Relevance of gutmicrobiota in cognition, behaviour and Alzheimer’s disease

de J.R. De-Paula, Vanessa; Forlenza, Andrea S.; Forlenza, Orestes V.

doi:10.1016/j.phrs.2018.07.007

Cited by 145Gut microbiota and healthGastrointestinal motility and disordersTryptophan and brain disorders

Relevance of gutmicrobiota in cognition, behaviour and Alzheimer’s disease

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de J.R. De-Paula, Vanessa, Forlenza, Andrea S., Forlenza, Orestes V.·2018·Pharmacological Research

DOI 10.1016/j.phrs.2018.07.007

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Abstract

Approximately 95% of the symbiotic microbes in human body are located in the gut. This microbioma is involved in important homeostatic processes, not only related to gastrointestinal function but also to several complex modulatory processes, such as glucose and bone metabolism, inflammation and immune response, peripheral (enteric) and central neurotransmission. For that reason, recent studies proposed that abnormalities in gut microbiota may play a role in systemic and central nervous system (CNS) conditions. Therefore, the integrity of gut microbiota be relevant to the pathophysiology and control of important medical diseases like diabetes mellitus, inflammatory and autoimmune diseases, and even neuropsychiatric disorders such as depression, autism spectrum disorder, Parkinson's and Alzheimer disease. Gut microbiota may affect brain function and behaviour through the microbiota-gut-brain axis, in bidirectional interplay with top-down and bottom-up regulations. Through metabolic activity of non- pathogenical microorganisms and secretion of functional by-products that increase the permeability of the intestinal mucosa, the gut microbiota influences both the production and absorption of neurotransmitters (e.g., serotonin and GABA), increasing their bioavailability to the CNS. It has been further shown some components of the gut microbiota - predominantly bacteria - synthesize and release amyloid peptides and lipopolysaccharides, which in turn activate inflammatory signalling through the release of cytokines, with potential effects on the pathophysiological cascade of Alzheimer disease.

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Recent Advancements in Pathogenesis, Diagnostics and Treatment of Alzheimer’s Disease
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“Gut microbes influence the formation, absorption and transport of serotonin and GABA in the brain, moreover some bacterial species influence the formation of amyloid plaque which initiates the inflammatory cascade and hence susceptibility to AD [23].”
Background
Altered Microbiomes Distinguish Alzheimer’s Disease from Amnestic Mild Cognitive Impairment and Health in a Chinese Cohort
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Western diet as a trigger of Alzheimer’s disease: From metabolic syndrome and systemic inflammation to neuroinflammation and neurodegeneration
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The impact of the microbiota-gut-brain axis on Alzheimer’s disease pathophysiology
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Self-citation
<i>Ruminococcus gnavus</i> : friend or foe for human health
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The Microbiota–Gut–Brain Axis and Alzheimer’s Disease: Neuroinflammation Is to Blame?
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Efficacy and Safety of Lactobacillus Plantarum C29-Fermented Soybean (DW2009) in Individuals with Mild Cognitive Impairment: A 12-Week, Multi-Center, Randomized, Double-Blind, Placebo-Controlled Clinical Trial
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Guts Imbalance Imbalances the Brain: A Review of Gut Microbiota Association With Neurological and Psychiatric Disorders
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Altered Gut Microbial Metabolites in Amnestic Mild Cognitive Impairment and Alzheimer’s Disease: Signals in Host–Microbe Interplay
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Associations between gut microbiota and Alzheimer’s disease, major depressive disorder, and schizophrenia
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The Potential Role of Gut Microbiota in Alzheimer’s Disease: From Diagnosis to Treatment
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Probiotics for Alzheimer’s Disease: A Systematic Review
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The extracellular vesicle of gut microbial Paenalcaligenes hominis is a risk factor for vagus nerve-mediated cognitive impairment
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Crosstalk between Gut and Brain in Alzheimer’s Disease: The Role of Gut Microbiota Modulation Strategies
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Effect of ultra-processed diet on gut microbiota and thus its role in neurodegenerative diseases
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Genetic correlations between Alzheimer’s disease and gut microbiome genera
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Dietary polyphenols: Regulate the advanced glycation end products-RAGE axis and the microbiota-gut-brain axis to prevent neurodegenerative diseases
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Probiotic treatment improves the impaired spatial cognitive performance and restores synaptic plasticity in an animal model of Alzheimer's disease
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Protection against Alzheimer's disease by luteolin: Role of brain glucose regulation, anti‐inflammatory activity, and the gut microbiota‐liver‐brain axis
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Roles and Mechanisms of Gut Microbiota in Patients With Alzheimer’s Disease
Wu, S., Liu, X., Jiang, R., Yan, X., & Ling, Z. (2021) · Frontiers in Aging Neuroscience · doi:10.3389/fnagi.2021.650047 · Cited by 146 · see citing works
The Immunopathogenesis of Alzheimer’s Disease Is Related to the Composition of Gut Microbiota
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Yeast β-glucan alleviates cognitive deficit by regulating gut microbiota and metabolites in Aβ1–42-induced AD-like mice
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Role of Microbiota-Derived Extracellular Vesicles in Gut-Brain Communication
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Oral treatment with Lactobacillus reuteri attenuates depressive-like behaviors and serotonin metabolism alterations induced by chronic social defeat stress
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Microbiota modulation as preventative and therapeutic approach in Alzheimer’s disease
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Dysbiosis and Alzheimer’s Disease: A Role for Chronic Stress?
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Effects of glyphosate and glyphosate-based herbicides like Roundup™ on the mammalian nervous system: A review
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Gut Microbiota: Implications in Alzheimer’s Disease
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The Links between Cardiovascular Diseases and Alzheimer's Disease
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Sleep, circadian rhythm and gut microbiota: alterations in Alzheimer’s disease and their potential links in the pathogenesis
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Silicon dioxide nanoparticles induced neurobehavioral impairments by disrupting microbiota–gut–brain axis
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Dysbiosis is one of the risk factor for stroke and cognitive impairment and potential target for treatment
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Gut Microbiota is an Impact Factor based on the Brain-Gut Axis to Alzheimer’s Disease: A Systematic Review
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Correlation between the gut microbiome and neurodegenerative diseases: a review of metagenomics evidence
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Gut microbiota-driven neuroinflammation in Alzheimer's disease: from mechanisms to therapeutic opportunities
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Food, gut barrier dysfunction, and related diseases: A new target for future individualized disease prevention and management
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Interplay of good bacteria and central nervous system: cognitive aspects and mechanistic considerations
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Probiotics treatment improves cognitive impairment in patients and animals: A systematic review and meta-analysis
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The Role of the Gut-Brain Axis in Attention-Deficit/Hyperactivity Disorder
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Therapeutic potential of short-chain fatty acid production by gut microbiota in neurodegenerative disorders
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Nutritional Modulation of Immune and Central Nervous System Homeostasis: The Role of Diet in Development of Neuroinflammation and Neurological Disease
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Gut microbiota and neuropsychiatric disorders: Implications for neuroendocrine-immune regulation
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Alzheimer’s disease and gastrointestinal microbiota; impact of Helicobacter pylori infection involvement
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Gut microbiota and intestinal barrier function in subjects with cognitive impairments: a cross-sectional study
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Recent advances in understanding the mechanisms of PM2.5-mediated neurodegenerative diseases
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Dysbiosis of the Gut Microbiota and Kynurenine (Kyn) Pathway Activity as Potential Biomarkers in Patients with Major Depressive Disorder
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The Immune System through the Lens of Alcohol Intake and Gut Microbiota
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Does the Gut Microbial Metabolome Really Matter? The Connection between GUT Metabolome and Neurological Disorders
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Study insights in the role of PGC-1α in neurological diseases: mechanisms and therapeutic potential
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Manipulation of the diet–microbiota–brain axis in Alzheimer’s disease
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Fecal Microbiota Transplantation in Alzheimer’s Disease: Mechanistic Insights Through the Microbiota–Gut–Brain Axis and Therapeutic Prospects
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Ultraprocessed Foods and Neuropsychiatric Outcomes: Putative Mechanisms
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Redox-Mechanisms of Molecular Hydrogen Promote Healthful Longevity
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Whole brain radiotherapy induces cognitive dysfunction in mice: key role of gut microbiota
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The Role of the Gut Microbiota and Microbial Metabolites in the Pathogenesis of Alzheimer’s Disease
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Active Compounds of Panax ginseng in the Improvement of Alzheimer’s Disease and Application of Spatial Metabolomics
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Maternal Influence and Murine Housing Confound Impact of NLRP1 Inflammasome on Microbiome Composition
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A urinary metabolomic study from subjects after long-term occupational exposure to low concentration acrylamide using UPLC-QTOF/MS
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Roles of Gut Microbiota in Pathogenesis of Alzheimer’s Disease and Therapeutic Effects of Chinese Medicine
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Urine Metabolite Analysis to Identify Pathomechanisms of Long COVID: A Pilot Study
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Multivariate genome-wide association study of depression, cognition, and memory phenotypes and validation analysis identify 12 cross-ethnic variants
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Lactobacillus rhamnosus GG and Bifidobacterium bifidum TMC3115 Can Affect Development of Hippocampal Neurons Cultured In Vitro in a Strain-Dependent Manner
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The Microbiome and Mental Health Across the Lifespan
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Authors: de J.R. De-Paula, V., Forlenza, A. S., & Forlenza, O. V.
Affiliations: Universidade de São Paulo (BR)
Corresponding author: Forlenza, Orestes V.
ORCID: Forlenza, Orestes V.
Venue: Pharmacological Research
Publisher: Elsevier BV
Published: 2018-10
Volume: 136
Pages: 29-34
ISSN: 1043-6618 (ISSN-L)
DOI: 10.1016/j.phrs.2018.07.007
OpenAlex: W2888024736
Cited by: 145
References: 82
Citations by year: 2026: 5 · 2025: 16 · 2024: 13 · 2023: 26 · 2022: 22 · 2021: 22 · 2020: 26 · 2019: 15
FWCI: 1.54
Type: journal article
Language: en
Open access: green
observatorio.fm.usp.br
Licence: other-oa
www.elsevier.com/tdm/userlicense/1.0/ (tdm)
Locations: Pharmacological Research (publishedVersion)
PubMed (publishedVersion)
LA Referencia (Red Federada de Repositorios Institucionales de Publicaciones Científicas) (submittedVersion, other-oa)
Funders: FAPESP (Fundação de Amparo à Pesquisa de São Paulo (2013/20695-3, 2009/52825-8, 2016/01302-9)
CNPq (Conselho Nacional de Pesquisa Científica
ABADHS (Associação Beneficente Alzira Denise Hertzog da Silva)
Topics: Life Sciences › Biochemistry, Genetics and Molecular Biology › Molecular Biology › Gut microbiota and health
Health Sciences › Medicine › Gastroenterology › Gastrointestinal motility and disorders
Life Sciences › Neuroscience › Biological Psychiatry › Tryptophan and brain disorders
Keywords: gut microbiota, Alzheimer's disease, microbiota-gut-brain axis, cognition, behavior, neurotransmitter production, serotonin, GABA, intestinal permeability, amyloid peptides, lipopolysaccharide, neuroinflammation, cytokines, neuropsychiatric disorders, Parkinson's disease, depression, autism spectrum disorder
MeSH terms: Gastrointestinal Microbiome, Alzheimer Disease, Animals, Behavior, Brain, Cognition, Humans, Neurotransmitter Agents

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Relevance of gutmicrobiota in cognition, behaviour and Alzheimer’s disease

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