The Intestinal Microbiome in Nonalcoholic Fatty Liver Disease
Abstract
Nonalcoholic fatty liver disease is the most common cause of chronic liver disease in North America and is growing as a cause of chronic liver disease in many other parts of the world as well. It has 2 principal clinical-pathologic phenotypes: (1) nonalcoholic fatty liver and (2) nonalcoholic steatohepatitis. The development of both phenotypes is tightly linked to excess body weight and insulin resistance. This review discusses the emerging tools for the analysis of the microbiome, their limitations, and the existing literature with respect to the intestinal microbiome and their role in nonalcoholic fatty liver.
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Chronic liver disorders are associated with changes in gut microbiome composition and disruption of the intestinal barrier.
“Chronic liver disorders have also been associated with changes in gut microbiome composition and the disruption of the intestinal barrier3,5–8.”
From Cholestasis induced by bile duct ligation promotes changes in the intestinal microbiome in mice (2019) · cites this paper as [6]
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- Authors
- Puri, P., & Sanyal, A. J.
- Affiliations
- Virginia Commonwealth University (US)
- Corresponding author
- Sanyal, Arun J.
- ORCID
- Sanyal, Arun J.
- Venue
- Clinics in Liver Disease
- Publisher
- Elsevier BV
- Published
- 2018-02
- Volume
- 22
- Issue
- 1
- Pages
- 121-132
- ISSN
- 1089-3261 (ISSN-L)
- OpenAlex
- W2767236586
- Cited by
- 33
- References
- 49
- Citations by year
- 2026: 1 · 2025: 2 · 2024: 3 · 2023: 2 · 2022: 5 · 2021: 8 · 2020: 2 · 2019: 7 · 2018: 3
- FWCI
- 0.31
- Type
- journal article
- Language
- en
- Open access
- closed
- Locations
- Clinics in Liver Disease (publishedVersion)
- PubMed (publishedVersion)
- Funders
- National Institute on Alcohol Abuse and Alcoholism (K23AA021179)
- National Institute of Diabetes and Digestive and Kidney Diseases (R01DK105961)
- Topics
- Life Sciences › Biochemistry, Genetics and Molecular Biology › Molecular Biology › Gut microbiota and health
- Health Sciences › Medicine › Epidemiology › Liver Disease Diagnosis and Treatment
- Health Sciences › Medicine › Pathology and Forensic Medicine › Alcohol Consumption and Health Effects
- Keywords
- gut microbiota, non-alcoholic fatty liver disease, nonalcoholic steatohepatitis, obesity, insulin resistance
- MeSH terms
- Gastrointestinal Microbiome, Hepatitis, Humans, Immunity, Innate, Intestines, Liver Cirrhosis, Obesity, Computational Biology, Toll-Like Receptors, Non-alcoholic Fatty Liver Disease
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