Cited by 191Infant Nutrition and HealthGut microbiota and healthProbiotics and Fermented Foods

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Supplementation with a probiotic mixture accelerates gut microbiome maturation and reduces intestinal inflammation in extremely preterm infants

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Samara, Jumana, Moossavi, Shirin, Alshaikh, Belal, Ortega, Van A., Pettersen, Veronika Kuchařová, Ferdous, Tahsin, Hoops, Suzie L., Soraisham, Amuchou, Vayalumkal, Joseph, Dersch-Mills, Deonne, Gerber, Jeffrey S., Mukhopadhyay, Sagori, Puopolo, Karen, Tompkins, Thomas A., Knights, Dan, Walter, Jens, Amin, Harish, Arrieta, Marie-Claire·2022·Cell Host & Microbe

DOI 10.1016/j.chom.2022.04.005

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Abstract

Probiotics are increasingly administered to premature infants to prevent necrotizing enterocolitis and neonatal sepsis. However, their effects on gut microbiome assembly and immunity are poorly understood. Using a randomized intervention trial in extremely premature infants, we tested the effects of a probiotic product containing four strains of Bifidobacterium species autochthonous to the infant gut and one Lacticaseibacillus strain on the compositional and functional trajectory of microbiome. Daily administration of the mixture accelerated the transition into a mature, term-like microbiome with higher stability and species interconnectivity. Besides infant age, Bifidobacterium strains and stool metabolites were the best predictors of microbiome maturation, and structural equation modeling confirmed probiotics as a major determinant for the trajectory of microbiome assembly. Bifidobacterium-driven microbiome maturation was also linked to an anti-inflammatory intestinal immune milieu. This demonstrates that Bifidobacterium strains are ecosystem engineers that lead to an acceleration of microbiome maturation and immunological consequences in extremely premature infants.

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Self-citation
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Authors: Samara, J., Moossavi, S., Alshaikh, B., Ortega, V. A., Pettersen, V. K., Ferdous, T., Hoops, S. L., Soraisham, A., Vayalumkal, J., Dersch-Mills, D., Gerber, J. S., Mukhopadhyay, S., Puopolo, K., Tompkins, T. A., Knights, D., Walter, J., Amin, H., & Arrieta, M.-C.
Affiliations: University of Calgary (CA)
University of Minnesota (US)
Children's Hospital of Philadelphia (US)
Lallemand (Canada) (CA)
University College Cork (IE)
Corresponding author: Arrieta, Marie-Claire
ORCID: Samara, Jumana
Moossavi, Shirin
Alshaikh, Belal
Ortega, Van A.
Pettersen, Veronika Kuchařová
Hoops, Suzie L.
Soraisham, Amuchou
Gerber, Jeffrey S.
Mukhopadhyay, Sagori
Puopolo, Karen
Tompkins, Thomas A.
Knights, Dan
Walter, Jens
Arrieta, Marie-Claire
Venue: Cell Host & Microbe
Publisher: Elsevier BV
Published: 2022-05
Volume: 30
Issue: 5
Pages: 696-711.e5
ISSN: 1931-3128 (ISSN-L)
DOI: 10.1016/j.chom.2022.04.005
OpenAlex: W4280585986
Cited by: 191
References: 93
Citations by year: 2026: 36 · 2025: 50 · 2024: 50 · 2023: 46 · 2022: 9
FWCI: 23.89
Type: journal article
Language: en
Open access: bronze
doi.org
Licence: www.elsevier.com/tdm/userlicense/1.0/ (tdm)
www.elsevier.com/legal/tdmrep-license (tdm)
www.elsevier.com/open-access/userlicense/1.0/ (vor, 375 d)
doi.org/10.15223/policy-017 (stm-asf)
doi.org/10.15223/policy-037 (stm-asf)
doi.org/10.15223/policy-012 (stm-asf)
doi.org/10.15223/policy-029 (stm-asf)
doi.org/10.15223/policy-004 (stm-asf)
Locations: Cell Host & Microbe (publishedVersion)
PubMed (publishedVersion)
NORA - Norwegian Open Research Archives (submittedVersion, other-oa)
Funders: Alberta Children's Hospital Research Institute
Cumming School of Medicine, University of Calgary
Canadian Institutes of Health Research
Science Foundation Ireland (19/RP/6853, APC/SFI/12/RC/2273_P2)
Mitacs
Topics: Health Sciences › Nursing › Nutrition and Dietetics › Infant Nutrition and Health
Life Sciences › Biochemistry, Genetics and Molecular Biology › Molecular Biology › Gut microbiota and health
Life Sciences › Agricultural and Biological Sciences › Food Science › Probiotics and Fermented Foods
Keywords: probiotics, extremely preterm infants, Bifidobacterium, Lacticaseibacillus, intestinal inflammation, necrotizing enterocolitis, neonatal sepsis, microbiome assembly, fecal metabolites, intestinal immunity, microbiome stability
MeSH terms: Gastrointestinal Microbiome, Bifidobacterium, Humans, Infant, Infant, Newborn, Inflammation, Ecosystem, Probiotics, Infant, Extremely Premature

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Supplementation with a probiotic mixture accelerates gut microbiome maturation and reduces intestinal inflammation in extremely preterm infants

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