Dietary Melatonin Protects Against Behavioural, Metabolic, Oxidative, and Organ Morphological Changes in Mice that are Fed High-Fat, High- Sugar Diet
Abstract
Background : Metabolic syndrome is a complex pattern of disorders that occur jointly and is associated with an increased risk of cardiovascular and cerebrovascular disease. Therefore the need for more-efficient options of treatment has become imperative. Objective : This study examined the effect of dietary-melatonin in the management of behavioural, metabolic, antioxidant, and organ changes due to high-fat/high-sugar (HFHS) diet-induced metabolic syndrome in mice. Methods: Mice were randomly assigned into five groups of ten animals each. Groups were normal control [fed standard diet (SD)], HFHS control, and 3 groups of melatonin incorporated into HFHS at 2.5, 5, and 10 mg/kg of feed. Mice were fed for seven weeks, and body weight was assessed weekly. Open-field behaviours, radial-arm, and Y-maze spatial memory were scored at the end of the experimental period. Twenty-four hours after the last behavioural test, blood was taken for estimation of blood glucose levels after an overnight fast. Animals were then euthanised, and blood was taken for estimation of plasma insulin, leptin, and adiponectin levels, and serum lipid profile. The liver, kidneys, and brain were excised and processed for general histology, while homogenates of the liver and whole brain were used to assess oxidative stress parameters. Results: Results showed that dietary melatonin (compared to HFHS diet) was associated with a decrease in body weight, food intake, and novelty-induced behaviours; and an increase in spatial-working memory scores. A decrease in glucose, insulin, leptin, and malondialdehyde levels; and an increase in adiponectin levels and superoxide dismutase activity were also observed. Histomorphological/ histomorphometric examination revealed evidence of organ injury with HFHS diet, and varying degrees of amelioration with melatonin-supplemented diet. Conclusion: In conclusion, dietary melatonin supplementation may have beneficial effects in the management of the metabolic syndrome..
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Growing evidence showed that melatonin supplementation decreased weight in animals.
“Growing evidence showed that melatonin supplementation decreased weight in animals. 17,36-38”
From Melatonin supplementation improves glycemic hemostasis, lipid profile, and adipokine concentrations of obese women: A double-blind randomized clinical trial (2024) · cites this paper as [36]
Cites
Grundy, S. M., Brewer, H. B., Cleeman, J. I., Smith, S. C., & Lenfant, C. (2004) · Circulation · doi:10.1161/01.cir.0000111245.75752.c6 · Cited by 5,982 · see citing works
Yamauchi, T., Kamon, J., Waki, H., Terauchi, Y., Kubota, N., Hara, K., Mori, Y., Ide, T., Murakami, K., Tsuboyama-Kasaoka, N., et al. (2001) · Nature Medicine · doi:10.1038/90984 · Cited by 4,915 · see citing works
The Global Epidemic of the Metabolic Syndrome
Saklayen, M. G. (2018) · Current Hypertension Reports · doi:10.1007/s11906-018-0812-z · Cited by 3,990 · see citing works
Sugar-Sweetened Beverages and Risk of Metabolic Syndrome and Type 2 Diabetes
Malik, V. S., Popkin, B. M., Bray, G. A., Després, J.-P., Willett, W. C., & Hu, F. B. (2010) · Diabetes Care · doi:10.2337/dc10-1079 · Cited by 2,116 · see citing works
The role of fructose in the pathogenesis of NAFLD and the metabolic syndrome
Lim, J. S., Mietus-Snyder, M., Valente, A., Schwarz, J.-M., & Lustig, R. H. (2010) · Nature Reviews Gastroenterology & Hepatology · doi:10.1038/nrgastro.2010.41 · Cited by 771 · see citing works
Defining high-fat-diet rat models: Metabolic and molecular effects of different fat types
Buettner, R., Parhofer, K. G., Woenckhaus, M., Wrede, C. E., Kunz-Schughart, L. A., Schölmerich, J., & Bollheimer, L. C. (2006) · Journal of Molecular Endocrinology · doi:10.1677/jme.1.01909 · Cited by 704 · see citing works
Role of leptin and adiponectin in insulin resistance
Yadav, A., Kataria, M. A., Saini, V., & Yadav, A. (2012) · Clinica Chimica Acta · doi:10.1016/j.cca.2012.12.007 · Cited by 636 · see citing works
High-carbohydrate High-fat Diet–induced Metabolic Syndrome and Cardiovascular Remodeling in Rats
Panchal, S. K., Poudyal, H., Iyer, A., Nazer, R., Alam, M. A., Diwan, V., Kauter, K., Sernia, C., Campbell, F., Ward, L. C., et al. (2010) · Journal of Cardiovascular Pharmacology · doi:10.1097/fjc.0b013e3181feb90a · Cited by 457 · see citing works
Tran, L. T., Yuen, V. G., & McNeill, J. H. (2009) · Molecular and Cellular Biochemistry · doi:10.1007/s11010-009-0184-4 · Cited by 359 · see citing works
Damaging effects of a high-fat diet to the brain and cognition: A review of proposed mechanisms
Freeman, L. R., Haley‐Zitlin, V., Rosenberger, D. S., & Granholm, A. (2013) · Nutritional Neuroscience · doi:10.1179/1476830513y.0000000092 · Cited by 325 · see citing works
Koziróg, M., Poliwczak, A. R., Duchnowicz, P., Koter-Michalak, M., Sikora, J., & Broncel, M. (2011) · Journal of Pineal Research · doi:10.1111/j.1600-079x.2010.00835.x · Cited by 299 · see citing works
Melatonin Reduces Body Weight Gain in Sprague Dawley Rats with Diet-Induced Obesity
Prunet‐Marcassus, B., Desbazeille, M., Bros, A., Louche, K., Delagrange, P., Renard, P., Casteilla, L., & Pénicaud, L. (2003) · Endocrinology · doi:10.1210/en.2003-0693 · Cited by 281 · see citing works
High Fat/High Glucose Diet Induces Metabolic Syndrome in an Experimental Rat Model
Moreno-Fernández, S., Garcés‐Rimón, M., Vera, G., Astier, J., Landrier, J., & Miguel, M. (2018) · Nutrients · doi:10.3390/nu10101502 · Cited by 237 · see citing works
A Western-like fat diet is sufficient to induce a gradual enhancement in fat mass over generations
Massiéra, F., Barbry, P., Guesnet, P., Joly‐Amado, A., Luquet, S. H., Moreilhon, C., Mohsen‐Kanson, T., Amri, E., & Ailhaud, G. P. (2010) · Journal of Lipid Research · doi:10.1194/jlr.m006866 · Cited by 186 · see citing works
Lew, C. C. H., Wong, G. J. Y., Cheung, K., Chua, A.-P., Chong, S. C., & Miller, M. (2017) · Nutrients · doi:10.3390/nu10010010 · Cited by 160 · see citing works
Wang, Q., Yuan, J., Yu, Z., Lin, L., Jiang, Y., Cao, Z., Zhuang, P., Whalen, M. J., Song, B., Wang, X., et al. (2017) · Molecular Neurobiology · doi:10.1007/s12035-017-0663-7 · Cited by 157 · see citing works
Melatonin inhibits lipid peroxidation and stimulates the antioxidant status of diabetic rats
Vural, H., Sabuncu, T., Arslan, S. O., & Aksoy, N. (2001) · Journal of Pineal Research · doi:10.1034/j.1600-079x.2001.310301.x · Cited by 152 · see citing works
Aksoy, N., Vural, H., Sabuncu, T., & Aksoy, Ş. (2002) · Cell Biochemistry and Function · doi:10.1002/cbf.1006 · Cited by 139 · see citing works
The effects of high‐fat diet on the renal structure and morphometric parametric of kidneys in rats
Altunkaynak, M. E., Özbek, E., Altunkaynak, B. Z., Can, İ., Ünal, D., & Ünal, B. (2008) · Journal of Anatomy · doi:10.1111/j.1469-7580.2008.00902.x · Cited by 138 · see citing works
Today's and yesterday's of pathophysiology: Biochemistry of metabolic syndrome and animal models
Aydın, S., Aksoy, A., Aydın, S., Kalaycı, M. Z., Yılmaz, M., Kuloğlu, T., Çitil, C., & Çatak, Z. (2013) · Nutrition · doi:10.1016/j.nut.2013.05.013 · Cited by 133 · see citing works
Melatonin in experimental seizures and epilepsy
Banach, M., Gurdziel, E., Jędrych, M., & Borowicz, K. K. (2011) · Pharmacological Reports · doi:10.1016/s1734-1140(11)70393-0 · Cited by 101 · see citing works
Lipman, R. D., Bronson, R. T., Wu, D., Smith, D. E., Prior, R. L., Cao, G., Han, S. N., Martin, K. R., Meydani, S. N., & Meydani, M. (1998) · Mechanisms of Ageing and Development · doi:10.1016/s0047-6374(98)00048-7 · Cited by 99 · see citing works
Effect of Pinealectomy on Plasma Glucose, Insulin and Glucagon Levels in the Rat
Dı́az, B., & Blázquez, E. (1986) · Hormone and Metabolic Research · doi:10.1055/s-2007-1012279 · Cited by 98 · see citing works
An assessment of the nutraceutical potential of Juglans regia L. leaf powder in diabetic rats
Mollica, A., Zengin, G., Locatelli, M., Stefanucci, A., Macedonio, G., Bellagamba, G., Onaolapo, O. J., Onaolapo, A. Y., Azeez, F., Ayileka, A., et al. (2017) · Food and Chemical Toxicology · doi:10.1016/j.fct.2017.03.056 · Cited by 95 · see citing works
Self-citationMohammadi-Sartang, M., Ghorbani, M., & Mazloom, Z. (2018) · Clinical Nutrition · doi:10.1016/j.clnu.2017.11.003 · Cited by 94 · see citing works
Gainey, S. J., Kwakwa, K. A., Bray, J. K., Pillote, M. M., Tir, V. L., Towers, A. E., & Freund, G. G. (2016) · Frontiers in Behavioral Neuroscience · doi:10.3389/fnbeh.2016.00156 · Cited by 92 · see citing works
Melatonin Effect on Rat Body Weight Regulation in Response to High-Fat Diet at Middle Age
Puchalski, S. S., Green, J. N., & Rasmussen, D. D. (2003) · Endocrine · doi:10.1385/endo:21:2:163 · Cited by 88 · see citing works
The GABAA receptor mediates the hypnotic activity of melatonin in rats
Wang, F., Li, J.-C., Wu, C., Yang, J., Xu, F., & Zhao, Q. (2003) · Pharmacology Biochemistry and Behavior · doi:10.1016/s0091-3057(02)01045-6 · Cited by 79 · see citing works
Melatonin reduces body weight gain and increases nocturnal activity in male Wistar rats.
Terrón, M., Delgado-Adámez, J., Pariente, J., Barriga, C., Paredes, S., & Rodríguez, A. B. (2013) · Physiology and Behavior · doi:10.1016/j.physbeh.2013.04.006 · Cited by 77 · see citing works
Luengo, E., Buendía, I., Fernández‐Mendívil, C., Trigo-Alonso, P., Negredo, P., Michalska, P., Hernández-García, B. J., Sánchez‐Ramos, C., Bernal, J. A., Ikezu, T., et al. (2019) · Journal of Pineal Research · doi:10.1111/jpi.12578 · Cited by 76 · see citing works
Melatonin supplementation to treat the metabolic syndrome: a randomized controlled trial
Goyal, A., Terry, P., Superak, H. M., Nell‐Dybdahl, C., Chowdhury, R., Phillips, L. S., & Kutner, M. H. (2014) · Diabetology & Metabolic Syndrome · doi:10.1186/1758-5996-6-124 · Cited by 74 · see citing works
Underwood, E. L., & Thompson, L. T. (2015) · Neural Plasticity · doi:10.1155/2016/7385314 · Cited by 69 · see citing works
Salmanoglu, D. S., Gürpınar, T., Vural, K., Ekerbiçer, N., Darıverenli, E., & Var, A. (2016) · Redox Biology · doi:10.1016/j.redox.2015.11.007 · Cited by 67 · see citing works
Metabolic Syndrome, its Pathophysiology and the Role of Melatonin
Srinivasan, V., Ohta, Y., Espino, J., Pariente, J. A., Rodríguez, A. B., Mohamed, M., & Zakaria, R. (2012) · Recent Patents on Endocrine Metabolic & Immune Drug Discovery · doi:10.2174/187221413804660953 · Cited by 65 · see citing works
Protective effect of melatonin on β-cell damage in streptozotocin-induced diabetes in rats
Yavuz, Ö., Çam, M., Bukan, N. C., Güven, A., & Sılan, F. (2003) · Acta Histochemica · doi:10.1078/0065-1281-00711 · Cited by 62 · see citing works
Onaolapo, A. Y., Ayeni, O. J., Ogundeji, M. O., Ajao, A. A., Onaolapo, O. J., & Owolabi, R. A. (2018) · Journal of Chemical Neuroanatomy · doi:10.1016/j.jchemneu.2018.12.002 · Cited by 60 · see citing works
Self-citationOnaolapo, A. Y., Aina, O. A., & Onaolapo, O. J. (2017) · Biomedicine & Pharmacotherapy · doi:10.1016/j.biopha.2017.05.094 · Cited by 58 · see citing works
Self-citationOnaolapo, O. J., Adekola, M. A., Azeez, T. O., Salami, K., & Onaolapo, A. Y. (2016) · Biomedicine & Pharmacotherapy · doi:10.1016/j.biopha.2016.11.033 · Cited by 56 · see citing works
Self-citationLeptin's Sexual Dimorphism Results from Genotype by Sex Interactions Mediated by Testosterone
Martin, L. J., Mahaney, M. C., Almasy, L. A., MacCluer, J. W., Blangero, J., Jaquish, C. E., & Comuzzie, A. G. (2002) · Obesity Research · doi:10.1038/oby.2002.3 · Cited by 55 · see citing works
Cardinali, D. P., Bernasconi, P., Reynoso, R., Toso, C., & Scacchi, P. A. (2013) · International Journal of Molecular Sciences · doi:10.3390/ijms14022502 · Cited by 54 · see citing works
High-fat diet consumption alters energy metabolism in the mouse hypothalamus
Lizarbe, B., Cherix, A., Duarte, J. M. N., Cardinaux, J., & Rolf Gruetter, A. (2018) · International Journal of Obesity · doi:10.1038/s41366-018-0224-9 · Cited by 53 · see citing works
Li, L., Zhao, Z., Xia, J., Xin, L., Chen, Y., Yang, S., & Li, K. (2015) · PLoS ONE · doi:10.1371/journal.pone.0142884 · Cited by 50 · see citing works
White, P. A. S., Cercato, L. M., Araújo, J. M. D., de Souza, L. A. J., Soares, A. F., Barbosa, A. P. O., Neto, J., Marçal, A. C., Machado, U. F., Camargo, E. A., et al. (2013) · Arquivos Brasileiros de Endocrinologia & Metabologia · doi:10.1590/s0004-27302013000500002 · Cited by 48 · see citing works
Abadi, S. H. M. H., Shirazi, A., Alizadeh, A. M., Changizi, V., Najafi, M., Khalighfard, S., & Nosrati, H. (2018) · Current Molecular Pharmacology · doi:10.2174/1874467211666180830150154 · Cited by 42 · see citing works
Effects of melatonin on biochemical factors and food and water consumption in diabetic rats
Hadjzadeh, M., Bibak, B., Khalili, M., Rajaei, Z., Soukhtanloo, M., & Hayatdavoudi, P. (2014) · Advanced Biomedical Research · doi:10.4103/2277-9175.139191 · Cited by 39 · see citing works
Lo, C., Lin, S., Chang, J., & Chien, Y. (2017) · Nutrients · doi:10.3390/nu9111187 · Cited by 36 · see citing works
Kim, S., Song, Y., Lee, J. E., Jun, S., Shin, S., Wie, G.-A., Cho, Y. H., & Joung, H. (2017) · Nutrients · doi:10.3390/nu9101055 · Cited by 35 · see citing works
Lorenzo, C. D., Dell’Agli, M., Colombo, E., Sangiovanni, E., & Restani, P. (2013) · Evidence-based Complementary and Alternative Medicine · doi:10.1155/2013/782461 · Cited by 34 · see citing works
Onaolapo, O. J., & Onaolapo, A. Y. (2017) · Birth Defects Research · doi:10.1002/bdr2.1171 · Cited by 31 · see citing works
Self-citationOnaolapo, O. J., Onaolapo, A. Y., Akanmu, M. A., & Olayiwola, G. (2016) · AIMS neuroscience · doi:10.3934/neuroscience.2016.3.317 · Cited by 29 · see citing works
Self-citationEndocannabinoids and Metabolic Disorders
Gatta‐Cherifi, B., & Cota, D. (2015) · Handbook of experimental pharmacology · doi:10.1007/978-3-319-20825-1_13 · Cited by 26 · see citing works
Akçay, Y., Yalçın, A., & Sözmen, E. Y. (2005) · PubMed · Cited by 23 · see citing works
Kuş, I., Sarsılmaz, M., Çolakoğlu, N., Kükner, A., Özen, O. A., Yılmaz, B., & Keleştimur, H. (2004) · Physiological Research · doi:10.33549/physiolres.930478 · Cited by 23 · see citing works
Endogenous Melatonin and Epileptogenesis: Facts and Hypothesis
Stewart, L. S. (2001) · International Journal of Neuroscience · doi:10.3109/00207450109149758 · Cited by 22 · see citing works
The effect of dietary fat on behavior in mice
Keleher, M. R., Zaidi, R., Patel, K., Ahmed, A. A. B., Bettler, C., Pavlatos, C., Shah, S., & Cheverud, J. M. (2018) · Journal of Diabetes & Metabolic Disorders · doi:10.1007/s40200-018-0373-3 · Cited by 19 · see citing works
Central depressant and nootropic effects of daytime melatonin in mice
Onaolapo, O. J., Onaolapo, A. Y., Abiola, A. A., & Lillian, E. A. (2014) · Annals of Neurosciences · doi:10.5214/ans.0972.7531.210304 · Cited by 18 · see citing works
Self-citationOnaolapo, A. Y., Adebayo, A. N., & Onaolapo, O. J. (2016) · Naunyn-Schmiedeberg s Archives of Pharmacology · doi:10.1007/s00210-016-1314-7 · Cited by 18 · see citing works
Self-citationOnaolapo, A. Y., Onaolapo, O. J., & Adewole, S. O. (2011) · Macedonian Journal of Medical Sciences · doi:10.3889/mjms.1857-5773.2011.0172 · Cited by 17 · see citing works
Self-citationMozaffari, S., Hasani-Ran, S., & Abdollahi, M. R. (2012) · International Journal of Pharmacology · doi:10.3923/ijp.2012.496.509 · Cited by 14 · see citing works
Ran, D., Xie, B., Gan, Z., Sun, X., Gu, H., & Yang, J. (2018) · Biomedical Reports · doi:10.3892/br.2018.1125 · Cited by 13 · see citing works
Onaolapo, A. Y., & Onaolapo, O. J. (2018) · Annals of Medical Research · doi:10.5455/annalsmedres.2018.06.118 · Cited by 7 · see citing works
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- Authors
- Onaolapo, A. Y., Adebisi, E. O., Adeleye, A. E., Olofinnade, A. T., & Onaolapo, O. J.
- Affiliations
- Ladoke Akintola University of Technology (NG)
- Lagos State University (NG)
- Corresponding author
- Onaolapo, Olakunle James
- Venue
- Endocrine, Metabolic & Immune Disorders - Drug Targets
- Publisher
- Bentham Science Publishers Ltd.
- Published
- 2020-05-18
- Volume
- 20
- Issue
- 4
- Pages
- 570-583
- ISSN
- 1871-5303 (ISSN-L)
- OpenAlex
- W3010004388
- Cited by
- 20
- References
- 61
- Citations by year
- 2026: 1 · 2025: 3 · 2024: 3 · 2023: 6 · 2022: 3 · 2021: 4
- FWCI
- 1.67
- Type
- journal article
- Language
- en
- Open access
- closed
- Locations
- Endocrine Metabolic & Immune Disorders - Drug Targets (publishedVersion)
- PubMed (publishedVersion)
- Topics
- Life Sciences › Neuroscience › Endocrine and Autonomic Systems › Circadian rhythm and melatonin
- Life Sciences › Neuroscience › Endocrine and Autonomic Systems › Regulation of Appetite and Obesity
- Health Sciences › Medicine › Physiology › Dietary Effects on Health
- Keywords
- dietary melatonin, high-fat high-sugar diet, metabolic syndrome, oxidative stress, spatial working memory, insulin, leptin, adiponectin, malondialdehyde, superoxide dismutase, organ histopathology, liver injury, kidney injury, brain injury, body weight
- MeSH terms
- Dietary Sugars, Animals, Antioxidants, Blood Glucose, Body Weight, Brain, Eating, Exploratory Behavior, Kidney, Liver, Male, Melatonin, Random Allocation, Oxidative Stress, Mice, Diet, High-Fat
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