CoChat
Sign Up
Cited by 129Genetically Modified Organisms ResearchMicrofluidic and Capillary Electrophoresis ApplicationsMetabolomics and Mass Spectrometry Studies

The DOI matches its Crossref record; 55 of the 55 references it cites were found in a registry or an index.

Comparative metabolomic study of transgenic versus conventional soybean using capillary electrophoresis-time-of-flight mass spectrometry

Open access
García-Villalba, Rocio, León, Carlos, Dinelli, Giovanni, Segura-Carretero, Antonio, Fernández-Gutiérrez, Alberto, Garcia-Cañas, Virginia, Cifuentes, Alejandro·2008·Journal of Chromatography A
DOI 10.1016/j.chroma.2008.05.018
Open this paper in CoChat — free account

Abstract

In this work, capillary electrophoresis-time-of-flight mass spectrometry (CE-TOF-MS) is proposed to identify and quantify the main metabolites found in transgenic soybean and its corresponding non-transgenic parental line both grown under identical conditions. The procedure includes optimization of metabolites extraction, separation by CE, on-line electrospray-TOF-MS analysis and data evaluation. A large number of extraction procedures and background electrolytes are tested in order to obtain a highly reproducible and sensitive analytical methodology. Using this approach, a large number of metabolites were tentatively identified based on the high mass accuracy provided by TOF-MS analyzer, together with the isotopic pattern and expected electrophoretic mobility of these compounds. In general, the same metabolites and in similar amounts were found in the conventional and transgenic variety. However, significant differences were also observed in some specific cases when the conventional variety was compared with its corresponding transgenic line. The selection of these metabolites as possible biomarkers of transgenic soybean is discussed, although a larger number of samples need to be analyzed in order to validate this point. It is concluded that metabolomic procedures based on CE-MS can open new perspectives in the study of transgenic foods in order to corroborate (or not) the equivalence with their conventional counterparts.

Overview

Integrity signals

Registry

Crossref · 10.1016/j.chroma.2008.05.018

Cites

55 of 55 references verified0 citation errors · 0 not checkable

Statistics

Recomputing p-values needs the paper’s full text.

Verification

Claims the paper makes

We couldn’t retrieve this paper’s full text, so its claims and self-check weren’t run. The registry and citation checks still apply.

Claims other papers make about this one

Each is checked against this paper’s own text: does it say what the citing paper says it does?

Citations

Cites

Flagged first, then by citations

Show all 55 references

Research works printed but not linked: 1

  1. Wei, 2004, J. Food Drug Anal., 12, 324

Cited by

Sorted by citations

Items 101–129 of 129

Related

See all

Metadata

Authors
García-Villalba, R., León, C., Dinelli, G., Segura-Carretero, A., Fernández-Gutiérrez, A., Garcia-Cañas, V., & Cifuentes, A.
Affiliations
  • Consejo Superior de Investigaciones Científicas (ES)
  • University of Bologna (IT)
ORCID
Venue
Journal of Chromatography A
Publisher
Elsevier BV
Published
2008-06
Volume
1195
Issue
1-2
Pages
164-173
ISSN
0021-9673 (ISSN-L)
DOI
10.1016/j.chroma.2008.05.018
OpenAlex
W1966413091
Cited by
129
References
55
Citations by year
2025: 2 · 2023: 7 · 2022: 4 · 2021: 5 · 2020: 8 · 2019: 8 · 2018: 5 · 2017: 7 · 2016: 7 · 2015: 8 · 2014: 12 · 2013: 15 · 2012: 9
FWCI
12.50
Type
journal article
Language
en
Open access
Licence
Locations
  • Journal of Chromatography A (publishedVersion)
  • PubMed (publishedVersion)
  • Archivio istituzionale della ricerca (Alma Mater Studiorum Università di Bologna) (submittedVersion)
  • Institutional Repository of the University of Granada (University of Granada) (submittedVersion, cc-by-nc-nd)
  • DIGITAL.CSIC (Spanish National Research Council (CSIC)) (submittedVersion, other-oa)
Topics
  • Life Sciences › Agricultural and Biological Sciences › Plant Science › Genetically Modified Organisms Research
  • Physical Sciences › Engineering › Biomedical Engineering › Microfluidic and Capillary Electrophoresis Applications
  • Life Sciences › Biochemistry, Genetics and Molecular Biology › Molecular Biology › Metabolomics and Mass Spectrometry Studies
Keywords
transgenic soybean, metabolomics, metabolite extraction, supporting electrolyte
MeSH terms
Glycine max, Electrophoresis, Capillary, Spectrometry, Mass, Electrospray Ionization, Plant Preparations, Plants, Genetically Modified

About these checks

Registry, retraction, Cites and statistics results are computed, not judged, with one exception: a printed reference that no index lists is read once by a model before it counts as a citation error. Claims are extracted by a model and kept only when their quote appears verbatim in the text; each cited source is then checked, with a model’s help, for whether it says what the claim relies on. Those verdicts can be wrong — read the claim’s quote and the cited source before relying on one.

Statistics and arithmetic are recomputed, not judged.

Confidence bands are shown only for fields calibrated on our annotated test set. None is calibrated yet, so no band is shown.

What counts as a claim ›How we measure confidence ›How we check this ›

Are you an author, or do you see a problem with this page? Request a review