Clinical trial: oral feeding with a soft diet compared with clear liquid diet as initial meal in mild acute pancreatitis
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Summary: Background In mild acute pancreatitis, traditional treatment has been initial fasting and oral refeeding with clear liquids to prevent adverse gastrointestinal events such as pain. The diet is gradually progressed to soft solids and hospital discharge is planned based on patients’ tolerance to a solid diet. Aim To determine the length of hospitalization and tolerance to oral refeeding when initiated on a soft diet as compared to a clear liquid diet. Methods One hundred and one patients with mild acute pancreatitis were randomized to receive either a clear liquid diet or soft diet when oral feeding was initiated. Frequency of pain, total and postrefeeding length of hospitalization, and dietary intake were monitored. Hospital discharge was decided by the medical team without input from the study coordinators. Results A statistically significant decrease in the length of hospitalization (total and postrefeeding) of a median of 2 days was seen in patients receiving a soft diet (P < 0.001). No significant difference in the need for cessation of diet because of pain was observed between the two groups. Patients initiated on a soft diet consumed significantly more calories and fats on study day 1 (P < 0.001). Conclusion Oral refeeding with a soft diet in patients with mild acute pancreatitis can be considered safe and can result in shorter length of hospitalization.
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Starting early feeding with clear liquids, soft diet, low-fat diet, or solid food was shown to be safe in different RCTs.
“Starting early feeding with clear liquids, soft diet, low-fat diet,”
From ESPEN guideline on hospital nutrition (2021) · cites this paper as [197]
The Methods and Results (pages unavailable) describe a randomized comparison of clear liquids and a soft diet in patients with mild acute pancreatitis, with no significant difference in stopping the diet because of pain. The Conclusion calls soft-diet refeeding safe. This trial does not establish the safety of starting with a separate low-fat or solid-food diet, or of feeding earlier in the illness. (LLM, conf=0.86)
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Oral Refeeding in Acute Pancreatitis: Solid Evidence on Solid Food?
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Intestinal Dysfunction and Failure in Acute Pancreatitis
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- Authors
- SATHIARAJ, E., MURTHY, S., MANSARD, M. J., RAO, G. V., MAHUKAR, S., & REDDY, D. N.
- Affiliations
- Asian Institute of Gastroenterology (IN)
- Corresponding author
- SATHIARAJ, E.
- Venue
- Alimentary Pharmacology & Therapeutics
- Publisher
- Wiley
- Published
- 2008-08-20
- Volume
- 28
- Issue
- 6
- Pages
- 777-781
- ISSN
- 0269-2813 (ISSN-L)
- 1365-2036
- OpenAlex
- W2004088562
- Cited by
- 121
- References
- 14
- Citations by year
- 2026: 4 · 2025: 6 · 2024: 5 · 2023: 6 · 2022: 8 · 2021: 9 · 2020: 5 · 2019: 7 · 2018: 5 · 2017: 8 · 2016: 7 · 2015: 11 · 2014: 8 · 2013: 6 · 2012: 10
- FWCI
- 5.63
- Type
- journal article
- Language
- en
- Open access
- bronze
- doi.org
- Locations
- Alimentary Pharmacology & Therapeutics (publishedVersion)
- PubMed (publishedVersion)
- Topics
- Health Sciences › Medicine › Surgery › Pancreatitis Pathology and Treatment
- Health Sciences › Nursing › Nutrition and Dietetics › Clinical Nutrition and Gastroenterology
- Health Sciences › Medicine › Surgery › Enhanced Recovery After Surgery
- Keywords
- mild acute pancreatitis, oral refeeding, soft diet, clear liquid diet, length of hospital stay, dietary intake, hospital discharge
- MeSH terms
- Adult, Enteral Nutrition, Female, Humans, Length of Stay, Male, Pancreatic Function Tests, Pancreatitis, Treatment Outcome
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