The DOI matches its Crossref record; 2 of the 2 references it cites were found in a registry or an index.
Humanized mice in translational biomedical research
Overview
The claims and statistics of this paper haven’t been checked yet.
Run the check — free, no account needed. It reads the open-access text and checks the sources it cites.
Integrity signals
Registry
Cites
Statistics
Verification
Claims the paper makes
The claims and statistics of this paper haven’t been checked yet.
Run the check — free, no account needed. It reads the open-access text and checks the sources it cites.
Self-check
Percentages, sums and reported differences re-computed from the paper’s own numbers.
The self-check needs the paper’s full text.
Citations
Cites
Interactions Between Human Mesenchymal Stem Cells and Natural Killer Cells
Sotiropoulou, P. A., Perez, S. A., Gritzapis, A. D., Baxevanis, C. N., & Papamichail, M. (2006) · Stem Cells · doi:10.1634/stemcells.2004-0359 · Cited by 956
Kent, S. C., Chen, Y., Bregoli, L., Clemmings, S. M., Kenyon, N. S., Ricordi, C., Hering, B. J., & Hafler, D. A. (2005) · Nature · doi:10.1038/nature03625 · Cited by 409
Research works printed but not linked: 137
- Bosma, G. C., Custer, R. P. & Bosma, M. J. A severe combined immunodeficiency mutation in the mouse. Nature 301, 527–530 (1983). · DOI · Paper page
- Mosier, D. E., Gulizia, R. J., Baird, S. M. & Wilson, D. B. Transfer of a functional human immune system to mice with severe combined immunodeficiency. Nature 335, 256–259 (1988). The original description of the use of CB17- scid mice as hosts for human PBMCs, known as the Hu-PBL-SCID model. · DOI · Paper page
- McCune, J. M. et al. The SCID-hu mouse: murine model for the analysis of human hematolymphoid differentiation and function. Science 241, 1632–1639 (1988). The original description of the use of CB17- scid mice as hosts for human haematopoietic fetal liver and thymus, resulting in the development of the SCID-hu model. This model is still used, in particular for testing HIV therapeutics. · doi:10.1126/science.2971269 · Paper page
- Lapidot, T. et al. Cytokine stimulation of multi-lineage hematopoiesis from immature human cells engrafted in SCID mice. Science 255, 1137–1141 (1992). The original description of the use of CB17- scid mice as hosts for human HSCs and the development of the Hu-SRC-SCID model. · DOI · Paper page
- Greiner, D. L., Hesselton, R. A. & Shultz, L. D. SCID mouse models of human stem cell engraftment. Stem Cells 16, 166–177 (1998). · DOI · Paper page
- Fulop, G. M. & Phillips, R. A. The scid mutation in mice causes a general defect in DNA repair. Nature 347, 479–482 (1990). · DOI · Paper page
- Mombaerts, P. et al. RAG-1-deficient mice have no mature B and T lymphocytes. Cell 68, 869–877 (1992). · DOI · Paper page
- Shinkai, Y. et al. RAG-2-deficient mice lack mature lymphocytes owing to inability to initiate V(D)J rearrangement. Cell 68, 855–867 (1992). · DOI · Paper page
- Shultz, L. D. et al. Multiple defects in innate and adaptive immunologic function in NOD/LtSz-scid mice. J. Immunol. 154, 180–191 (1995). · DOI · Paper page
- Hesselton, R. M. et al. High levels of human peripheral blood mononuclear cell engraftment and enhanced susceptibility to HIV-1 infection in NOD/LtSz-scid/scid mice. J. Infect. Dis. 172, 974–982 (1995). · DOI · Paper page
- Christianson, S. W. et al. Role of natural killer cells on engraftment of human lymphoid cells and on metastasis of human T-lymphoblastoid leukemia cells in C57BL/6J-scid mice and in C57BL/6J-scid bg mice. Cell. Immunol. 171, 186–199 (1996).
- Lowry, P. A. et al. Improved engraftment of human cord blood stem cells in NOD/LtSz-scid/scid mice after irradiation or multiple-day injections into unirradiated recipients. Biol. Blood Marrow Transplant. 2, 15–23 (1996).
- Pflumio, F. et al. Phenotype and function of human hematopoietic cells engrafting immune-deficient CB17-severe combined immunodeficiency mice and nonobese diabetic-severe combined immunodeficiency mice after transplantation of human cord blood mononuclear cells. Blood 88, 3731–3740 (1996). · DOI · Paper page
- Ito, M. et al. NOD/SCID/γcnull mouse: an excellent recipient mouse model for engraftment of human cells. Blood 100, 3175–3182 (2002). This paper describes the development of a human immune system in NOD/Shi- scid Il2rg−/− mice engrafted as adults with human CD34+ cord-blood HSCs. · DOI · Paper page
- Traggiai, E. et al. Development of a human adaptive immune system in cord blood cell-transplanted mice. Science 304, 104–107 (2004). This paper shows the development of a complete human immune system in BALB/c- Rag2−/−Il2rg−/− mice engrafted intrahepatically as newborns with human cord-blood CD34+ HSCs. · DOI · Paper page
- Shultz, L. et al. Human lymphoid and myeloid cell development in NOD/LtSz-scid IL2rgnull mice engrafted with mobilized human hematopoietic stem cells. J. Immunol. 174, 6477–6489 (2005). One of the first studies to show the development of a complete human immune system in NOD- scid Il2rg−/− mice engrafted with human mobilized peripheral-blood CD34+ stem cells. · DOI · Paper page
- Ishikawa, F. et al. Development of functional human blood and immune systems in NOD/SCID/IL2 receptor γ-chainnull mice. Blood 106, 1565–1573 (2005). The first paper to show that engraftment of newborn NOD/LtSz- scid Il2rg−/− mice with human CD34+ HSCs leads to the generation of a complete haematopoietic system, including red blood cells and platelets. · DOI · Paper page
- Sugamura, K. et al. The interleukin-2 receptor γ-chain: its role in the multiple cytokine receptor complexes and T cell development in XSCID. Annu. Rev. Immunol. 14, 179–205 (1996). · DOI · Paper page
- Cao, X. et al. Defective lymphoid development in mice lacking expression of the common cytokine receptor γ-chain. Immunity 2, 223–238 (1995). · DOI · Paper page
- DiSanto, J. P., Muller, W., Guy-Grand, D., Fischer, A. & Rajewsky, K. Lymphoid development in mice with a targeted deletion of the interleukin 2 receptor γ-chain. Proc. Natl Acad. Sci. USA 92, 377–381 (1995). · DOI · Paper page
- Ohbo, K. et al. Modulation of hematopoiesis in mice with a truncated mutant of the interleukin-2 receptor γ-chain. Blood 87, 956–967 (1996). · DOI · Paper page
- Jacobs, H. et al. PIM1 reconstitutes thymus cellularity in interleukin-7- and common γ-chain-mutant mice and permits thymocyte maturation in Rag- but not CD3γ-deficient mice. J. Exp. Med. 190, 1059–1068 (1999). · DOI
- Yahata, T. et al. A highly sensitive strategy for SCID-repopulating cell assay by direct injection of primitive human hematopoietic cells into NOD/SCID mice bone marrow. Blood 101, 2905–2913 (2003). · DOI · Paper page
- Gimeno, R. et al. Monitoring the effect of gene silencing by RNA interference in human CD34+ cells injected into newborn Rag2−/−γ c−/− mice: functional inactivation of p53 in developing T cells. Blood 104, 3886–3893 (2004). · DOI · Paper page
- Bryder, D., Rossi, D. J. & Weissman, I. L. Hematopoietic stem cells: the paradigmatic tissue-specific stem cell. Am. J. Pathol. 169, 338–346 (2006). · DOI · Paper page
- Zanjani, E. D., Almeida-Porada, G. & Flake, A. W. Retention and multilineage expression of human hematopoietic stem cells in human–sheep chimeras. Stem Cells 13, 101–111 (1995). · doi:10.1002/stem.5530130202
- Clutterbuck, R. D. et al. Studies on the development of human acute myeloid leukaemia xenografts in immune-deprived mice: comparison with cells in short-term culture. Leuk. Res. 9, 1511–1518 (1985). · doi:10.1016/0145-2126(85)90044-x
- Ganick, D. J., Sarnwick, R. D., Shahidi, N. T. & Manning, D. D. Inability of intravenously injected monocellular suspensions of human bone marrow to establish in the nude mouse. Int. Arch. Allergy Appl. Immunol. 62, 330–333 (1980). · DOI
- Shultz, L. D. et al. NOD/LtSz-Rag1null mice: an immunodeficient and radioresistant model for engraftment of human hematolymphoid cells, HIV infection, and adoptive transfer of NOD mouse diabetogenic T cells. J. Immunol. 164, 2496–2507 (2000). · DOI · Paper page
- Mazurier, F., Doedens, M., Gan, O. I. & Dick, J. E. Rapid myeloerythroid repopulation after intrafemoral transplantation of NOD-SCID mice reveals a new class of human stem cells. Nature Med. 9, 959–963 (2003). · DOI · Paper page
- Schoeberlein, A. et al. Engraftment kinetics of human cord blood and murine fetal liver stem cells following in utero transplantation into immunodeficient mice. Stem Cells Dev. 13, 677–684 (2004). · doi:10.1089/scd.2004.13.677
- Glimm, H. et al. Previously undetected human hematopoietic cell populations with short- term repopulating activity selectively engraft NOD/SCID-β2 microglobulin-null mice. J. Clin. Invest. 107, 199–206 (2001). · DOI · Paper page
- Miyoshi, H., Smith, K. A., Mosier, D. E., Verma, I. M. & Torbett, B. E. Transduction of human CD34+ cells that mediate long-term engraftment of NOD/SCID mice by HIV vectors. Science 283, 682–686 (1999). · DOI · Paper page
- Cohen-Haguenauer, O. et al. In vivo repopulation ability of genetically corrected bone marrow cells from Fanconi anemia patients. Proc. Natl Acad. Sci. USA 103, 2340–2345 (2006). · doi:10.1073/pnas.0510613103
- Bleeker, W. K. et al. Dual mode of action of a human anti-epidermal growth factor receptor monoclonal antibody for cancer therapy. J. Immunol. 173, 4699–4707 (2004). · DOI
- Kolar, G. R., Yokota, T., Rossi, M. I., Nath, S. K. & Capra, J. D. Human fetal, cord blood, and adult lymphocyte progenitors have similar potential for generating B cells with a diverse immunoglobulin repertoire. Blood 104, 2981–2987 (2004). · DOI
- Yahata, T. et al. Functional human T lymphocyte development from cord blood CD34+ cells in nonobese diabetic/Shi-scid, IL-2 receptor-γ-null mice. J. Immunol. 169, 204–209 (2002). · DOI · Paper page
- Legrand, N., Weijer, K. & Spits, H. Experimental models to study development and function of the human immune system in vivo. J. Immunol. 176, 2053–2058 (2006). · DOI · Paper page
- Matsumura, T. et al. Functional CD5+ B cells develop predominantly in the spleen of NOD/SCID/γcnull (NOG) mice transplanted either with human umbilical cord blood, bone marrow, or mobilized peripheral blood CD34+ cells. Exp. Hematol. 31, 789–797 (2003). · doi:10.1016/s0301-472x(03)00193-0
- Legrand, N. et al. Transient accumulation of human mature thymocytes and regulatory T cells with CD28 superagonist in 'human immune system' Rag2−/−γ c−/− mice. Blood 108, 238–245 (2006). · DOI · Paper page
- Banuelos, S. J. et al. Rejection of human islets and human HLA-A2.1-transgenic mouse islets by alloreactive human lymphocytes in immunodeficient NOD-scid and NOD-Rag1nullPrf1null mice. Clin. Immunol. 112, 273–283 (2004). · DOI
- Camacho, R. E. et al. Intra-thymic/splenic engraftment of human T cells in HLA-DR1 transgenic NOD/scid mice. Cell. Immunol. 232, 86–95 (2004). · doi:10.1016/j.cellimm.2005.02.003
- Bajenoff, M. et al. Stromal cell networks regulate lymphocyte entry, migration, and territoriality in lymph nodes. Immunity 25, 989–1001 (2006). · DOI · Paper page
- Suematsu, S. & Watanabe, T. Generation of a synthetic lymphoid tissue-like organoid in mice. Nature Biotechnol. 22, 1539–1545 (2004). · DOI · Paper page
- Melkus, M. W. et al. Humanized mice mount specific adaptive and innate immune responses to EBV and TSST-1. Nature Med. 12, 1316–1322 (2006). · DOI · Paper page
- Ifversen, P. & Borrebaeck, C. A. SCID-hu-PBL: a model for making human antibodies? Semin. Immunol. 8, 243–248 (1996). · doi:10.1006/smim.1996.0030
- Murphy, W. J., Taub, D. D. & Longo, D. L. The huPBL-SCID mouse as a means to examine human immune function in vivo. Semin. Immunol. 8, 233–241 (1996). · doi:10.1006/smim.1996.0029
- Shultz, L. D. et al. NOD/LtSz-Rag1nullPfpnull mice: a new model system to increase levels of human peripheral leukocyte and hematopoietic stem cell engraftment. Transplantation 76, 1036–1042 (2003). · DOI
- Christianson, S. W. et al. Enhanced human CD4+ T cell engraftment in β2-microglobulin-deficient NOD-scid mice. J. Immunol. 158, 3578–3586 (1997). · DOI
- Tary-Lehmann, M., Lehmann, P. V., Schols, D., Roncarolo, M. G. & Saxon, A. Anti-SCID mouse reactivity shapes the human CD4+ T cell repertoire in hu-PBL-SCID chimeras. J. Exp. Med. 180, 1817–1827 (1994). · doi:10.1084/jem.180.5.1817
- Greiner, D. L. & Shultz, L. D. in NOD Mice and Related Strains: Research Applications in Diabetes, AIDS, Cancer and Other Diseases (eds Leiter, E. & Atkinson, M.) 173–203 (Landes Bioscience, Austin, 1998).
- May, K. F. Jr et al. Anti-human CTLA-4 monoclonal antibody promotes T-cell expansion and immunity in a hu-PBL-SCID model: a new method for preclinical screening of costimulatory monoclonal antibodies. Blood 105, 1114–1120 (2005). · DOI
- Murray, A. G. et al. Human T-cell-mediated destruction of allogeneic dermal microvessels in a severe combined immunodeficient mouse. Proc. Natl Acad. Sci. USA 91, 9146–9150 (1994). · DOI
- Chang, S. K., Arendt, B. K., Darce, J. R., Wu, X. & Jelinek, D. F. A role for BLyS in the activation of innate immune cells. Blood 108, 2687–2694 (2006). · DOI
- Woodland, R. T. & Schmidt, M. R. Homeostatic proliferation of B cells. Semin. Immunol. 17, 209–217 (2005). · DOI
- Mosier, D. E. et al. EBV-induced human B cell lymphomas in hu-PBL-SCID mice. AIDS Res. Hum. Retroviruses 8, 735–740 (1992). · DOI
- Wagar, E. J. et al. Regulation of human cell engraftment and development of EBV-related lymphoproliferative disorders in Hu-PBL-scid mice. J. Immunol. 165, 518–527 (2000). · DOI
- van Rijn, R. S. et al. A new xenograft model for graft-versus-host disease by intravenous transfer of human peripheral blood mononuclear cells in Rag2−/−γ c−/− double-mutant mice. Blood 102, 2522–2531 (2003). · DOI · Paper page
- Jung, S. et al. In vivo depletion of CD11c+ dendritic cells abrogates priming of CD8+ T cells by exogenous cell-associated antigens. Immunity 17, 211–220 (2002). · DOI · Paper page
- Mosier, D. E. Human immunodeficiency virus infection of human cells transplanted to severe combined immunodeficient mice. Adv. Immunol. 63, 79–125 (1996). · DOI
- McCune, J. et al. The SCID-hu mouse: a small animal model for HIV infection and pathogenesis. Annu. Rev. Immunol. 9, 399–429 (1991). · doi:10.1146/annurev.iy.09.040191.002151
- Davis, P. H. & Stanley, S. L. Jr Breaking the species barrier: use of SCID mouse–human chimeras for the study of human infectious diseases. Cel. Microbiol. 5, 849–860 (2003). · doi:10.1046/j.1462-5822.2003.00321.x
- Bente, D. A., Melkus, M. W., Garcia, J. V. & Rico-Hesse, R. Dengue fever in humanized NOD/SCID mice. J. Virol. 79, 13797–13799 (2005). · DOI · Paper page
- Islas-Ohlmayer, M. et al. Experimental infection of NOD/SCID mice reconstituted with human CD34+ cells with Epstein–Barr virus. J. Virol. 78, 13891–13900 (2004). · DOI
- Kneteman, N. M. et al. Anti-HCV therapies in chimeric scid-Alb/uPA mice parallel outcomes in human clinical application. Hepatology 43, 1346–1353 (2006). · doi:10.1002/hep.21209
- Nelson, F. K., Greiner, D. L., Shultz, L. D. & Rajan, T. V. The immunodeficient scid mouse as a model for human lymphatic filariasis. J. Exp. Med. 173, 659–663 (1991). · DOI
- Guirado, E. et al. Passive serum therapy with polyclonal antibodies against Mycobacterium tuberculosis protects against post-chemotherapy relapse of tuberculosis infection in SCID mice. Microbes Infect. 8, 1252–1259 (2006). · DOI
- Morosan, S. et al. Liver-stage development of Plasmodium falciparum, in a humanized mouse model. J. Infect. Dis. 193, 996–1004 (2006). · doi:10.1086/500840
- Moreno, A. et al. The course of infections and pathology in immunomodulated NOD/LtSz-SCID mice inoculated with Plasmodium falciparum laboratory lines and clinical isolates. Int. J. Parasitol. 36, 361–369 (2006). · doi:10.1016/j.ijpara.2005.10.012
- Macchiarini, F., Manz, M. G., Palucka, A. K. & Shultz, L. D. Humanized mice: are we there yet? J. Exp. Med. 202, 1307–1311 (2005). · DOI
- Lapenta, C. et al. Pertussis toxin B-oligomer inhibits HIV infection and replication in hu-PBL-SCID mice. Int. Immunol. 17, 469–475 (2005). · doi:10.1093/intimm/dxh226
- Mosier, D. E. Viral pathogenesis in hu-PBL-SCID mice. Semin. Immunol. 8, 255–262 (1996). · doi:10.1006/smim.1996.0032
- Ichiyama, K. et al. A duodenally absorbable CXC-chemokine receptor 4 antagonist, KRH-1636, exhibits a potent and selective anti-HIV-1 activity. Proc. Natl Acad. Sci. USA 100, 4185–4190 (2003). · DOI
- Baenziger, S. et al. Disseminated and sustained HIV infection in CD34+ cord blood cell-transplanted Rag2−/−γc−/− mice. Proc. Natl Acad. Sci. USA 103, 15951–15956 (2006). · DOI · Paper page
- Berges, B. K., Wheat, W. H., Palmer, B. E., Connick, E. & Akkina, R. HIV-1 infection and CD4 T cell depletion in the humanized Rag2−/−γ c−/− (RAG-hu) mouse model. Retrovirology 3, 76 (2006). · DOI · Paper page
- Watanabe, S. et al. Hematopoietic stem cell-engrafted NOD/SCID/Il2rγnull mice develop human lymphoid system and induce long-lasting HIV-1 infection with specific humoral immune responses. Blood 109, 212–218 (2007). · DOI · Paper page
- Petersen, J. S. et al. Transfer of type 1 (insulin-dependent) diabetes mellitus associated autoimmunity to mice with severe combined immunodeficiency (SCID). Diabetologia 36, 510–515 (1993). · DOI
- Martin, A. et al. Characteristics of long-term human thyroid peroxidase autoantibody secretion in scid mice transplanted with lymphocytes from patients with autoimmune thyroiditis. Int. Arch. Allergy Immunol. 98, 317–323 (1992). · DOI
- Davis, L. S. et al. Inflammation, immune reactivity, and angiogenesis in a severe combined immunodeficiency model of rheumatoid arthritis. Am. J. Pathol. 160, 357–367 (2002). · doi:10.1016/s0002-9440(10)64379-9
- Tighe, H. et al. Autoantibody production by severe combined immunodeficient mice reconstituted with synovial cells from rheumatoid arthritis patients. Eur. J. Immunol. 20, 1843–1848 (1990). · DOI
- Gregersen, J. W., Holmes, S. & Fugger, L. Humanized animal models for autoimmune diseases. Tissue Antigens 63, 383–394 (2004). · DOI
- Friese, M. A., Jensen, L. T., Willcox, N. & Fugger, L. Humanized mouse models for organ-specific autoimmune diseases. Curr. Opin. Immunol. 18, 704–709 (2006). · DOI
- Takaki, T. et al. HLA-A*0201-restricted T cells from humanized NOD mice recognize autoantigens of potential clinical relevance to type 1 diabetes. J. Immunol. 176, 3257–3265 (2006). · DOI
- Wen, L., Chen, N. Y., Tang, J., Sherwin, R. & Wong, F. S. The regulatory role of DR4 in a spontaneous diabetes DQ8 transgenic model. J. Clin. Invest. 107, 871–880 (2001). · DOI
- Marron, M. P., Graser, R. T., Chapman, H. D. & Serreze, D. V. Functional evidence for the mediation of diabetogenic T cell responses by HLA-A2.1 MHC class I molecules through transgenic expression in NOD mice. Proc. Natl Acad. Sci. USA 99, 13753–13758 (2002). · DOI
- Ellmerich, S. et al. High incidence of spontaneous disease in an HLA-DR15 and TCR transgenic multiple sclerosis model. J. Immunol. 174, 1938–1946 (2005). · DOI
- Mallone, R. et al. Differential recognition and activation thresholds in human autoreactive GAD-specific T cells. Diabetes 53, 971–977 (2004). · DOI
- Holst, J., Vignali, K. M., Burton, A. R. & Vignali, D. A. Rapid analysis of T-cell selection in vivo using T cell-receptor retrogenic mice. Nature Methods 3, 191–197 (2006). · DOI
- Fogh, J., Fogh, J. M. & Orfeo, T. One hundred and twenty-seven cultured human tumor cell lines producing tumors in nude mice. J. Natl Cancer Inst. 59, 221–226 (1977). · DOI · Paper page
- Hudson, W. A., Li, Q., Le, C. & Kersey, J. H. Xenotransplantation of human lymphoid malignancies is optimized in mice with multiple immunologic defects. Leukemia 12, 2029–2033 (1998). · DOI
- Dick, J. E. & Lapidot, T. Biology of normal and acute myeloid leukemia stem cells. Int. J. Hematol. 82, 389–396 (2005). · DOI
- Kawano, N. et al. Efficient engraftment of primary adult T-cell leukemia cells in newborn NOD/SCID/β2-microglobulinnull mice. Leukemia 19, 1384–1390 (2005). · DOI
- Nakamura, Y. et al. Engraftment of NOD/SCID/γcnull mice with multilineage neoplastic cells from patients with juvenile myelomonocytic leukaemia. Br. J. Haematol. 130, 51–57 (2005). · DOI
- Pardal, R., Clarke, M. F. & Morrison, S. J. Applying the principles of stem-cell biology to cancer. Nature Rev. Cancer 3, 895–902 (2003). · DOI · Paper page
- Reya, T., Morrison, S. J., Clarke, M. F. & Weissman, I. L. Stem cells, cancer, and cancer stem cells. Nature 414, 105–111 (2001). · DOI · Paper page
- Bonnet, D. & Dick, J. E. Human acute myeloid leukemia is organized as a hierarchy that originates from a primitive hematopoietic cell. Nature Med. 3, 730–737 (1997). · DOI · Paper page
- Pilarski, L. M. & Belch, A. R. Clonotypic myeloma cells able to xenograft myeloma to nonobese diabetic severe combined immunodeficient mice copurify with CD34+ hematopoietic progenitors. Clin. Cancer Res. 8, 3198–3204 (2002).
- Al-Hajj, M., Wicha, M. S., Benito-Hernandez, A., Morrison, S. J. & Clarke, M. F. Prospective identification of tumorigenic breast cancer cells. Proc. Natl Acad. Sci. USA 100, 3983–3988 (2003). · DOI · Paper page
- O'Brien, C. A., Pollett, A., Gallinger, S. & Dick, J. E. A human colon cancer cell capable of initiating tumour growth in immunodeficient mice. Nature 445, 106–110 (2007). · DOI · Paper page
- Singh, S. K. et al. Identification of human brain tumour initiating cells. Nature 432, 396–401 (2004). · DOI · Paper page
- Yoshida, S. et al. Long-term engraftment and self-renewal of AML stem cells in the newborn NOD-scid/Il2rgnull immunodeficient mouse model. Blood 106, A1261 (2005). · DOI
- Nomura, T. et al. Induction of cancer, actinic keratosis, and specific p53 mutations by UVB light in human skin maintained in severe combined immunodeficient mice. Cancer Res. 57, 2081–2084 (1997).
- Mitsiades, C. S. et al. Fluorescence imaging of multiple myeloma cells in a clinically relevant SCID/NOD in vivo model: biologic and clinical implications. Cancer Res. 63, 6689–6696 (2003).
- O'Reilly, M. S., Holmgren, L., Chen, C. & Folkman, J. Angiostatin induces and sustains dormancy of human primary tumors in mice. Nature Med. 2, 689–692 (1996). · DOI · Paper page
- Siegler, U. et al. Activated natural killer cells from patients with acute myeloid leukemia are cytotoxic against autologous leukemic blasts in NOD/SCID mice. Leukemia 19, 2215–2222 (2005). · DOI
- Flavell, D. J. et al. The anti-CD20 antibody rituximab augments the immunospecific therapeutic effectiveness of an anti-CD19 immunotoxin directed against human B-cell lymphoma. Br. J. Haematol. 134, 157–170 (2006). · doi:10.1111/j.1365-2141.2006.06155.x
- Trieu, Y. et al. Soluble interleukin-13Rα2 decoy receptor inhibits Hodgkin's lymphoma growth in vitro and in vivo. Cancer Res. 64, 3271–3275 (2004). · DOI
- Dewan, M. Z. et al. Rapid tumor formation of human T-cell leukemia virus type 1-infected cell lines in novel NOD-SCID/γcnull mice: suppression by an inhibitor against NF-κB. J. Virol. 77, 5286–5294 (2003). · DOI
- Watanabe, M. et al. A novel NF-κB inhibitor DHMEQ selectively targets constitutive NF-κB activity and induces apoptosis of multiple myeloma cells in vitro and in vivo. Int. J. Cancer 114, 32–38 (2005). · DOI
- Chalandon, Y. et al. BCR–ABL-transduced human cord blood cells produce abnormal populations in immunodeficient mice. Leukemia 19, 442–448 (2005). · doi:10.1038/sj.leu.2403650
- Serakinci, N. & Keith, W. N. Therapeutic potential of adult stem cells. Eur. J. Cancer 42, 1243–1246 (2006). · DOI
- Solter, D. From teratocarcinomas to embryonic stem cells and beyond: a history of embryonic stem cell research. Nature Rev. Genet. 7, 319–327 (2006). · DOI · Paper page
- Kakinuma, S. et al. Human umbilical cord blood as a source of transplantable hepatic progenitor cells. Stem Cells 21, 217–227 (2003). · DOI · Paper page
- Tateno, C. et al. Near completely humanized liver in mice shows human-type metabolic responses to drugs. Am. J. Pathol. 165, 901–912 (2004). · DOI · Paper page
- Ishikawa, F. et al. Purified human hematopoietic stem cells contribute to the generation of cardiomyocytes through cell fusion. FASEB J. 20, 950–952 (2006). · DOI
- Ma, N. et al. Umbilical cord blood cell transplantation for myocardial regeneration. Transplant Proc. 38, 771–773 (2006). · doi:10.1016/j.transproceed.2006.01.061
- Torrente, Y. et al. Human circulating AC133+ stem cells restore dystrophin expression and ameliorate function in dystrophic skeletal muscle. J. Clin. Invest. 114, 182–195 (2004). · doi:10.1172/jci20325 · Paper page
- Ishikawa, F. et al. Human cord blood- and bone marrow-derived CD34+ cells regenerate gastrointestinal epithelial cells. FASEB J. 18, 1958–1960 (2004). · DOI
- Droetto, S. et al. Vasculogenic potential of long term repopulating cord blood progenitors. FASEB J. 18, 1273–1275 (2004). · DOI
- Taguchi, A. et al. Administration of CD34+ cells after stroke enhances neurogenesis via angiogenesis in a mouse model. J. Clin. Invest. 114, 330–338 (2004). · DOI · Paper page
- Pauwelyn, K. A. & Verfaillie, C. M. Transplantation of undifferentiated, bone marrow-derived stem cells. Curr. Top. Dev. Biol. 74, 201–251 (2006). · DOI
- Hess, D. et al. Bone marrow-derived stem cells initiate pancreatic regeneration. Nature Biotechnol. 21, 763–770 (2003). · DOI · Paper page
- Yoshida, S. et al. Human cord blood-derived cells generate insulin-producing cells in vivo. Stem Cells 23, 1409–1416 (2005). · DOI
- Vassilopoulos, G., Wang, P. R. & Russell, D. W. Transplanted bone marrow regenerates liver by cell fusion. Nature 422, 901–904 (2003). · DOI · Paper page
- Zhang, S. et al. Both cell fusion and transdifferentiation account for the transformation of human peripheral blood CD34+ cells into cardiomyocytes in vivo. Circulation 110, 3803–3807 (2004). · DOI · Paper page
- Stamm, C., Liebold, A., Steinhoff, G. & Strunk, D. Stem cell therapy for ischemic heart disease: beginning or end of the road? Cell Transplant. 15 (Suppl. 1), 47–56 (2006). · doi:10.3727/000000006783982313
- Brolen, G. K., Heins, N., Edsbagge, J. & Semb, H. Signals from the embryonic mouse pancreas induce differentiation of human embryonic stem cells into insulin-producing β-cell-like cells. Diabetes 54, 2867–2874 (2005). · DOI
- Cooke, M. J., Stojkovic, M. & Przyborski, S. A. Growth of teratomas derived from human pluripotent stem cells is influenced by the graft site. Stem Cells Dev. 15, 254–259 (2006). · DOI
- Przyborski, S. A. Differentiation of human embryonic stem cells after transplantation in immune-deficient mice. Stem Cells 23, 1242–1250 (2005). · DOI · Paper page
- Wang, L. et al. Generation of hematopoietic repopulating cells from human embryonic stem cells independent of ectopic HOXB4 expression. J. Exp. Med. 201, 1603–1614 (2005). · DOI · Paper page
- Tian, X., Woll, P. S., Morris, J. K., Linehan, J. L. & Kaufman, D. S. Hematopoietic engraftment of human embryonic stem cell-derived cells is regulated by recipient innate immunity. Stem Cells 24, 1370–1380 (2006). · DOI
- Galic, Z. et al. T-lineage differentiation from human embryonic stem cells. Proc. Natl Acad. Sci. USA 103, 11742–11747 (2006). · DOI
- Robert, J. S. The science and ethics of making part-human animals in stem cell biology. FASEB J. 20, 838–845 (2006). · DOI
- Flanagan, S. P. 'Nude', a new hairless gene with pleiotropic effects in the mouse. Genet. Res. 8, 295–309 (1966). · DOI · Paper page
- Mosier, D. E., Stell, K. L., Gulizia, R. J., Torbett, B. E. & Gilmore, G. L. Homozygous scid/scid;beige/beige mice have low levels of spontaneous or neonatal T cell-induced B cell generation. J. Exp. Med. 177, 191–194 (1993). · DOI
- Lapidot, T. Mechanism of human stem cell migration and repopulation of NOD/SCID and B2mnull NOD/SCID mice. The role of SDF-1/CXCR4 interactions. Ann. NY Acad. Sci. 938, 83–95 (2001). · DOI · Paper page
- Nicolini, F. E., Cashman, J. D., Hogge, D. E., Humphries, R. K. & Eaves, C. J. NOD/SCID mice engineered to express human IL-3, GM-CSF and Steel factor constitutively mobilize engrafted human progenitors and compromise human stem cell regeneration. Leukemia 18, 341–347 (2004). · DOI
Cited by
Dependency of Colorectal Cancer on a TGF-β-Driven Program in Stromal Cells for Metastasis Initiation
Calon, A., Espinet, E., Palomo-Ponce, S., Tauriello, D. V. F., Iglesias, M., Céspedes, M. V., Sevillano, M., Nadal, C., Jung, P., Zhang, X. H.-F., et al. (2012) · Cancer Cell · doi:10.1016/j.ccr.2012.08.013 · Cited by 1,060
Isolation of Single Human Hematopoietic Stem Cells Capable of Long-Term Multilineage Engraftment
Notta, F., Doulatov, S., Laurenti, E., Poeppl, A., Jurisica, I., & Dick, J. E. (2011) · Science · doi:10.1126/science.1201219 · Cited by 919
Hematopoiesis: a human perspective
Doulatov, S., Notta, F., Laurenti, E., & Dick, J. E. (2012) · Cell stem cell · doi:10.1016/j.stem.2012.01.006 · Cited by 895
Deuse, T., Hu, X., Gravina, A., Wang, D., Tediashvili, G., De, C., Thayer, W. O., Wahl, A., Garcia, J. V., Reichenspurner, H., et al. (2019) · Nature Biotechnology · doi:10.1038/s41587-019-0016-3 · Cited by 758
T-helper-1-cell cytokines drive cancer into senescence
Braumüller, H., Wieder, T., Brenner, E., Aßmann, S., Hahn, M., Alkhaled, M., Schilbach, K., Essmann, F., Kneilling, M., Griessinger, C., et al. (2013) · Nature · doi:10.1038/nature11824 · Cited by 720
Metadata
- Authors
- Shultz, L. D., Ishikawa, F., & Greiner, D. L.
- Venue
- Nature Reviews Immunology
- Published
- 2007-02
- Volume
- 7
- Issue
- 2
- Pages
- 118-130
- ISSN
- 1474-1733 (ISSN-L)
- 1474-1741
- OpenAlex
- W2021586066
- Cited by
- 1,279
- References
- 2
- FWCI
- 5.07
- Type
- journal article
- Language
- en
- Open access
- closed
- Licence
- www.springer.com/tdm (tdm)
About these checks
Registry, retraction, Cites and statistics results are computed, not judged, with one exception: a printed reference that no index lists is read once by a model before it counts as a citation error. Claims are extracted by a model and kept only when their quote appears verbatim in the text; each cited source is then checked, with a model’s help, for whether it says what the claim relies on. Those verdicts can be wrong — read the claim’s quote and the cited source before relying on one.
Statistics and arithmetic are recomputed, not judged.
Confidence bands are shown only for fields calibrated on our annotated test set. None is calibrated yet, so no band is shown.
What counts as a claim ›How we measure confidence ›How we check this ›
Are you an author, or do you see a problem with this page? Request a review
How to cite
Cite CoChat for the checks on this page, and the paper for its own findings.
- This page
- CoChat. (2026). Citation check: Humanized mice in translational biomedical research. https://app.cochat.ai/papers/10.1038/nri2017
- The paper
- Shultz, L. D., Ishikawa, F., & Greiner, D. L. (2007). Humanized mice in translational biomedical research. Nature Reviews Immunology. https://doi.org/10.1038/nri2017
Data sources
Bibliographic data: Semantic Scholar, OpenAlex, Crossref.
Contains information from the Semantic Scholar Academic Graph Datasets, made available under the ODC Attribution License (ODC-BY 1.0).
Semantic Scholar’s data is described in: Kinney, R., et al. (2023). The Semantic Scholar Open Data Platform. arXiv:2301.10140.