Cited by 699Peroxisome Proliferator-Activated ReceptorsAdipokines, Inflammation, and Metabolic DiseasesAdipose Tissue and Metabolism

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Adipocyte-Derived Th2 Cytokines and Myeloid PPARδ Regulate Macrophage Polarization and Insulin Sensitivity

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Kang, Kihwa, Reilly, Shannon M., Karabacak, Volkan, Gangl, Matthew R., Fitzgerald, Kelly, Hatano, Ben, Lee, Chih-Hao·2008·Cell Metabolism

DOI 10.1016/j.cmet.2008.04.002PMC PMC2586840

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Abstract

The polarization of adipose tissue-resident macrophages toward the alternatively activated, anti-inflammatory M2 phenotype is believed to improve insulin sensitivity. However, the mechanisms controlling tissue macrophage activation remain unclear. Here we show that adipocytes are a source of Th2 cytokines, including IL-13 and to a lesser extent IL-4, which induce macrophage PPARdelta/beta (Ppard/b) expression through a STAT6 binding site on its promoter to activate alternative activation. Coculture studies indicate that Ppard ablation renders macrophages incapable of transition to the M2 phenotype, which in turns causes inflammation and metabolic derangement in adipocytes. Remarkably, a similar regulatory mechanism by hepatocyte-derived Th2 cytokines and macrophage PPARdelta is found to control hepatic lipid metabolism. The physiological relevance of this paracrine pathway is demonstrated in myeloid-specific PPARdelta(-/-) mice, which develop insulin resistance and show increased adipocyte lipolysis and severe hepatosteatosis. These findings provide a molecular basis to modulate tissue-resident macrophage activation and insulin sensitivity.

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Weisberg, S. P., McCann, D., Desai, M., Rosenbaum, M., Leibel, R. L., & Ferrante, A. W. (2003) · Journal of Clinical Investigation · doi:10.1172/jci200319246 · Cited by 10,041
Inflammation and metabolic disorders
Hotamisligil, G. S. (2006) · Nature · doi:10.1038/nature05485 · Cited by 9,199
Chronic inflammation in fat plays a crucial role in the development of obesity-related insulin resistance
Xu, H., Barnes, G. T., Yang, Q., Tan, G., Yang, D., Chou, C. J., Sole, J., Nichols, A., Ross, J. S., Tartaglia, L. A., et al. (2003) · Journal of Clinical Investigation · doi:10.1172/jci200319451 · Cited by 6,760
The chemokine system in diverse forms of macrophage activation and polarization
MANTOVANI, A., SICA, A., SOZZANI, S., ALLAVENA, P., VECCHI, A., & LOCATI, M. (2004) · Trends in Immunology · doi:10.1016/j.it.2004.09.015 · Cited by 6,534
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Lumeng, C. N., Bodzin, J. L., & Saltiel, A. R. (2007) · Journal of Clinical Investigation · doi:10.1172/jci29881 · Cited by 4,664
HIF-1-mediated expression of pyruvate dehydrogenase kinase: A metabolic switch required for cellular adaptation to hypoxia
Kim, J.-W., Tchernyshyov, I., Semenza, G. L., & Dang, C. V. (2006) · Cell Metabolism · doi:10.1016/j.cmet.2006.02.002 · Cited by 3,905
TLR4 links innate immunity and fatty acid-induced insulin resistance
Shi, H., Kokoeva, M. V., Inouye, K., Tzameli, I., Yin, H., & Flier, J. S. (2006) · Journal of Clinical Investigation · doi:10.1172/jci28898 · Cited by 3,690
Stimulation of adipogenesis in fibroblasts by PPARγ2, a lipid-activated transcription factor
Tontonoz, P., Hu, E., & Spiegelman, B. M. (1994) · Cell · doi:10.1016/0092-8674(94)90006-x · Cited by 3,564
A central role for JNK in obesity and insulin resistance
Hirosumi, J., Tuncman, G., Chang, L., Görgün, C. Z., Uysal, K. T., Maeda, K., Karin, M., & Hotamisligil, G. S. (2002) · Nature · doi:10.1038/nature01137 · Cited by 3,359

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[Cells of innate and adaptive immunity in type 2 diabetes and obesity].
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Fedorov, A. A., Ermak, N. A., Gerashchenko, T. S., Топольницкий, Е. Б., Шефер, Н. А., Родионов, Е. О., & Stakheyeva, M. N. (2022) · Siberian Journal of Oncology · doi:10.21294/1814-4861-2022-21-4-124-136 · Cited by 23
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Duan, S., Usher, M. G., Foley, E. L., Milstone, D. S., Brosius, F. C., & Mortensen, R. M. (2010) · Diabetologia · doi:10.1007/s00125-010-1748-2 · Cited by 20
All-trans retinoic acid inhibits lipopolysaccharide-induced inflammatory responses in bovine adipocytes via TGFβ1/Smad3 signaling pathway
Xu, Q., Jia, H., Ma, L., Liu, G., Xu, C., Li, Y., Li, X., & Li, X. (2019) · BMC Veterinary Research · doi:10.1186/s12917-019-1791-2 · Cited by 20
Macrophage fatty acid oxidation in atherosclerosis
Xiao, S., Qi, M., Zhou, Q., Gong, H.-Q., Wei, D., Wang, G., Feng, Q., Wang, Z., Liu, Z., Zhou, Y., et al. (2023) · Biomedicine & Pharmacotherapy · doi:10.1016/j.biopha.2023.116092 · Cited by 25
GIPR Signaling in Immune Cells Maintains Metabolically Beneficial Type 2 Immune Responses in the White Fat From Obese Mice
Efimova, I., Steinberg, I., Zvibel, I., Neumann, A., Mantelmacher, F. D., Drucker, D. J., Fishman, S., & Varol, C. (2021) · Frontiers in Immunology · doi:10.3389/fimmu.2021.643144 · Cited by 20
Prolonged Endoplasmic Reticulum–Stressed Hepatocytes Drive an Alternative Macrophage Polarization
Xiu, F., Catapano, M. S., Diao, L., Stanojcic, M., & Jeschke, M. G. (2015) · Shock · doi:10.1097/shk.0000000000000373 · Cited by 20
Distinct Hepatic Macrophage Populations in Lean and Obese Mice
Mayoral, R., Johnson, A. M. F., Osborn, O., Través, P. G., & Mahata, S. K. (2016) · Frontiers in Endocrinology · doi:10.3389/fendo.2016.00152 · Cited by 20
Cell Type-Specific Immunomodulation Induced by Helminthes: Effect on Metainflammation, Insulin Resistance and Type-2 Diabetes
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Liu, C., Qin, L., Ding, J., Zhou, L., Gao, C., Zhang, T., Guo, M., Huang, W. G., Jiang, Z., Long, Y., et al. (2019) · Journal of Diabetes Research · doi:10.1155/2019/8512028 · Cited by 19
Dendritic cells activated by an anti‐inflammatory agent induce CD4+ T helper type 2 responses without impairing CD8+ memory and effector cytotoxic T‐lymphocyte responses
Wang, Y., Da’dara, A. A., Thomas, P. G., & Harn, D. A. (2009) · Immunology · doi:10.1111/j.1365-2567.2009.03193.x · Cited by 20
Adipocyte microRNA-802 promotes adipose tissue inflammation and insulin resistance by modulating macrophages in obesity
Yang, Y. S., Huang, B., Qin, Y., Wang, D., Jin, Y., Su, L., Wang, Q., Pan, Y., Zhang, Y., Shen, Y., et al. (2024) · eLife · doi:10.7554/elife.99162 · Cited by 19
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Binder, F., Hayakawa, M., Choo, M., Sano, Y., & Park, J. M. (2012) · Molecular Immunology · doi:10.1016/j.molimm.2012.12.004 · Cited by 18
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Zha, L.-F., Nie, S.-F., Chen, Q.-W., Liao, Y.-H., Zhang, H., Dong, J.-T., Xie, T., Wang, F., Tang, T., Xia, N., et al. (2018) · Scientific Reports · doi:10.1038/s41598-018-24592-9 · Cited by 18
Heterogeneity of adipose tissue-resident macrophages-beyond M1/M2 paradigm
Nawaz, A., Fujisaka, S., Kado, T., Jeelani, I., & Tobe, K. (2023) · Diabetology International · doi:10.1007/s13340-023-00624-2 · Cited by 19
Crosstalk between macrophage and T cell in atherosclerosis: Potential therapeutic targets for cardiovascular diseases.
Song, M., Xu, S.-X., Zhong, A.-Q., & Zhang, J.-P. (2019) · Clinical Immunology · doi:10.1016/j.clim.2019.03.001 · Cited by 16
Role of obesity related inflammation in pathogenesis of peripheral artery disease in patients of type 2 diabetes mellitus
Yadav, U., Kumar, N., & Sarvottam, K. (2023) · Journal of Diabetes & Metabolic Disorders · doi:10.1007/s40200-023-01221-5 · Cited by 22
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PAFR in adipose tissue macrophages is associated with anti-inflammatory phenotype and metabolic homoeostasis
Filgueiras, L. R., Koga, M. M., Quaresma, P. G. F., Ishizuka, E. K., Montes, M. B. A., Prada, P. O., Saad, M. J. A., Jancar, S., & Rios, F. J. O. (2016) · Clinical Science · doi:10.1042/cs20150538 · Cited by 17
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Drohomyrecky, P. C., Doroshenko, E. R., Akkermann, R., Moshkova, M., Yi, T. J., Zhao, F. L., Ahn, J. J., McGaha, T. L., Pahan, K., & Dunn, S. E. (2019) · The Journal of Immunology · doi:10.4049/jimmunol.1801200 · Cited by 18
Galectin-3 and Inflammation
Liu, L. (2016) · Glycobiology Insights · doi:10.4137/gbi.s13921 · Cited by 17
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Regulation of TAK1/TAB1-Mediated IL-1β Signaling by Cytoplasmic PPARβ/δ
Stockert, J., Wolf, A., Kaddatz, K., Schnitzer, E., Finkernagel, F., Meißner, W., Müller‐Brüsselbach, S., Kracht, M., & Müller, R. (2013) · PLoS ONE · doi:10.1371/journal.pone.0063011 · Cited by 16

Authors: Kang, K., Reilly, S. M., Karabacak, V., Gangl, M. R., Fitzgerald, K., Hatano, B., & Lee, C.-H.
Affiliations: Harvard University (US)
Corresponding author: Lee, Chih-Hao
ORCID: Reilly, Shannon M.
Karabacak, Volkan
Fitzgerald, Kelly
Lee, Chih-Hao
Venue: Cell Metabolism
Publisher: Elsevier BV
Published: 2008-06
Volume: 7
Issue: 6
Pages: 485-495
ISSN: 1550-4131 (ISSN-L)
DOI: 10.1016/j.cmet.2008.04.002
PMC: PMC2586840
OpenAlex: W2046935888
Cited by: 699
References: 41
Citations by year: 2026: 14 · 2025: 24 · 2024: 25 · 2023: 21 · 2022: 25 · 2021: 44 · 2020: 42 · 2019: 32 · 2018: 39 · 2017: 40 · 2016: 43 · 2015: 46 · 2014: 40 · 2013: 76 · 2012: 51
FWCI: 18.81
Type: journal article
Language: en
Open access: bronze
doi.org
Licence: www.elsevier.com/tdm/userlicense/1.0/ (tdm)
www.elsevier.com/open-access/userlicense/1.0/ (vor, 1908 d)
Locations: Cell Metabolism (publishedVersion)
PubMed (publishedVersion)
Europe PMC (PubMed Central) (acceptedVersion)
PubMed Central (acceptedVersion)
Funders: National Institutes of Health (5t32es007155-24)
National Institute of Diabetes and Digestive and Kidney Diseases (P30DK34845, R90DK071507, R01DK075046, P30DK034854)
National Institute of Environmental Health Sciences (T32-ES07155, T32-ES007155, T32ES016645)
Topics: Life Sciences › Biochemistry, Genetics and Molecular Biology › Molecular Biology › Peroxisome Proliferator-Activated Receptors
Health Sciences › Medicine › Endocrinology, Diabetes and Metabolism › Adipokines, Inflammation, and Metabolic Diseases
Health Sciences › Medicine › Physiology (medical) › Adipose Tissue and Metabolism
Keywords: adipose tissue macrophages, macrophage polarization, M2 phenotype, Th2 cytokines, IL-13, IL-4, PPARδ, STAT6, adipocytes, hepatocytes, insulin sensitivity, insulin resistance, hepatic lipid metabolism, hepatic steatosis, adipocyte lipolysis, paracrine signaling, myeloid-specific knockout
MeSH terms: Animals, Gene Expression Regulation, Inflammation, Insulin Resistance, Macrophage Activation, Macrophages, Promoter Regions, Genetic, Cytokines, Adipocytes, Mice, Knockout, Th2 Cells, Coculture Techniques, Paracrine Communication, Hepatocytes, PPAR delta, PPAR-beta, Lipid Metabolism, Mice

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Adipocyte-Derived Th2 Cytokines and Myeloid PPARδ Regulate Macrophage Polarization and Insulin Sensitivity

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