Sweat and Sebum Preferences of the Human Skin Microbiota
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Abstract
The human skin microbiome is adapted to survive and thrive in the harsh environment of the skin, which is low in nutrient availability. To study skin microorganisms in a system that mimics the natural skin environment, we developed and tested a physiologically relevant, synthetic skin-like growth medium that is composed of compounds found in the human skin secretions sweat and sebum.
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Skin is a nutrient-poor environment that is not particularly hospitable to an incoming pathogen.
“Skin is a nutrient-poor environment that is not particularly hospitable to an incoming pathogen (27).”
From <i>Candida auris</i> metabolism and growth preferences in physiologically relevant skin-like conditions (2026) · cites this paper as [27]
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Byrd, A. L., Belkaid, Y., & Segre, J. A. (2018) · Nature Reviews Microbiology · doi:10.1038/nrmicro.2017.157 · Cited by 2,806 · see citing works
Temporal Stability of the Human Skin Microbiome
Oh, J., Byrd, A. L., Park, M., Kong, H. H., & Segre, J. A. (2016) · Cell · doi:10.1016/j.cell.2016.04.008 · Cited by 1,036 · see citing works
Variations in Regional Sweat Composition in Normal Human Males
Patterson, M. J., Galloway, S. D. R., & Nimmo, M. A. (2000) · Experimental Physiology · doi:10.1111/j.1469-445x.2000.02058.x · Cited by 438 · see citing works
Baker, L. B. (2017) · Sports Medicine · doi:10.1007/s40279-017-0691-5 · Cited by 403 · see citing works
Picardo, M., Ottaviani, M., Camera, E., & Mastrofrancesco, A. (2009) · Dermato-Endocrinology · doi:10.4161/derm.1.2.8472 · Cited by 368 · see citing works
Physiological mechanisms determining eccrine sweat composition
Baker, L. B., & Wolfe, A. S. (2020) · European Journal of Applied Physiology · doi:10.1007/s00421-020-04323-7 · Cited by 353 · cited 3× · see citing works
“Eccrine sweat, composed of mainly 156 salt water, contains a variety of other solutes in varying concentrations, including lactate, urea, 157 glucose, bicarbonate, amino acids, electrolytes (in addition to Na+ and Cl-), and vitamins (23, 24).”
BackgroundWhat lives on our skin: ecology, genomics and therapeutic opportunities of the skin microbiome
Scharschmidt, T. C., & Fischbach, M. A. (2013) · Drug Discovery Today: Disease Mechanisms · doi:10.1016/j.ddmec.2012.12.003 · Cited by 215 · see citing works
Candida auris Forms High-Burden Biofilms in Skin Niche Conditions and on Porcine Skin
Horton, M. V., Johnson, C. J., Kernien, J. F., Patel, T. D., Lam, B. C., Cheong, J. Z. A., Meudt, J. J., Shanmuganayagam, D., Kalan, L. R., & Nett, J. E. (2020) · mSphere · doi:10.1128/msphere.00910-19 · Cited by 159 · cited 4× · see citing works
“158 To develop an artificial sweat that is consistent with the composition of human eccrine sweat and 159 is suitable for microbial growth, we developed a formulation considering previously described 160 synthetic sweat media (12, 14) and through extrapolating eccrine sweat constituents and their 161 concentrations as…”
BackgroundMethodInfluentialSelf-citationMark, H., & Harding, C. R. (2013) · International Journal of Cosmetic Science · doi:10.1111/ics.12019 · Cited by 75 · see citing works
Sweat Facilitated Amino Acid Losses in Male Athletes during Exercise at 32-34°C
Dunstan, R. H., Sparkes, D. L., Dascombe, B. J., Macdonald, M. M., Evans, C. A., Stevens, C. J., Crompton, M. J., Gottfries, J., Franks, J., Murphy, G., et al. (2016) · PLOS ONE · doi:10.1371/journal.pone.0167844 · Cited by 43 · see citing works
Ben-Dov, E., Ben Yosef, D. Z., Pavlov, V., & Kushmaro, A. (2009) · INTERNATIONAL JOURNAL OF SYSTEMATIC AND EVOLUTIONARY MICROBIOLOGY · doi:10.1099/ijs.0.007468-0 · Cited by 36 · see citing works
Flagged first, then by citations
Research works printed but not linked: 70
- [2]Zheng Y, Hunt RL, Villaruz AE, Fisher EL, Liu R, Liu Q, Cheung GYC, Li M, Otto M. 2022. Commensal Staphylococcus epidermidis contributes to skin barrier homeostasis by generating protective ceramides. Cell Host Microbe 30: 301– 313.e9. doi: 10.1016/j.chom.2022.01.004. 35123653 PMC8917079 · DOI
- [3]Dwyer LR, Scharschmidt TC. 2022. Early life host-microbe interactions in skin. Cell Host Microbe 30: 684– 695. doi: 10.1016/j.chom.2022.02.016. 35550671 PMC9178950 · DOI
- [4]Flowers L, Grice EA. 2020. The skin microbiota: balancing risk and reward. Cell Host Microbe 28: 190– 200. doi: 10.1016/j.chom.2020.06.017. 32791112 PMC7444652 · DOI
- [5]Swaney MH, Kalan LR. 2021. Living in your skin: microbes, molecules, and mechanisms. Infect Immun 89: e00695-20. doi: 10.1128/IAI.00695-20. 33468585 PMC8090955 · DOI
- [6]Belkaid Y, Segre JA. 2014. Dialogue between skin microbiota and immunity. Science 346: 954– 959. doi: 10.1126/science.1260144. 25414304 · DOI · Paper page
- [7]Whiteside JA, Voss JG. 1973. Incidence and lipolytic activity of Propionibacterium acnes (Corynebacterium acnes group I) and P. granulosum (C. acnes group II) in acne and in normal skin. J Invest Dermatol 60: 94– 97. doi: 10.1111/1523-1747.ep12724177. 4266325 · DOI
- [8]Puhvel SM, Reisner RM. 1970. Effect of fatty acids on the growth of Corynebacterium acnes in vitro. J Invest Dermatol 54: 48– 52. doi: 10.1111/1523-1747.ep12551667. 5416678 · DOI
- [9]Gribbon EM, Cunliffe WJ, Holland KT. 1993. Interaction of Propionibacterium acnes with skin lipids in vitro. J Gen Microbiol 139: 1745– 1751. doi: 10.1099/00221287-139-8-1745. 8409917 · DOI
- [10]Kwaszewska A, Sobiś-Glinkowska M, Szewczyk EM. 2014. Cohabitation—relationships of corynebacteria and staphylococci on human skin. Folia Microbiol (Praha) 59: 495– 502. doi: 10.1007/s12223-014-0326-2. 24880250 PMC4194702 · DOI
- [11]Tauch A, Kaiser O, Hain T, Goesmann A, Weisshaar B, Albersmeier A, Bekel T, Bischoff N, Brune I, Chakraborty T, Kalinowski J, Meyer F, Rupp O, Schneiker S, Viehoever P, Pühler A. 2005. Complete genome sequence and analysis of the multiresistant nosocomial pathogen Corynebacterium jeikeium K411, a lipid-requiring bacterium of the human skin flora. J Bacteriol 187: 4671– 4682. doi: 10.1128/JB.187.13.4671-4682.2005. 15968079 PMC1151758 · DOI
- [13]Watson F, Keevil CW, Chewins J, Wilks SA. 2022. Artificial human sweat as a novel growth condition for clinically relevant pathogens on hospital surfaces. Microbiol Spectr 10: e02137-21. doi: 10.1128/spectrum.02137-21. PMC9045197 35357242 · DOI
- [14]Otberg N, Richter H, Schaefer H, Blume-Peytavi U, Sterry W, Lademann J. 2004. Variations of hair follicle size and distribution in different body sites. J Invest Dermatol 122: 14– 19. doi: 10.1046/j.0022-202X.2003.22110.x. 14962084 · DOI
- [15]Taylor NAS, Machado-Moreira CA. 2013. Regional variations in transepidermal water loss, eccrine sweat gland density, sweat secretion rates and electrolyte composition in resting and exercising humans. Extrem Physiol Med 2: 4. doi: 10.1186/2046-7648-2-4. 23849497 PMC3710196 · DOI · Paper page
- [16]Wilson M. 2005. Microbial inhabitants of humans: their ecology and role in health and disease. Cambridge University Press, Cambridge, United Kingdom.
- [17]Smith CJ, Havenith G. 2011. Body mapping of sweating patterns in male athletes in mild exercise-induced hyperthermia. Eur J Appl Physiol 111: 1391– 1404. doi: 10.1007/s00421-010-1744-8. 21153660 · DOI · Paper page
- [18]Oh J, Byrd AL, Deming C, Conlan S, NISC Comparative Sequencing Program, Kong HH, Segre JA. 2014. Biogeography and individuality shape function in the human skin metagenome. Nature 514: 59– 64. doi: 10.1038/nature13786. 25279917 PMC4185404 · DOI · Paper page
- [20]Swaney MH, Sandstrom S, Kalan LR. 2021. Cobamide sharing drives skin microbiome dynamics. bioRxiv. doi: 10.1101/2020.12.02.407395. PMC9600381 35968974 · DOI
- [21]Claesen J, Spagnolo JB, Ramos SF, Kurita KL, Byrd AL, Aksenov AA, Melnik AV, Wong WR, Wang S, Hernandez RD, Donia MS, Dorrestein PC, Kong HH, Segre JA, Linington RG, Fischbach MA, Lemon KP. 2020. A Cutibacterium acnes antibiotic modulates human skin microbiota composition in hair follicles. Sci Transl Med 12: eaay5445. doi: 10.1126/scitranslmed.aay5445. 33208503 PMC8478231 · DOI
- [22]Machado H, Weng LL, Dillon N, Seif Y, Holland M, Pekar JE, Monk JM, Nizet V, Palsson BO, Feist AM. 2019. Strain-specific metabolic requirements revealed by a defined minimal medium for systems analyses of Staphylococcus aureus. Appl Environ Microbiol 85: e01773-19. doi: 10.1128/AEM.01773-19. 31471305 PMC6803309 · DOI
- [23]Yang P, Chen Y, Gong A-D. 2021. Development of a defined medium for Corynebacterium glutamicum using urea as nitrogen source. 3 Biotech 11: 405. doi: 10.1007/s13205-021-02959-6. PMC8355296 34471588 · DOI
- [24]Mounier J, Rea MC, O’Connor PM, Fitzgerald GF, Cogan TM. 2007. Growth characteristics of Brevibacterium, Corynebacterium, Microbacterium, and Staphylococcus spp. isolated from surface-ripened cheese. Appl Environ Microbiol 73: 7732– 7739. doi: 10.1128/AEM.01260-07. 17921266 PMC2168080 · DOI
- [25]Swaney MH, Sandstrom S, Kalan LR. 2022. Cobamide sharing is predicted in the human skin microbiome. mSystems 7: e00677-22. doi: 10.1128/msystems.00677-22. 35968974 PMC9600381 · DOI
- [27]Baker LB. 2019. Physiology of sweat gland function: the roles of sweating and sweat composition in human health. Temperature (Austin) 6: 211– 259. doi: 10.1080/23328940.2019.1632145. 31608304 PMC6773238 · DOI · Paper page
- [28]Callewaert C, Buysschaert B, Vossen E, Fievez V, Van de Wiele T, Boon N. 2014. Artificial sweat composition to grow and sustain a mixed human axillary microbiome. J Microbiol Methods 103: 6– 8. doi: 10.1016/j.mimet.2014.05.005. 24858451 · DOI
- [29]Thody AJ, Shuster S. 1989. Control and function of sebaceous glands. Physiol Rev 69: 383– 416. doi: 10.1152/physrev.1989.69.2.383. 2648418 · DOI
- [31]Lu GW, Valiveti S, Spence J, Zhuang C, Robosky L, Wade K, Love A, Hu L-Y, Pole D, Mollan M. 2009. Comparison of artificial sebum with human and hamster sebum samples. Int J Pharm 367: 37– 43. doi: 10.1016/j.ijpharm.2008.09.025. 18929636 · DOI
- [32]Nakatsuji T, Kao MC, Zhang L, Zouboulis CC, Gallo RL, Huang C-M. 2010. Sebum free fatty acids enhance the innate immune defense of human sebocytes by upregulating beta-defensin-2 expression. J Invest Dermatol 130: 985– 994. doi: 10.1038/jid.2009.384. 20032992 PMC3057125 · DOI · Paper page
- [33]Nielsen CK, Kjems J, Mygind T, Snabe T, Meyer RL. 2016. Effects of Tween 80 on growth and biofilm formation in laboratory media. Front Microbiol 7: 1878. doi: 10.3389/fmicb.2016.01878. 27920774 PMC5118432 · DOI
- [34]Zhou W, Spoto M, Hardy R, Guan C, Fleming E, Larson PJ, Brown JS, Oh J. 2020. Host-specific evolutionary and transmission dynamics shape the functional diversification of Staphylococcus epidermidis in human skin. Cell 180: 454– 470.e18. doi: 10.1016/j.cell.2020.01.006. 32004459 PMC7192218 · DOI
- [35]Dover LG, Thompson AR, Sutcliffe IC, Sangal V. 2021. Phylogenomic reappraisal of fatty acid biosynthesis, mycolic acid biosynthesis and clinical relevance among members of the genus Corynebacterium. Front Microbiol 12: 802532. doi: 10.3389/fmicb.2021.802532. 35003033 PMC8733736 · DOI
- [36]Grice EA, Kong HH, Renaud G, Young AC, NISC Comparative Sequencing Program, Bouffard GG, Blakesley RW, Wolfsberg TG, Turner ML, Segre JA. 2008. A diversity profile of the human skin microbiota. Genome Res 18: 1043– 1050. doi: 10.1101/gr.075549.107. 18502944 PMC2493393 · DOI
- [37]Ogai K, Nana BC, Lloyd YM, Arios JP, Jiyarom B, Awanakam H, Esemu LF, Hori A, Matsuoka A, Nainu F, Megnekou R, Leke RGF, Ekali GL, Okamoto S, Kuraishi T. 2022. Skin microbiome profile of healthy Cameroonians and Japanese. Sci Rep 12: 1364. doi: 10.1038/s41598-022-05244-5. 35079063 PMC8789912 · DOI
- [38]Gerrett N, Griggs K, Redortier B, Voelcker T, Kondo N, Havenith G. 2018. Sweat from gland to skin surface: production, transport, and skin absorption. J Appl Physiol (1985) 125: 459– 469. doi: 10.1152/japplphysiol.00872.2017. 29745799 · DOI
- [39]Ely MR, Kenefick RW, Cheuvront SN, Chinevere TD, Lacher CP, Lukaski HC, Montain SJ. 2011. Surface contamination artificially elevates initial sweat mineral concentrations. J Appl Physiol (1985) 110: 1534– 1540. doi: 10.1152/japplphysiol.01437.2010. 21512152 · DOI · Paper page
- [41]Sprouffske K, Wagner A. 2016. Growthcurver: an R package for obtaining interpretable metrics from microbial growth curves. BMC Bioinformatics 17: 172. doi: 10.1186/s12859-016-1016-7. 27094401 PMC4837600 · DOI
- [42]Gill SR, Fouts DE, Archer GL, Mongodin EF, Deboy RT, Ravel J, Paulsen IT, Kolonay JF, Brinkac L, Beanan M, Dodson RJ, Daugherty SC, Madupu R, Angiuoli SV, Durkin AS, Haft DH, Vamathevan J, Khouri H, Utterback T, Lee C, Dimitrov G, Jiang L, Qin H, Weidman J, Tran K, Kang K, Hance IR, Nelson KE, Fraser CM. 2005. Insights on evolution of virulence and resistance from the complete genome analysis of an early methicillin-resistant Staphylococcus aureus strain and a biofilm-producing methicillin-resistant Staphylococcus epidermidis strain. J Bacteriol 187: 2426– 2438. doi: 10.1128/JB.187.7.2426-2438.2005. 15774886 PMC1065214 · DOI
- [43]Otto M. 2010. Staphylococcus colonization of the skin and antimicrobial peptides. Expert Rev Dermatol 5: 183– 195. doi: 10.1586/edm.10.6. 20473345 PMC2867359 · DOI
- [45]Robinson S, Robinson AH. 1954. Chemical composition of sweat. Physiol Rev 34: 202– 220. doi: 10.1152/physrev.1954.34.2.202. 13155186 · DOI · Paper page
- [46]Thurmon FM, Ottenstein B. 1952. Studies on the chemistry of human perspiration with especial reference to its lactic acid content. J Invest Dermatol 18: 333– 339. doi: 10.1038/jid.1952.38. 14927981 · DOI
- [47]Montain SJ, Cheuvront SN, Lukaski HC. 2007. Sweat mineral-element responses during 7 h of exercise-heat stress. Int J Sport Nutr Exerc Metab 17: 574– 582. doi: 10.1123/ijsnem.17.6.574. 18156662 · DOI · Paper page
- [50]Harvey CJ, LeBouf RF, Stefaniak AB. 2010. Formulation and stability of a novel artificial human sweat under conditions of storage and use. Toxicol In Vitro 24: 1790– 1796. doi: 10.1016/j.tiv.2010.06.016. 20599493 · DOI
- [51]Huang C-T, Chen M-L, Huang L-L, Mao I-F. 2002. Uric acid and urea in human sweat. Chin J Physiol 45: 109– 115. 12817713
- [52]Mitchell HH, Hamilton TS. 1949. The dermal excretion under controlled environmental conditions of nitrogen and minerals in human subjects, with particular reference to calcium and iron. J Biol Chem 178: 345– 361. doi: 10.1016/S0021-9258(18)56964-7. 18112118 · DOI · Paper page
- [53]Lee H, Song C, Hong YS, Kim MS, Cho HR, Kang T, Shin K, Choi SH, Hyeon T, Kim D-H. 2017. Wearable/disposable sweat-based glucose monitoring device with multistage transdermal drug delivery module. Sci Adv 3: e1601314. doi: 10.1126/sciadv.1601314. 28345030 PMC5342654 · DOI · Paper page
- [54]Lam TH, Verzotto D, Brahma P, Ng AHQ, Hu P, Schnell D, Tiesman J, Kong R, Ton TMU, Li J, Ong M, Lu Y, Swaile D, Liu P, Liu J, Nagarajan N. 2018. Understanding the microbial basis of body odor in pre-pubescent children and teenagers. Microbiome 6: 213. doi: 10.1186/s40168-018-0588-z. 30497517 PMC6267001 · DOI
- [56]Kunin CM, Rudy J. 1991. Effect of NaCl-induced osmotic stress on intracellular concentrations of glycine betaine and potassium in Escherichia coli, Enterococcus faecalis, and staphylococci. J Lab Clin Med 118: 217– 224. 1919294
- [57]Onyango LA, Alreshidi MM. 2018. Adaptive metabolism in staphylococci: survival and persistence in environmental and clinical settings. J Pathog 2018: 1092632. doi: 10.1155/2018/1092632. 30327733 PMC6171259 · DOI
- [58]Rahman SS, Siddique R, Tabassum N. 2017. Isolation and identification of halotolerant soil bacteria from coastal Patenga area. BMC Res Notes 10: 531. doi: 10.1186/s13104-017-2855-7. 29084602 PMC5663095 · DOI
- [60]Rückert C, Albersmeier A, Al-Dilaimi A, Niehaus K, Szczepanowski R, Kalinowski J. 2012. Genome sequence of the halotolerant bacterium Corynebacterium halotolerans type strain YIM 70093T (= DSM 44683T). Stand Genomic Sci 7: 284– 293. doi: 10.4056/sigs.3236691. 23408721 PMC3569386 · DOI
- [61]Irlinger F, Helinck S, Jany JL. 2017. Secondary and adjunct cultures, p 273– 300. In McSweeney PLH, Fox PF, Cotter PD, Everett DW (ed), Cheese, 4th ed. Academic Press, San Diego, CA.
- [62]Bharti N, Pandey SS, Barnawal D, Patel VK, Kalra A. 2016. Plant growth promoting rhizobacteria Dietzia natronolimnaea modulates the expression of stress responsive genes providing protection of wheat from salinity stress. Sci Rep 6: 34768. doi: 10.1038/srep34768. 27708387 PMC5052518 · DOI
- [63]Stackebrandt E, Koch C, Gvozdiak O, Schumann P. 1995. Taxonomic dissection of the genus Micrococcus: Kocuria gen. nov., Nesterenkonia gen. nov., Kytococcus gen. nov., Dermacoccus gen. nov., and Micrococcus Cohn 1872 gen. emend. Int J Syst Bacteriol 45: 682– 692. doi: 10.1099/00207713-45-4-682. 7547287 · DOI
- [64]Novitsky TJ, Kushner DJ. 1975. Influence of temperature and salt concentration on the growth of a facultatively halophilic “Micrococcus” sp. Can J Microbiol 21: 107– 110. doi: 10.1139/m75-017. 1116036 · DOI
- [65]Yang Z-W, Salam N, Mohany M, Chinnathambi A, Alharbi SA, Xiao M, Hozzein WN, Li W-J. 2018. Microbacterium album sp. nov. and Microbacterium deserti sp. nov., two halotolerant actinobacteria isolated from desert soil. Int J Syst Evol Microbiol 68: 217– 222. doi: 10.1099/ijsem.0.002485. 29125456 · DOI
- [66]Orji OU, Awoke JN, Aja PM, Aloke C, Obasi OD, Alum EU, Udu-Ibiam OE, Oka GO. 2021. Halotolerant and metalotolerant bacteria strains with heavy metals biorestoration possibilities isolated from Uburu Salt Lake, Southeastern, Nigeria. Heliyon 7: e07512. doi: 10.1016/j.heliyon.2021.e07512. 34355076 PMC8321926 · DOI
- [67]Tóth Á, Bata-Vidács I, Kosztik J, Máté R, Kutasi J, Tóth E, Bóka K, Táncsics A, Nagy I, Kovács G, Kukolya J. 2021. Sphingobacterium pedocola sp. nov. a novel halotolerant bacterium isolated from agricultural soil. Antonie Van Leeuwenhoek 114: 1575– 1584. doi: 10.1007/s10482-021-01623-6. 34363180 PMC8448689 · DOI
- [68]Salamzade R, Cheong JZA, Sandstrom S, Swaney MH, Stubbendieck RM, Starr NL, Currie CR, Singh AM, Kalan LR. 2022. lsaBGC provides a comprehensive framework for evolutionary analysis of biosynthetic gene clusters within focal taxa. bioRxiv. doi: 10.1101/2022.04.20.488953. · DOI
- [69]Wille JJ, Kydonieus A. 2003. Palmitoleic acid isomer (C16:1Δ6) in human skin sebum is effective against Gram-positive bacteria. Skin Pharmacol Appl Skin Physiol 16: 176– 187. doi: 10.1159/000069757. 12677098 · DOI · Paper page
- [70]Drake DR, Brogden KA, Dawson DV, Wertz PW. 2008. Thematic review series: skin lipids. Antimicrobial lipids at the skin surface. J Lipid Res 49: 4– 11. doi: 10.1194/jlr.R700016-JLR200. 17906220 · DOI · Paper page
- [71]Chamberlain NR, Brueggemann SA. 1997. Characterisation and expression of fatty acid modifying enzyme produced by Staphylococcus epidermidis. J Med Microbiol 46: 693– 697. doi: 10.1099/00222615-46-8-693. 9511818 · DOI
- [72]Pyle HJ, Artami M, Edwards M, Raj P, Zhang B, Arana C, Harris-Tryon TA. 17 September 2022. Saprophytic bacteria and fungi colonize stearoyl coenzyme-A desaturase-1 knockout skin. Exp Dermatol. doi: 10.1111/exd.14676. 36114818 · DOI
- [73]Brüggemann H, Henne A, Hoster F, Liesegang H, Wiezer A, Strittmatter A, Hujer S, Dürre P, Gottschalk G. 2004. The complete genome sequence of Propionibacterium acnes, a commensal of human skin. Science 305: 671– 673. doi: 10.1126/science.1100330. 15286373 · DOI
- [74]Miskin JE, Farrell AM, Cunliffe WJ, Holland KT. 1997. Propionibacterium acnes, a resident of lipid-rich human skin, produces a 33 kDa extracellular lipase encoded by gehA. Microbiology (Reading) 143(Part 5): 1745– 1755. doi: 10.1099/00221287-143-5-1745. 9168624 · DOI
- [75]Brüggemann H, Salar-Vidal L, Gollnick HPM, Lood R. 2021. A Janus-faced bacterium: host-beneficial and -detrimental roles of Cutibacterium acnes. Front Microbiol 12: 673845. doi: 10.3389/fmicb.2021.673845. 34135880 PMC8200545 · DOI
- [76]Klous L, De Ruiter C, Alkemade P, Daanen H, Gerrett N. 2020. Sweat rate and sweat composition during heat acclimation. J Therm Biol 93: 102697. doi: 10.1016/j.jtherbio.2020.102697. 33077118 · DOI
- [77]Pappas A. 2009. Epidermal surface lipids. Dermatoendocrinol 1: 72– 76. doi: 10.4161/derm.1.2.7811. 20224687 PMC2835894 · DOI · Paper page
- [78]Rieg S, Seeber S, Steffen H, Humeny A, Kalbacher H, Stevanovic S, Kimura A, Garbe C, Schittek B. 2006. Generation of multiple stable dermcidin-derived antimicrobial peptides in sweat of different body sites. J Invest Dermatol 126: 354– 365. doi: 10.1038/sj.jid.5700041. 16374474 · DOI
- [79]Rieg S, Garbe C, Sauer B, Kalbacher H, Schittek B. 2004. Dermcidin is constitutively produced by eccrine sweat glands and is not induced in epidermal cells under inflammatory skin conditions. Br J Dermatol 151: 534– 539. doi: 10.1111/j.1365-2133.2004.06081.x. 15377337 · DOI
- [80]Murakami M, Ohtake T, Dorschner RA, Schittek B, Garbe C, Gallo RL. 2002. Cathelicidin anti-microbial peptide expression in sweat, an innate defense system for the skin. J Invest Dermatol 119: 1090– 1095. doi: 10.1046/j.1523-1747.2002.19507.x. 12445197 · DOI
- [81]Liebl W, Klamer R, Schleifer K-H. 1989. Requirement of chelating compounds for the growth of Corynebacterium glutamicum in synthetic media. Appl Microbiol Biotechnol 32: 205– 210. doi: 10.1007/BF00165889. · DOI
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- Authors
- Swaney, M. H., Nelsen, A., Sandstrom, S., & Kalan, L. R.
- Affiliations
- University of Wisconsin–Madison (US)
- Corresponding author
- Kalan, Lindsay R.
- Venue
- Microbiology Spectrum
- Publisher
- American Society for Microbiology
- Published
- 2023-02-14
- Volume
- 11
- Issue
- 1
- Pages
- e0418022-e0418022
- ISSN
- 2165-0497 (ISSN-L)
- PMC
- PMC9927561
- OpenAlex
- W4313545980
- Cited by
- 96
- References
- 11
- Citations by year
- 2026: 31 · 2025: 37 · 2024: 20 · 2023: 7 · 2022: 1
- FWCI
- 26.20
- Type
- journal article
- Language
- en
- Open access
- gold
- doi.org
- Licence
- Locations
- Microbiology Spectrum (publishedVersion, cc-by)
- bioRxiv (Cold Spring Harbor Laboratory) (acceptedVersion, cc-by)
- PubMed Central (publishedVersion, cc-by)
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- Funders
- HHS | NIH | National Institute of Allergy and Infectious Diseases (U19AI142720, T32AI055397)
- HHS | NIH | National Institute of Arthritis and Musculoskeletal and Skin Diseases (F31AR079846)
- HHS | NIH | National Institute of General Medical Sciences (R35GM137828)
- Topics
- Health Sciences › Medicine › Dermatology › Dermatology and Skin Diseases
- Physical Sciences › Environmental Science › Ecology › Microbial Community Ecology and Physiology
- Health Sciences › Medicine › Epidemiology › Nail Diseases and Treatments
- Keywords
- human skin microbiome, sweat, sebum, skin secretions, bacterial growth conditions
- MeSH terms
- Bacteria, Humans, Sebum, Skin, Sweat, Microbiota
About these checks
Registry, retraction, Cites and statistics results are computed, not judged, with one exception: a printed reference that no index lists is read once by a model before it counts as a citation error. Claims are extracted by a model and kept only when their quote appears verbatim in the text; each cited source is then checked, with a model’s help, for whether it says what the claim relies on. Those verdicts can be wrong — read the claim’s quote and the cited source before relying on one.
Statistics and arithmetic are recomputed, not judged.
Confidence bands are shown only for fields calibrated on our annotated test set. None is calibrated yet, so no band is shown.
What counts as a claim ›How we measure confidence ›How we check this ›
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