Excess weight risk factor for alcoholic liver disease
Abstract
Though the hepatotoxicity of ethanol has been established, only 8% to 20% of chronic alcoholics develop cirrhosis. The aim of this study was to assess whether being overweight is a risk factor for alcoholic liver disease. One thousand six hundred four alcoholic patients were studied. According to the liver biopsies, 194 patients had a normal liver; 402 had steatosis without fibrosis; 281 presented with fibrosis, with or without steatosis; 119 presented with acute alcoholic hepatitis (AAH) without cirrhosis; 232 indicated cirrhosis without AAH; and 179 presented with cirrhosis with AAH. One hundred ninety-seven patients had clinically obvious cirrhosis. In the study, five variables were studied as risk factors: age, sex, daily consumption of alcohol during the previous 5 years, the total duration of alcohol abuse, and tendency to be overweight (body mass index [BMI] > or = 25 in women and > or = 27 in men). The BMI was calculated according to the minimum weight over the 10 previous years. In the first stepwise logistic regression analysis, age, being overweight for at least 10 years, being of the female sex, and the total duration of alcohol abuse were independently correlated with the presence of cirrhosis. In the second analysis, female sex being overweight were the two independent risk factors of AAH. In the third analysis, being overweight for at least 10 years was the only independent risk factor of steatosis. These results show that the presence of excess weight for at least 10 years is a risk factor for cirrhosis, AAH, and steatosis. Our results suggest that there is a possible potential for the metabolic effects of ethanol ingestion caused by excess weight in patients with alcoholic liver disease.
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Older findings corroborate BMI as an independent risk factor for fibrosis in individuals with ALD.
“This corroborates older fi ndings of BMI as an independent risk factor for fi brosis in individuals with ALD.”
From EASL-EASD-EASO Clinical Practice Guidelines on the management of metabolic dysfunction-associated steatotic liver disease (MASLD). (2024) · cites this paper as [85]
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“There is a strong epidemiological link between alcohol consumption, obesity, and insulin resistance on the progression of steatohepatitis (Naveau et al., 1997).”
BackgroundImpact of Diabetes on the Severity of Liver Disease
Hickman, I. J., & Macdonald, G. A. (2007) · The American Journal of Medicine · doi:10.1016/j.amjmed.2007.03.025 · Cited by 175 · see citing works
Treatment of alcoholic liver disease
Frazier, T. H., Stocker, A. M., Kershner, N. A., Marsano, L. S., & McClain, C. J. (2010) · Therapeutic Advances in Gastroenterology · doi:10.1177/1756283x10378925 · Cited by 165 · see citing works
The genetics of alcohol dependence and alcohol-related liver disease
Stickel, F., Moreno, C., Hampe, J., & Morgan, M. Y. (2016) · Journal of Hepatology · doi:10.1016/j.jhep.2016.08.011 · Cited by 165 · see citing works
Genes or environment to determine alcoholic liver disease and non‐alcoholic fatty liver disease
Day, C. (2006) · Liver International · doi:10.1111/j.1478-3231.2006.01323.x · Cited by 162 · see citing works
“A more obvious role for diet in ALD risk has been suggested by two studies showing that obesity and associated hyperglycemia increase the incidence of all stages of ALD in heavy drinkers (13, 14).”
BackgroundLiver disease in alcohol abusers
Diehl, A. M. (2002) · Alcohol · doi:10.1016/s0741-8329(02)00204-5 · Cited by 161 · see citing works
Biomarkers for the prediction of liver fibrosis in patients with chronic alcoholic liver disease
Naveau, S., Raynard, B., Ratziu, V., et al. (2005) · Clinical Gastroenterology and Hepatology · doi:10.1016/s1542-3565(04)00625-1 · Cited by 160 · see citing works
Self-citationXu, J., Lai, K. K. Y., Verlinsky, A., Lugea, A., French, S. W., Cooper, M. P., Ji, C., & Tsukamoto, H. (2011) · Journal of Hepatology · doi:10.1016/j.jhep.2010.12.034 · Cited by 159 · see citing works
“Epidemiological evidence shows that obese alcoholics have an accentuated rise in serum alanine aminotransferase (ALT) [2,3] and 2–3 times higher risk of developing steatohepatitis or cirrhosis [4,5] as compared to non-obese alcoholics or obese non-alcoholics.”
Boyle, M., Masson, S., & Anstee, Q. M. (2017) · Journal of Hepatology · doi:10.1016/j.jhep.2017.11.006 · Cited by 159 · see citing works
“The available evidence supports the view that obesity confers a predisposition to the development of both ALD [100] and NAFLD [121].”
BackgroundWilliams, J. L., Roberts, S., Ali, M., Cheung, W., Cohen, D. R., Demery, G., Edwards, A., Greer, M.-L., Hellier, M. D., Hutchings, H. A., et al. (2007) · Gut · doi:10.1136/gut.2006.117598 · Cited by 157 · see citing works
Salameh, H. M., Raff, E., Erwin, A., Seth, D., Nischalke, H. D., Falleti, E., Burza, M. A., Leathert, J., Romeo, S., Molinaro, A., et al. (2015) · The American Journal of Gastroenterology · doi:10.1038/ajg.2015.137 · Cited by 156 · see citing works
Adipocytokines and liver disease
Kamada, Y., Takehara, T., & Hayashi, N. (2008) · Journal of Gastroenterology · doi:10.1007/s00535-008-2213-6 · Cited by 153 · see citing works
(2004) · Wiley eBooks · doi:10.1002/9780470987438 · Cited by 156 · see citing works
Alcohol, Inflammation, and Microbiota in Alcoholic Liver Disease
Dukić, M., Radonjić, T., Jovanović, I., Zdravkovic, M. D., Todorović, Z., Kraišnik, N., Aranđelović, B., Mandić, O., Popadić, V., Nikolić, N., et al. (2023) · International Journal of Molecular Sciences · doi:10.3390/ijms24043735 · Cited by 155 · see citing works
“Genetic factors also determine the risk of developing this condition [14].”
BackgroundFibrosis progression occurs in a subgroup of heavy drinkers with typical histological features
Mathurin, P., Beuzin, F., Louvet, A., Ganne‐Carrié, N., Balian, A., Trinchet, J.-C., Soglio, D. B. D., Prevot, S., & Naveau, S. (2007) · Alimentary Pharmacology & Therapeutics · doi:10.1111/j.1365-2036.2007.03302.x · Cited by 151 · see citing works
Self-citation
- Authors
- Naveau, S., Giraud, V., Borotto, E., Aubert, A., Capron, F., & Chaput, J.
- Affiliations
- Hôpital Antoine-Béclère (FR)
- Venue
- Hepatology
- Published
- 1997-01
- Volume
- 25
- Issue
- 1
- Pages
- 108-111
- ISSN
- 0270-9139 (ISSN-L)
- OpenAlex
- W1987296974
- Cited by
- 666
- References
- 0
- Citations by year
- 2026: 4 · 2025: 19 · 2024: 27 · 2023: 40 · 2022: 19 · 2021: 21 · 2020: 27 · 2019: 22 · 2018: 41 · 2017: 29 · 2016: 36 · 2015: 45 · 2014: 37 · 2013: 21 · 2012: 27
- FWCI
- 6.31
- Type
- journal article
- Language
- en
- Open access
- closed
- Locations
- Hepatology (publishedVersion)
- PubMed (publishedVersion)
- Topics
- Health Sciences › Medicine › Pathology and Forensic Medicine › Alcohol Consumption and Health Effects
- Health Sciences › Medicine › Epidemiology › Liver Disease Diagnosis and Treatment
- Health Sciences › Medicine › Hepatology › Liver Disease and Transplantation
- Keywords
- alcoholic liver disease, overweight, body mass index, alcoholic cirrhosis, alcoholic hepatitis, steatosis, risk factors, sex differences, ethanol-induced hepatotoxicity
- MeSH terms
- Adult, Aged, Female, Humans, Liver Cirrhosis, Alcoholic, Male, Middle Aged, Obesity, Risk Factors, Multivariate Analysis
About these checks
Registry, retraction, Cites and statistics results are computed, not judged, with one exception: a printed reference that no index lists is read once by a model before it counts as a citation error. Claims are extracted by a model and kept only when their quote appears verbatim in the text; each cited source is then checked, with a model’s help, for whether it says what the claim relies on. Those verdicts can be wrong — read the claim’s quote and the cited source before relying on one.
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