Bidirectional ephrinB2-EphB4 signaling controls bone homeostasis

Rho GTPases in cell biology

Etienne-Manneville, S., & Hall, A. (2002) · Nature · doi:10.1038/nature01148 · Cited by 4,965

Osf2/Cbfa1: A Transcriptional Activator of Osteoblast Differentiation

Ducy, P., Zhang, R., Geoffroy, V., Ridall, A. L., & Karsenty, G. (1997) · Cell · doi:10.1016/s0092-8674(00)80257-3 · Cited by 4,246

Targeted Disruption of Results in a Complete Lack of Bone Formation owing to Maturational Arrest of Osteoblasts

Komori, T., Yagi, H., Nomura, S., Yamaguchi, A., Sasaki, K., Deguchi, K., Shimizu, Y., Bronson, R. T., Gao, Y.-H., Inada, M., et al. (1997) · Cell · doi:10.1016/s0092-8674(00)80258-5 · Cited by 4,244

Cell Shape, Cytoskeletal Tension, and RhoA Regulate Stem Cell Lineage Commitment

McBeath, R., Pirone, D. M., Nelson, C. M., Bhadriraju, K., & Chen, C. S. (2004) · Developmental Cell · doi:10.1016/s1534-5807(04)00075-9 · Cited by 4,182

The Novel Zinc Finger-Containing Transcription Factor Osterix Is Required for Osteoblast Differentiation and Bone Formation

Nakashima, K., Zhou, X., Kunkel, G., Zhang, Z., Deng, J. M., Behringer, R. R., & de Crombrugghe, B. (2002) · Cell · doi:10.1016/s0092-8674(01)00622-5 · Cited by 3,608

Induction and Activation of the Transcription Factor NFATc1 (NFAT2) Integrate RANKL Signaling in Terminal Differentiation of Osteoclasts

Takayanagi, H., Kim, S., Koga, T., Nishina, H., Isshiki, M., Yoshida, H., Saiura, A., Isobe, M., Yokochi, T., Inoue, J.-I., et al. (2002) · Developmental Cell · doi:10.1016/s1534-5807(02)00369-6 · Cited by 2,701

Conditional gene targeting in macrophages and granulocytes using LysMcre mice

Clausen, B. E., Burkhardt, C., Reith, W., Renkawitz, R., & Förster, I. (1999) · Transgenic Research · doi:10.1023/a:1008942828960 · Cited by 2,098

Genetic regulation of osteoclast development and function

Teitelbaum, S. L., & Ross, F. P. (2003) · Nature Reviews Genetics · doi:10.1038/nrg1122 · Cited by 1,720

Molecular Distinction and Angiogenic Interaction between Embryonic Arteries and Veins Revealed by ephrin-B2 and Its Receptor Eph-B4

Wang, H. U., Chen, Z., & Anderson, D. J. (1998) · Cell · doi:10.1016/s0092-8674(00)81436-1 · Cited by 1,684

Reaching a Genetic and Molecular Understanding of Skeletal Development

Karsenty, G., & Wagner, E. F. (2002) · Developmental Cell · doi:10.1016/s1534-5807(02)00157-0 · Cited by 1,611

Progressive ankylosis protein (ANK) in osteoblasts and osteoclasts controls bone formation and bone remodeling

Kim, H. J., Minashima, T., McCarthy, E. F., Winkles, J. A., & Kirsch, T. (2010) · Journal of Bone and Mineral Research · doi:10.1002/jbmr.60 · Cited by 69

CHMP5 controls bone turnover rates by dampening NF-κB activity in osteoclasts

Greenblatt, M. B., Park, K. H., Oh, H., Kim, J., Shin, D. Y., Lee, J. M., Lee, J. W., Singh, A., Lee, K.-Y., Hu, D. Z., et al. (2015) · The Journal of Experimental Medicine · doi:10.1084/jem.20150407 · Cited by 70

Targeting receptor tyrosine kinase EphB4 in cancer therapy

Chen, Y., Zhang, H., & Zhang, Y. (2017) · Seminars in Cancer Biology · doi:10.1016/j.semcancer.2017.10.002 · Cited by 70

Effects of anti-tumor necrosis factor α agents on bone

Kawai, V. K., Stein, C., Perrien, D. S., & Griffin, M. R. (2012) · Current Opinion in Rheumatology · doi:10.1097/bor.0b013e328356d212 · Cited by 70

Intermittent PTH Administration Stimulates Pre-Osteoblastic Proliferation Without Leading to Enhanced Bone Formation in Osteoclast-Less c-fos−/− Mice

de Freitas, P. H. L., Li, M., Ninomiya, T., Nakamura, M., Sobhan, U., Oda, K., Udagawa, N., Maeda, T., Takagi, R., & Amizuka, N. (2009) · Journal of Bone and Mineral Research · doi:10.1359/jbmr.090413 · Cited by 66

The Role of Bone-Derived Exosomes in Regulating Skeletal Metabolism and Extraosseous Diseases

Lyu, H., Xiao, Y., Guo, Q., Huang, Y., & Luo, X. (2020) · Frontiers in Cell and Developmental Biology · doi:10.3389/fcell.2020.00089 · Cited by 66

Novel insights into the coupling of osteoclasts and resorption to bone formation

Durdan, M., Azaria, R. D., & Weivoda, M. M. (2021) · Seminars in Cell and Developmental Biology · doi:10.1016/j.semcdb.2021.10.008 · Cited by 69

Controlling hypoxia-inducible factor-2α is critical for maintaining bone homeostasis in mice

Lee, S. Y., Park, K. H., Yu, H.-G., Kook, E., Song, W., Lee, G., Koh, J., Shin, H., Choi, J., Huh, Y. H., et al. (2019) · Bone Research · doi:10.1038/s41413-019-0054-y · Cited by 63

Crosstalk between skeletal and neural tissues is critical for skeletal health

Abeynayake, N., Arthur, A., & Gronthos, S. (2020) · Bone · doi:10.1016/j.bone.2020.115645 · Cited by 65

From Stem Cells to Bone-Forming Cells

Donsante, S., Palmisano, B., Serafini, M., Robey, P. G., Corsi, A., & Riminucci, M. (2021) · International Journal of Molecular Sciences · doi:10.3390/ijms22083989 · Cited by 66

MicroRNAs Regulate Vascular Medial Calcification

Leopold, J. A. (2014) · Cells · doi:10.3390/cells3040963 · Cited by 65

An integrated multi-omics analysis reveals osteokines involved in global regulation

Liang, W., Wei, T., Hu, L., Chen, M., Tong, L., Zhou, W., Duan, X., Zhao, X., Zhou, W., Jiang, Q., et al. (2024) · Cell Metabolism · doi:10.1016/j.cmet.2024.03.006 · Cited by 67

Eph- and ephrin-dependent mechanisms in tumor and stem cell dynamics

Gucciardo, E., Sugiyama, N., & Lehti, K. (2014) · Cellular and Molecular Life Sciences · doi:10.1007/s00018-014-1633-0 · Cited by 59

Growth and differentiation of a long bone in limb development, repair and regeneration

Egawa, S., Miura, S., Yokoyama, H., Endo, T., & Tamura, K. (2014) · Development Growth & Differentiation · doi:10.1111/dgd.12136 · Cited by 59

A 3D Vascularized Bone Remodeling Model Combining Osteoblasts and Osteoclasts in a CaP Nanoparticle-Enriched Matrix

Bongio, M., Lopa, S., Gilardi, M., Bersini, S., & Moretti, M. (2016) · Nanomedicine · doi:10.2217/nnm-2015-0021 · Cited by 59

Bisphosphonate-related osteonecrosis of the jaw: a mechanobiology perspective

George, E. L., Lin, Y., & Saunders, M. M. (2018) · Bone Reports · doi:10.1016/j.bonr.2018.03.003 · Cited by 64

Osteoclasts and osteoarthritis: Novel intervention targets and therapeutic potentials during aging

Wang, H., Yuan, T., Wang, Y., Liu, C., Li, D., Li, Z., & Sun, S. (2024) · Aging Cell · doi:10.1111/acel.14092 · Cited by 64

Does complement play a role in bone development and regeneration?

Schoengraf, P., Lambris, J. D., Recknagel, S., Kreja, L., Liedert, A., Brenner, R. E., Huber-Lang, M. S., & Ignatius, A. A. (2012) · Immunobiology · doi:10.1016/j.imbio.2012.01.020 · Cited by 57

Osteoblastic Wnts differentially regulate bone remodeling and the maintenance of bone marrow mesenchymal stem cells

Wan, Y., Lu, C. Y., Cao, J., Zhou, R., Yao, Y., Yu, J., Zhang, L., Zhao, H., Li, H., Zhao, J., et al. (2013) · Bone · doi:10.1016/j.bone.2012.12.052 · Cited by 55

Regulation of cell differentiation by Eph receptor and ephrin signaling

Wilkinson, D. G. (2014) · Cell Adhesion & Migration · doi:10.4161/19336918.2014.970007 · Cited by 57

High levels of ephrinB2 over-expression increases the osteogenic differentiation of human mesenchymal stem cells and promotes enhanced cell mediated mineralisation in a polyethyleneimine-ephrinB2 gene-activated matrix

Tierney, E. G., McSorley, K., Hastings, C. L., Cryan, S., O’Brien, T., Murphy, M. J., Barry, F., O’Brien, F. J., & Duffy, G. P. (2012) · Journal of Controlled Release · doi:10.1016/j.jconrel.2012.11.013 · Cited by 56

Nociceptor-Expressed Ephrin-B2 Regulates Inflammatory and Neuropathic Pain

Zhao, J., Yuan, G., Cendán, C. M., Nassar, M. A., Lagerström, M. C., Kullander, K., Gavazzi, I., & Wood, J. N. (2010) · Molecular Pain · doi:10.1186/1744-8069-6-77 · Cited by 56

Adipose-Derived Stem Cells Enhance Bone Regeneration in Vascular Necrosis of the Femoral Head in the Rabbit

Aimaiti, A., Aihemaitijiang, Y., Wang, Y.-H., Cui, L., Maimaitiming, S., & Abulikemu, M. (2011) · Journal of International Medical Research · doi:10.1177/147323001103900528 · Cited by 56

Targeting Bone Remodeling for the Treatment of Osteoporosis: Summary of the Proceedings of an ASBMR Workshop

Bilezikian, J. P., Matsumoto, T., Bellido, T., Khosla, S., Martin, J. W., Recker, R. R., Heaney, R. P., Seeman, E., Papapoulos, S. E., & Goldring, S. R. (2009) · Journal of Bone and Mineral Research · doi:10.1359/jbmr.090105 · Cited by 59

Osteoclast regulation of osteoblasts via RANK-RANKL reverse signal transduction in vitro

Zhang, S., Wang, X., Li, G., Chong, Y., Zhang, J., Guo, X., Li, B., & Bi, Z. (2017) · Molecular Medicine Reports · doi:10.3892/mmr.2017.7039 · Cited by 56

Cell fusion in osteoclasts plays a critical role in controlling bone mass and osteoblastic activity

Iwasaki, R., Ninomiya, K., Miyamoto, K., Suzuki, T., Sato, Y., Kawana, H., Nakagawa, T., Suda, T., & Miyamoto, T. K. (2008) · Biochemical and Biophysical Research Communications · doi:10.1016/j.bbrc.2008.10.076 · Cited by 57

Alendronate Affects Osteoblast Functions by Crosstalk through EphrinB1-EphB

Shimizu, E., Tamasi, J. A., & Partridge, N. C. (2011) · Journal of Dental Research · doi:10.1177/0022034511432170 · Cited by 55

Efnb1 and Efnb2 Proteins Regulate Thymocyte Development, Peripheral T Cell Differentiation, and Antiviral Immune Responses and Are Essential for Interleukin-6 (IL-6) Signaling

Luo, H., Charpentier, T., Wang, X., Qi, S., Han, B., Wu, T., Terra, R., Lamarre, A., & Wu, J. (2011) · Journal of Biological Chemistry · doi:10.1074/jbc.m111.302596 · Cited by 54

Coexistence of Eph receptor B1 and ephrin B2 in port-wine stain endothelial progenitor cells contributes to clinicopathological vasculature dilatation

Tan, W., Wang, J., Zhou, F., Gao, L., Yin, R., Liu, H., Sukanthanag, A., Wang, G., Mihm, M. C., Chen, D.-B., et al. (2017) · British Journal of Dermatology · doi:10.1111/bjd.15716 · Cited by 55

Pharmacological agents for bone fracture healing: talking points from recent clinical trials

Migliorini, F., Cocconi, F., Vecchio, G., Schäfer, L., Koettnitz, J., & Maffulli, N. (2023) · Expert Opinion on Investigational Drugs · doi:10.1080/13543784.2023.2263352 · Cited by 54

Dancing with the dead: Eph receptors and their kinase-null partnersThis paper is one of a selection of papers published in a Special Issue entitled CSBMCB 53rd Annual Meeting — Membrane Proteins in Health and Disease, and has undergone the Journal’s usual peer review process.

Truitt, L., & Freywald, A. (2011) · Biochemistry and Cell Biology · doi:10.1139/o10-145 · Cited by 54

Ephrin B2/EphB4 Mediates the Actions of IGF-I Signaling in Regulating Endochondral Bone Formation

Wang, Y., Menendez, A., Fong, C., Elalieh, H. Z., Chang, W., & Bikle, D. D. (2014) · Journal of Bone and Mineral Research · doi:10.1002/jbmr.2196 · Cited by 54

Chitosan-gold nanoparticles mediated gene delivery of c-myb facilitates osseointegration of dental implants in ovariectomized rat

Takanche, J. S., Kim, J.-E., Kim, J., Lee, M., Jeon, J., Park, I., & Yi, H. (2018) · Artificial Cells Nanomedicine and Biotechnology · doi:10.1080/21691401.2018.1513940 · Cited by 56

The Crosstalk between Osteoclasts and Osteoblasts Is Dependent upon the Composition and Structure of Biphasic Calcium Phosphates

Shiwaku, Y., Neff, L., Nagano, K., Takeyama, K., de Bruijn, J. D., Dard, M. M., Gori, F., & Baron, R. (2015) · PLoS ONE · doi:10.1371/journal.pone.0132903 · Cited by 53

Osteoblastogenesis and tumor growth in myeloma

Yaccoby, S. (2009) · Leukemia & lymphoma/Leukemia and lymphoma · doi:10.3109/10428190903503438 · Cited by 52

Cell interactions in bone tissue engineering

Pirraco, R. P., Marques, A. P., & Reis, R. L. (2009) · Journal of Cellular and Molecular Medicine · doi:10.1111/j.1582-4934.2009.01005.x · Cited by 54

Effect of age on biomaterial-mediated in situ bone tissue regeneration

Liu, M., Nakasaki, M., Shih, Y.-R. V., & Varghese, S. (2018) · Acta Biomaterialia · doi:10.1016/j.actbio.2018.06.035 · Cited by 52

Eph receptor tyrosine kinases in cancer stem cells

Chen, J., Song, W., & Amato, K. R. (2014) · Cytokine & Growth Factor Reviews · doi:10.1016/j.cytogfr.2014.05.001 · Cited by 51

Mechanisms of multiple myeloma bone disease

Galson, D. L., Silbermann, R. W., & Roodman, G. D. (2012) · BoneKEy Reports · doi:10.1038/bonekey.2012.135 · Cited by 50

Galectin-3 as a novel regulator of osteoblast-osteoclast interaction and bone homeostasis

Simon, D., Derer, A., Andes, F. T., Lezuo, P., Bözec, A., Schett, G. A., i, M. H., & Harre, U. (2017) · Bone · doi:10.1016/j.bone.2017.08.013 · Cited by 51

Bioinspired Glycopeptide Hydrogel Reestablishing Bone Homeostasis through Mediating Osteoclasts and Osteogenesis in Periodontitis Treatment

Zhao, Z., Wu, C., Huangfu, Y., Zhang, Y., Zhang, J., Huang, P., Dong, A., Wang, Y., Deng, J., Wang, W., et al. (2024) · ACS Nano · doi:10.1021/acsnano.4c05677 · Cited by 51

Activation of the receptor EphB4 by its specific ligand ephrin B2 in human osteoarthritic subchondral bone osteoblasts

Tat, S. K., Pelletier, J., Amiable, N., Boileau, C., Lajeunesse, D., Duval, N., & Martel‐Pelletier, J. (2008) · Arthritis & Rheumatism · doi:10.1002/art.24029 · Cited by 50

Molecular signaling in bone cells: Regulation of cell differentiation and survival

Plotkin, L. I., & Bruzzaniti, A. (2019) · Advances in protein chemistry and structural biology · doi:10.1016/bs.apcsb.2019.01.002 · Cited by 50

Pathogenesis and Treatment of Myeloma-Related Bone Disease

Gau, Y.-C., Yeh, T.-J., Hsu, C.-M., Hsiao, S. Y., & Hsiao, H.-H. (2022) · International Journal of Molecular Sciences · doi:10.3390/ijms23063112 · Cited by 48

Osteoclastic activity induces osteomodulin expression in osteoblasts

Ninomiya, K., Miyamoto, T. K., Imai, J., Fujita, N., Suzuki, T., Iwasaki, R., Yagi, M., Watanabe, S., Toyama, Y., & Suda, T. (2007) · Biochemical and Biophysical Research Communications · doi:10.1016/j.bbrc.2007.07.193 · Cited by 52

Strain-dependent Up-regulation of Ephrin-B2 Protein in Periodontal Ligament Fibroblasts Contributes to Osteogenesis during Tooth Movement

Diercke, K., Kohl, A., Lux, C. J., & Erber, R. (2011) · Journal of Biological Chemistry · doi:10.1074/jbc.m110.166900 · Cited by 50

Shear stress inhibits IL-17A-mediated induction of osteoclastogenesis via osteocyte pathways

Liao, C., Cheng, T., Wang, S., Zhang, C., Jin, L., & Yang, Y. (2017) · Bone · doi:10.1016/j.bone.2017.04.003 · Cited by 49

Insulin Like Growth Factor-I: A Critical Mediator of the Skeletal Response to Parathyroid Hormone

Bikle, D. D., & Wang, Y. (2012) · Current Molecular Pharmacology · doi:10.2174/1874467211205020135 · Cited by 49

Bone Marrow Mesenchymal Stromal Cells in Multiple Myeloma: Their Role as Active Contributors to Myeloma Progression

Maiso, P., Mogollón, P., Ocio, E. M., & Garayoa, M. (2021) · Cancers · doi:10.3390/cancers13112542 · Cited by 48

EphB4 enhances the process of endochondral ossification and inhibits remodeling during bone fracture repair

Arthur, A., Panagopoulos, R. A., Cooper, L., Menicanin, D., Parkinson, I. H., Codrington, J. D., Vandyke, K., Zannettino, A. C. W., Koblar, S. A., Sims, N. A., et al. (2012) · Journal of Bone and Mineral Research · doi:10.1002/jbmr.1821 · Cited by 48

Role of Osteocytes in Myeloma Bone Disease: Anti-sclerostin Antibody as New Therapeutic Strategy

Toscani, D., Bolzoni, M., Ferretti, M., Palumbo, C., & Giuliani, N. (2018) · Frontiers in Immunology · doi:10.3389/fimmu.2018.02467 · Cited by 49

Absence of Dipeptidyl Peptidase 3 Increases Oxidative Stress and Causes Bone Loss

Menale, C., Robinson, L. J., Palagano, E., Rigoni, R., Erreni, M., Almarza, A. J., Strina, D., Mantero, S., Lizier, M., Forlino, A., et al. (2019) · Journal of Bone and Mineral Research · doi:10.1002/jbmr.3829 · Cited by 48

Eph/ephrinB Mediate Dental Pulp Stem Cell Mobilization and Function

Arthur, A., Koblar, S. A., Shi, S., & Gronthos, S. (2009) · Journal of Dental Research · doi:10.1177/0022034509342363 · Cited by 48

Regulation of Osteoclastogenesis and Bone Resorption by miRNAs

Inoue, K., Ng, C., Xia, Y., & Zhao, B. (2021) · Frontiers in Cell and Developmental Biology · doi:10.3389/fcell.2021.651161 · Cited by 50

Osteoblast-specific Angiopoietin 1 overexpression increases bone mass

Suzuki, T., Miyamoto, T. K., Fujita, N., Ninomiya, K., Iwasaki, R., Toyama, Y., & Suda, T. (2007) · Biochemical and Biophysical Research Communications · doi:10.1016/j.bbrc.2007.08.099 · Cited by 47

Eph receptors: New players in Alzheimer's disease pathogenesis

Cissé, M., & Checler, F. (2014) · Neurobiology of Disease · doi:10.1016/j.nbd.2014.08.028 · Cited by 50

Exosomes from the tumor microenvironment as reciprocal regulators that enhance prostate cancer progression

Liu, C., Hsieh, C., Shen, C., Lin, C., Shigemura, K., & Sung, S. (2016) · International Journal of Urology · doi:10.1111/iju.13145 · Cited by 47

Eph-Ephrin Signaling Mediates Cross-Talk Within the Bone Microenvironment

Arthur, A., & Gronthos, S. (2021) · Frontiers in Cell and Developmental Biology · doi:10.3389/fcell.2021.598612 · Cited by 47

PI3K/AKT Pathway Involvement in the Osteogenic Effects of Osteoclast Culture Supernatants on Preosteoblast Cells

Chen, L., Huang, M., Tan, J., Chen, X.-T., Lei, L., Wu, Y., & Zhang, D.-Y. (2013) · Tissue Engineering Part A · doi:10.1089/ten.tea.2012.0469 · Cited by 47

Novel Genetic Variants Associated With Increased Vertebral Volumetric BMD, Reduced Vertebral Fracture Risk, and Increased Expression of SLC1A3 and EPHB2

Nielson, C. M., Liu, C., Smith, A. V., Ackert‐Bicknell, C. L., Reppe, S., Jakobsdóttir, J., Wassel, C. L., Register, T. C., Oei, L., Alonso, N., et al. (2016) · Journal of Bone and Mineral Research · doi:10.1002/jbmr.2913 · Cited by 47

Tumor necrosis factor‐alpha inhibits osteogenic differentiation of pre‐osteoblasts by downregulation of EphB4 signaling via activated nuclear factor‐kappaB signaling pathway

Wang, L., Zhao, N., Zhang, J., Sun, Q. F., Yang, C., & Yang, P. (2017) · Journal of Periodontal Research · doi:10.1111/jre.12488 · Cited by 46

Regulatory mechanisms of sclerostin expression during bone remodeling

Koide, M., & Kobayashi, Y. (2018) · Journal of Bone and Mineral Metabolism · doi:10.1007/s00774-018-0971-7 · Cited by 47

Modeling and Remodeling

Seeman, E. (2008) · Elsevier eBooks · doi:10.1016/b978-0-12-373884-4.00023-9 · Cited by 47

The Osteoclast Traces the Route to Bone Tumors and Metastases

Russo, S., di Carlo, F. S., & Gianfrancesco, F. (2022) · Frontiers in Cell and Developmental Biology · doi:10.3389/fcell.2022.886305 · Cited by 50

The roles of bone remodeling in normal hematopoiesis and age-related hematological malignancies

Zhang, H., Liesveld, J. L., Calvi, L. M., Lipe, B. C., Xing, L., Becker, M. W., Schwarz, E. M., & Yeh, S.-C. A. (2023) · Bone Research · doi:10.1038/s41413-023-00249-w · Cited by 48

Bone Physiology and Biology

Gasser, J. A., & Kneissel, M. (2017) · Molecular and integrative toxicology · doi:10.1007/978-3-319-56192-9_2 · Cited by 53

β-Arrestin2 Regulates RANKL and Ephrins Gene Expression in Response to Bone Remodeling in Mice

Pierroz, D. D., Rufo, A., Bianchi, E. N., Glatt, V., Capulli, M., Rucci, N., Cavat, F., Rizzoli, R., Teti, A. M., Bouxsein, M., et al. (2008) · Journal of Bone and Mineral Research · doi:10.1359/jbmr.081237 · Cited by 46

Enhanced ectopic bone formation by strontium-substituted calcium phosphate ceramics through regulation of osteoclastogenesis and osteoblastogenesis

Chen, F., Tian, L., Pu, X., Zeng, Q., Xiao, Y., Chen, X., & Zhang, X. (2022) · Biomaterials Science · doi:10.1039/d2bm00348a · Cited by 44

Measles virus nucleocapsid protein increases osteoblast differentiation in Paget’s disease

Teramachi, J., Nagata, Y., Mohammad, K. S., Inagaki, Y., Ohata, Y., Guise, T. A., Michou, L., Brown, J. P., Windle, J. J., Kurihara, N., et al. (2016) · Journal of Clinical Investigation · doi:10.1172/jci82012 · Cited by 46

Effect of calcium phosphate phases affecting the crosstalk between osteoblasts and osteoclasts in vitro

Shiwaku, Y., Tsuchiya, K., Xiao, L., & Suzuki, O. (2019) · Journal of Biomedical Materials Research Part A · doi:10.1002/jbm.a.36626 · Cited by 44

Impact of simultaneous hydrolysis of OCP and PLGA on bone induction of a PLGA-OCP composite scaffold in a rat femoral defect

Oizumi, I., Hamai, R., Shiwaku, Y., Mori, Y., Anada, T., Baba, K., Miyatake, N., Hamada, S., Tsuchiya, K., Nishimura, S., et al. (2021) · Acta Biomaterialia · doi:10.1016/j.actbio.2021.01.048 · Cited by 44

Bone circuitry and interorgan skeletal crosstalk

Zaidi, M., Kim, S.-M., Mathew, M., Korkmaz, F., Sultana, F., Miyashita, S., Gumerova, A. A., Frolinger, T., Moldavski, O., Barak, O., et al. (2023) · eLife · doi:10.7554/elife.83142 · Cited by 45

Interleukin-9 Facilitates Osteoclastogenesis in Rheumatoid Arthritis

Kar, S., Gupta, R., Malhotra, R., Sharma, V., Farooque, K., Kumar, V. L., Chakraborty, S., & Mitra, D. K. (2021) · International Journal of Molecular Sciences · doi:10.3390/ijms221910397 · Cited by 41

Ephrin-B1 Is a Novel Specific Component of the Lateral Membrane of the Cardiomyocyte and Is Essential for the Stability of Cardiac Tissue Architecture Cohesion

Genet, G., Guilbeau‐Frugier, C., Honton, B., Dague, É., Schneider, M. D., Coatrieux, C., Calise, D., Cardin, C., Nieto, C., Payré, B., et al. (2012) · Circulation Research · doi:10.1161/circresaha.111.262451 · Cited by 43

Afamin secreted from nonresorbing osteoclasts acts as a chemokine for preosteoblasts via the Akt-signaling pathway

Kim, B., Lee, Y., Lee, S.-Y., Park, S., Dieplinger, H., Ryu, S. H., Yea, K., Choi, S., Lee, S. H., Koh, J., et al. (2012) · Bone · doi:10.1016/j.bone.2012.06.015 · Cited by 42

Activation of EphA4 and EphB2 Reverse Signaling Restores the Age-Associated Reduction of Self-Renewal, Migration, and Actin Turnover in Human Tendon Stem/Progenitor Cells

Popov, C., Kohler, J., & Docheva, D. (2016) · Frontiers in Aging Neuroscience · doi:10.3389/fnagi.2015.00246 · Cited by 42

Genome-wide association study provides insights into genes related with horn development in Nelore beef cattle

Stafuzza, N. B., Silva, R. M. D. O., Peripolli, E., Bezerra, L. A. F., Lôbo, R. B., Magnabosco, C. D. U., Croce, F. A. D., Osterstock, J. B., Munari, D. P., Lourenco, D. A. L., et al. (2018) · PLoS ONE · doi:10.1371/journal.pone.0202978 · Cited by 41

Targeted Disruption of Ephrin B1 in Cells of Myeloid Lineage Increases Osteoclast Differentiation and Bone Resorption in Mice

Cheng, S., Zhao, S. L., Nelson, B., Kesavan, C., Qin, X., Wergedal, J. E., Mohan, S., & Xing, W. (2012) · PLoS ONE · doi:10.1371/journal.pone.0032887 · Cited by 41

Multiple myeloma mesenchymal stromal cells: Contribution to myeloma bone disease and therapeutics

García-Gómez, A. (2014) · World Journal of Stem Cells · doi:10.4252/wjsc.v6.i3.322 · Cited by 43

The essential role of osteoclast-derived exosomes in magnetic nanoparticle-infiltrated hydroxyapatite scaffold modulated osteoblast proliferation in an osteoporosis model

Zhu, Y. F., Li, Z., Zhang, Y., Lan, F., He, J. H., & Wu, Y. (2020) · Nanoscale · doi:10.1039/d0nr00867b · Cited by 41

Osteoblasts, Osteoclasts, and Osteocytes: Unveiling Their Intimate-Associated Responses to Applied Orthodontic Forces

Lerner, U. H. (2012) · Seminars in Orthodontics · doi:10.1053/j.sodo.2012.06.002 · Cited by 49

PEGylation Potentiates the Effectiveness of an Antagonistic Peptide That Targets the EphB4 Receptor with Nanomolar Affinity

Noberini, R., Mitra, S., Salvucci, O., Valencia, F., Duggineni, S., Prigozhina, N. L., Wei, K., Tosato, G., Huang, Z., & Pasquale, E. B. (2011) · PLoS ONE · doi:10.1371/journal.pone.0028611 · Cited by 40

Abrogation of Cbl–PI3K Interaction Increases Bone Formation and Osteoblast Proliferation

Brennan, T. A., Adapala, N. S., Barbe, M. F., Yingling, V. R., & Sanjay, A. (2011) · Calcified Tissue International · doi:10.1007/s00223-011-9531-z · Cited by 40

A specific subtype of osteoclasts secretes factors inducing nodule formation by osteoblasts

Henriksen, K., Andreassen, K. V., Thudium, C. S., Gudmann, K. N. S., Moscatelli, I., Crüger-Hansen, C., Schulz, A., Dziegiel, M. H., Richter, J., Karsdal, M. A., et al. (2012) · Bone · doi:10.1016/j.bone.2012.06.007 · Cited by 40

CD200R/CD200 Inhibits Osteoclastogenesis: New Mechanism of Osteoclast Control by Mesenchymal Stem Cells in Human

Varin, A., Pontikoglou, C. G., Labat, E., Deschaseaux, F., & Sensebé, L. (2013) · PLoS ONE · doi:10.1371/journal.pone.0072831 · Cited by 42

Non-viral gene-activated matrices

Tierney, E. G., Duffy, G. P., Cryan, S., Curtin, C. M., & O’Brien, F. J. (2013) · Organogenesis · doi:10.4161/org.24329 · Cited by 40

The Pathophysiology of Osteoporosis after Spinal Cord Injury

Shams, R., Drasites, K. P., Zaman, V., Matzelle, D. D., Shields, D. C., Garner, D. P., Sole, C. J., Haque, A., & Banik, N. L. (2021) · International Journal of Molecular Sciences · doi:10.3390/ijms22063057 · Cited by 43

BMP2 immune complexes promote new bone formation by facilitating the direct contact between osteoclasts and osteoblasts

Xu, Y., Yang, Y., Hua, Z., Li, S., Yang, Z., Liu, Q., Fu, G., Ji, P., & Wu, Q. (2021) · Biomaterials · doi:10.1016/j.biomaterials.2021.120890 · Cited by 41

Receptor Tyrosine Kinase Ephb6 Regulates Vascular Smooth Muscle Contractility and Modulates Blood Pressure in Concert with Sex Hormones

Luo, H., Wu, Z., Tremblay, J., Thorin, É., Peng, J., Lavoie, J. L., Hu, B., Stoyanova, É., Cloutier, G., Qi, S., et al. (2012) · Journal of Biological Chemistry · doi:10.1074/jbc.m111.293365 · Cited by 40

Eph receptors and their ligands: Promising molecular biomarkers and therapeutic targets in prostate cancer

Lisle, J. E., Mertens‐Walker, I., Rutkowski, R., Herington, A. C., & Stephenson, S. (2013) · Biochimica et Biophysica Acta (BBA) - Reviews on Cancer · doi:10.1016/j.bbcan.2013.01.003 · Cited by 42

Bone scaffolds loaded with siRNA-Semaphorin4d for the treatment of osteoporosis related bone defects

Zhang, Y., Wei, L., Miron, R. J., Shi, B., & Bian, Z. (2016) · Scientific Reports · doi:10.1038/srep26925 · Cited by 40

Physiological Cues Involved in the Regulation of Adhesion Mechanisms in Hematopoietic Stem Cell Fate Decision

Kulkarni, R. S., & Kale, V. P. (2020) · Frontiers in Cell and Developmental Biology · doi:10.3389/fcell.2020.00611 · Cited by 42

Molecular mechanisms of triggering, amplifying and targeting RANK signaling in osteoclasts

Kuroda, Y. (2012) · World Journal of Orthopedics · doi:10.5312/wjo.v3.i11.167 · Cited by 42

3D Biomimetic Calcified Cartilaginous Callus that Induces Type H Vessels Formation and Osteoclastogenesis

Qiu, M., Li, C., Cai, Z., Li, C., Yang, K., Tulufu, N., Chen, B., Cheng, L., Zhuang, C., Liu, Z., et al. (2023) · Advanced Science · doi:10.1002/advs.202207089 · Cited by 37

Treatment with ephrin B2 positively impacts the abnormal metabolism of human osteoarthritic chondrocytes

Tat, S. K., Pelletier, J., Amiable, N., Boileau, C., Lavigne, M. J. F., & Martel‐Pelletier, J. (2009) · Arthritis Research & Therapy · doi:10.1186/ar2782 · Cited by 38

The pathogenesis of bone metastasis in solid tumors: a review

Vičić, I., & Belev, B. (2021) · Croatian Medical Journal · doi:10.3325/cmj.2021.62.270 · Cited by 38

Role of heterodimerization of c-Fos and Fra1 proteins in osteoclast differentiation

Bakiri, L., Takada, Y., Radolf, M., Eferl, R., Yaniv, M., Wagner, E. F., & Matsuo, K. (2007) · Bone · doi:10.1016/j.bone.2006.11.005 · Cited by 39

Compression-dependent Up-regulation of Ephrin-A2 in PDL Fibroblasts Attenuates Osteogenesis

Diercke, K., Şen, S., Kohl, A., Lux, C. J., & Erber, R. (2011) · Journal of Dental Research · doi:10.1177/0022034511413926 · Cited by 38

New Roles for Osteoclasts in Bone

Boyce, B. F., Yao, Z., Zhang, Q., GUO, R., Lu, Y., Schwarz, E. M., & Xing, L. (2007) · Annals of the New York Academy of Sciences · doi:10.1196/annals.1402.084 · Cited by 40

Positively charged polymers modulate the fate of human mesenchymal stromal cells via ephrinB2/EphB4 signaling

Luca, I. D., Salle, A. D., Alessio, N., Margarucci, S., Simeone, M., Galderisi, U., Calarco, A., & Peluso, G. (2016) · Stem Cell Research · doi:10.1016/j.scr.2016.07.005 · Cited by 38

Boning up on Ephrin Signaling

Mundy, G. R., & Elefteriou, F. (2006) · Cell · doi:10.1016/j.cell.2006.07.015 · Cited by 111

Bidirectional Signaling through EphrinA2-EphA2 Enhances Osteoclastogenesis and Suppresses Osteoblastogenesis

Irie, N., Takada, Y., Watanabe, Y., Matsuzaki, Y., Naruse, C., Asano, M., Iwakura, Y., Suda, T., & Matsuo, K. (2009) · Journal of Biological Chemistry · doi:10.1074/jbc.m807598200 · Cited by 182

Bi-directional signaling pathway of erythropoietin-producing hepatocyte receptors between osteoblasts and osteoclasts

Ge, Y., & Zhu, Z.-A. (2018) · doi:10.3877/cma.j.issn.1674-134x.2018.03.018

Communication Between EphrinB2 and EphB4 Within the Osteoblast Lineage

Martin, T. J., Allan, E. H., Ho, P. W. M., Gooi, J. H., Quinn, J. M. W., Gillespie, M. T., Krasnoperov, V. G., & Sims, N. A. (2009) · Advances in experimental medicine and biology · doi:10.1007/978-1-4419-1050-9_6 · Cited by 77

EphrinB2/EphB4 signaling can enhance and inhibit osteoclastogenesis

(2013) · BoneKEy Reports · doi:10.1038/bonekey.2013.29