Caffeine intake and atrial fibrillation incidence: dose response meta‐analysis of prospective cohort studies
Abstract
Background The association between habitual caffeine intake with incident atrial fibrillation (AF) was unknown. We conducted a meta-analysis to investigate the association between chronic exposure of caffeine and the risk of AF and to evaluate the potential dose-response relation.Methods We searched PubMed, EMBASE, and the Cochrane Library up to November 2013 and references of relevant retrieved articles. Prospective cohort studies were included with relative risk (RR) or hazard ratio and 95% confidence intervals (CIs) for AF according to coffee/caffeine intake.Results Six prospective cohort studies with 228,465 participants were included. In the primary meta-analysis, caffeine exposure was weakly associated with a reduced risk of AF (RR, 0.90; 95% CI, 0.81-1.01; P = 0.07; I(2) = 73%). In subgroup analyses, pooled results from studies with adjustment of potential confounders showed an 11% reduction for low doses (RR, 0.89; 95% CI, 0.80-0.99, P = 0.032; I(2) = 30.9%, P = 0.227) and 16% for high doses (RR, 0.84; 95% CI, 0.75-0.94, P = 0.002; I(2) = 24.1%, P = 0.267) of caffeine consumption in AF risk. An inverse relation was found between habitual caffeine intake and AF risk (P for overall trend = 0.015; P for nonlinearity = 0.27) in dose-response meta-analysis and the incidence of AF decreased by 6% (RR, 0.94; 95% CI, 0.90-0.99) for every 300 mg/d increment in habitual caffeine intake.Conclusions It is unlikely that caffeine consumption causes or contributes to AF. Habitual caffeine consumption might reduce AF risk.
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In the AF meta-analyses, there was no significant association between caffeine exposure and AF risk in primary or subgroup analyses considering age, sex, race, study quality, caffeine from coffee versus all sources, caffeine dose or duration of follow-up.
“There was no significant association between caffeine exposure and AF risk in primary or subgroup analyses, considering age, sex, race, study quality, caffeine from coffee versus caffeine from all sources, caffeine dose or duration of follow-up.”
From Scientific Opinion on the safety of caffeine (2015) · cites this paper as Cheng et al., 2014
Incidence of AF decreased by 6% (RR=0.94, 95% CI 0.90-0.99) for every 300 mg/day increment in habitual caffeine intake up to about 1,000 mg/day.
“Incidence of AF decreased by 6 % (RR = 0.94, 95 % CI = 0.90-0.99)for every 300 mg per day increment in habitual caffeine intake up to about 1 000 mg per day.”
From Scientific Opinion on the safety of caffeine (2015) · cites this paper as Cheng et al., 2014
The Panel notes that habitual caffeine consumption from all sources up to about 1,000 mg/day was not significantly associated with an increased risk of AF in the two meta-analyses.
“The Panel notes that habitual caffeine consumption from all sources up to about 1 000 mg per day was not significantly associated with an increased risk of AF in these two meta-analyses.”
From Scientific Opinion on the safety of caffeine (2015) · cites this paper as Cheng et al., 2014
An inverse relationship was found between habitual caffeine intake and risk of AF in a dose-response analysis (Cheng et al., 2014).
“An inverse relationship was found between habitual caffeine intake and the risk of AF in a dose-response analysis (Cheng et al., 2014).”
From Scientific Opinion on the safety of caffeine (2015) · cites this paper as Cheng et al., 2014
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Coffee and Cardiovascular Disease
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- Authors
- Cheng, M., Hu, Z., Lu, X., Huang, J., & Gu, D.
- Affiliations
- Chinese Academy of Medical Sciences & Peking Union Medical College (CN)
- Corresponding author
- Gu, Dongfeng
- Venue
- Canadian Journal of Cardiology
- Publisher
- Elsevier BV
- Published
- 2014-04
- Volume
- 30
- Issue
- 4
- Pages
- 448-454
- ISSN
- 0828-282X (ISSN-L)
- OpenAlex
- W2017903258
- Cited by
- 106
- References
- 36
- Citations by year
- 2026: 1 · 2025: 8 · 2024: 10 · 2023: 10 · 2022: 8 · 2021: 14 · 2020: 8 · 2019: 6 · 2018: 11 · 2017: 7 · 2016: 8 · 2015: 9 · 2014: 6
- FWCI
- 1.28
- Type
- journal article
- Language
- en
- Open access
- closed
- Locations
- Canadian Journal of Cardiology (publishedVersion)
- PubMed (publishedVersion)
- Topics
- Health Sciences › Medicine › Pharmacology › Coffee research and impacts
- Health Sciences › Medicine › Cardiology and Cardiovascular Medicine › Atrial Fibrillation Management and Outcomes
- Health Sciences › Medicine › Public Health, Environmental and Occupational Health › Nutritional Studies and Diet
- Keywords
- caffeine consumption, atrial fibrillation, dose-response relationship, coffee consumption, cardiovascular risk
- MeSH terms
- Central Nervous System Stimulants, Atrial Fibrillation, Caffeine, Dose-Response Relationship, Drug, Humans, Prospective Studies, Incidence
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