Regulatory effects of osteoprotegerin on cellular and humoral immune responses.
Abstract
The interaction between receptor activator of nuclear factor-kappaB ligand (RANKL) and RANK has been reported to regulate immunity in addition to bone metabolism. The aim of this study was to determine if osteoprotegerin (OPG), an inhibitor of the RANKL-RANK interaction and possibly a new drug against osteoporosis, would adversely affect immunity. OPG was used to treat mice developing different models of cellular and humoral immune responses and also in vitro in T and B cell assays. In mice, OPG does not affect cell-mediated reactions such as contact hypersensitivity to the hapten oxazolone and liver damage, granuloma formation, and infectious load induced by mycobacterial infection. However, OPG increases humoral reactions such as the production of IgM, IgG, and IgE against the T cell dependent antigen keyhole limpet hemocyanin and the production of IgM against the T cell independent antigen Pneumovax. In vitro, OPG modestly co-stimulates T cells but does not affect the proliferation of B cells. OPG has modest immunoregulatory effects that seem to be confined to the humoral response to specific antigens.
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Short-term (up to 2 weeks) RANKL inhibition by OPG in mice did not impair cell-mediated reactions, innate immunity, humoral responses, or influenza infection.
“Short-term (up to 2-wk) mouse studies have show that RANKL inhibition by OPG did not impair cell-mediated reactions such as contact hypersensitivity or granuloma formation, innate immunity, humoral responses to defined immune challenges (175), or influenza infection (173).”
From Receptor Activator of Nuclear Factor κB Ligand and Osteoprotegerin Regulation of Bone Remodeling in Health and Disease (2008) · cites this paper as [175]
Cites
Osteoprotegerin ligand is a cytokine that regulates osteoclast differentiation and activation.
Lacey, D. L., Timms, E., Tan, H.-L., Kelley, M. J., Dunstan, C. R., Burgess, T., Elliott, R., Colombero, A., Elliott, G., Scully, S., et al. (1998) · Cell · doi:10.1016/s0092-8674(00)81569-x · Cited by 5,439 · see citing works
Self-citationOsteoprotegerin: a novel secreted protein involved in the regulation of bone density.
Simonet, W. S., Lacey, D. L., Dunstan, C. R., Kelley, M., Chang, M.-S., Lüthy, R., Nguyen, H. Q., Wooden, S., Bennett, L., Boone, T., et al. (1997) · Cell · doi:10.1016/s0092-8674(00)80209-3 · Cited by 5,130 · see citing works
Tuberculosis Associated with Infliximab, a Tumor Necrosis Factor α–Neutralizing Agent
Keane, J., Gershon, S. K., Wise, R. P., Mirabile‐Levens, E., Kasznica, J. M., Schwieterman, W. D., Siegel, J. N., & Braun, M. M. (2001) · New England Journal of Medicine · doi:10.1056/nejmoa011110 · Cited by 3,683 · see citing works
OPGL is a key regulator of osteoclastogenesis, lymphocyte development and lymph node organogenesis.
Kong, Y.-Y., Yoshida, H., Sarosi, I., Tan, H.-L., Timms, E., Capparelli, C., Morony, S., Oliveira-dos-Santos, A. J., Van, G., Itie, A., et al. (1999) · Nature · doi:10.1038/16852 · Cited by 3,351 · see citing works
Osteoprotegerin-deficient mice develop early onset osteoporosis and arterial calcification.
Bucay, N., Sarosi, I., Dunstan, C. R., Morony, S., Tarpley, J., Capparelli, C., Scully, S., Tan, H. L., Xu, W., Lacey, D. L., et al. (1998) · Genes & Development · doi:10.1101/gad.12.9.1260 · Cited by 2,483 · see citing works
Suda, T., Takahashi, N., Udagawa, N., Jimi, E., Gillespie, M. T., & Martin, T. J. (1999) · Endocrine Reviews · doi:10.1210/edrv.20.3.0367 · Cited by 2,317 · see citing works
A homologue of the TNF receptor and its ligand enhance T-cell growth and dendritic-cell function.
Anderson, D. M., Maraskovsky, E., Billingsley, W. L., Dougall, W. C., Tometsko, M. E., Roux, E. R., Teepe, M. C., DuBose, R. F., Cosman, D., & Galibert, L. (1997) · Nature · doi:10.1038/36593 · Cited by 2,290 · see citing works
RANK is essential for osteoclast and lymph node development.
Dougall, W. C., Glaccum, M., Charrier, K., Rohrbach, K., Brasel, K., De Smedt, T., Daro, E., Smith, J., Tometsko, M. E., Maliszewski, C. R., et al. (1999) · Genes & Development · doi:10.1101/gad.13.18.2412 · Cited by 1,478 · see citing works
Apoptosis control by death and decoy receptors
Ashkenazi, A., & Dixit, V. M. (1999) · Current Opinion in Cell Biology · doi:10.1016/s0955-0674(99)80034-9 · Cited by 1,281 · see citing works
Osteoprotegerin Is a Receptor for the Cytotoxic Ligand TRAIL
Emery, J. G., McDonnell, P., Burke, M. B., Deen, K. C., Lyn, S. D., Silverman, C., Dul, E., Appelbaum, E. R., Eichman, C., DiPrinzio, R., et al. (1998) · Journal of Biological Chemistry · doi:10.1074/jbc.273.23.14363 · Cited by 1,183 · see citing works
An Essential Role for BAFF in the Normal Development of B Cells Through a BCMA-Independent Pathway
Schiemann, B. J., Gommerman, J. L., Vora, K. A., Cachero, T. G., Shulga‐Morskaya, S., Dobles, M., Frew, E. M., & Scott, M. L. (2001) · Science · doi:10.1126/science.1061964 · Cited by 1,070 · see citing works
Wong, B. R., Rho, J., Arron, J. R., Robinson, E. A., Orlinick, J. R., Chao, M. V., Kalachikov, S. M., Cayani, E., Bartlett, F. S., Frankel, W. N., et al. (1997) · Journal of Biological Chemistry · doi:10.1074/jbc.272.40.25190 · Cited by 1,042 · see citing works
Wong, B. R., Josien, R., Lee, S. Y., Sauter, B., Li, H.-L., Steinman, R. M., & Choi, Y. (1997) · The Journal of Experimental Medicine · doi:10.1084/jem.186.12.2075 · Cited by 853 · see citing works
T-cell co-stimulation through B7RP-1 and ICOS
Yoshinaga, S. K., Whoriskey, J. S., Khare, S. D., Sarmiento, U. M., Guo, J., Horan, T., Shih, G. C., Zhang, M., Coccia, M. A., Kohno, T., et al. (1999) · Nature · doi:10.1038/45582 · Cited by 772 · see citing works
Self-citationPrimer on the metabolic bone diseases and disorders of mineral metabolism.
Laurence, M. (2000) · Journal of Bone and Joint Surgery - British Volume · doi:10.1302/0301-620x.82b7.0821087b · Cited by 684 · see citing works
Suda, T. (1999) · Endocrine Reviews · doi:10.1210/er.20.3.345 · Cited by 485 · see citing works
The effect of a single dose of osteoprotegerin in postmenopausal women.
Bekker, P. J., Holloway, D., Nakanishi, A., Arrighi, M., Leese, P. T., & Dunstan, C. R. (2001) · Journal of Bone and Mineral Research · doi:10.1359/jbmr.2001.16.2.348 · Cited by 484 · see citing works
Journal of Bone and Mineral Research
Delmas, P. D. (1993) · Journal of Bone and Mineral Research · doi:10.1002/jbmr.5650081323 · Cited by 454 · see citing works
APRIL and TALL-1 and receptors BCMA and TACI: system for regulating humoral immunity
Yu, G., Boone, T., Delaney, J., Hawkins, N., Kelley, M. J., Ramakrishnan, M., McCabe, S., Qiu, W., Kornuc, M., Xia, X.-Z., et al. (2000) · Nature Immunology · doi:10.1038/79802 · Cited by 362 · see citing works
Self-citationJosien, R., Wong, B. R., Li, H., Steinman, R. M., & Choi, Y. (1999) · The Journal of Immunology · doi:10.4049/jimmunol.162.5.2562 · Cited by 317 · see citing works
Yun, T. J., Chaudhary, P. M., Shu, G. L., Frazer, J. K., Ewings, M. K., Schwartz, S. M., Pascual, V., Hood, L. E., & Clark3, E. A. (1998) · The Journal of Immunology · doi:10.4049/jimmunol.161.11.6113 · Cited by 307 · see citing works
Morony, S., Capparelli, C., Sarosi, I., Lacey, D. L., Dunstan, C. R., & Kostenuik, P. J. (2001) · PubMed · Cited by 289 · see citing works
Bachmann, M. F., Wong, B. R., Josien, R., Steinman, R. M., Oxenius, A., & Choi, Y. (1999) · The Journal of Experimental Medicine · doi:10.1084/jem.189.7.1025 · Cited by 260 · see citing works
Yun, T. J., Tallquist, M. D., Aicher, A., Rafferty, K. L., Marshall, A. J., Moon, J. J., Ewings, M. K., Mohaupt, M., Herring, S. W., & Clark, E. A. (2001) · The Journal of Immunology · doi:10.4049/jimmunol.166.3.1482 · Cited by 195 · see citing works
Morony, S., Capparelli, C., Lee, R., Shimamoto, G., Boone, T., Lacey, D. L., & Dunstan, C. R. (1999) · Journal of Bone and Mineral Research · doi:10.1359/jbmr.1999.14.9.1478 · Cited by 187 · see citing works
Capparelli, C., Kostenuik, P. J., Morony, S., Starnes, C. O., Weimann, B., Van, G. Y., Scully, S. A., Qi, M., Lacey, D. L., & Dunstan, C. R. (2000) · PubMed · Cited by 147 · see citing works
Kostenuik, P. J., Capparelli, C., Morony, S., Adamu, S., Shimamoto, G., Shen, V., Lacey, D. L., & Dunstan, C. R. (2001) · Endocrinology · doi:10.1210/endo.142.10.8437 · Cited by 140 · see citing works
Characterization of osteoclast precursors in human blood
Shalhoub, V., Elliott, G., Chiu, L., Manoukian, R., Kelley, M., Hawkins, N., Davy, E., Shimamoto, G. T., Beck, J., Kaufman, S., et al. (2000) · British Journal of Haematology · doi:10.1046/j.1365-2141.2000.02379.x · Cited by 130 · see citing works
Clodi, K., Wimmer, D., Li, Y., Goodwin, R. G., Jaeger, U., Mann, G., Gadner, H., & Younes, A. (2000) · British Journal of Haematology · doi:10.1046/j.1365-2141.2000.02404.x · Cited by 75 · see citing works
Senaldi, G., Stolina, M., Guo, J., Faggioni, R., McCabe, S., Kaufman, S. A., Van, G. Y., Xu, W., Fletcher, F. A., Boone, T. C., et al. (2002) · The Journal of Immunology · doi:10.4049/jimmunol.168.11.5690 · Cited by 54 · see citing works
Self-citationStimulatory Effects of B7-Related Protein-1 on Cellular and Humoral Immune Responses in Mice
Guo, J., Stolina, M., BREADY, J. V., Yin, S., Horan, T., Yoshinaga, S. K., & Senaldi, G. (2001) · The Journal of Immunology · doi:10.4049/jimmunol.166.9.5578 · Cited by 47 · see citing works
Self-citationTo B or not to B: TNF family signaling in lymphocytes
Siegel, R. M., & Lenardo, M. J. (2001) · Nature Immunology · doi:10.1038/89715 · Cited by 29 · see citing works
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Kearns, A. E., Khosla, S., & Kostenuik, P. J. (2008) · Endocrine Reviews · doi:10.1210/er.2007-0014 · Cited by 824 · see citing works
Bench to bedside: elucidation of the OPG–RANK–RANKL pathway and the development of denosumab
Lacey, D. L., Boyle, W. J., Simonet, W. S., Kostenuik, P. J., Dougall, W. C., Sullivan, J. K., Martín, J. S., & Dansey, R. (2012) · Nature Reviews Drug Discovery · doi:10.1038/nrd3705 · Cited by 692 · see citing works
Effects of Denosumab on Bone Mineral Density and Bone Turnover in Postmenopausal Women
Bone, H. G., Bolognese, M. A., Yuen, C. K., Kendler, D. L., Wang, H., Liu, Y., & Martín, J. S. (2008) · The Journal of Clinical Endocrinology & Metabolism · doi:10.1210/jc.2007-2814 · Cited by 421 · see citing works
Bennett, B. J., Scatena, M., Kirk, E. A., Rattazzi, M., Varon, R. M., Averill, M., Schwartz, S. M., Giachelli, C. M., & Rosenfeld, M. E. (2006) · Arteriosclerosis, Thrombosis, and Vascular Biology · doi:10.1161/01.atv.0000236428.91125.e6 · Cited by 304 · see citing works
Do RANKL inhibitors (denosumab) affect inflammation and immunity?
Ferrari, S., & Ferrari, S. (2010) · Osteoporosis International · doi:10.1007/s00198-010-1326-y · Cited by 157 · see citing works
Clinical development of anti-RANKL therapy
Schwarz, E. M., & Ritchlin, C. T. (2007) · Arthritis Research & Therapy · doi:10.1186/ar2171 · Cited by 138 · see citing works
Watts, N. B., Roux, C., Modlin, J. F., Brown, J. P., Daniels, A., Jackson, S. M., Smith, S. Y., Zack, D. J., Zhou, L., Grauer, A., et al. (2011) · Osteoporosis International · doi:10.1007/s00198-011-1755-2 · Cited by 134 · see citing works
Dempster, D. W., Lambing, C. L., Kostenuik, P. J., & Grauer, A. (2012) · Clinical Therapeutics · doi:10.1016/j.clinthera.2012.02.002 · Cited by 134 · see citing works
The anti-tumor effect of RANKL inhibition in malignant solid tumors – A systematic review
de Groot, A. F., Appelman‐Dijkstra, N. M., van der Burg, S. H., & Kroep, J. R. (2017) · Cancer Treatment Reviews · doi:10.1016/j.ctrv.2017.10.010 · Cited by 127 · see citing works
RANK ligand as a therapeutic target for bone metastases and multiple myeloma
Roodman, G. D., & Dougall, W. C. (2007) · Cancer Treatment Reviews · doi:10.1016/j.ctrv.2007.09.002 · Cited by 127 · see citing works
Cross, S. S., Yang, Z., Brown, N. J., Balasubramanian, S. P., Evans, C. A., Woodward, J. K. L., Neville-Webbe, H. L., Down, J. M., Reed, M., Coleman, R. E., et al. (2005) · International Journal of Cancer · doi:10.1002/ijc.21606 · Cited by 108 · see citing works
HMGB1 is a bone‐active cytokine
Yang, J., Shah, R., Robling, A. G., Templeton, E., Yang, H., Tracey, K. J., & Bidwell, J. P. (2008) · Journal of Cellular Physiology · doi:10.1002/jcp.21268 · Cited by 97 · see citing works
Syndecan-1 Is Involved in Osteoprotegerin-Induced Chemotaxis in Human Peripheral Blood Monocytes
Mosheimer, B. A., Kaneider, N. C., Feistritzer, C., Djanani, A. M., Sturn, D. H., Patsch, J. R., & Wiedermann, C. J. (2005) · The Journal of Clinical Endocrinology & Metabolism · doi:10.1210/jc.2004-1895 · Cited by 89 · see citing works
Effects of RANKL-Targeted Therapy in Immunity and Cancer
Cheng, M. L., & Fong, L. H. (2014) · Frontiers in Oncology · doi:10.3389/fonc.2013.00329 · Cited by 87 · see citing works
Extraskeletal benefits and risks of calcium, vitamin D and anti-osteoporosis medications
Body, J. J., Bergmann, P., Boonen, S., Devogelaer, J.-P., Gielen, E., Goemaere, S., Kaufman, J., Rozenberg, S., & Reginster, J.-Y. (2012) · Osteoporosis International · doi:10.1007/s00198-011-1891-8 · Cited by 83 · see citing works
Schett, G. A. (2007) · Arthritis Research & Therapy · doi:10.1186/ar2166 · Cited by 73 · see citing works
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Koole, D., Hurks, R., Schoneveld, A. H., Vink, A., Golledge, J., Moran, C. S., de Kleijn, D. P. V., van Herwaarden, J. A., de Vries, J. P. P. M., Laman, J. D., et al. (2012) · Arteriosclerosis Thrombosis and Vascular Biology · doi:10.1161/atvbaha.111.243592 · Cited by 63 · see citing works
Titanji, K. (2017) · Frontiers in Immunology · doi:10.3389/fimmu.2017.01851 · Cited by 61 · see citing works
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Yuan, H., Gupte, R. K., Zelkha, S., & Amar, S. (2011) · Journal Of Clinical Periodontology · doi:10.1111/j.1600-051x.2011.01780.x · Cited by 52 · see citing works
Miller, R. E., Branstetter, D. G., Armstrong, A. P., Kennedy, B., Jones, J. C., Cowan, L. A., Bussiere, J. L., & Dougall, W. C. (2007) · The Journal of Immunology · doi:10.4049/jimmunol.179.1.266 · Cited by 46 · see citing works
Influence of RANKL inhibition on immune system in the treatment of bone diseases
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Goessl, C. D., Katz, L., Dougall, W. C., Kostenuik, P. J., Zoog, H. B., Braun, A., Dansey, R., & Wagman, R. B. (2012) · Annals of the New York Academy of Sciences · doi:10.1111/j.1749-6632.2012.06674.x · Cited by 40 · see citing works
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Moran, C. S., Jose, R. J., Biroš, E., & Golledge, J. (2014) · Arteriosclerosis Thrombosis and Vascular Biology · doi:10.1161/atvbaha.114.304587 · Cited by 36 · see citing works
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Li, D., Gromov, K., Proulx, S. T., Xie, C. L., Li, J., Crane, D. P., Søballé, K., O’Keefe, R. J., Awad, H. A., Xing, L., et al. (2010) · Annals of the New York Academy of Sciences · doi:10.1111/j.1749-6632.2009.05210.x · Cited by 33 · see citing works
Verdrengh, M., Bokarewa, M. I., Ohlsson, C., Stolina, M., & Tarkowski, A. (2009) · Bone · doi:10.1016/j.bone.2009.10.028 · Cited by 32 · see citing works
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RANKL Inhibition: From Mice to Men (and Women)
Stolina, M., Kostenuik, P. J., Dougall, W. C., Fitzpatrick, L. A., & Zack, D. J. (2007) · Advances in experimental medicine and biology · doi:10.1007/978-0-387-72009-8_18 · Cited by 30 · see citing works
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Effects of RANKL inhibition on inflammation and immunity
Ferrari‐Lacraz, S., & Ferrari, S. (2009) · IBMS BoneKEy · doi:10.1138/20090369 · Cited by 6 · see citing works
Miyake, T., Miyake, T., & Morishita, R. (2022) · Cellular Immunology · doi:10.1016/j.cellimm.2022.104559 · Cited by 4 · see citing works
Breast Cancer: Rank Ligand Inhibition
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Мялюк, О. П., Марущак, М. І., Баб’як, О. В., Sabadyshyn, R. O., & Палапа, В. В. (2023) · doi:10.32782/2226-2008-2023-3-15 · Cited by 1 · see citing works
Nair, A. S., Woodford, J., Loughland, J. R., Andrew, D. W., Piera, K. A., Amante, F. H., William, T., Grigg, M. J., McCarthy, J. S., Anstey, N. M., et al. (2024) · medRxiv · doi:10.1101/2024.07.22.24310838 · Cited by 1 · see citing works
Bedeutung von RANK-Ligand und Osteoprotegerin für den Knochenstoffwechsel
Hofbauer, L. C., & Schoppet, M. (2006) · Springer eBooks · doi:10.1007/3-540-28782-5_21
Denosumab: A Novel Agent for Osteoporosis
Horning, K. K., Hegge, K. A., & Bottenberg, M. M. (2009) · Journal of Pharmacy Technology · doi:10.1177/875512250902500205
Fouque-Aubert, A., & Chapurlat, R. D. (2007) · Revue du Rhumatisme · doi:10.1016/j.rhum.2007.05.018
OSTEOCLASTOGENESIS AND LYMPH NODE ORGANOGENESIS IN DIFFERENT SPECIES OF EGYPTIAN RATS
Saad, A.-H., & Abdel‐Gaber, R. (2013) · Journal of the Egyptian Society of Parasitology · doi:10.12816/0006367
CHAPTER 18 RANKL INHIBITION: FROM MICE TO MEN (AND WOMEN)
Stolina, M., Kostenuik, P. J., Dougall, W. C., & Zack, D. J. (2007)
Self-citationOsteoprotegerin and its ligands RANKL and TRAIL in falciparum, vivax, and knowlesi malaria
Nair, A. S., Woodford, J., Loughland, J. R., Andrew, D. W., Piera, K. A., Amante, F. H., William, T., Grigg, M. J., McCarthy, J. S., Anstey, N. M., et al. (2025) · iScience · doi:10.1016/j.isci.2025.112768
- Authors
- Stolina, M., Guo, J., Faggioni, R., Brown, H., & Senaldi, G.
- Affiliations
- Amgen (United States) (US)
- Corresponding author
- Stolina, Marina
- Venue
- Clinical Immunology
- Publisher
- Elsevier BV
- Published
- 2003-12
- Volume
- 109
- Issue
- 3
- Pages
- 347-354
- ISSN
- 1521-6616 (ISSN-L)
- OpenAlex
- W2089558624
- Cited by
- 44
- References
- 31
- Citations by year
- 2025: 1 · 2024: 1 · 2023: 1 · 2022: 1 · 2017: 2 · 2014: 4 · 2013: 2 · 2012: 5
- FWCI
- 0.58
- Type
- journal article
- Language
- en
- Open access
- closed
- Locations
- Clinical Immunology (publishedVersion)
- PubMed (publishedVersion)
- Topics
- Life Sciences › Biochemistry, Genetics and Molecular Biology › Molecular Biology › Bone Metabolism and Diseases
- Life Sciences › Immunology and Microbiology › Immunology › T-cell and B-cell Immunology
- Life Sciences › Immunology and Microbiology › Immunology › Immune Response and Inflammation
- Keywords
- osteoprotegerin, immunomodulation, humoral immune response, cell-mediated immunity, T cell costimulation, B cell proliferation, IgM, IgG, IgE, keyhole limpet hemocyanin, pneumococcal polysaccharide, mycobacterial infection, granuloma formation, contact hypersensitivity, osteoporosis
- MeSH terms
- Animals, Antibody Formation, B-Lymphocytes, Cell Division, Female, Glycoproteins, Hemocyanins, Humans, Hypersensitivity, Delayed, Immunity, Cellular, Immunoglobulins, Liver, Mice, Inbred BALB C, Mycobacterium bovis, Oxazolone, T-Lymphocytes, Receptors, Tumor Necrosis Factor, Receptors, Cytoplasmic and Nuclear, Pneumococcal Vaccines, Mice, Osteoprotegerin
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