbach MA Sonnenburg JL 2013 A metabolomic view of how the human gut microbiota impacts the host metabolome using humanized and gnotobiotic mice ISME J 7 10 1933 43 23739052 PMC3965317
- Marsland BJ 2016 Regulating inflammation with microbial metabolites Nat Med 22 6 581 3 27270775
- Mawe GM Hoffman JM 2013 Serotonin signalling in the gut--functions, dysfunctions and therapeutic targets Nat Rev Gastroenterol Hepatol 10 8 473 86 23797870 PMC4048923
- McGowan K Kane A Asarkof N Wicks J Guerina V Kellum J Baron S Gintzler AR Donowitz M 1983 Entamoeba histolytica causes intestinal secretion: role of serotonin Science 221 4612 762 4 6308760
- Mustala O Solatunturi E Tarpila S 1969 Monoamine oxidase activity in the human small intestine Acta Med Scand 185 3 145 6 5811158
- Neis EP Dejong CH Rensen SS 2015 The role of microbial amino acid metabolism in host metabolism Nutrients 7 4 2930 46 25894657 PMC4425181
- Paley EL Perry G Sokolova O 2013 Tryptamine induces axonopathy and mitochondriopathy mimicking neurodegenerative diseases via tryptophanyl-tRNA deficiency Curr Alzheimer Res 10 9 987 1004 24117115
- Palmer KL Mashburn LM Singh PK Whiteley M 2005 Cystic fibrosis sputum supports growth and cues key aspects of Pseudomonas aeruginosa physiology J Bacteriol 187 15 5267 77 16030221 PMC1196007
- Prager M Büttner J Grunert P Ellinghaus D Büning C 2016 A Promoter Variant Within the Aryl Hydrocarbon Receptor Gene Is Associated with an Epithelial Barrier Defect in Smokers with Crohn’s Disease Inflamm Bowel Dis 22 10 2356 68 27598741
- Reigstad CS Salmonson CE Rainey JF Szurszewski JH Linden DR Sonnenburg JL Farrugia G Kashyap PC 2015 Gut microbes promote colonic serotonin production through an effect of short-chain fatty acids on enterochromaffin cells FASEB J 29 4 1395 403 25550456 PMC4396604
- Richard DM Dawes MA Mathias CW Acheson A Hill-Kapturczak N Dougherty DM 2009 L-Tryptophan: Basic Metabolic Functions, Behavioral Research and Therapeutic Indications Int J Tryptophan Res 2 45 60 20651948 PMC2908021
- Rothhammer V Mascanfroni ID Bunse L Takenaka MC Kenison JE Mayo L Chao CC Patel B Yan R Blain M Alvarez JI Kébir H Anandasabapathy N Izquierdo G Jung S Obholzer N Pochet N Clish CB Prinz M Prat A Antel J Quintana FJ 2016 Type I interferons and microbial metabolites of tryptophan modulate astrocyte activity and central nervous system inflammation via the aryl hydrocarbon receptor Nat Med 22 6 586 97 27158906 PMC4899206
- Sagrada A Schiavi GB Cereda E Ladinsky H 1994 Antagonistic properties of McNeil-A-343 at 5-HT4 and 5-HT3 receptors Br J Pharmacol 113 3 711 6 7532081 PMC1510439
- Sakurai-Yamashita Y Yamashita K Kanematsu T Taniyama K 1999 Localization of the 5-HT(4) receptor in the human and the guinea pig colon Eur J Pharmacol 383 3 281 5 10594320
- Soret R Chevalier J De Coppet P Poupeau G Derkinderen P Segain JP Neunlist M 2010 Short-chain fatty acids regulate the enteric neurons and control gastrointestinal motility in rats Gastroenterology 138 5 1772 82 20152836
- Stacy A Fleming D Lamont RJ Rumbaugh KP Whiteley M 2016 A Commensal Bacterium Promotes Virulence of an Opportunistic Pathogen via Cross-Respiration MBio 7 3 PMC4916382 27353758
- Swift S Downie JA Whitehead NA Barnard AM Salmond GP Williams P 2001 Quorum sensing as a population-density-dependent determinant of bacterial physiology Adv Microb Physiol 45 199 270 11450110
- Tack J Camilleri M Chang L Chey WD Galligan JJ Lacy BE Müller-Lissner S Quigley EM Schuurkes J De Maeyer JH Stanghellini V 2012 Systematic review: cardiovascular safety profile of 5-HT(4) agonists developed for gastrointestinal disorders Aliment Pharmacol Ther 35 7 745 67 22356640 PMC3491670
- Thomas RH Allmond K 2013 Linaclotide (Linzess) for Irritable Bowel syndrome With Constipation and For Chronic Idiopathic Constipation P T 38 3 154 60 23641133 PMC3638410
- Tonini M Messori E Franceschetti GP Rizzi CA Castoldi AF Coccini T Candura SM 1994 Characterization of the 5-HT receptor potentiating neuromuscular cholinergic transmission in strips of human isolated detrusor muscle Br J Pharmacol 113 1 1 2 7812598 PMC1510065
- Tuladhar BR Costall B Naylor RJ 1996 Pharmacological characterization of the 5-hydroxytryptamine receptor mediating relaxation in the rat isolated ileum Br J Pharmacol 119 2 303 10 8886413 PMC1915858
- Tuladhar BR Costall B Naylor RJ 2002 Modulation of 5-HT4 receptor function in the rat isolated ileum by fluoxetine: the involvement of endogenous 5-hydroxytryptamine Br J Pharmacol 136 1 150 6 11976280 PMC1762121
- Van Oekelen D Megens A Meert T Luyten WH Leysen JE 2002 Role of 5-HT(2) receptors in the tryptamine-induced 5-HT syndrome in rats Behav Pharmacol 13 4 313 8 12218512
- Venkatesh M Mukherjee S Wang H Li H Sun K Benechet AP Qiu Z Maher L Redinbo MR Phillips RS Fleet JC Kortagere S Mukherjee P Fasano A Le Ven J Nicholson JK Dumas ME Khanna KM Mani S 2014 Symbiotic bacterial metabolites regulate gastrointestinal barrier function via the xenobiotic sensor PXR and Toll-like receptor 4 Immunity 41 2 296 310 25065623 PMC4142105
- Visick KL Fuqua C 2005 Decoding microbial chatter: cell-cell communication in bacteria J Bacteriol 187 16 5507 19 16077095 PMC1196057
- Weissenburger J Funck-Brentano C Jaillon P Charbit B 2009 Droperidol and ondansetron in vitro electrophysiological drug interaction study Fundam Clin Pharmacol 23 6 719 26 19678851
- Whitaker WR Shepherd ES Sonnenburg JL 2017 Tunable Expression Tools Enable Single-Cell Strain Distinction in the Gut Microbiome Cell 169 3 538 546.e12 28431251 PMC5576361
- Williams BB Van Benschoten AH Cimermancic P Donia MS Zimmermann M Taketani M Ishihara A Kashyap PC Fraser JS Fischbach MA 2014 Discovery and characterization of gut microbiota decarboxylases that can produce the neurotransmitter tryptamine Cell host & microbe 16 4 495 503 25263219 PMC4260654
- Wurtman RJ Hefti F Melamed E 1980 Precursor control of neurotransmitter synthesis Pharmacol Rev 32 4 315 35 6115400
- Yano JM Yu K Donaldson GP Shastri GG Ann P Ma L Nagler CR Ismagilov RF Mazmanian SK Hsiao EY 2015 Indigenous bacteria from the gut microbiota regulate host serotonin biosynthesis Cell 161 2 264 76 25860609 PMC4393509
- Yeo CJ Couse NF Zinner MJ 1989 Serotonin and substance P stimulate intestinal secretion in the isolated perfused ileum Surgery 105 1 86 92 2463683
- Zhang LS Davies SS 2016 Microbial metabolism of dietary components to bioactive metabolites: opportunities for new therapeutic interventions Genome Med 8 1 46 27102537 PMC4840492
Cited by
Sorted by citations
Cryan, J. F., O'Riordan, K. J., Cowan, C. S. M., Sandhu, K. V., Bastiaanssen, T. F. S., Boehme, M., Codagnone, M. G., Cussotto, S., Fulling, C., Golubeva, A. V., et al. (2019) · Physiological Reviews · doi:10.1152/physrev.00018.2018 · Cited by 5,286 · see citing works
The microbiota-gut-brain axis: from motility to mood
Margolis, K. G., Cryan, J. F., & Mayer, E. A. (2021) · Gastroenterology · doi:10.1053/j.gastro.2020.10.066 · Cited by 999 · see citing works
Chen, Y., Xu, J., & Chen, Y. (2021) · Nutrients · doi:10.3390/nu13062099 · Cited by 917 · see citing works
Dynamic modulation of the gut microbiota and metabolome by bacteriophages in a mouse model
Hsu, B. B., Gibson, T. E., Yeliseyev, V., Liu, Q., Lyon, L., Bry, L., Silver, P. A., & Gerber, G. K. (2019) · Cell Host & Microbe · doi:10.1016/j.chom.2019.05.001 · Cited by 573 · see citing works
Longitudinal Multi-omics Reveals Subset-Specific Mechanisms Underlying Irritable Bowel Syndrome
Mars, R. A. T., Yang, Y., Ward, T., Houtti, M., Priya, S., Lekatz, H. R., Tang, X., Sun, Z., Kalari, K. R., Korem, T., et al. (2020) · Cell · doi:10.1016/j.cell.2020.08.007 · Cited by 456 · see citing works
“As expected from our findings in gnotobiotic mice (Bhattarai et al., 2018), we found colonic biopsies from IBS-D patients also exhibited significantly higher baseline Isc (Figure 2F), Mars et al.”
Self-citationMicrobiota-derived metabolites as drivers of gut–brain communication
Ahmed, H., Leyrolle, Q., Koistinen, V., Kärkkäinen, O., Layé, S., Delzenne, N., & Hanhineva, K. (2022) · Gut Microbes · doi:10.1080/19490976.2022.2102878 · Cited by 462 · see citing works
<i>Ruminococcus gnavus</i> : friend or foe for human health
Crost, E. H., Coletto, E., Bell, A., & Juge, N. (2023) · FEMS Microbiology Reviews · doi:10.1093/femsre/fuad014 · Cited by 335 · see citing works
Mining the microbiota for microbial and metabolite-based immunotherapies
Skelly, A. N., Sato, Y., Kearney, S., & Honda, K. (2019) · Nature Reviews Immunology · doi:10.1038/s41577-019-0144-5 · Cited by 306 · see citing works
From gut microbiota to host appetite: gut microbiota-derived metabolites as key regulators
Han, H., Yi, B., Zhong, R., Wang, M., Zhang, S., Ma, J., Yin, Y., Yin, J., Chen, L., & Zhang, H. (2021) · Microbiome · doi:10.1186/s40168-021-01093-y · Cited by 292 · see citing works
Focus on the essentials: tryptophan metabolism and the microbiome-gut-brain axis
Gheorghe, C. E., Martin, J. A., Manriquez, F. V., Dinan, T. G., Cryan, J. F., & Clarke, G. (2019) · Current Opinion in Pharmacology · doi:10.1016/j.coph.2019.08.004 · Cited by 212 · see citing works
Deciphering the Chemical Lexicon of Host–Gut Microbiota Interactions
Nicolas, G. R., & Chang, P. V. (2019) · Trends in Pharmacological Sciences · doi:10.1016/j.tips.2019.04.006 · Cited by 195 · see citing works
The Gut Microbial Bile Acid Modulation and Its Relevance to Digestive Health and Diseases
Fogelson, K. A., Dorrestein, P. C., Zarrinpar, A., & Knight, R. (2023) · Gastroenterology · doi:10.1053/j.gastro.2023.02.022 · Cited by 177 · see citing works
Short-chain fatty acids and microbiota metabolites attenuate ghrelin receptor signaling
Torres‐Fuentes, C., Golubeva, A. V., Zhdanov, A. V., Wallace, S., Arboleya, S., Papkovsky, D. B., Aidy, S. E., Ross, P., Roy, B. L., Stanton, C., et al. (2019) · The FASEB Journal · doi:10.1096/fj.201901433r · Cited by 154 · see citing works
Pan, R., Wang, L., Xu, X., Chen, Y., Wang, H., Wang, G., Zhao, J., & Chen, W. (2022) · Nutrients · doi:10.3390/nu14183704 · Cited by 149 · see citing works
Zhang, C., Jiang, J., Tian, F., Zhao, J., Zhang, H., Zhai, Q., & Chen, W. (2020) · Clinical Nutrition · doi:10.1016/j.clnu.2020.01.005 · Cited by 131 · see citing works
Bhattarai, Y., Si, J., Pu, M., Ross, O. A., McLean, P. J., Till, L., Moor, W., Grover, M., Kandimalla, K. K., Margolis, K. G., et al. (2021) · Gut Microbes · doi:10.1080/19490976.2020.1866974 · Cited by 126 · see citing works
Self-citationXu, Y., Wang, J., Wu, X., Jing, H., Zhang, S., Hu, Z., Rao, L., Chang, Q., Wang, L., & Zhang, Z. (2023) · Gut Microbes · doi:10.1080/19490976.2023.2168101 · Cited by 61 · see citing works
A Microbial Drugstore for Motility
Cryan, J. F., Clarke, G., Dinan, T. G., & Schellekens, H. (2018) · Cell Host & Microbe · doi:10.1016/j.chom.2018.05.020 · Cited by 34 · see citing works
- Authors
- Bhattarai, Y., Williams, B. B., Battaglioli, E. J., Whitaker, W. R., Till, L., Grover, M., Linden, D. R., Akiba, Y., Kandimalla, K. K., Zachos, N. C., Kaunitz, J. D., Sonnenburg, J. L., Fischbach, M. A., Farrugia, G., & Kashyap, P. C.
- Affiliations
- Mayo Clinic (US)
- Stanford University (US)
- Stanford Medicine (US)
- University of California, Los Angeles (US)
- University of Minnesota (US)
- Johns Hopkins University (US)
- Corresponding author
- Kashyap, Purna C.
- ORCID
- Venue
- Cell Host & Microbe
- Publisher
- Elsevier BV
- Published
- 2018-06
- Volume
- 23
- Issue
- 6
- Pages
- 775-785.e5
- ISSN
- 1931-3128 (ISSN-L)
- PMC
- PMC6055526
- OpenAlex
- W2807927929
- Cited by
- 436
- References
- 7
- Citations by year
- 2026: 52 · 2025: 54 · 2024: 82 · 2023: 61 · 2022: 64 · 2021: 53 · 2020: 35 · 2019: 30 · 2018: 4
- FWCI
- 10.65
- Type
- journal article
- Language
- en
- Open access
- bronze
- doi.org
- Licence
- Locations
- Cell Host & Microbe (publishedVersion)
- PubMed (publishedVersion)
- PubMed Central (acceptedVersion)
- eScholarship (California Digital Library) (submittedVersion)
- Funders
- Mayo Clinic
- National Institutes of Health (DK100638, DK114007, DK111850)
- National Institute of Diabetes and Digestive and Kidney Diseases (K23 103911)
- Topics
- Life Sciences › Biochemistry, Genetics and Molecular Biology › Molecular Biology › Gut microbiota and health
- Health Sciences › Medicine › Gastroenterology › Gastrointestinal motility and disorders
- Life Sciences › Neuroscience › Biological Psychiatry › Tryptophan and brain disorders
- Keywords
- tryptamine, gut microbiota, 5-HT4 receptor, G protein-coupled receptors, colonic epithelium, intestinal secretion, bacterial metabolites, Bacteroides thetaiotaomicron, germ-free mice, humanized mice, gastrointestinal transit, ion flux, 5-HT4 receptor antagonists
- MeSH terms
- Gastrointestinal Microbiome, Bacteroides thetaiotaomicron, Animals, Colon, Epithelium, Feces, Humans, Intestinal Secretions, Sex Factors, Specific Pathogen-Free Organisms, Tryptamines, Mice, Knockout, Receptors, Serotonin, 5-HT4, Mice, Mice, 129 Strain, Primary Cell Culture
About these checks
Registry, retraction, Cites and statistics results are computed, not judged, with one exception: a printed reference that no index lists is read once by a model before it counts as a citation error. Claims are extracted by a model and kept only when their quote appears verbatim in the text; each cited source is then checked, with a model’s help, for whether it says what the claim relies on. Those verdicts can be wrong — read the claim’s quote and the cited source before relying on one.
Statistics and arithmetic are recomputed, not judged.
Confidence bands are shown only for fields calibrated on our annotated test set. None is calibrated yet, so no band is shown.
What counts as a claim ›How we measure confidence ›How we check this ›
Are you an author, or do you see a problem with this page? Request a review
