Effect of melatonin on the maintenance of cholesterol homeostasis in the rat
Abstract
The effect of melatonin on cholesterol metabolism in the rat was investigated in the dietary and hypothyroid models of hypercholesterolemia. In normal and dietary hypercholesterolemia (induced by 1% cholesterol, 0.5% bile acid), melatonin treatment (12.5mg/kg i.p.) reduced total serum cholesterol concentration and total low density lipoprotein (VLDL+LDL) cholesterol. The protective action of melatonin was manifested only following the induction of cholesterolemia in such animals. Enhanced catabolism of cholesterol to bile acids is likely involved as shown by an increase in fecal bile acid excretion following melatonin treatment. Incorporation of 1-14C acetate into sterols was unaffected by melatonin treatment which suggests its lack of influence on sterol biosynthesis. In secondary hypercholesterolemia (hypothyroidism induced by 2-thiouracil), melatonin exerted a beneficial effect by increasing the HDL/total LDL cholesterol ratio. These findings suggest that the hypocholesterolemic effect of melatonin may work through the augmentation of endogenous cholesterol clearance mechanisms. This is accompanied by the lowering of the cholesterol fraction associated with low density lipoproteins.
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The lipid-promoting effects of melatonin arise from the promotion of innate cholesterol release through the production of bilirubin acid and the prevention of low-density lipoprotein receptor function.
“The lipid-promoting effects of melatonin arise from the promotion of innate cholesterol release through the production of bilirubin acid and the prevention of low-density lipoprotein receptor function. Moreover, enhancement of irisin levels and improvement fecal cholesterol repulsion are some pathways that melatonin acts. 16,34,35”
From Melatonin supplementation improves glycemic hemostasis, lipid profile, and adipokine concentrations of obese women: A double-blind randomized clinical trial (2024) · cites this paper as [34]
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“16,34,35 39-42 It was reported that melatonin is effective in weight reduction in those subjects with mental disease and consumed drugs led to adverse effects like weight variations.”
- Authors
- Chan, T. Y., & Tang, P. L.
- Affiliations
- Hong Kong Polytechnic University (HK)
- ORCID
- Tang, P. L.
- Venue
- Endocrine Research
- Publisher
- Informa UK Limited
- Published
- 1995-01
- Volume
- 21
- Issue
- 3
- Pages
- 681-696
- ISSN
- 0743-5800 (ISSN-L)
- 1532-4206
- OpenAlex
- W2096623349
- Cited by
- 80
- References
- 27
- Citations by year
- 2026: 1 · 2025: 1 · 2024: 3 · 2023: 3 · 2022: 3 · 2021: 6 · 2020: 3 · 2019: 7 · 2018: 5 · 2017: 6 · 2016: 1 · 2015: 4 · 2014: 2 · 2013: 6
- FWCI
- 1.28
- Type
- journal article
- Language
- en
- Open access
- closed
- Locations
- Endocrine Research (publishedVersion)
- PubMed (publishedVersion)
- Topics
- Health Sciences › Medicine › Surgery › Cholesterol and Lipid Metabolism
- Life Sciences › Neuroscience › Endocrine and Autonomic Systems › Circadian rhythm and melatonin
- Health Sciences › Medicine › Surgery › Lipoproteins and Cardiovascular Health
- Keywords
- melatonin, cholesterol homeostasis, hypercholesterolemia, dietary cholesterol, fecal bile acid excretion, hypothyroidism, 2-thiouracil, HDL/LDL ratio, LDL cholesterol, sterol biosynthesis, cholesterol clearance, cholesterol-lowering effect
- MeSH terms
- Animals, Anticholesteremic Agents, Bile Acids and Salts, Cholesterol, Cholesterol, Dietary, Feces, Homeostasis, Hypercholesterolemia, Hypothyroidism, Cholesterol, HDL, Cholesterol, LDL, Male, Melatonin, Thiouracil, Cholesterol, VLDL, Rats, Sprague-Dawley, Rats
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