The DOI matches its Crossref record; 147 of the 149 references it cites were found in a registry or an index.
Clinical aspects and molecular diagnostics of skin aging
Abstract
This contribution will address the effect of aging on skin functions, with a particular focus on skin permeability, wound healing, angiogenesis, lipogenesis, sweat production, immune function, and vitamin D synthesis. With accelerating age, skin functions deteriorate due to structural and morphologic changes. Skin is prone to the development of several diseases, varying from benign to malignant. Because the number of persons aged 80 and older is expected to rise in the next decades, disease prevention will become an important issue. Screening examinations and prevention through public education starting at an early age regarding sun avoidance, the use of sunscreens and the importance of a balanced nutrition are the first steps for successful healthy aging. Although the fundamental mechanisms in the pathogenesis of aged skin are still poorly understood, a growing body of evidence points toward the involvement of multiple pathways. Recent data obtained by expression profiling studies and studies of progeroid syndromes illustrate that among the most important biologic processes involved in skin aging are alterations in DNA repair and stability, mitochondrial function, cell cycle and apoptosis, extracellular matrix, lipid synthesis, ubiquitin-induced proteolysis and cellular metabolism. Among others, a major factor that has been implicated in the initiation of aging is the physiologic decline of hormones occurring with age. However, hormones at age-specific levels may regulate not only age-associated mechanisms but also tumor suppressor pathways that influence carcinogenesis. Understanding the molecular mechanisms of aging may open new strategies to deal with the various diseases accompanying high age, including cancer.
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“Oxidative stress plays an important role in skin aging and skin damage processes, and its main feature is increased intracellular ROS.”
From Diet and Skin Aging—From the Perspective of Food Nutrition (2020) · cites this paper as [31]
In the citing paper
“The accumulation of ROS causes DNA damage, induces skin inflammatory response, reduces antioxidant enzymes, activates nuclear factor kappa B (NF-kB) and activator protein1 (AP–1) to inhibit collagen production, and increases matrix metalloproteinases to decompose collagen and binding proteins in the dermis, which eventually leads to skin aging [30,31,32,33].”
From Diet and Skin Aging—From the Perspective of Food Nutrition (2020) · cites this paper as [31]
Citations
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Cited by
Sorted by citations
Oxidative Stress in Aging Human Skin
Rinnerthaler, M., Bischof, J., Streubel, M., Trost, A., & Richter, K. (2015) · Biomolecules · doi:10.3390/biom5020545 · Cited by 1,053
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“People invest much time and money in rejuvenation procedures, of which many lack proven efficacy (Zouboulis and Makrantonaki, 2011).”
BackgroundThe Dynamics of the Skin’s Immune System
Nguyen, A. V., & Soulika, A. M. (2019) · International Journal of Molecular Sciences · doi:10.3390/ijms20081811 · Cited by 759
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Metadata
- Authors
- Zouboulis, C. C., & Makrantonaki, E.
- Affiliations
- Städtisches Klinikum Dessau (DE)
- Corresponding author
- Zouboulis, Christos C.
- Venue
- Clinics in Dermatology
- Publisher
- Elsevier BV
- Published
- 2011-01
- Volume
- 29
- Issue
- 1
- Pages
- 3-14
- ISSN
- 0738-081X (ISSN-L)
- OpenAlex
- W2025725196
- Cited by
- 341
- References
- 149
- Citations by year
- 2026: 12 · 2025: 15 · 2024: 14 · 2023: 25 · 2022: 25 · 2021: 24 · 2020: 28 · 2019: 27 · 2018: 20 · 2017: 26 · 2016: 35 · 2015: 25 · 2014: 26 · 2013: 16 · 2012: 20
- FWCI
- 2.13
- Type
- journal article
- Language
- en
- Open access
- closed
- Locations
- Clinics in Dermatology (publishedVersion)
- PubMed (publishedVersion)
- Topics
- Health Sciences › Medicine › Dermatology › Skin Protection and Aging
- Life Sciences › Biochemistry, Genetics and Molecular Biology › Aging › Genetics, Aging, and Longevity in Model Organisms
- Life Sciences › Biochemistry, Genetics and Molecular Biology › Cell Biology › Skin and Cellular Biology Research
- Keywords
- skin aging, skin permeability, wound healing, angiogenesis, lipogenesis, sweating, skin immune function, vitamin D synthesis, progeroid syndromes, DNA repair, mitochondrial function, apoptosis, extracellular matrix, cellular metabolism, carcinogenesis, healthy aging, sun protection, sunscreen use, gene expression profiling
- MeSH terms
- Animals, Humans, Nutritional Physiological Phenomena, Skin, Skin Diseases, Skin Physiological Phenomena, Sunscreening Agents, Skin Aging, Genomics
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