Cited by 33Gut microbiota and healthLiver Disease Diagnosis and TreatmentAlcohol Consumption and Health Effects

The Intestinal Microbiome in Nonalcoholic Fatty Liver Disease

Puri, Puneet, Sanyal, Arun J.·2018·Clinics in Liver Disease

Abstract

Nonalcoholic fatty liver disease is the most common cause of chronic liver disease in North America and is growing as a cause of chronic liver disease in many other parts of the world as well. It has 2 principal clinical-pathologic phenotypes: (1) nonalcoholic fatty liver and (2) nonalcoholic steatohepatitis. The development of both phenotypes is tightly linked to excess body weight and insulin resistance. This review discusses the emerging tools for the analysis of the microbiome, their limitations, and the existing literature with respect to the intestinal microbiome and their role in nonalcoholic fatty liver.

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Crossref · 10.1016/j.cld.2017.08.009

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Authors
Puri, P., & Sanyal, A. J.
Affiliations
Virginia Commonwealth University (US)
Corresponding author
Sanyal, Arun J.
Venue
Clinics in Liver Disease
Publisher
Elsevier BV
Published
2018-02
Volume
22
Issue
1
Pages
121-132
ISSN
1089-3261 (ISSN-L)
OpenAlex
W2767236586
Cited by
33
References
49
Citations by year
2026: 1 · 2025: 2 · 2024: 3 · 2023: 2 · 2022: 5 · 2021: 8 · 2020: 2 · 2019: 7 · 2018: 3
FWCI
0.31
Type
journal article
Language
en
Open access
closed
Locations
  • Clinics in Liver Disease (publishedVersion)
  • PubMed (publishedVersion)
Funders
  • National Institute on Alcohol Abuse and Alcoholism (K23AA021179)
  • National Institute of Diabetes and Digestive and Kidney Diseases (R01DK105961)
Topics
  • Life Sciences › Biochemistry, Genetics and Molecular Biology › Molecular Biology › Gut microbiota and health
  • Health Sciences › Medicine › Epidemiology › Liver Disease Diagnosis and Treatment
  • Health Sciences › Medicine › Pathology and Forensic Medicine › Alcohol Consumption and Health Effects
Keywords
gut microbiota, non-alcoholic fatty liver disease, nonalcoholic steatohepatitis, obesity, insulin resistance
MeSH terms
Gastrointestinal Microbiome, Hepatitis, Humans, Immunity, Innate, Intestines, Liver Cirrhosis, Obesity, Computational Biology, Toll-Like Receptors, Non-alcoholic Fatty Liver Disease

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