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Cited by 237Muscle metabolism and nutritionNutrition and Health in AgingClinical Nutrition and Gastroenterology

The DOI matches its Crossref record; 33 of the 35 references it cites were found in a registry or an index.

EAA supplementation to increase nitrogen intake improves muscle function during bed rest in the elderly

Ferrando, Arny A., Paddon-Jones, Doug, Hays, Nicholas P., Kortebein, Patrick, Ronsen, Ola, Williams, Rick H., McComb, Ashley, Symons, T. Brock, Wolfe, Robert R., Evans, William·2010·Clinical Nutrition
DOI 10.1016/j.clnu.2009.03.009
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Abstract

Background & aims Older individuals are more likely to experience extended hospitalization and become protein malnourished during hospitalization. The concomitant compulsory inactivity results in functional decline. Increasing protein intake in hospitalized patients improves nitrogen balance, but effects on function are unknown. In the present study, we examined the effects of increasing protein intake by essential amino acid (EAA) supplementation in older individuals subjected to 10 d bed rest on LBM and muscle function. Methods Subjects were given a placebo (n=12, 68+/-5 (SD) yrs, 83+/-19 kg) or 15 g of EAA (n=10, 71+/-6, 72+/-8 kg) 3 times per day throughout 10d of bed rest. LBM, muscle protein synthesis, and muscle function were determined before and after bed rest. Due to an imbalance in randomized gender distribution between groups, gender and beginning functional and LBM measures were utilized for analyses by repeated measures analysis of covariance (RMANCOVA). Results Analyses revealed the potential for the preservation of functional outcomes with EAA supplementation. Conclusions Increasing protein intake above the RDA may preserve muscle function in the elderly during compulsory inactivity. EAA supplementation is potentially an efficient method of increasing protein intake without affecting satiety.

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Crossref · 10.1016/j.clnu.2009.03.009

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Metadata

Authors
Ferrando, A. A., Paddon-Jones, D., Hays, N. P., Kortebein, P., Ronsen, O., Williams, R. H., McComb, A., Symons, T. B., Wolfe, R. R., & Evans, W.
Affiliations
  • University of Arkansas for Medical Sciences (US)
  • University of Kentucky (US)
Corresponding author
Ferrando, Arny A.
ORCID
Venue
Clinical Nutrition
Publisher
Elsevier BV
Published
2010-02
Volume
29
Issue
1
Pages
18-23
ISSN
0261-5614 (ISSN-L)
DOI
10.1016/j.clnu.2009.03.009
OpenAlex
W2060119724
Cited by
237
References
35
Citations by year
2026: 3 · 2025: 10 · 2024: 8 · 2023: 9 · 2022: 11 · 2021: 18 · 2020: 23 · 2019: 19 · 2018: 16 · 2017: 20 · 2016: 13 · 2015: 16 · 2014: 14 · 2013: 22 · 2012: 20
FWCI
4.70
Type
journal article
Language
en
Open access
closed
Licence
Locations
  • Clinical Nutrition (publishedVersion)
  • PubMed (publishedVersion)
Funders
National Institutes of Health (PO1 AG023591, M01-RR-00073)
Topics
  • Health Sciences › Nursing › Nutrition and Dietetics › Muscle metabolism and nutrition
  • Health Sciences › Medicine › Physiology (medical) › Nutrition and Health in Aging
  • Health Sciences › Nursing › Nutrition and Dietetics › Clinical Nutrition and Gastroenterology
Keywords
essential amino acid supplementation, protein intake, nitrogen balance, muscle function, muscle protein synthesis, muscle mass, bed rest, inactivity, older adults, protein malnutrition, functional decline
MeSH terms
Aged, Aging, Amino Acids, Essential, Analysis of Variance, Bed Rest, Body Composition, Female, Hospitalization, Humans, Male, Muscle Proteins, Nitrogen, Protein-Energy Malnutrition, Absorptiometry, Photon, Muscle, Skeletal, Dietary Supplements

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