The DOI matches its Crossref record; 82 of the 82 references it cites were found in a registry or an index.
Commensal Staphylococcus epidermidis contributes to skin barrier homeostasis by generating protective ceramides
Open accessAbstract
Summary Previously either regarded as insignificant or feared as potential sources of infection, the bacteria living on our skin are increasingly recognized to benefit human health. Skin commensals modulate mucosal immune defenses and directly interfere with pathogens; however, their contribution to the skin’s physical integrity is less understood. Here we show that the abundant skin commensal Staphylococcus epidermidis contributes to skin barrier integrity. S. epidermidis secretes a sphingomyelinase that acquires essential nutrients for the bacteria but also assists the host in producing ceramides, the main constituent of the epithelial barrier that averts skin dehydration and aging. In mouse models, S. epidermidis significantly increases skin ceramide levels and prevents water loss of damaged skin in a fashion entirely dependent on its sphingomyelinase. Our findings reveal a symbiotic mechanism that demonstrates an important role of the skin microbiota in the maintenance of the skin’s protective barrier.
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Staphylococcus epidermidis and its dual lifestyle in skin health and infection
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Skin Barrier Function and the Microbiome
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Bacterial Biofilm in Chronic Wounds and Possible Therapeutic Approaches
Cavallo, I., Sivori, F., Mastrofrancesco, A., Abril, E., Pontone, M., Di Domenico, E. G., & Pimpinelli, F. (2024) · Biology · doi:10.3390/biology13020109 · Cited by 213
Sweat and Sebum Preferences of the Human Skin Microbiota
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Skin Microbiome, Metabolome and Skin Phenome, from the Perspectives of Skin as an Ecosystem
Chen, H., Zhao, Q., Zhong, Q., Duan, C., Krutmann, J., Wang, J., & Xia, J. (2022) · Phenomics · doi:10.1007/s43657-022-00073-y · Cited by 79
Metadata
- Authors
- Zheng, Y., Hunt, R. L., Villaruz, A. E., Fisher, E. L., Liu, R., Liu, Q., Cheung, G. Y. C., Li, M., & Otto, M.
- Venue
- Cell Host & Microbe
- Publisher
- Elsevier BV
- Published
- 2022-03
- Volume
- 30
- Issue
- 3
- Pages
- 301-313.e9
- ISSN
- 1931-3128 (ISSN-L)
- OpenAlex
- W4210719890
- Cited by
- 285
- References
- 82
- FWCI
- 43.65
- Type
- journal article
- Language
- en
- Open access
- bronze
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- Zheng, Y., Hunt, R. L., Villaruz, A. E., Fisher, E. L., Liu, R., Liu, Q., Cheung, G. Y. C., Li, M., & Otto, M. (2022). Commensal Staphylococcus epidermidis contributes to skin barrier homeostasis by generating protective ceramides. Cell Host & Microbe. https://doi.org/10.1016/j.chom.2022.01.004
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Contains information from the Semantic Scholar Academic Graph Datasets, made available under the ODC Attribution License (ODC-BY 1.0).
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