Osteoprotegerin, a crucial regulator of bone metabolism, also regulates B cell development and function.
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Osteoprotegerin (OPG) is a CD40-regulated gene in B cells and dendritic cells (DCs). We investigated the role of OPG in the immune system by generating opg−/− mice. Like its role as a regulator of bone metabolism, OPG also influences processes in the immune system, notably in B cell development. Ex vivo, opg−/− pro-B cells have enhanced proliferation to IL-7, and in opg−/− spleen, there is an accumulation of type 1 transitional B cells. Furthermore, opg−/− bone marrow-derived DCs are more effective in stimulating allogeneic T cells than control DCs. When challenged with a T-dependent Ag, opg−/− mice had a compromised ability to sustain an IgG3 Ag-specific response. Thus, in the immune system, OPG regulates B cell maturation and development of efficient Ab responses.
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Mice deficient in RANKL, RANK, or OPG show no overt dendritic cell defects.
“Examination of mice genetically deficient in RANKL, RANK, or OPG also revealed no overt dendritic cell defects (62,64,170).”
From Receptor Activator of Nuclear Factor κB Ligand and Osteoprotegerin Regulation of Bone Remodeling in Health and Disease (2008) · cites this paper as [170]
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- Authors
- Yun, T. J., Tallquist, M. D., Aicher, A., Rafferty, K. L., Marshall, A. J., Moon, J. J., Ewings, M. K., Mohaupt, M., Herring, S. W., & Clark, E. A.
- Affiliations
- University of Washington (US)
- Fred Hutch Cancer Center (US)
- Max Delbrück Center (DE)
- ORCID
- Venue
- The Journal of Immunology
- Publisher
- Oxford University Press (OUP)
- Published
- 2001-02-01
- Volume
- 166
- Issue
- 3
- Pages
- 1482-1491
- ISSN
- 0022-1767 (ISSN-L)
- 1550-6606
- OpenAlex
- W2158299560
- Cited by
- 195
- References
- 47
- Citations by year
- 2026: 2 · 2025: 4 · 2024: 1 · 2022: 12 · 2021: 6 · 2020: 6 · 2019: 9 · 2018: 2 · 2017: 6 · 2016: 9 · 2015: 11 · 2014: 8 · 2013: 7 · 2012: 8
- FWCI
- 3.35
- Type
- journal article
- Language
- en
- Open access
- bronze
- doi.org
- Locations
- The Journal of Immunology (publishedVersion)
- PubMed (publishedVersion)
- Nottingham Trent University's Institutional Repository (Nottingham Trent Repository) (submittedVersion)
- Funders
- National Institutes of Health (AI44257)
- National Institute of Allergy and Infectious Diseases (AI44257)
- National Institute of Dental and Craniofacial Research (DE13061, P60DE013061)
- Eunice Kennedy Shriver National Institute of Child Health and Human Development (HD-24875, R01HD024875)
- Topics
- Life Sciences › Immunology and Microbiology › Immunology › T-cell and B-cell Immunology
- Life Sciences › Biochemistry, Genetics and Molecular Biology › Molecular Biology › Bone Metabolism and Diseases
- Life Sciences › Immunology and Microbiology › Immunology › Immune Response and Inflammation
- Keywords
- osteoprotegerin, B cell development, bone metabolism, CD40, pro-B cells, transitional B cells, dendritic cells, T cell stimulation, antibody response, IgG3, IL-7
- MeSH terms
- Animals, B-Lymphocytes, Bone and Bones, Cell Differentiation, Dendritic Cells, Glycoproteins, Hematopoiesis, Immunoglobulin D, Immunoglobulin M, Immunoglobulin Isotypes, Lymphocyte Activation, Lymphocytosis, Mice, Inbred Strains, Osteoporosis, T-Lymphocytes, B-Lymphocyte Subsets, Immunoglobulin Class Switching, Receptors, Tumor Necrosis Factor, Receptors, Cytoplasmic and Nuclear, Mice, Knockout, Gene Targeting, Lymphocyte Count, Mice, Osteoprotegerin
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