Utility of Noninvasive Markers of Fibrosis in Cholestatic Liver Diseases
Abstract
Methods of liver fibrosis assessment have changed considerably in the last 20 years, and noninvasive markers now have been recognized as major first-line tools in the management of patients with chronic viral hepatitis infection. But what about the efficiency and utility of these surrogate indices for the more uncommon chronic cholestatic liver diseases, namely primary biliary cirrhosis and primary sclerosing cholangitis? This article provides clinicians with a global overview of what is currently known in the field. Both diagnostic and prognostic aspects of noninvasive markers of fibrosis in cholestatic liver diseases are presented and discussed.
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Liver stiffness measurement (LSM), assessed by vibration-controlled transient elastography (VCTE), has been shown as one of the best surrogate markers for the detection of cirrhosis or severe fibrosis (ie, bridging fibrosis) in patients with PBC.
“Liver stiffness measurement (LSM), assessed by vibration-controlled transient elastography (VCTE), has been shown as one of the best surrogate markers for the detection of cirrhosis or severe fibrosis (ie, bridging fibrosis) in patients with PBC.107 220”
From The British Society of Gastroenterology/UK-PBC primary biliary cholangitis treatment and management guidelines (2018) · cites this paper as [220]
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Trivedi, P. J., & Hirschfield, G. M. (2019) · Wiley eBooks · doi:10.1002/9781119211419.ch38 · Cited by 1 · see citing works
Elastography in Autoimmune Liver Diseases
Cristoferi, L., Carbone, M., & Invernizzi, P. (2021) · Springer eBooks · doi:10.1007/978-3-030-74132-7_7
Li, Z., Zhang, F., Lu, W., Lü, C., Yuan, Z., & Wang, Z. (2025) · Current Medical Imaging Formerly Current Medical Imaging Reviews · doi:10.2174/0115734056379090250611073434
Detection of Liver Fibrosis and Portal Hypertension
Selvan, B., & Price, J. C. (2026) · Clinics in Liver Disease · doi:10.1016/j.cld.2026.08.006
- Authors
- Corpechot, C.
- Affiliations
- Inserm (FR)
- Corresponding author
- Corpechot, Christophe
- Venue
- Clinics in Liver Disease
- Publisher
- Elsevier BV
- Published
- 2016-02
- Volume
- 20
- Issue
- 1
- Pages
- 143-158
- ISSN
- 1089-3261 (ISSN-L)
- OpenAlex
- W2161873403
- Cited by
- 19
- References
- 75
- Citations by year
- 2026: 1 · 2025: 1 · 2024: 1 · 2022: 1 · 2021: 3 · 2020: 3 · 2019: 3 · 2018: 4 · 2017: 1 · 2016: 1
- FWCI
- 0.29
- Type
- journal article
- Language
- en
- Open access
- closed
- Locations
- Clinics in Liver Disease (publishedVersion)
- PubMed (publishedVersion)
- Topics
- Health Sciences › Medicine › Hepatology › Liver Diseases and Immunity
- Health Sciences › Medicine › Epidemiology › Liver Disease Diagnosis and Treatment
- Health Sciences › Medicine › Hepatology › Liver Disease and Transplantation
- Keywords
- liver fibrosis, non-invasive fibrosis markers, cholestatic liver disease, primary biliary cirrhosis, primary sclerosing cholangitis, chronic viral hepatitis, fibrosis staging, prognosis, diagnosis
- MeSH terms
- Biopsy, Humans, Liver, Liver Cirrhosis, Liver Cirrhosis, Biliary, Magnetic Resonance Imaging, Prognosis, Cholangitis, Sclerosing, Biomarkers, Elasticity Imaging Techniques
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