Macroalga Padina pavonica water extracts obtained by pressurized liquid extraction and microwave-assisted extraction inhibit hyaluronidase activity as shown by capillary electrophoresis
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Hyaluronidase degrades hyaluronic acid, the principal component of the extracellular matrix. Inhibition of this enzyme is thus expected to hinder skin aging. Brown alga Padina pavonica activity toward hyaluronidase was evaluated using capillary electrophoresis (CE)-based enzymatic assays. This green technique allows evaluation of the biological activity of the natural material in an economic manner. Pressurized liquid extraction (PLE), microwave assisted extraction (MAE), supercritical fluid extraction and electroporation extraction techniques were used. Extraction conditions were optimized to obtain cosmetically acceptable Padina pavonica extracts with the best inhibition activity. CE-based assays were conducted using only a few nanoliters of reactants, a capillary of 60cm total length and of 50μm internal diameter, +20kV voltage for separation in 50mM ammonium acetate buffer (pH 9.0) and 200nm wavelength for detection. The reaction mixture was incubated for 1h and CE analysis time was about 11min. A novel online CE-assay using transverse diffusion of laminar flow profiles for in-capillary reactant mixing allowed efficient monitoring of hyaluronidase kinetics with K m and V max equal to 0.46±0.04mgmL-1 and 137.1±0.3nMs-1 (r 2=0.99; n=3), respectively. These values compared well with literature, which validates the assay. Water extracts obtained by PLE (60°C; 2 cycles) and MAE (60°C; 1000W; 2min) presented the highest anti-hyaluronidase activity. The half maximal effective concentration (IC 50) of water PLE extract was 0.04±0.01mgmL-1 (r 2=0.99; n=3). This value is comparable to the one obtained for Einsenia bicyclis phlorotannin fractions (IC 50=0.03mgmL-1), which makes Padina pavonica bioactivity very promising.
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Extracts and bioactive compounds from SWE have shown bioactivity such as antioxidant, antiviral, antimicrobial, and anti-hyaluronidase activity.
“The extracts and bioactive compounds have shown bioactivity such as antioxidant, antiviral, antimicrobial and anti-hyaluronidase activity [14,34,58,59].”
From Overview on the Application of Modern Methods for the Extraction of Bioactive Compounds from Marine Macroalgae (2018) · cites this paper as [58]
Hyaluronidase inhibition is highly influenced by the extraction temperature rather than the extraction time.
“The hyaluronidase inhibition is highly influenced by the extraction temperature rather than the extraction time”
From Overview on the Application of Modern Methods for the Extraction of Bioactive Compounds from Marine Macroalgae (2018) · cites this paper as [58]
Extracts obtained by MAE also showed anti-hyaluronidase activity.
“Except antioxidant activity, the extracts obtained by MAE also showed anti-hyaluronidase activity.”
From Overview on the Application of Modern Methods for the Extraction of Bioactive Compounds from Marine Macroalgae (2018) · cites this paper as [58]
Water and ethyl acetate showed the best inhibition results, which indicates that anti-hyaluronidase bioactive compounds are mostly polar.
“According to the results, water and ethyl acetate showed the best inhibition results, which indicates that anti-hyaluronidase bioactive compounds are mostly polar.”
From Overview on the Application of Modern Methods for the Extraction of Bioactive Compounds from Marine Macroalgae (2018) · cites this paper as [58]
Fayad et al. used capillary electrophoresis-based enzymatic assays for evaluation of activity towards hyaluronidase of Padina pavonica extracts obtained by SWE; water extract obtained by SWE yielded most potent inhibition compared to MAE, SFE, and PLE.
“Fayad et al. [58] used capillary electrophoresis-based enzymatic assays for the evaluation of the activity towards hyaluronidase of Padina pavonica extracts obtained by SWE. Results showed that water extract obtained by SWE yielded the most potent inhibition when compared to other extraction methods such as MAE, SFE and pressurized liquid extraction (PLE).”
From Overview on the Application of Modern Methods for the Extraction of Bioactive Compounds from Marine Macroalgae (2018) · cites this paper as [58]
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- Authors
- Fayad, S., Nehmé, R., Tannoury, M., Lesellier, E., Pichon, C., & Morin, P.
- Affiliations
- Université d'Orléans (FR)
- Lebanese University (LB)
- Corresponding author
- Nehmé, Reine
- Venue
- Journal of Chromatography A
- Publisher
- Elsevier BV
- Published
- 2017-05
- Volume
- 1497
- Pages
- 19-27
- ISSN
- 0021-9673 (ISSN-L)
- OpenAlex
- W2602185947
- Cited by
- 54
- References
- 55
- Citations by year
- 2026: 1 · 2025: 1 · 2024: 6 · 2023: 3 · 2022: 7 · 2021: 11 · 2020: 10 · 2019: 5 · 2018: 5 · 2017: 5
- FWCI
- 7.88
- Type
- journal article
- Language
- en
- Open access
- green
- hal.science
- Locations
- Journal of Chromatography A (publishedVersion)
- PubMed (publishedVersion)
- HAL (submittedVersion, cc-by)
- HAL (submittedVersion)
- Topics
- Life Sciences › Agricultural and Biological Sciences › Aquatic Science › Seaweed-derived Bioactive Compounds
- Life Sciences › Biochemistry, Genetics and Molecular Biology › Cell Biology › Proteoglycans and glycosaminoglycans research
- Health Sciences › Medicine › Dermatology › Skin Protection and Aging
- Keywords
- Padina pavonica, hyaluronidase inhibition, brown algae extract, accelerated solvent extraction, microwave-assisted extraction, supercritical fluid extraction, skin aging, hyaluronic acid, extraction optimization
- MeSH terms
- Phaeophyceae, Diffusion, Hyaluronoglucosaminidase, Kinetics, Microwaves, Pressure, Seaweed, Water, Reproducibility of Results, Electroporation, Electrophoresis, Capillary, Inhibitory Concentration 50, Chromatography, Supercritical Fluid, Liquid-Liquid Extraction
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