Cited by 350Coffee research and impactsBlood Pressure and Hypertension StudiesSodium Intake and Health

The Effect of Coffee on Blood Pressure and Cardiovascular Disease in Hypertensive Individuals: A Systematic Review and Meta-Analysis

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Mesas, Arthur Eumann, Leon-Muñoz, Luz M, Rodriguez-Artalejo, Fernando, Lopez-Garcia, Esther·2011·The American Journal of Clinical Nutrition

Abstract

Background The effect of coffee and caffeine on blood pressure (BP) and cardiovascular disease (CVD) in hypertensive persons is uncertain.Objective The objective was to summarize the evidence on the acute and longer-term effects of caffeine and coffee intake on BP and on the association between habitual coffee consumption and risk of CVD in hypertensive individuals.Design A systematic review and meta-analysis of publications identified in a PubMed and EMBASE search up to 30 April 2011 was undertaken. Data were extracted from controlled trials on the effect of caffeine or coffee intake on BP change and from cohort studies on the association between habitual coffee consumption and CVD.Results In 5 trials, the administration of 200-300 mg caffeine produced a mean increase of 8.1 mm Hg (95% CI: 5.7, 10.6 mm Hg) in systolic BP and of 5.7 mm Hg (95% CI: 4.1, 7.4 mm Hg) in diastolic BP. The increase in BP was observed in the first hour after caffeine intake and lasted ≥3 h. In 3 studies of the longer-term effect (2 wk) of coffee, no increase in BP was observed after coffee was compared with a caffeine-free diet or was compared with decaffeinated coffee. Last, 7 cohort studies found no evidence of an association between habitual coffee consumption and a higher risk of CVD.Conclusions In hypertensive individuals, caffeine intake produces an acute increase in BP for ≥3 h. However, current evidence does not support an association between longer-term coffee consumption and increased BP or between habitual coffee consumption and an increased risk of CVD in hypertensive subjects.

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Crossref · 10.3945/ajcn.111.016667

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  • In other contexts, pre-exercise caffeine may transiently elevate blood pressure, alter vascular reactivity, and impose additional cardiovascular strain in susceptible populations.

    “In other contexts, however, it may transiently elevate blood pressure, alter vascular reactivity, and impose additional cardiovascular strain in susceptible populations [21,22].”

    From Pre-Exercise Caffeine as a Modulator of Exercise-Induced Acute Cardiometabolic Responses: A Narrative Review (2026) · cites this paper as [21]

    The Results (Table 1) report an acute rise in systolic blood pressure after caffeine intake in hypertensive individuals. The Discussion (section 3) says that this rise may temporarily increase cardiovascular-event risk, particularly warranting caution in patients with uncontrolled blood pressure. The paper does not establish effects of pre-exercise caffeine on vascular reactivity or measure additional cardiovascular strain during exercise. (LLM, conf=0.86)

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  • Acute caffeine-induced blood pressure responses are notably more pronounced in non-habitual users, individuals with borderline elevated blood pressure, and those with latent hypertension.

    “Acute caffeine-induced blood pressure responses are notably more pronounced in non-habitual users, individuals with borderline elevated blood pressure, and those with latent hypertension [21].”

    From Pre-Exercise Caffeine as a Modulator of Exercise-Induced Acute Cardiometabolic Responses: A Narrative Review (2026) · cites this paper as [21]

    The Discussion reports an acute blood-pressure increase after caffeine in hypertensive patients. It does not establish a more pronounced response in non-habitual users, people with borderline elevated blood pressure, or those with latent hypertension: the acute-effect studies included habitual coffee drinkers, and the Discussion describes the effects in normotensive and hypertensive individuals as comparable. Page numbers are not available in our copy. (LLM, conf=0.87)

    Experimental — accuracy not yet measured
  • In subjects with hypertension, single caffeine doses of 200 to 300 mg induce a mean increase in systolic blood pressure of 8.1 mmHg and diastolic blood pressure of 5.7 mmHg, observed in the first 60 minutes after intake and persisting up to 180 minutes afterwards.

    “single caffeine doses of 200 to 300 mg induced a mean increase in SBP and DBP of 8.1 mmHg (95 % confidence interval (CI) = 5.7-10.6 mmHg) and 5.7 mmHg (95 % CI = 4.1-7.4mmHg), respectively, which was observed in the first 60 minutes after intake and persisted up to 180 minutes afterwards.”

    From Scientific Opinion on the safety of caffeine (2015) · cites this paper as Mesas et al., 2011

  • Short-term metabolic studies have shown that caffeine can acutely increase blood pressure and could also acutely adversely affect arterial stiffness and endothelium-dependent vasodilation.

    “However, short-term metabolic studies have shown that caffeine can acutely increase blood pressure by antagonizing the adenosine A1 and A2A receptor,35–37 and could also acutely adversely affect arterial stiffness and endothelium dependent vasodilation.38, 39”

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Research works printed but not linked: 2

  1. [17]17. Stroup DF, Berlin JA, Morton SC, Olkin I, Williamson GD, Rennie D, Moher D, Becker BJ, Sipe TA, Thacker SB. Meta-analysis of obser- vational studies in epidemiology: a proposal for reporting. Meta- analysis Of Observational Studies in Epidemiology (MOOSE) group. JAMA 2000;283:2008-12.
  2. [30]30. Higgins JPT, Green S, eds. Cochrane handbook for systematic re- views of interventions, version 5.0.2. In: The Cochrane Collaboration. Chippenham, United Kingdom: Wiley, 2009.

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Authors
Mesas, A. E., Leon-Muñoz, L. M., Rodriguez-Artalejo, F., & Lopez-Garcia, E.
Affiliations
Universidad Autónoma de Madrid (ES)
Venue
The American Journal of Clinical Nutrition
Publisher
Elsevier BV
Published
2011-10
Volume
94
Issue
4
Pages
1113-1126
ISSN
0002-9165 (ISSN-L)
OpenAlex
W2121680741
Cited by
350
References
53
Citations by year
2026: 19 · 2025: 18 · 2024: 27 · 2023: 20 · 2022: 22 · 2021: 17 · 2020: 26 · 2019: 17 · 2018: 29 · 2017: 32 · 2016: 31 · 2015: 24 · 2014: 31 · 2013: 26 · 2012: 9
FWCI
2.66
Type
journal article
Language
en
Open access
Locations
  • American Journal of Clinical Nutrition (publishedVersion)
  • PubMed (publishedVersion)
Funders
Agencia Española de Cooperación Internacional para el Desarrollo
Topics
  • Health Sciences › Medicine › Pharmacology › Coffee research and impacts
  • Health Sciences › Medicine › Cardiology and Cardiovascular Medicine › Blood Pressure and Hypertension Studies
  • Health Sciences › Nursing › Nutrition and Dietetics › Sodium Intake and Health
Keywords
coffee consumption, caffeine, blood pressure, hypertension, cardiovascular risk, acute blood pressure response, decaffeinated coffee
MeSH terms
Adult, Aged, Aged, 80 and over, Blood Pressure, Caffeine, Cardiovascular Diseases, Coffee, Feeding Behavior, Female, Humans, Hypertension, Male, Middle Aged, Risk, Young Adult

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