The DOI matches its Crossref record; 33 of the 35 references it cites were found in a registry or an index.
EAA supplementation to increase nitrogen intake improves muscle function during bed rest in the elderly
Abstract
Background & aims Older individuals are more likely to experience extended hospitalization and become protein malnourished during hospitalization. The concomitant compulsory inactivity results in functional decline. Increasing protein intake in hospitalized patients improves nitrogen balance, but effects on function are unknown. In the present study, we examined the effects of increasing protein intake by essential amino acid (EAA) supplementation in older individuals subjected to 10 d bed rest on LBM and muscle function. Methods Subjects were given a placebo (n=12, 68+/-5 (SD) yrs, 83+/-19 kg) or 15 g of EAA (n=10, 71+/-6, 72+/-8 kg) 3 times per day throughout 10d of bed rest. LBM, muscle protein synthesis, and muscle function were determined before and after bed rest. Due to an imbalance in randomized gender distribution between groups, gender and beginning functional and LBM measures were utilized for analyses by repeated measures analysis of covariance (RMANCOVA). Results Analyses revealed the potential for the preservation of functional outcomes with EAA supplementation. Conclusions Increasing protein intake above the RDA may preserve muscle function in the elderly during compulsory inactivity. EAA supplementation is potentially an efficient method of increasing protein intake without affecting satiety.
Overview
Integrity signals
Registry
Cites
Statistics
Verification
Claims the paper makes
Claims other papers make about this one
Each is checked against this paper’s own text: does it say what the citing paper says it does?
In the citing paper
“Evidence supports the combination of exercise and protein/amino acid supplementation for prevention and treatment of muscle loss in certain debilitating clinical conditions, including bed rest for acute critical illness or injury 153e160 and also for chronic diseases, such as COPD 161e165 and congestive heart failure (CHF).99,163,166”
From Evidence-Based Recommendations for Optimal Dietary Protein Intake in Older People: A Position Paper From the PROT-AGE Study Group (2013) · cites this paper as [156]
Citations
Cites
Exercise training and nutritional supplementation for physical frailty in very elderly people
Fiatarone, M. A., O'Neill, E. F., Ryan, N. D., Clements, K. M., Solares, G. R., Nelson, M. E., Roberts, S. B., Kehayias, J. J., Lipsitz, L. A., & Evans, W. J. (1994) · New England Journal of Medicine · doi:10.1056/nejm199406233302501 · Cited by 2,857
Self-citationHazards of Hospitalization of the Elderly
Creditor, M. C. (1993) · Annals of Internal Medicine · doi:10.7326/0003-4819-118-3-199302010-00011 · Cited by 1,409
Identifying the elderly at risk for malnutrition
Guigoz, Y., Lauque, S., & Vellas, B. J. (2002) · Clinics in Geriatric Medicine · doi:10.1016/s0749-0690(02)00059-9 · Cited by 983
Effect of 10 Days of Bed Rest on Skeletal Muscle in Healthy Older Adults
Kortebein, P., Ferrando, A., Lombeida, J., Wolfe, R., & Evans, W. J. (2007) · JAMA · doi:10.1001/jama.297.16.1772-b · Cited by 933
Self-citationVolpi, E., Kobayashi, H., Sheffield-Moore, M., Mittendorfer, B., & Wolfe, R. R. (2003) · The American Journal of Clinical Nutrition · doi:10.1093/ajcn/78.2.250 · Cited by 846
Self-citationFunctional Outcomes of Acute Medical Illness and Hospitalization in Older Persons
Sager, M. A. (1996) · Archives of Internal Medicine · doi:10.1001/archinte.1996.00440060067008 · Cited by 578
Balagopal, P., Rooyackers, O., Adey, D., Ades, P. A., & Nair, K. S. (1997) · American Journal of Physiology-Endocrinology and Metabolism · doi:10.1152/ajpendo.1997.273.4.e790 · Cited by 541
Protein-Energy Undernutrition Among Elderly Hospitalized Patients: A Prospective Study
Sullivan, D. H., Sun, S., & Walls, R. C. (1999) · JAMA · doi:10.1001/jama.281.21.2013 · Cited by 501
Prolonged bed rest decreases skeletal muscle and whole body protein synthesis
Ferrando, A. A., Lane, H. W., Stuart, C. A., Davis-Street, J. E., & Wolfe, R. R. (1996) · American Journal of Physiology-Endocrinology and Metabolism · doi:10.1152/ajpendo.1996.270.4.e627 · Cited by 498
Self-citationThe Natural History of Functional Morbidity in Hospitalized Older Patients
Hirsch, C. H., Sommers, L., Olsen, A., Mullen, L., & Winograd, C. H. (1990) · Journal of the American Geriatrics Society · doi:10.1111/j.1532-5415.1990.tb03451.x · Cited by 485
Cited by
Sorted by citations
Items 201–233 of 233
Aasodi, R. R., Murugan, V., & Premakumari, K. B. (2020) · Journal of Applied Pharmaceutical Science · doi:10.7324/japs.2020.10505 · Cited by 2
Mosoni, L., Jarzaguet, M., David, J., Polakof, S., Savary‐Auzeloux, I., Rémond, D., & Dardevet, D. P. (2019) · Nutrients · doi:10.3390/nu11040727 · Cited by 2
Pauk, M., Amigo‐Benavent, M., Patel, B., Jakeman, P. M., & Carson, B. P. (2020) · Preprints.org · doi:10.20944/preprints202003.0010.v1 · Cited by 1
Noh, K.-W., & Park, S. (2025) · Physical Activity and Nutrition · doi:10.20463/pan.2025.0026 · Cited by 1
Corsetti, G., & Pasini, E. (2026) · Nutrients · doi:10.3390/nu18111703 · Cited by 2
Schlaganfall – Lifestyle und Umwelt
Gerischer, L. M., Flöel, A., & Endres, M. (2015) · Der Nervenarzt · doi:10.1007/s00115-014-4250-0 · Cited by 2
Protein Intake and Physical Performance Following Long-Term Stay on the International Space Station
Nozawa, Y., & Wagatsuma, Y. (2021) · Aerospace Medicine and Human Performance · doi:10.3357/amhp.5640.2021 · Cited by 1
An Amino Acid Mixture to Counteract Skeletal Muscle Atrophy: Impact on Mitochondrial Bioenergetics
Bellanti, F., Buglio, A. L., Pannone, G., Pedicillo, M. C., Stefano, I. S. D., Pignataro, A., Capurso, C. A., & Vendemiale, G. (2024) · International Journal of Molecular Sciences · doi:10.3390/ijms25116056 · Cited by 1
Promotion of Physical Activity for Acutely Unwell Older People
Beyer, N., & Suetta, C. (2018) · Springer eBooks · doi:10.1007/978-3-319-71291-8_10 · Cited by 1
Limiting deconditioned muscle atrophy and strength loss with appropriate nutrition: can it be done?
Millward, D. J. (2020) · American Journal of Clinical Nutrition · doi:10.1093/ajcn/nqaa150 · Cited by 1
Background and Management of Muscular Atrophy
Cseri, J. (2020) · IntechOpen eBooks · doi:10.5772/intechopen.90959 · Cited by 1
Nutrition and the Assessment of Sarcopenia
Evans, W. J., & Wolfe, R. R. (2022) · Nutrition and health · doi:10.1007/978-3-030-82515-7_25 · Cited by 1
Self-citationMuscle Metabolism, Nutrition, and Functional Status in Older Adults
Paddon‐Jones, D., & Russell, A. P. (2014) · Springer eBooks · doi:10.1007/978-1-4939-1929-1_7 · Cited by 1
Self-citationden Kamp, C. M. O. (2014) · Research Publications (Maastricht University) · doi:10.26481/dis.20140516co
El hidroximetril butirato como ayuda ergogénica nutricional en la sarcopenia senil
Puertas, E. Á. (2015) · UVaDOC UVaDOC University of Valladolid Documentary Repository (University of Valladolid)
Whey Protein Nutritional Power House of Future
Kumar, M. P., Nikhil, N., & Shilpa, L. (2014)
Nutritional interventions to preserve skeletal muscle mass
Backx, E. M. P. (2016) · doi:10.18174/389376
Disuse （Physical Inactivity） of Elderly People and Nutrition Support
Kondo, K. (2017) · リハビリテーション医学 : 日本リハビリテーション医学会誌 · doi:10.2490/jjrmc.54.87
van den Heuvel, E. (2018) · Bournemouth University Research Online (Bournemouth University)
Jamieson, R., & Porter, J. A. (2013)
Skeletal muscle mitochondrial clearance
Leermakers (2019) · Research Publications (Maastricht University) · doi:10.26481/dis.20190405pl
Arai, H. (2018) · Nihon Naika Gakkai Zasshi · doi:10.2169/naika.107.2444
Nutritional Requirements in Patients with Neurogenic Dysphagia
Warnecke, T., Dziewas, R., & Langmore, S. E. (2021) · Springer eBooks · doi:10.1007/978-3-030-42140-3_8
β-hydroxy-β-methylbutyrate: role and prospects applications in gerontology
Nikitina, E., Orlova, S., Pigareva, Y., & Магомедова, Х. А. (2021) · Medical alphabet · doi:10.33667/2078-5631-2021-21-94-100
The Role of Dietary Essential Amino Acids in Muscle and Health
Jung, J., Park, S., Kim, C., Wolfe, R., & Kim, I.-Y. (2022) · Food Supplements and Biomaterials for Health · doi:10.52361/fsbh.2022.2.e4
Self-citationGasperini, B., Volpato, S., & Cherubini, A. (2021) · Wiley eBooks · doi:10.1002/9781119597896.ch9
Coker, R. H., Miller, S. L., Schutzler, S. E., Deutz, N. E. P., & Wolfe, R. R. (2016) · Apple Academic Press eBooks · doi:10.1201/b19985-7
Self-citationMoving towards better care for hospitalized older adults
Scheerman, K. (2022) · doi:10.5463/thesis.62
Kilroe, S. P. (2023) · Research Publications (Maastricht University) · doi:10.26481/dis.20230925sk
Evaluation of muscle aging using high density surface electromyography
Imrani, L. (2021) · theses.fr (ABES) · doi:10.70675/84b22176z946ez4ca9zb88bz68cc53374e66
Jin, S., Ye, Z., Fu, H., Xiong, Y., Qiao, H., Zhang, W., & Jiang, S. (2026) · Animals · doi:10.3390/ani16111591
Jang, J., Wolfe, R. R., & Kim, I. (2026) · Nutrients · doi:10.3390/nu18121990 · Cited by 1
Self-citation
Metadata
- Authors
- Ferrando, A. A., Paddon-Jones, D., Hays, N. P., Kortebein, P., Ronsen, O., Williams, R. H., McComb, A., Symons, T. B., Wolfe, R. R., & Evans, W.
- Affiliations
- University of Arkansas for Medical Sciences (US)
- University of Kentucky (US)
- Corresponding author
- Ferrando, Arny A.
- Venue
- Clinical Nutrition
- Publisher
- Elsevier BV
- Published
- 2010-02
- Volume
- 29
- Issue
- 1
- Pages
- 18-23
- ISSN
- 0261-5614 (ISSN-L)
- OpenAlex
- W2060119724
- Cited by
- 237
- References
- 35
- Citations by year
- 2026: 3 · 2025: 10 · 2024: 8 · 2023: 9 · 2022: 11 · 2021: 18 · 2020: 23 · 2019: 19 · 2018: 16 · 2017: 20 · 2016: 13 · 2015: 16 · 2014: 14 · 2013: 22 · 2012: 20
- FWCI
- 4.70
- Type
- journal article
- Language
- en
- Open access
- closed
- Locations
- Clinical Nutrition (publishedVersion)
- PubMed (publishedVersion)
- Funders
- National Institutes of Health (PO1 AG023591, M01-RR-00073)
- Topics
- Health Sciences › Nursing › Nutrition and Dietetics › Muscle metabolism and nutrition
- Health Sciences › Medicine › Physiology (medical) › Nutrition and Health in Aging
- Health Sciences › Nursing › Nutrition and Dietetics › Clinical Nutrition and Gastroenterology
- Keywords
- essential amino acid supplementation, protein intake, nitrogen balance, muscle function, muscle protein synthesis, muscle mass, bed rest, inactivity, older adults, protein malnutrition, functional decline
- MeSH terms
- Aged, Aging, Amino Acids, Essential, Analysis of Variance, Bed Rest, Body Composition, Female, Hospitalization, Humans, Male, Muscle Proteins, Nitrogen, Protein-Energy Malnutrition, Absorptiometry, Photon, Muscle, Skeletal, Dietary Supplements
About these checks
Registry, retraction, Cites and statistics results are computed, not judged, with one exception: a printed reference that no index lists is read once by a model before it counts as a citation error. Claims are extracted by a model and kept only when their quote appears verbatim in the text; each cited source is then checked, with a model’s help, for whether it says what the claim relies on. Those verdicts can be wrong — read the claim’s quote and the cited source before relying on one.
Statistics and arithmetic are recomputed, not judged.
Confidence bands are shown only for fields calibrated on our annotated test set. None is calibrated yet, so no band is shown.
What counts as a claim ›How we measure confidence ›How we check this ›
Are you an author, or do you see a problem with this page? Request a review
