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EAA supplementation to increase nitrogen intake improves muscle function during bed rest in the elderly
Abstract
Background & aims Older individuals are more likely to experience extended hospitalization and become protein malnourished during hospitalization. The concomitant compulsory inactivity results in functional decline. Increasing protein intake in hospitalized patients improves nitrogen balance, but effects on function are unknown. In the present study, we examined the effects of increasing protein intake by essential amino acid (EAA) supplementation in older individuals subjected to 10 d bed rest on LBM and muscle function. Methods Subjects were given a placebo (n=12, 68+/-5 (SD) yrs, 83+/-19 kg) or 15 g of EAA (n=10, 71+/-6, 72+/-8 kg) 3 times per day throughout 10d of bed rest. LBM, muscle protein synthesis, and muscle function were determined before and after bed rest. Due to an imbalance in randomized gender distribution between groups, gender and beginning functional and LBM measures were utilized for analyses by repeated measures analysis of covariance (RMANCOVA). Results Analyses revealed the potential for the preservation of functional outcomes with EAA supplementation. Conclusions Increasing protein intake above the RDA may preserve muscle function in the elderly during compulsory inactivity. EAA supplementation is potentially an efficient method of increasing protein intake without affecting satiety.
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“Evidence supports the combination of exercise and protein/amino acid supplementation for prevention and treatment of muscle loss in certain debilitating clinical conditions, including bed rest for acute critical illness or injury 153e160 and also for chronic diseases, such as COPD 161e165 and congestive heart failure (CHF).99,163,166”
From Evidence-Based Recommendations for Optimal Dietary Protein Intake in Older People: A Position Paper From the PROT-AGE Study Group (2013) · cites this paper as [156]
Citations
Cites
Exercise training and nutritional supplementation for physical frailty in very elderly people
Fiatarone, M. A., O'Neill, E. F., Ryan, N. D., Clements, K. M., Solares, G. R., Nelson, M. E., Roberts, S. B., Kehayias, J. J., Lipsitz, L. A., & Evans, W. J. (1994) · New England Journal of Medicine · doi:10.1056/nejm199406233302501 · Cited by 2,857
Self-citationHazards of Hospitalization of the Elderly
Creditor, M. C. (1993) · Annals of Internal Medicine · doi:10.7326/0003-4819-118-3-199302010-00011 · Cited by 1,409
Identifying the elderly at risk for malnutrition
Guigoz, Y., Lauque, S., & Vellas, B. J. (2002) · Clinics in Geriatric Medicine · doi:10.1016/s0749-0690(02)00059-9 · Cited by 983
Effect of 10 Days of Bed Rest on Skeletal Muscle in Healthy Older Adults
Kortebein, P., Ferrando, A., Lombeida, J., Wolfe, R., & Evans, W. J. (2007) · JAMA · doi:10.1001/jama.297.16.1772-b · Cited by 933
Self-citationVolpi, E., Kobayashi, H., Sheffield-Moore, M., Mittendorfer, B., & Wolfe, R. R. (2003) · The American Journal of Clinical Nutrition · doi:10.1093/ajcn/78.2.250 · Cited by 846
Self-citationFunctional Outcomes of Acute Medical Illness and Hospitalization in Older Persons
Sager, M. A. (1996) · Archives of Internal Medicine · doi:10.1001/archinte.1996.00440060067008 · Cited by 578
Balagopal, P., Rooyackers, O., Adey, D., Ades, P. A., & Nair, K. S. (1997) · American Journal of Physiology-Endocrinology and Metabolism · doi:10.1152/ajpendo.1997.273.4.e790 · Cited by 541
Protein-Energy Undernutrition Among Elderly Hospitalized Patients: A Prospective Study
Sullivan, D. H., Sun, S., & Walls, R. C. (1999) · JAMA · doi:10.1001/jama.281.21.2013 · Cited by 501
Prolonged bed rest decreases skeletal muscle and whole body protein synthesis
Ferrando, A. A., Lane, H. W., Stuart, C. A., Davis-Street, J. E., & Wolfe, R. R. (1996) · American Journal of Physiology-Endocrinology and Metabolism · doi:10.1152/ajpendo.1996.270.4.e627 · Cited by 498
Self-citationThe Natural History of Functional Morbidity in Hospitalized Older Patients
Hirsch, C. H., Sommers, L., Olsen, A., Mullen, L., & Winograd, C. H. (1990) · Journal of the American Geriatrics Society · doi:10.1111/j.1532-5415.1990.tb03451.x · Cited by 485
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Volpi, E., Campbell, W. W., Dwyer, J. T., Johnson, M. A., Jensen, G. L., Morley, J. E., & Wolfe, R. R. (2012) · The Journals of Gerontology Series A · doi:10.1093/gerona/gls229 · Cited by 408
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Stroke induced Sarcopenia: muscle wasting and disability after stroke.
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Deutz, N. E. P., Pereira, S. L., Hays, N. P., Oliver, J. S., Edens, N. K., Evans, C. M., & Wolfe, R. R. (2013) · Clinical Nutrition · doi:10.1016/j.clnu.2013.02.011 · Cited by 287
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Self-citationDirks, M. L., Wall, B. T., Snijders, T., Ottenbros, C. L. P., Verdijk, L. B., & van Loon, L. J. C. (2013) · Acta Physiologica · doi:10.1111/apha.12200 · Cited by 266
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Deutz, N. E. P., Safar, A., Schutzler, S. E., Memelink, R., Ferrando, A., Spencer, H., van Helvoort, A., & Wolfe, R. (2011) · Clinical Nutrition · doi:10.1016/j.clnu.2011.05.008 · Cited by 204
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Paddon‐Jones, D., & Leidy, H. J. (2013) · Current Opinion in Clinical Nutrition & Metabolic Care · doi:10.1097/mco.0000000000000011 · Cited by 210
Self-citationGillis, C., Loiselle, S., Fiore, J. F., Awasthi, R., Wykes, L., Liberman, A. S., Stein, B., Charlebois, P., & Carli, F. (2015) · Journal of the Academy of Nutrition and Dietetics · doi:10.1016/j.jand.2015.06.007 · Cited by 199
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Wall, B. T., & van Loon, L. J. (2013) · Nutrition Reviews · doi:10.1111/nure.12019 · Cited by 228
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Brook, M. S., Wilkinson, D. J., Phillips, B. E., Pérez‐Schindler, J., Philp, A., Smith, K., & Atherton, P. J. (2015) · Acta Physiologica · doi:10.1111/apha.12532 · Cited by 214
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Self-citationNunes, E. A., Stokes, T., McKendry, J., Currier, B. S., & Phillips, S. M. (2022) · American Journal of Physiology-Cell Physiology · doi:10.1152/ajpcell.00425.2021 · Cited by 194
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Self-citationWolfe, R. R., Rutherfurd, S. M., Kim, I., & Moughan, P. J. (2016) · Nutrition Reviews · doi:10.1093/nutrit/nuw022 · Cited by 191
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Dirks, M. L., Wall, B. T., Nilwik, R., Weerts, D. H. J. M., Verdijk, L. B., & van Loon, L. J. C. (2014) · The Journal of Nutrition · doi:10.3945/jn.114.194217 · Cited by 137
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Van Ancum, J. M., Scheerman, K., Jonkman, N. H., Smeenk, H. E., Kruizinga, R. C., Meskers, C. G. M., & Maier, A. B. (2017) · Experimental Gerontology · doi:10.1016/j.exger.2017.03.006 · Cited by 118
Wall, B. T., Morton, J. P., & van Loon, L. J. C. (2014) · European Journal of Sport Science · doi:10.1080/17461391.2014.936326 · Cited by 128
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Dideriksen, K., Reitelseder, S., & Holm, L. (2013) · Nutrients · doi:10.3390/nu5030852 · Cited by 110
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Rondanelli, M., Opizzi, A., Antoniello, N., Boschi, F., Iadarola, P., Pasini, E., Aquilani, R., & Dioguardi, F. S. (2011) · Clinical Nutrition · doi:10.1016/j.clnu.2011.04.005 · Cited by 100
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Ispoglou, T., Witard, O. C., Duckworth, L. C., & Lees, M. J. (2020) · Proceedings of The Nutrition Society · doi:10.1017/s0029665120008010 · Cited by 55
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Fukagawa, N. K. (2013) · Amino Acids · doi:10.1007/s00726-013-1480-6 · Cited by 43
Vellas, B. J., Pahor, M., Manini, T. M., Rooks, D., Guralnik, J. M., Morley, J. E., Studenski, S. A., Evans, W. J., Asbrand, C., Fariello, R. G., et al. (2013) · The journal of nutrition health & aging · doi:10.1007/s12603-013-0362-7 · Cited by 46
Self-citationOttestad, I. O., Løvstad, A., Gjevestad, G. O., Hamarsland, H., Benth, J. Š., Andersen, L. F., Bye, A., Biong, A. S., Retterstøl, K., Iversen, P. O., et al. (2016) · The journal of nutrition health & aging · doi:10.1007/s12603-016-0856-1 · Cited by 51
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Wiggs, M. P. (2015) · Frontiers in Physiology · doi:10.3389/fphys.2015.00063 · Cited by 46
Beaudart, C., Rabenda, V., Simmons, M., Geerinck, A., de Carvalho, I. A., Reginster, J., Thiyagarajan, J. A., & Bruyère, O. (2017) · The journal of nutrition health & aging · doi:10.1007/s12603-017-0934-z · Cited by 42
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Bozzetti, F., & Bozzetti, V. (2012) · Clinical Nutrition · doi:10.1016/j.clnu.2012.10.017 · Cited by 41
Wright, J., & Baldwin, C. (2017) · Clinical Nutrition · doi:10.1016/j.clnu.2017.09.004 · Cited by 41
Kilroe, S. P., Fulford, J., Jackman, S. R., Holwerda, A. M., Gijsen, A. P., van Loon, L. J. C., & Wall, B. T. (2020) · American Journal of Clinical Nutrition · doi:10.1093/ajcn/nqaa136 · Cited by 39
Gao, R., & Chilibeck, P. D. (2020) · Nutrition Research · doi:10.1016/j.nutres.2020.07.001 · Cited by 43
Prehabilitation for esophagectomy
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Self-citationOlaniyan, E. T., O’Halloran, F., & McCarthy, A. L. (2020) · Nutrition Research Reviews · doi:10.1017/s0954422420000219 · Cited by 39
Metadata
- Authors
- Ferrando, A. A., Paddon-Jones, D., Hays, N. P., Kortebein, P., Ronsen, O., Williams, R. H., McComb, A., Symons, T. B., Wolfe, R. R., & Evans, W.
- Affiliations
- University of Arkansas for Medical Sciences (US)
- University of Kentucky (US)
- Corresponding author
- Ferrando, Arny A.
- Venue
- Clinical Nutrition
- Publisher
- Elsevier BV
- Published
- 2010-02
- Volume
- 29
- Issue
- 1
- Pages
- 18-23
- ISSN
- 0261-5614 (ISSN-L)
- OpenAlex
- W2060119724
- Cited by
- 237
- References
- 35
- Citations by year
- 2026: 3 · 2025: 10 · 2024: 8 · 2023: 9 · 2022: 11 · 2021: 18 · 2020: 23 · 2019: 19 · 2018: 16 · 2017: 20 · 2016: 13 · 2015: 16 · 2014: 14 · 2013: 22 · 2012: 20
- FWCI
- 4.70
- Type
- journal article
- Language
- en
- Open access
- closed
- Locations
- Clinical Nutrition (publishedVersion)
- PubMed (publishedVersion)
- Funders
- National Institutes of Health (PO1 AG023591, M01-RR-00073)
- Topics
- Health Sciences › Nursing › Nutrition and Dietetics › Muscle metabolism and nutrition
- Health Sciences › Medicine › Physiology (medical) › Nutrition and Health in Aging
- Health Sciences › Nursing › Nutrition and Dietetics › Clinical Nutrition and Gastroenterology
- Keywords
- essential amino acid supplementation, protein intake, nitrogen balance, muscle function, muscle protein synthesis, muscle mass, bed rest, inactivity, older adults, protein malnutrition, functional decline
- MeSH terms
- Aged, Aging, Amino Acids, Essential, Analysis of Variance, Bed Rest, Body Composition, Female, Hospitalization, Humans, Male, Muscle Proteins, Nitrogen, Protein-Energy Malnutrition, Absorptiometry, Photon, Muscle, Skeletal, Dietary Supplements
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