Cited by 64Heavy Metal Exposure and ToxicityAutism Spectrum Disorder ResearchTrace Elements in Health

Relationship between chronic lead toxicity and plasma neurotransmitters in autistic patients from Saudi Arabia

El-Ansary, Afaf K., Bacha, Abir Ben, Ayahdi, Layla Y. Al-·2011·Clinical Biochemistry

Abstract

Objective This study aims to clarify the relationship between blood Pb(2+) concentration as a ubiquitous environmental pollutant and plasma neurotransmitters as biochemical parameters that reflect brain function in Saudi autistic patients.Methods RBC's lead content together with plasma concentration of gamma aminobutyric acid (GABA), serotonin (5HT) and dopamine (DA) were measured in 25 Saudi autistic patients and compared to 16 age-matching control samples.Results The obtained data recorded that Saudi autistic patients have a remarkable higher levels of Pb(2+) and significantly elevated levels of GABA, 5HT and DA compared to healthy subjects. ROC analysis revealed satisfactory values of specificity and sensitivity of the measured parameters.Conclusion This study suggests that postnatal lead toxicity in autistic patients of Saudi Arabia could represent a causative factor in the pathogenesis of autism. Elevated GABA, 5HT and DA were discussed in relation to the chronic lead toxicity recorded in the investigated autistic samples.

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Crossref · 10.1016/j.clinbiochem.2011.06.982

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Authors
El-Ansary, A. K., Bacha, A. B., & Ayahdi, L. Y. A.
Affiliations
King Saud University (SA)
Corresponding author
El-Ansary, Afaf K.
Venue
Clinical Biochemistry
Publisher
Elsevier BV
Published
2011-09
Volume
44
Issue
13
Pages
1116-1120
ISSN
0009-9120 (ISSN-L)
OpenAlex
W2080488443
Cited by
64
References
47
Citations by year
2025: 2 · 2024: 4 · 2023: 1 · 2022: 1 · 2021: 2 · 2020: 5 · 2019: 2 · 2018: 6 · 2017: 5 · 2016: 4 · 2015: 5 · 2014: 13 · 2013: 9 · 2012: 5
FWCI
6.23
Type
journal article
Language
en
Open access
closed
Locations
  • Clinical Biochemistry (publishedVersion)
  • PubMed (publishedVersion)
Funders
King Abdul Aziz City for Science and Technology
Topics
  • Physical Sciences › Environmental Science › Health, Toxicology and Mutagenesis › Heavy Metal Exposure and Toxicity
  • Life Sciences › Neuroscience › Cognitive Neuroscience › Autism Spectrum Disorder Research
  • Health Sciences › Nursing › Nutrition and Dietetics › Trace Elements in Health
Keywords
chronic lead toxicity, autism spectrum disorder, blood lead levels, GABA, serotonin, dopamine, environmental lead exposure, autism pathogenesis, Saudi Arabia
MeSH terms
Autistic Disorder, Child, Child, Preschool, Dopamine, Erythrocytes, gamma-Aminobutyric Acid, Humans, Lead, Lead Poisoning, ROC Curve, Saudi Arabia, Serotonin, Case-Control Studies, Neurotransmitter Agents

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