Cited by 43Lung Cancer Treatments and MutationsHER2/EGFR in Cancer ResearchLung Cancer Diagnosis and Treatment

Epidermal Growth Factor Receptor Tyrosine Kinase Inhibitor-sensitive Exon 19 Insertion and Exon 20 Insertion in Patients With Advanced Non–Small-cell Lung Cancer

Lin, Yen-Ting, Liu, Yi-Nan, Wu, Shang-Gin, Yang, James Chih-Hsin, Shih, Jin-Yuan·2017·Clinical Lung Cancer

Abstract

Background The clinical responsiveness to epidermal growth factor receptor (EGFR) tyrosine kinase inhibitors (TKIs) in non-small-cell lung cancer (NSCLC) patients with exon 19 insertion and the specific exon 20 insertion (A763_Y764 insFQEA) are still not well known.Materials and methods We analyzed cancer specimens taken from NSCLC patients for EGFR mutations using RNA reverse transcription polymerase chain reaction or direct DNA sequencing. The clinical course and responsiveness to an EGFR TKI in patients with EGFR exon 19 insertion or exon 20 insertion (A763_Y764 insFQEA) were recorded. The published data regarding these mutations were also reviewed.Results From September 1995 to May 2015, we found 4 patients with an EGFR exon 19 insertion and 6 patients with an EGFR exon 20 insertion (A763_Y764 insFQEA) at the National Taiwan University Hospital. Among patients with an exon 19 insertion, 3 received an EGFR TKI. Of the 3 patients, 1 had a partial response, 1 had stable disease, and 1 had progressive disease. Of the 6 patients with the exon 20 insertion (A763_Y764 insFQEA), 3 received an EGFR TKI. Of those 3 patients, 2 had a partial response and 1 had progressive disease. A review of the published data, together with the data from our patients, patients with an exon 19 insertion and treated with an EGFR TKI (n = 18) had a response rate of 56% and a median time to progression of 10.4 months. Patients with the exon 20 insertion (A763_Y764 insFQEA) and treated with an EGFR TKI (n = 11) had a response rate of 73% and a median time to progression of 5.0 months.Conclusions Advanced NSCLC bearing the EGFR exon 19 insertion or exon 20 insertion (A763_Y764 insFQEA) is sensitive to EGFR TKIs.

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Crossref · 10.1016/j.cllc.2016.12.014

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Authors
Lin, Y.-T., Liu, Y.-N., Wu, S.-G., Yang, J. C.-H., & Shih, J.-Y.
Affiliations
  • National Taiwan University Hospital (TW)
  • National Taiwan University (TW)
Corresponding author
Shih, Jin-Yuan
Venue
Clinical Lung Cancer
Publisher
Elsevier BV
Published
2017-05
Volume
18
Issue
3
Pages
324-332.e1
ISSN
1525-7304 (ISSN-L)
OpenAlex
W2561330651
Cited by
43
References
40
Citations by year
2026: 1 · 2025: 5 · 2024: 3 · 2023: 2 · 2022: 4 · 2021: 4 · 2020: 10 · 2019: 5 · 2018: 7 · 2017: 1 · 2014: 1
FWCI
3.87
Type
journal article
Language
en
Open access
closed
Locations
  • Clinical Lung Cancer (publishedVersion)
  • PubMed (publishedVersion)
Funders
  • Ministry of Health and Welfare (MOHW103-TDU-PB-211-144002)
  • National Taiwan University (103R7601-3)
Topics
  • Health Sciences › Medicine › Pulmonary and Respiratory Medicine › Lung Cancer Treatments and Mutations
  • Health Sciences › Medicine › Oncology › HER2/EGFR in Cancer Research
  • Health Sciences › Medicine › Pulmonary and Respiratory Medicine › Lung Cancer Diagnosis and Treatment
Keywords
EGFR tyrosine kinase inhibitors, EGFR exon 20 insertion, non-small cell lung cancer, EGFR mutation, treatment response, time to progression, advanced non-small cell lung cancer
MeSH terms
Erlotinib Hydrochloride, Aged, Carcinoma, Non-Small-Cell Lung, Drug Resistance, Exons, Female, Humans, Lung Neoplasms, Male, Middle Aged, Neoplasm Staging, Taiwan, Mutagenesis, Insertional, Genes, erbB-1, Protein Kinase Inhibitors

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