Cited by 237Muscle metabolism and nutritionNutrition and Health in AgingClinical Nutrition and Gastroenterology

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EAA supplementation to increase nitrogen intake improves muscle function during bed rest in the elderly

Ferrando, Arny A., Paddon-Jones, Doug, Hays, Nicholas P., Kortebein, Patrick, Ronsen, Ola, Williams, Rick H., McComb, Ashley, Symons, T. Brock, Wolfe, Robert R., Evans, William·2010·Clinical Nutrition

DOI 10.1016/j.clnu.2009.03.009

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Abstract

Background & aims Older individuals are more likely to experience extended hospitalization and become protein malnourished during hospitalization. The concomitant compulsory inactivity results in functional decline. Increasing protein intake in hospitalized patients improves nitrogen balance, but effects on function are unknown. In the present study, we examined the effects of increasing protein intake by essential amino acid (EAA) supplementation in older individuals subjected to 10 d bed rest on LBM and muscle function. Methods Subjects were given a placebo (n=12, 68+/-5 (SD) yrs, 83+/-19 kg) or 15 g of EAA (n=10, 71+/-6, 72+/-8 kg) 3 times per day throughout 10d of bed rest. LBM, muscle protein synthesis, and muscle function were determined before and after bed rest. Due to an imbalance in randomized gender distribution between groups, gender and beginning functional and LBM measures were utilized for analyses by repeated measures analysis of covariance (RMANCOVA). Results Analyses revealed the potential for the preservation of functional outcomes with EAA supplementation. Conclusions Increasing protein intake above the RDA may preserve muscle function in the elderly during compulsory inactivity. EAA supplementation is potentially an efficient method of increasing protein intake without affecting satiety.

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Authors: Ferrando, A. A., Paddon-Jones, D., Hays, N. P., Kortebein, P., Ronsen, O., Williams, R. H., McComb, A., Symons, T. B., Wolfe, R. R., & Evans, W.
Affiliations: University of Arkansas for Medical Sciences (US)
University of Kentucky (US)
Corresponding author: Ferrando, Arny A.
ORCID: Ferrando, Arny A.
Hays, Nicholas P.
Symons, T. Brock
Wolfe, Robert R.
Evans, William
Venue: Clinical Nutrition
Publisher: Elsevier BV
Published: 2010-02
Volume: 29
Issue: 1
Pages: 18-23
ISSN: 0261-5614 (ISSN-L)
DOI: 10.1016/j.clnu.2009.03.009
OpenAlex: W2060119724
Cited by: 237
References: 35
Citations by year: 2026: 3 · 2025: 10 · 2024: 8 · 2023: 9 · 2022: 11 · 2021: 18 · 2020: 23 · 2019: 19 · 2018: 16 · 2017: 20 · 2016: 13 · 2015: 16 · 2014: 14 · 2013: 22 · 2012: 20
FWCI: 4.70
Type: journal article
Language: en
Open access: closed
Licence: www.elsevier.com/tdm/userlicense/1.0/ (tdm)
www.elsevier.com/legal/tdmrep-license (tdm)
Locations: Clinical Nutrition (publishedVersion)
PubMed (publishedVersion)
Funders: National Institutes of Health (PO1 AG023591, M01-RR-00073)
Topics: Health Sciences › Nursing › Nutrition and Dietetics › Muscle metabolism and nutrition
Health Sciences › Medicine › Physiology (medical) › Nutrition and Health in Aging
Health Sciences › Nursing › Nutrition and Dietetics › Clinical Nutrition and Gastroenterology
Keywords: essential amino acid supplementation, protein intake, nitrogen balance, muscle function, muscle protein synthesis, muscle mass, bed rest, inactivity, older adults, protein malnutrition, functional decline
MeSH terms: Aged, Aging, Amino Acids, Essential, Analysis of Variance, Bed Rest, Body Composition, Female, Hospitalization, Humans, Male, Muscle Proteins, Nitrogen, Protein-Energy Malnutrition, Absorptiometry, Photon, Muscle, Skeletal, Dietary Supplements

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EAA supplementation to increase nitrogen intake improves muscle function during bed rest in the elderly

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