Cited by 341Skin Protection and AgingGenetics, Aging, and Longevity in Model OrganismsSkin and Cellular Biology Research

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Clinical aspects and molecular diagnostics of skin aging

Zouboulis, Christos C., Makrantonaki, Evgenia·2011·Clinics in Dermatology

DOI 10.1016/j.clindermatol.2010.07.001

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Abstract

This contribution will address the effect of aging on skin functions, with a particular focus on skin permeability, wound healing, angiogenesis, lipogenesis, sweat production, immune function, and vitamin D synthesis. With accelerating age, skin functions deteriorate due to structural and morphologic changes. Skin is prone to the development of several diseases, varying from benign to malignant. Because the number of persons aged 80 and older is expected to rise in the next decades, disease prevention will become an important issue. Screening examinations and prevention through public education starting at an early age regarding sun avoidance, the use of sunscreens and the importance of a balanced nutrition are the first steps for successful healthy aging. Although the fundamental mechanisms in the pathogenesis of aged skin are still poorly understood, a growing body of evidence points toward the involvement of multiple pathways. Recent data obtained by expression profiling studies and studies of progeroid syndromes illustrate that among the most important biologic processes involved in skin aging are alterations in DNA repair and stability, mitochondrial function, cell cycle and apoptosis, extracellular matrix, lipid synthesis, ubiquitin-induced proteolysis and cellular metabolism. Among others, a major factor that has been implicated in the initiation of aging is the physiologic decline of hormones occurring with age. However, hormones at age-specific levels may regulate not only age-associated mechanisms but also tumor suppressor pathways that influence carcinogenesis. Understanding the molecular mechanisms of aging may open new strategies to deal with the various diseases accompanying high age, including cancer.

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Method
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“Aging is strongly associated with alterations of skin quality and function parameters (Zouboulis and Makrantonaki, 2011; Farage et al., 2017).”
Age-Associated Differences in Infection of Human Skin in the SCID Mouse Model of Varicella-Zoster Virus Pathogenesis
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“At the molecular level, age-related changes to skin include alterations in innate immune signaling, inflammation, tumorigenesis, and wound healing (21, 22) that might facilitate VZV replication in aging skin.”
Background
Nanoengineered biomaterials for skin regeneration
Milan, P. B., Kargozar, S., Joghataie, M. T., & Samadikuchaksaraei, A. (2018) · Elsevier eBooks · doi:10.1016/b978-0-12-813355-2.00011-9 · Cited by 12
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Vom Leben gezeichnet
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An ECM-mimicking assembled gelatin/hyaluronic acid hydrogel with antibacterial and radical scavenging functions for accelerating open wound healing
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Glycation and Skin Aging
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Background
Proteomic and secretomic comparison of young and aged dermal fibroblasts highlights cytoskeleton as a key component during aging
Boismal, F., Peltier, S., So, S. L. K., Chevreux, G., Blondel, L., Serror, K., Setterblab, N., Zuelgaray, E., Boccara, D., Mimoun, M., et al. (2024) · Aging · doi:10.18632/aging.206055 · Cited by 11
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Rapidly dissolving and detachable microneedles loaded with antimicrobial peptides for acne vulgaris treatment
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Aging-Associated Decline of Epidermal PSMD8 Contributes to Impaired Skin Function
Ishii, M. A., Miyachi, K., Cheng, B., & Sun, B. K. (2017) · Journal of Investigative Dermatology · doi:10.1016/j.jid.2017.10.034 · Cited by 10
Transcriptome Profile of Human Fibroblasts in an Ex Vivo Culture
Machaliński, B., Rogińska, D., Szumilas, K., Zawiślak, A., Wilk, A., Stecewicz, I., Brodkiewicz, A., & Wiszniewska, B. (2020) · International Journal of Medical Sciences · doi:10.7150/ijms.35693 · Cited by 10
Look at Your Hair the Way You Look at Your Face: Concept of Total Facial Skin and Hair Care
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Im, A., Nam, J., Ji, K.-Y., Cha, S., Yoon, J., Seo, Y. K., Chae, S., & Kim, J. Y. (2020) · European Journal of Integrative Medicine · doi:10.1016/j.eujim.2020.101070 · Cited by 10
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Georgakopoulou, E. A., Valsamidi, C., Veroutis, D., & Havaki, S. (2020) · Mechanisms of Ageing and Development · doi:10.1016/j.mad.2020.111409 · Cited by 12
Development of the facial glycation imaging system for in situ human face skin glycation index measurement
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Sex Hormones and Immunosenescence
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A low-swelling alginate hydrogel with antibacterial hemostatic and radical scavenging properties for open wound healing
Ma, X., Fu, X., Meng, J., Li, H., Wang, F., Shao, H., Liu, Y., Liu, F., Zhang, D., Chi, B., et al. (2024) · Biomedical Materials · doi:10.1088/1748-605x/ad792c · Cited by 9
“The skin, serving as the body’s principal defense barrier and the largest organ, is notably susceptible to harm [1, 2].”
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A progeroid syndrome with neonatal presentation and long survival maps to 19p13.3p13.2
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“Expression studies of progeroid syndromes demonstrated that among the most important mechanisms proposed to be involved in induction of aging are aberrations in lipid synthesis and cellular metabolism (Zouboulis and Makrantonaki, 2011).”
Background
miR ‐203 represses keratinocyte stemness by targeting survivin
Labarrade, F., Botto, J.-M., & Imbert, I. (2022) · Journal of Cosmetic Dermatology · doi:10.1111/jocd.15147 · Cited by 8
A retrospective study of neck rejuvenation using a noninsulated microneedle radiofrequency in Chinese subjects
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The Brain of the Skin: Sebaceous Gland
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Molecular mechanisms of action of topical antiaging compounds
Elewa, R. M., & Zouboulis, C. C. (2014) · Journal of the Egyptian Womenʼs Dermatologic Society · doi:10.1097/01.ewx.0000446076.96563.ab · Cited by 8
Fructose-Induced Glycation End Products Promote Skin-Aging Phenotypes and Senescence Marker Expression in Human Dermal Fibroblasts
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“Furthermore, aged skin has disturbed permeability, angiogenesis, lipid and sweat production, immune function, and vitamin D synthesis; manifesting as impaired wound healing, atrophy, vulnerability to external stimuli, and the development of several benign and malignant diseases [3].”
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Biological Aging Modulates Cell Migration via Lamin A/C-Dependent Nuclear Motion
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Genital diseases in the mature man
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How Wounding via Lasers Has Potential Photocarcinogenic Preventative Effects via Dermal Remodeling
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“Along these lines, several groups have shown the ability of aging skin to repair UV-induced oxidative DNA damage diminishes over time [22, 23].”
Molecular Docking, Pharmacokinetics, and Toxicity Prediction of Epigallocatechin-3-Gallate (EGCG) on IKK Receptor in Photoaging Prevention
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“(1,2,3,4) Geriatric population in the United States in 2000 was 13 % (35 million people), and predicted it would be 30% in 2030.”
Background
Endogene Faktoren, Gene und Hautalterung
Makrantonaki, E., Pfeifer, G. P., & Zouboulis, C. C. (2016) · Der Hautarzt · doi:10.1007/s00105-015-3746-2 · Cited by 6

Authors: Zouboulis, C. C., & Makrantonaki, E.
Affiliations: Städtisches Klinikum Dessau (DE)
Corresponding author: Zouboulis, Christos C.
ORCID: Zouboulis, Christos C.
Makrantonaki, Evgenia
Venue: Clinics in Dermatology
Publisher: Elsevier BV
Published: 2011-01
Volume: 29
Issue: 1
Pages: 3-14
ISSN: 0738-081X (ISSN-L)
DOI: 10.1016/j.clindermatol.2010.07.001
OpenAlex: W2025725196
Cited by: 341
References: 149
Citations by year: 2026: 12 · 2025: 15 · 2024: 14 · 2023: 25 · 2022: 25 · 2021: 24 · 2020: 28 · 2019: 27 · 2018: 20 · 2017: 26 · 2016: 35 · 2015: 25 · 2014: 26 · 2013: 16 · 2012: 20
FWCI: 2.13
Type: journal article
Language: en
Open access: closed
Licence: www.elsevier.com/tdm/userlicense/1.0/ (tdm)
Locations: Clinics in Dermatology (publishedVersion)
PubMed (publishedVersion)
Topics: Health Sciences › Medicine › Dermatology › Skin Protection and Aging
Life Sciences › Biochemistry, Genetics and Molecular Biology › Aging › Genetics, Aging, and Longevity in Model Organisms
Life Sciences › Biochemistry, Genetics and Molecular Biology › Cell Biology › Skin and Cellular Biology Research
Keywords: skin aging, skin permeability, wound healing, angiogenesis, lipogenesis, sweating, skin immune function, vitamin D synthesis, progeroid syndromes, DNA repair, mitochondrial function, apoptosis, extracellular matrix, cellular metabolism, carcinogenesis, healthy aging, sun protection, sunscreen use, gene expression profiling
MeSH terms: Animals, Humans, Nutritional Physiological Phenomena, Skin, Skin Diseases, Skin Physiological Phenomena, Sunscreening Agents, Skin Aging, Genomics

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