Dynamic Functional Relay between Insulin Receptor Substrate 1 and 2 in Hepatic Insulin Signaling during Fasting and Feeding

Akt Promotes Cell Survival by Phosphorylating and Inhibiting a Forkhead Transcription Factor

Brunet, A., Bonni, A., Zigmond, M. J., Lin, M. Z., Juo, P., Hu, L. S., Anderson, M. J., Arden, K. C., Blenis, J., & Greenberg, M. E. (1999) · Cell · doi:10.1016/s0092-8674(00)80595-4 · Cited by 5,594

Insulin signalling and the regulation of glucose and lipid metabolism

Saltiel, A. R., & Kahn, C. R. (2001) · Nature · doi:10.1038/414799a · Cited by 5,326

Cloning of adiponectin receptors that mediate antidiabetic metabolic effects

Yamauchi, T., Kamon, J., Ito, Y., Tsuchida, A., Yokomizo, T., Kita, S., Sugiyama, T., Miyagishi, M., Hara, K., Tsunoda, M., et al. (2003) · Nature · doi:10.1038/nature01705 · Cited by 3,176

Critical nodes in signalling pathways: insights into insulin action

Taniguchi, C. M., Emanuelli, B., & Kahn, C. R. (2006) · Nature Reviews Molecular Cell Biology · doi:10.1038/nrm1837 · Cited by 2,760

Disruption of IRS-2 causes type 2 diabetes in mice

Withers, D. J., Gutierrez, J. S., Towery, H. H., Burks, D. J., Ren, J., Previs, S. F., Zhang, Y., Bernal, D., Pons, S., Shulman, G. I., et al. (1998) · Nature · doi:10.1038/36116 · Cited by 1,775

PPARγ Mediates High-Fat Diet–Induced Adipocyte Hypertrophy and Insulin Resistance

Kubota, N., Terauchi, Y., Miki, H., Tamemoto, H., Yamauchi, T., Komeda, K., Satoh, S., Nakano, R., Ishii, C., 杉山, 拓., et al. (1999) · Molecular Cell · doi:10.1016/s1097-2765(00)80210-5 · Cited by 1,351

Loss of insulin signaling in hepatocytes leads to severe insulin resistance and progressive hepatic dysfunction.

Michael, M. D., Kulkarni, R. N., Postic, C., Previs, S. F., Shulman, G. I., Magnuson, M. A., & Kahn, C. R. (2000) · Molecular Cell · doi:10.1016/s1097-2765(05)00015-8 · Cited by 1,296

Alternative pathway of insulin signalling in mice with targeted disruption of the IRS-1 gene

Araki, E., Lipes, M. A., Patti, M.-E., Brüning, J. C., Haag III, B., Johnson, R. S., & Kahn, C. R. (1994) · Nature · doi:10.1038/372186a0 · Cited by 1,252

Insulin resistance and growth retardation in mice lacking insulin receptor substrate-1

Tamemoto, H., Kadowaki, T., Tobe, K., Yagi, T., Sakura, H., Hayakawa, T., Terauchi, Y., Ueki, K., Kaburagi, Y., Satoh, S., et al. (1994) · Nature · doi:10.1038/372182a0 · Cited by 1,081

Microsomal triglyceride transfer protein and nonalcoholic fatty liver disease

Pereira, I. V. A., Stefano, J. T., & Oliveira, C. P. (2011) · Expert Review of Gastroenterology & Hepatology · doi:10.1586/egh.11.22 · Cited by 33

Isocaloric intake of a high‐fat diet promotes insulin resistance and inflammation in Wistar rats

Jacob, P., Fujii, T. M. D. M., Yamada, M., Borges, M. C., Pantaleão, L. C., Borelli, P., Fock, R. A., & Rogero, M. M. (2012) · Cell Biochemistry and Function · doi:10.1002/cbf.2894 · Cited by 30

Insulin Concentration Modulates Hepatic Lipid Accumulation in Mice in Part via Transcriptional Regulation of Fatty Acid Transport Proteins

Softic, S., Kirby, M., Berger, N. G., Shroyer, N. F., Woods, S. C., & Kohli, R. (2012) · PLoS ONE · doi:10.1371/journal.pone.0038952 · Cited by 29

Tissue-specific effects of protein malnutrition on insulin signaling pathway and lipid accumulation in growing rats

Toyoshima, Y., Tokita, R., Taguchi, Y., Akanishi, N., Takenaka, A., Kato, H., Chida, K., Hakuno, F., Minami, S., & Takahashi, S. (2014) · Endocrine Journal · doi:10.1507/endocrj.ej13-0514 · Cited by 31

Altered hepatic insulin signalling in male offspring of obese mice

Martin‐Gronert, M. S., Fernandez‐Twinn, D. S., Poston, L., & Ozanne, S. E. (2010) · Journal of Developmental Origins of Health and Disease · doi:10.1017/s2040174410000231 · Cited by 29

TOX4, an insulin receptor-independent regulator of hepatic glucose production, is activated in diabetic liver

Wang, L., Yu, J., Zhou, Q., Wang, X., Mukhanova, M., Du, W. J., Sun, L., Pajvani, U. B., & Accili, D. (2021) · Cell Metabolism · doi:10.1016/j.cmet.2021.11.013 · Cited by 28

Phosphorylation of Serine 1137/1138 of Mouse Insulin Receptor Substrate (IRS) 2 Regulates cAMP-dependent Binding to 14-3-3 Proteins and IRS2 Protein Degradation

Neukamm, S. S., Ott, J., Dammeier, S., Lehmann, R., Häring, H., Schleicher, E. D., & Weigert, C. (2013) · Journal of Biological Chemistry · doi:10.1074/jbc.m113.474593 · Cited by 28

Changes in glucose metabolism and reversion of genes expression in the liver of insulin-resistant rats exposed to malathion. The protective effects of N-acetylcysteine

Lasram, M. M., El-Golli, N., Jrad-Lamine, A., Douib, I. B., Bouzid, K., Annabi, A. B., Fazâa, S. E., Abdelmoula, J., & Gharbi, N. (2014) · General and Comparative Endocrinology · doi:10.1016/j.ygcen.2014.10.002 · Cited by 27

IRS2 and PTP1B: Two opposite modulators of hepatic insulin signalling

Valverde, Á. M., & González‐Rodríguez, Á. (2011) · Archives of Physiology and Biochemistry · doi:10.3109/13813455.2011.557386 · Cited by 25

Increase in hepatic and decrease in peripheral insulin clearance characterize abnormal temporal patterns of serum insulin in diabetic subjects

Ohashi, K., Fujii, M., Uda, S., Kubota, H., Komada, H., Sakaguchi, K., Ogawa, W., & Kuroda, S. (2018) · npj Systems Biology and Applications · doi:10.1038/s41540-018-0051-6 · Cited by 26

Inhibition of NF-κB Reduces Renal Inflammation and Expression of PEPCK in Type 2 Diabetic Mice

Liu, Q., Zhang, L., Zhang, W., Hao, Q., Qiu, W., Wen, Y., Wang, H., & Li, X. (2018) · Inflammation · doi:10.1007/s10753-018-0845-0 · Cited by 27

Deficiency of a Glycogen Synthase-associated Protein, Epm2aip1, Causes Decreased Glycogen Synthesis and Hepatic Insulin Resistance

Turnbull, J., Tiberia, E., Pereira, S., Zhao, X., Pencea, N., Wheeler, A. L., Yu, W., Ivovic, A., Naranian, T., Israelian, N., et al. (2013) · Journal of Biological Chemistry · doi:10.1074/jbc.m113.483198 · Cited by 24

The role of quantitative changes in the epxression of insulin receptor substrate-1 and nuclear ubiquitin in abnormal glycometabolism in the livers of KKay mice and the relative therapeutic mechanisms of Astragalus polysaccharide

Yan, Y., Deng, T., Wan, X., Ouyang, J., Liu, M., & Mao, X. (2013) · International Journal of Molecular Medicine · doi:10.3892/ijmm.2013.1580 · Cited by 24

PHD3 regulates glucose metabolism by suppressing stress-induced signalling and optimising gluconeogenesis and insulin signalling in hepatocytes

Yano, H., Sakai, M., Matsukawa, T., Yagi, T., Naganuma, T., Mitsushima, M., Iida, S., Inaba, Y., Inoue, H., Unoki‐Kubota, H., et al. (2018) · Scientific Reports · doi:10.1038/s41598-018-32575-z · Cited by 22

Growth signaling and longevity in mouse models

Kim, S.-S., & Lee, C. (2019) · BMB Reports · doi:10.5483/bmbrep.2019.52.1.299 · Cited by 25

Tissue-specific activation of insulin signaling as a potential target for obesity-related metabolic disorders

Okuma, H., & Tsuchiya, K. (2024) · Pharmacology & Therapeutics · doi:10.1016/j.pharmthera.2024.108699 · Cited by 23

Short-term Cudrania tricuspidata fruit vinegar administration attenuates obesity in high-fat diet-fed mice by improving fat accumulation and metabolic parameters

Choi, J., Kim, M.-K., Yeo, S., & Kim, S. (2020) · Scientific Reports · doi:10.1038/s41598-020-78166-9 · Cited by 22

Reduced insulin signaling in neurons induces sex-specific health benefits

Baghdadi, M., Nespital, T., Mesaros, A., Buschbaum, S., Withers, D. J., Grönke, S., & Partridge, L. (2023) · Science Advances · doi:10.1126/sciadv.ade8137 · Cited by 24

Gymnema Sylvestre Supplementation Restores Normoglycemia, Corrects Dyslipidemia, and Transcriptionally Modulates Pancreatic and Hepatic Gene Expression in Alloxan-Induced Hyperglycemic Rats

Muzaffar, H., Qamar, I., Bashir, M., Jabeen, F., Irfan, S., & Anwar, H. (2023) · Metabolites · doi:10.3390/metabo13040516 · Cited by 21

Genetic Analysis of Type-1 Insulin-like Growth Factor Receptor Signaling through Insulin Receptor Substrate-1 and -2 in Pancreatic β Cells

Xuan, S., Szabolcs, M. J., Cinti, F., Perincheri, S., Accili, D., & Efstratiadis, A. (2010) · Journal of Biological Chemistry · doi:10.1074/jbc.m110.144790 · Cited by 21

Acetylcholinesterase (AChE) inhibition aggravates fasting‐induced triglyceride accumulation in the mouse liver

Yokota, S.-I., Nakamura, K., Ando, M., Kamei, H., Hakuno, F., Takahashi, S., & Shibata, S. (2014) · FEBS Open Bio · doi:10.1016/j.fob.2014.10.009 · Cited by 20

A long-lasting dipeptidyl peptidase-4 inhibitor, teneligliptin, as a preventive drug for the development of hepatic steatosis in high-fructose diet-fed ob/ob mice

Nakamura, K., Fukunishi, S., Yokohama, K., Ohama, H., Tsuchimoto, Y., Asai, A., Tsuda, Y., & Higuchi, K. (2017) · International Journal of Molecular Medicine · doi:10.3892/ijmm.2017.2899 · Cited by 21

Low-arginine and low-protein diets induce hepatic lipid accumulation through different mechanisms in growing rats

Otani, L., Nishi, H., Koyama, A., Akasaka, Y., Taguchi, Y., Toyoshima, Y., Yamanaka, D., Hakuno, F., Jia, H., Takahashi, S., et al. (2020) · Nutrition & Metabolism · doi:10.1186/s12986-020-00477-5 · Cited by 22

An integrative transcriptional logic model of hepatic insulin resistance

Kitamoto, T., Kuo, T., Okabe, A., Kaneda, A., & Accili, D. (2021) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.2102222118 · Cited by 20

Persistence of improved glucose homeostasis in Gclm null mice with age and cadmium treatment

Schaupp, C. M., Botta, D., White, C. C., Scoville, D., Srinouanprachanh, S. L., Bammler, T. K., MacDonald, J. W., & Kavanagh, T. J. (2021) · Redox Biology · doi:10.1016/j.redox.2021.102213 · Cited by 20

Pathogenesis of the Metabolic Syndrome: Insights from Monogenic Disorders

Murphy, R., Carroll, R. W., & Krebs, J. D. (2013) · Mediators of Inflammation · doi:10.1155/2013/920214 · Cited by 22

Insulin resistance disrupts epithelial repair and niche-progenitor Fgf signaling during chronic liver injury

Manzano‐Núñez, F., Arámbul-Anthony, M. J., Albiñana, A. G., Leal‐Tassias, A., Umanzor, C. A., Gascó, I. B., Herrera, A., Vila, J. F., Burks, D. J., & Noon, L. A. (2019) · PLoS Biology · doi:10.1371/journal.pbio.2006972 · Cited by 20

Polarity Protein AF6 Controls Hepatic Glucose Homeostasis and Insulin Sensitivity by Modulating IRS1/AKT Insulin Pathway in an SHP2-Dependent Manner

Dai, C., Wang, X., Wu, Y., Xu, Y., Zhuo, S., Qi, M., Ji, W., & Zhan, L. (2019) · Diabetes · doi:10.2337/db18-0695 · Cited by 20

Anagliptin increases insulin-induced skeletal muscle glucose uptake via an NO-dependent mechanism in mice

Sato, H., Kubota, N., Kubota, T., Takamoto, I., Iwayama, K., Tokuyama, K., Moroi, M., Sugi, K., Nakaya, K., Goto, M., et al. (2016) · Diabetologia · doi:10.1007/s00125-016-4071-8 · Cited by 19

Increasing prevalence of diabetes mellitus in association with fatty liver in a Japanese population

Imamura, Y., Uto, H., Hiramine, Y., Hosoyamada, K., Ijuin, S., Yoshifuku, S., Miyahara, H., Maenohara, S., Oketani, M., Ido, A., et al. (2013) · Journal of Gastroenterology · doi:10.1007/s00535-013-0902-2 · Cited by 18

Lactobacillus plantarum improves lipogenesis and IRS-1/AKT/eNOS signalling pathway in the liver of high-fructose-fed rats

Şumlu, E., Bostancı, A., Sadı, G., Alçığır, M. E., & Akar, F. (2020) · Archives of Physiology and Biochemistry · doi:10.1080/13813455.2020.1727527 · Cited by 17

Changes in lipid metabolism and capillary density of the skeletal muscle following low-intensity exercise training in a rat model of obesity with hyperinsulinemia

Fujita, N., Aono, S., Karasaki, K., Sera, F., Kurose, T., Fujino, H., & Urakawa, S. (2018) · PLoS ONE · doi:10.1371/journal.pone.0196895 · Cited by 17

Physiological and pathophysiological actions of insulin in the liver

Kubota, N., Kubota, T., & Kadowaki, T. (2025) · Endocrine Journal · doi:10.1507/endocrj.ej24-0192 · Cited by 19

A mathematical model of the impact of insulin secretion dynamics on selective hepatic insulin resistance

Zhao, G., Wirth, D., Schmitz, I., & Meyer‐Hermann, M. (2017) · Nature Communications · doi:10.1038/s41467-017-01627-9 · Cited by 16

Dipeptidyl peptidase-4 inhibitor anagliptin ameliorates diabetes in mice with haploinsufficiency of glucokinase on a high-fat diet

Nakaya, K., Kubota, N., Takamoto, I., Kubota, T., Katsuyama, H., Sato, H., Tokuyama, K., Hashimoto, S., Goto, M., Jomori, T., et al. (2013) · Metabolism · doi:10.1016/j.metabol.2013.01.010 · Cited by 16

Insulin-Receptor Substrate-2 (IRS-2) Is Required for Maintaining Glucokinase and Glucokinase Regulatory Protein Expression in Mouse Liver

Roncero, I., Álvarez, E., Acosta, C., Sanz, C., Barrio, P. A., Hurtado-Carneiro, V., Burks, D. J., & Blázquez, E. (2013) · PLoS ONE · doi:10.1371/journal.pone.0058797 · Cited by 16

Long-Term Administration of Dehydroepiandrosterone Accelerates Glucose Catabolism via Activation of PI3K/Akt-PFK-2 Signaling Pathway in Rats Fed a High-Fat Diet

Kang, J., Ge, C., Yu, L., Li, L., & Ma, H. (2016) · PLoS ONE · doi:10.1371/journal.pone.0159077 · Cited by 15

The Insulin Receptor Adaptor IRS2 is an APC/C Substrate That Promotes Cell Cycle Protein Expression and a Robust Spindle Assembly Checkpoint

Manohar, S., Yu, Q., Gygi, S. P., & King, R. W. (2020) · Molecular & Cellular Proteomics · doi:10.1074/mcp.ra120.002069 · Cited by 15

Association of IRS1 (Gly972Arg) and IRS2 (Gly1057Asp) genes polymorphisms with OSA and NAFLD in Asian Indians

Bhatt, S. P., & Guleria, R. (2021) · PLoS ONE · doi:10.1371/journal.pone.0245408 · Cited by 15

Systematic modeling for the insulin signaling network mediated by IRS1 and IRS2

Huang, C., Wu, M., Du, J., Liu, D., & Chan, C. (2014) · Journal of Theoretical Biology · doi:10.1016/j.jtbi.2014.03.030 · Cited by 15

Insulin resistance in diabetes: The promise of using induced pluripotent stem cell technology

Elsayed, A. K., Vimalraj, S., Nandakumar, M., & Abdelalim, E. M. (2021) · World Journal of Stem Cells · doi:10.4252/wjsc.v13.i3.221 · Cited by 15

Vagal Hyperactivity Due to Ventromedial Hypothalamic Lesions Increases Adiponectin Production and Release

Suzuki, Y., Shimizu, H., Ishizuka, N., Kubota, N., Kubota, T., Senoo, A., Kageyama, H., Osaka, T., Hirako, S., Kim, H.-J., et al. (2014) · Diabetes · doi:10.2337/db13-0636 · Cited by 14

WDFY2 Potentiates Hepatic Insulin Sensitivity and Controls Endosomal Localization of the Insulin Receptor and IRS1/2

Zhang, L., Li, X., Zhang, N., Yang, X. P., Hou, T., Fu, W., Yuan, F., Wang, L., He, W., Tian, Y., et al. (2020) · Diabetes · doi:10.2337/db19-0699 · Cited by 14

Fatty Acids, Insulin Resistance, and Protein Metabolism

Kalhan, S. C. (2009) · The Journal of Clinical Endocrinology & Metabolism · doi:10.1210/jc.2009-1235 · Cited by 14

Neuronal insulin receptor substrate 2 (IRS2) expression is regulated by ZBP89 and SP1 binding to the IRS2 promoter

Udelhoven, M., Pasieka, M., Leeser, U., Krone, W., & Schubert, M. (2009) · Journal of Endocrinology · doi:10.1677/joe-09-0266 · Cited by 13

The Mechanisms of Insulin Action

White, M. F., & Copps, K. D. (2015) · Elsevier eBooks · doi:10.1016/b978-0-323-18907-1.00033-0 · Cited by 12

A low-protein diet eliminates the circadian rhythm of serum insulin and hepatic lipid metabolism in mice

Yokota, S.-I., Nakamura, K., Ando, M., Haraguchi, A., Omori, K., & Shibata, S. (2018) · The Journal of Nutritional Biochemistry · doi:10.1016/j.jnutbio.2018.10.004 · Cited by 13

Nutritional state-dependent modulation of insulin-producing cells in DrosophilaPreprint

Bisen, R. S., Iqbal, F. M., Cascino-Milani, F., Bockemühl, T., & Ache, J. M. (2024) · eLife · doi:10.7554/elife.98514 · Cited by 13

Coronarin A modulated hepatic glycogen synthesis and gluconeogenesis via inhibiting mTORC1/S6K1 signaling and ameliorated glucose homeostasis of diabetic mice

Huang, S., Xie, W., Ye, Y., Liu, J., Qu, H., Shen, Y., Xu, T., Zhao, Z.-H., Shi, Y., Shen, J., et al. (2022) · Acta Pharmacologica Sinica · doi:10.1038/s41401-022-00985-5 · Cited by 12

Melatonin increases AKT and SOD gene and protein expressions in diabetic rats

Lotfy, M., Khattab, A., Shata, M., Alhasbani, A., Khalaf, A., Alsaeedi, S., Thaker, M., Said, H., Toumi, H. R., Alzahmi, H., et al. (2024) · Heliyon · doi:10.1016/j.heliyon.2024.e28639 · Cited by 14

Yerba Mate (Ilex paraguariensis) modulates NF-kappaB pathway and AKT expression in the liver of rats fed on a high-fat diet

Fujii, T. M. D. M., Jacob, P., Yamada, M., Borges, M. C., Norde, M. M., Pantaleão, L. C., de Oliveira, D. M., Tirapegui, J., de Castro, I. A., Borelli, P., et al. (2014) · International Journal of Food Sciences and Nutrition · doi:10.3109/09637486.2014.945153 · Cited by 12

Insulin receptor substrate 1 (IRS1) variants confer risk of diabetes in the Boston Puerto Rican Health Study.

Feng, X., Tucker, K. L., Parnell, L. D., Shen, J., Lee, Y., Ordovás, J. M., Ling, W., & Lai, C. (2013) · PubMed · doi:10.6133/apjcn.2013.22.1.09 · Cited by 12

Role of the liver in glucose homeostasis in PI 3-kinase p85α-deficient mice

Aoki, K., Matsui, J., Kubota, N., Nakajima, H., Iwamoto, K., Takamoto, I., Tsuji, Y., Ohno, A., Mori, S., Tokuyama, K., et al. (2009) · American Journal of Physiology-Endocrinology and Metabolism · doi:10.1152/ajpendo.90528.2008 · Cited by 12

A xanthene derivative, DS20060511, attenuates glucose intolerance by inducing skeletal muscle-specific GLUT4 translocation in mice

Furuzono, S., Kubota, T., Taura, J., Konishi, M., Naito, A., Tsutsui, M., Karasawa, H., Kubota, N., & Kadowaki, T. (2021) · Communications Biology · doi:10.1038/s42003-021-02491-6 · Cited by 11

Korean naked waxy barley (saechalssal) extract reduces blood glucose in diabetic mice by modulating the PI3K-Akt-GSK3β pathway

Ham, J. R., Son, Y., Lee, Y., Lee, H.-J., Yeo, J., Lee, M., & Lee, M. (2022) · Biomedicine & Pharmacotherapy · doi:10.1016/j.biopha.2022.112976 · Cited by 11

The effect of heat‐killed Lactobacillus brevis SBL88 on improving selective hepatic insulin resistance in non‐alcoholic fatty liver disease mice without altering the gut microbiota

Hayashi, H., Sawada, K., Tanaka, H., Muro, K., Hasebe, T., Nakajima, S., Okumura, T., & Fujiya, M. (2023) · Journal of Gastroenterology and Hepatology · doi:10.1111/jgh.16337 · Cited by 10

Single-cell RNA sequencing reveals the dysfunctional characteristics of PBMCs in patients with type 2 diabetes mellitus

Zhao, J., & Fang, Z. (2025) · Frontiers in Immunology · doi:10.3389/fimmu.2024.1501660 · Cited by 10

Psychology and Pathophysiological Outcomes of Eating

Takada, A., & Himmerich, H. (2021) · IntechOpen eBooks · doi:10.5772/intechopen.92917 · Cited by 10

Skipping breakfast is correlated with impaired fasting glucose in apparently healthy subjects

Voronova, N. V., Nikitin, A. G., Chistiakov, A. P., & Chistiakov, D. A. (2012) · Open Medicine · doi:10.2478/s11536-011-0150-x · Cited by 10

Relationship between skipping breakfast and impaired fasting glucose along with cardiovascular and pre-diabetes condition risk factors in apparently healthy subjects

Li, Y., Nemoto, T., Tobimatsu, S., Saito, M., Ebata, M., Munakata, H., & Nakajima, K. (2011) · Endocrinology Studies · doi:10.4081/es.2011.e17 · Cited by 10

Hepatic Insulin Resistance and Altered Gluconeogenic Pathway in Premature Baboons

McGill-Vargas, L. L., Gastaldelli, A., Liang, H., Anzueto, D. G., Johnson‐Pais, T. L., SEIDNER, S. R., McCurnin, D., Muscogiuri, G., DeFronzo, R. A., Musi, N., et al. (2017) · Endocrinology · doi:10.1210/en.2016-1806 · Cited by 10

miR-27b-5p regulates chicken liver disease via targeting IRS2 to suppress the PI3K/AKT signal pathway

Zhao, J., Ya-mei, W. U., ZHANG, Y., Shu-yue, T. A. N. G., Han, S., Can, C. U. I., Bo, T. A. N., Yu, J., Kang, H., Guang-deng, C. H. E. N., et al. (2023) · Journal of Integrative Agriculture · doi:10.1016/j.jia.2023.04.010 · Cited by 9

The Foxo Family: Partners in Crime or Silent Heroes

Estall, J. L. (2012) · Endocrinology · doi:10.1210/en.2011-2080 · Cited by 9

Sleeve Gastrectomy Improves Hepatic Glucose Metabolism by Downregulating FBXO2 and Activating the PI3K-AKT Pathway

Chen, N., Cao, R., Zhao, Z., Zhou, S. J., & Hu, S. (2023) · International Journal of Molecular Sciences · doi:10.3390/ijms24065544 · Cited by 8

IRS2 Amplification as a Predictive Biomarker in Response to Ceritinib in Small Cell Lung Cancer

Lee, M., Jung, K., Song, J., Sung, M., Ahn, S.-B., Lee, B., Oh, D., & Choi, Y. (2020) · Molecular Therapy — Oncolytics · doi:10.1016/j.omto.2019.12.009 · Cited by 8

Insulin Resistance in the Metabolic Syndrome

Biddinger, S. B., & Emanuelli, B. (2010) · Springer eBooks · doi:10.1007/978-1-4419-1607-5_10 · Cited by 8

Nutritional state-dependent modulation of insulin-producing cells in Drosophila

Bisen, R. S., Iqbal, F. M., Cascino-Milani, F., Bockemühl, T., & Ache, J. M. (2024) · eLife · doi:10.7554/elife.98514.3 · Cited by 23

A novel recombinant peptide INSR-IgG4Fc (Yiminsu) restores insulin sensitivity in experimental insulin resistance models

Wang, J., Shi, Z., Zou, T., Zou, M.-X., Yang, H.-X., Zhang, C., Xiang, D.-B., Lin, L.-M., Liu, H.-Y., Fang, D.-Y., et al. (2018) · Biomedicine & Pharmacotherapy · doi:10.1016/j.biopha.2018.10.074 · Cited by 6

Development of novel cell lines of diabetic dysfunction model fit for cell-based screening tests of medicinal materials

Saito, M., Hayakawa, A., Inagaki, N., & Matsuoka, H. (2012) · Cytotechnology · doi:10.1007/s10616-012-9466-x · Cited by 6

Relationship of Ageing to Insulin Resistance and Atherosclerosis

Hao, X., Tu, S., Pan, D., Liao, W., Yang, L., Wang, S., & Sun, G. (2025) · Metabolites · doi:10.3390/metabo15090613 · Cited by 5

Somatic genomics as a discovery engine for biomedicine

Brunner, S. F., Martincorena, I., Mannino, G., Fox, C. S., Stratton, M. R., Rubens, J. R., Campbell, P. J., & Zhu, H. (2026) · Cell · doi:10.1016/j.cell.2026.01.032 · Cited by 9

Chemogenetic engagement of different GPCR signaling pathways segregates the orexigenic activity from the control of whole-body glucose metabolism by AGRP neurons

Abreu, V. E., Barnes, R., Borra, V. J., Schurdak, J. D., & Pérez–Tilve, D. (2024) · Molecular Metabolism · doi:10.1016/j.molmet.2024.102079 · Cited by 5

The Effect of the 14:10-Hour Time-Restricted Feeding (TRF) Regimen on Selected Markers of Glucose Homeostasis in Diet-Induced Prediabetic Male Sprague Dawley Rats

Msane, S., Khathi, A., & Sosibo, A. M. (2025) · Nutrients · doi:10.3390/nu17020292 · Cited by 4

Unraveling the mysteries of hepatic insulin signaling: deconvoluting the nuclear targets of insulin

Kitamoto, T., & Accili, D. (2023) · Endocrine Journal · doi:10.1507/endocrj.ej23-0150 · Cited by 4

Activin B improves glucose metabolism via induction of Fgf21 and hepatic glucagon resistance

Kobayashi, N., Okazaki, Y., Iwane, A., Hara, K., Horikoshi, M., Awazawa, M., Soeda, K., Matsushita, M., Sasako, T., Yoshimura, K., et al. (2025) · Nature Communications · doi:10.1038/s41467-025-58836-w · Cited by 4

Hoofbeats, zebras, and insights into insulin resistance

Hegele, R. A., & Reue, K. (2009) · Journal of Clinical Investigation · doi:10.1172/jci38420 · Cited by 4

Reflections on the state of diabetes research and prospects for treatment

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Woo, S., Guo, T., & Wu, C. (2015) · Springer eBooks · doi:10.1007/978-3-319-25065-6_10 · Cited by 3

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Untitled work

(2008) · doi:10.1016/j.cmet.2008.06.010 · Cited by 67

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