Cited by 44Bone Metabolism and DiseasesT-cell and B-cell ImmunologyImmune Response and Inflammation

Regulatory effects of osteoprotegerin on cellular and humoral immune responses.

Stolina, Marina, Guo, Jane, Faggioni, Raffaella, Brown, Heather, Senaldi, Giorgio·2003·Clinical Immunology

Abstract

The interaction between receptor activator of nuclear factor-kappaB ligand (RANKL) and RANK has been reported to regulate immunity in addition to bone metabolism. The aim of this study was to determine if osteoprotegerin (OPG), an inhibitor of the RANKL-RANK interaction and possibly a new drug against osteoporosis, would adversely affect immunity. OPG was used to treat mice developing different models of cellular and humoral immune responses and also in vitro in T and B cell assays. In mice, OPG does not affect cell-mediated reactions such as contact hypersensitivity to the hapten oxazolone and liver damage, granuloma formation, and infectious load induced by mycobacterial infection. However, OPG increases humoral reactions such as the production of IgM, IgG, and IgE against the T cell dependent antigen keyhole limpet hemocyanin and the production of IgM against the T cell independent antigen Pneumovax. In vitro, OPG modestly co-stimulates T cells but does not affect the proliferation of B cells. OPG has modest immunoregulatory effects that seem to be confined to the humoral response to specific antigens.

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Crossref · 10.1016/j.clim.2003.09.001

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  • Short-term (up to 2 weeks) RANKL inhibition by OPG in mice did not impair cell-mediated reactions, innate immunity, humoral responses, or influenza infection.

    “Short-term (up to 2-wk) mouse studies have show that RANKL inhibition by OPG did not impair cell-mediated reactions such as contact hypersensitivity or granuloma formation, innate immunity, humoral responses to defined immune challenges (175), or influenza infection (173).”

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Authors
Stolina, M., Guo, J., Faggioni, R., Brown, H., & Senaldi, G.
Affiliations
Amgen (United States) (US)
Corresponding author
Stolina, Marina
Venue
Clinical Immunology
Publisher
Elsevier BV
Published
2003-12
Volume
109
Issue
3
Pages
347-354
ISSN
1521-6616 (ISSN-L)
OpenAlex
W2089558624
Cited by
44
References
31
Citations by year
2025: 1 · 2024: 1 · 2023: 1 · 2022: 1 · 2017: 2 · 2014: 4 · 2013: 2 · 2012: 5
FWCI
0.58
Type
journal article
Language
en
Open access
closed
Locations
  • Clinical Immunology (publishedVersion)
  • PubMed (publishedVersion)
Topics
  • Life Sciences › Biochemistry, Genetics and Molecular Biology › Molecular Biology › Bone Metabolism and Diseases
  • Life Sciences › Immunology and Microbiology › Immunology › T-cell and B-cell Immunology
  • Life Sciences › Immunology and Microbiology › Immunology › Immune Response and Inflammation
Keywords
osteoprotegerin, immunomodulation, humoral immune response, cell-mediated immunity, T cell costimulation, B cell proliferation, IgM, IgG, IgE, keyhole limpet hemocyanin, pneumococcal polysaccharide, mycobacterial infection, granuloma formation, contact hypersensitivity, osteoporosis
MeSH terms
Animals, Antibody Formation, B-Lymphocytes, Cell Division, Female, Glycoproteins, Hemocyanins, Humans, Hypersensitivity, Delayed, Immunity, Cellular, Immunoglobulins, Liver, Mice, Inbred BALB C, Mycobacterium bovis, Oxazolone, T-Lymphocytes, Receptors, Tumor Necrosis Factor, Receptors, Cytoplasmic and Nuclear, Pneumococcal Vaccines, Mice, Osteoprotegerin

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