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Cited by 119Coffee research and impactsNutritional Studies and DietAlcohol Consumption and Health Effects

A meta-analysis of prospective studies of coffee consumption and mortality for all causes, cancers and cardiovascular diseases

Malerba, Stefano, Turati, Federica, Galeone, Carlotta, Pelucchi, Claudio, Verga, Federica, La Vecchia, Carlo, Tavani, Alessandra·2013·European Journal of Epidemiology
DOI 10.1007/s10654-013-9834-7
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Abstract

Several prospective studies considered the relation between coffee consumption and mortality. Most studies, however, were underpowered to detect an association, since they included relatively few deaths. To obtain quantitative overall estimates, we combined all published data from prospective studies on the relation of coffee with mortality for all causes, all cancers, cardiovascular disease (CVD), coronary/ischemic heart disease (CHD/IHD) and stroke. A bibliography search, updated to January 2013, was carried out in PubMed and Embase to identify prospective observational studies providing quantitative estimates on mortality from all causes, cancer, CVD, CHD/IHD or stroke in relation to coffee consumption. A systematic review and meta-analysis was conducted to estimate overall relative risks (RR) and 95 % confidence intervals (CI) using random-effects models. The pooled RRs of all cause mortality for the study-specific highest versus low (≤1 cup/day) coffee drinking categories were 0.88 (95 % CI 0.84-0.93) based on all the 23 studies, and 0.87 (95 % CI 0.82-0.93) for the 19 smoking adjusting studies. The combined RRs for CVD mortality were 0.89 (95 % CI 0.77-1.02, 17 smoking adjusting studies) for the highest versus low drinking and 0.98 (95 % CI 0.95-1.00, 16 studies) for the increment of 1 cup/day. Compared with low drinking, the RRs for the highest consumption of coffee were 0.95 (95 % CI 0.78-1.15, 12 smoking adjusting studies) for CHD/IHD, 0.95 (95 % CI 0.70-1.29, 6 studies) for stroke, and 1.03 (95 % CI 0.97-1.10, 10 studies) for all cancers. This meta-analysis provides quantitative evidence that coffee intake is inversely related to all cause and, probably, CVD mortality.

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Authors
Malerba, S., Turati, F., Galeone, C., Pelucchi, C., Verga, F., La Vecchia, C., & Tavani, A.
Affiliations
  • Università Cattolica del Sacro Cuore (IT)
  • Mario Negri Institute for Pharmacological Research (IT)
  • University of Milan (IT)
  • University of Turin (IT)
Corresponding author
Malerba, Stefano
ORCID
Venue
European Journal of Epidemiology
Publisher
Springer Science and Business Media LLC
Published
2013-07
Volume
28
Issue
7
Pages
527-539
ISSN
  • 0393-2990 (ISSN-L)
  • 1573-7284
DOI
10.1007/s10654-013-9834-7
OpenAlex
W2109219983
Cited by
119
References
88
Citations by year
2026: 1 · 2025: 4 · 2024: 6 · 2023: 4 · 2022: 7 · 2021: 6 · 2020: 10 · 2019: 8 · 2018: 11 · 2017: 20 · 2016: 8 · 2015: 19 · 2014: 13 · 2013: 2
FWCI
1.75
Type
journal article
Language
en
Open access
closed
Licence
www.springer.com/tdm (tdm)
Locations
  • European Journal of Epidemiology (publishedVersion)
  • PubMed (publishedVersion)
Funders
Fondazione Italiana per la Ricerca sul Cancro
Topics
  • Health Sciences › Medicine › Pharmacology › Coffee research and impacts
  • Health Sciences › Medicine › Public Health, Environmental and Occupational Health › Nutritional Studies and Diet
  • Health Sciences › Medicine › Pathology and Forensic Medicine › Alcohol Consumption and Health Effects
Keywords
coffee consumption, mortality, all-cause mortality, cancer mortality, cardiovascular mortality, coronary artery disease, ischemic heart disease, stroke, relative risk
MeSH terms
Cardiovascular Diseases, Cause of Death, Coffee, Humans, Mortality, Neoplasms, Prospective Studies, Risk Factors

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