The DOI matches its Crossref record; 91 of the 93 references it cites were found in a registry or an index.
Supplementation with a probiotic mixture accelerates gut microbiome maturation and reduces intestinal inflammation in extremely preterm infants
Open accessAbstract
Probiotics are increasingly administered to premature infants to prevent necrotizing enterocolitis and neonatal sepsis. However, their effects on gut microbiome assembly and immunity are poorly understood. Using a randomized intervention trial in extremely premature infants, we tested the effects of a probiotic product containing four strains of Bifidobacterium species autochthonous to the infant gut and one Lacticaseibacillus strain on the compositional and functional trajectory of microbiome. Daily administration of the mixture accelerated the transition into a mature, term-like microbiome with higher stability and species interconnectivity. Besides infant age, Bifidobacterium strains and stool metabolites were the best predictors of microbiome maturation, and structural equation modeling confirmed probiotics as a major determinant for the trajectory of microbiome assembly. Bifidobacterium-driven microbiome maturation was also linked to an anti-inflammatory intestinal immune milieu. This demonstrates that Bifidobacterium strains are ecosystem engineers that lead to an acceleration of microbiome maturation and immunological consequences in extremely premature infants.
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“PS infants showed an earlier and more robust colonisation of infant-associated Bifidobacterium species, particularly B. breve and B. longum subsp. infantis, compared to NPS infants51–53.”
From Impact of early life antibiotic and probiotic treatment on gut microbiome and resistome of very-low-birth-weight preterm infants. (2025) · cites this paper as [53]
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Metadata
- Authors
- Samara, J., Moossavi, S., Alshaikh, B., Ortega, V. A., Pettersen, V. K., Ferdous, T., Hoops, S. L., Soraisham, A., Vayalumkal, J., Dersch-Mills, D., Gerber, J. S., Mukhopadhyay, S., Puopolo, K., Tompkins, T. A., Knights, D., Walter, J., Amin, H., & Arrieta, M.-C.
- Affiliations
- University of Calgary (CA)
- University of Minnesota (US)
- Children's Hospital of Philadelphia (US)
- Lallemand (Canada) (CA)
- University College Cork (IE)
- Corresponding author
- Arrieta, Marie-Claire
- ORCID
- Venue
- Cell Host & Microbe
- Publisher
- Elsevier BV
- Published
- 2022-05
- Volume
- 30
- Issue
- 5
- Pages
- 696-711.e5
- ISSN
- 1931-3128 (ISSN-L)
- OpenAlex
- W4280585986
- Cited by
- 191
- References
- 93
- Citations by year
- 2026: 36 · 2025: 50 · 2024: 50 · 2023: 46 · 2022: 9
- FWCI
- 23.89
- Type
- journal article
- Language
- en
- Open access
- bronze
- doi.org
- Licence
- www.elsevier.com/tdm/userlicense/1.0/ (tdm)
- www.elsevier.com/legal/tdmrep-license (tdm)
- www.elsevier.com/open-access/userlicense/1.0/ (vor, 375 d)
- doi.org/10.15223/policy-017 (stm-asf)
- doi.org/10.15223/policy-037 (stm-asf)
- doi.org/10.15223/policy-012 (stm-asf)
- doi.org/10.15223/policy-029 (stm-asf)
- doi.org/10.15223/policy-004 (stm-asf)
- Locations
- Cell Host & Microbe (publishedVersion)
- PubMed (publishedVersion)
- NORA - Norwegian Open Research Archives (submittedVersion, other-oa)
- Funders
- Alberta Children's Hospital Research Institute
- Cumming School of Medicine, University of Calgary
- Canadian Institutes of Health Research
- Science Foundation Ireland (19/RP/6853, APC/SFI/12/RC/2273_P2)
- Mitacs
- Topics
- Health Sciences › Nursing › Nutrition and Dietetics › Infant Nutrition and Health
- Life Sciences › Biochemistry, Genetics and Molecular Biology › Molecular Biology › Gut microbiota and health
- Life Sciences › Agricultural and Biological Sciences › Food Science › Probiotics and Fermented Foods
- Keywords
- probiotics, extremely preterm infants, Bifidobacterium, Lacticaseibacillus, intestinal inflammation, necrotizing enterocolitis, neonatal sepsis, microbiome assembly, fecal metabolites, intestinal immunity, microbiome stability
- MeSH terms
- Gastrointestinal Microbiome, Bifidobacterium, Humans, Infant, Infant, Newborn, Inflammation, Ecosystem, Probiotics, Infant, Extremely Premature
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