Functional identification of islet cell types by electrophysiological fingerprinting

Logistic Regression: A Brief Primer

Stoltzfus, J. C. (2011) · Academic Emergency Medicine · doi:10.1111/j.1553-2712.2011.01185.x · Cited by 1,290 · see citing works

Simulating, Analyzing, and Animating Dynamical Systems

Ermentrout, B. (2002) · Society for Industrial and Applied Mathematics eBooks · doi:10.1137/1.9780898718195 · Cited by 1,271 · see citing works

Simulating, analyzing, and animating dynamical systems : a guide to XPPAUT for researchers and students

Ermentrout, B. (1987) · Cited by 1,126 · see citing works

Foundations of Cellular Neurophysiology

Johnston, D., & Wu, S. M.-S. (1994) · Medical Entomology and Zoology · Cited by 918 · see citing works

Diabetes Mellitus and the β Cell: The Last Ten Years

Ashcroft, F. M., & Rorsman, P. (2012) · Cell · doi:10.1016/j.cell.2012.02.010 · Cited by 902 · see citing works

Glucagonocentric restructuring of diabetes: A pathophysiologic and therapeutic makeover

Unger, R. H., & Cherrington, A. D. (2012) · Journal of Clinical Investigation · doi:10.1172/jci60016 · Cited by 670 · see citing works

α-Cells of the Endocrine Pancreas: 35 Years of Research but the Enigma Remains

Gromada, J., Franklin, I., & Wollheim, C. B. (2007) · Endocrine Reviews · doi:10.1210/er.2006-0007 · Cited by 574 · see citing works

Pancreatic islet plasticity: Interspecies comparison of islet architecture and composition

Steiner, D. J., Kim, A., Miller, K. W. P., & Hara, M. (2010) · Islets · doi:10.4161/isl.2.3.11815 · Cited by 492 · see citing works

Your Chi-Square Test Is Statistically Significant: Now What?

Sharpe, D. (2015) · DOAJ (DOAJ: Directory of Open Access Journals) · Cited by 471 · see citing works

Essential role of Epac2/Rap1 signaling in regulation of insulin granule dynamics by cAMP

Shibasaki, T., Takahashi, H., Miki, T., Sunaga, Y., Matsumura, K., Yamanaka, M., Zhang, C., Tamamoto, A., Satoh, T., Miyazaki, J.-I., et al. (2007) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.0707054104 · Cited by 425 · see citing works

Voltage-Gated Ion Channels in Human Pancreatic β-Cells: Electrophysiological Characterization and Role in Insulin Secretion

Braun, M., Ramracheya, R., Bengtsson, M., Zhang, Q., Karanauskaite, J., Partridge, C., Johnson, P. R., & Rorsman, P. (2008) · Diabetes · doi:10.2337/db07-0991 · Cited by 417 · see citing works

Dynamics of insulin secretion and the clinical implications for obesity and diabetes

Seino, S., Shibasaki, T., & Minami, K. (2011) · Journal of Clinical Investigation · doi:10.1172/jci45680 · Cited by 364 · see citing works

Glucagon physiology and pathophysiology in the light of new advances

Unger, R. H. (1985) · Diabetologia · doi:10.1007/bf00281991 · Cited by 361 · see citing works

Somatostatin Inhibits Insulin and Glucagon Secretion via Two Receptor Subtypes: An in Vitro Study of Pancreatic Islets from Somatostatin Receptor 2 Knockout Mice

Strowski, M. Z., Parmar, R. M., Blake, A. D., & Schaeffer, J. M. (2000) · Endocrinology · doi:10.1210/endo.141.1.7263 · Cited by 358 · see citing works

Comprehensive alpha, beta and delta cell transcriptomes reveal that ghrelin selectively activates delta cells and promotes somatostatin release from pancreatic islets

DiGruccio, M. R., Mawla, A. M., Donaldson, C. J., Noguchi, G. M., Vaughan, J., Cowing-Zitron, C., van der Meulen, T., & Huising, M. O. (2016) · Molecular Metabolism · doi:10.1016/j.molmet.2016.04.007 · Cited by 353 · see citing works

Human islets contain four distinct subtypes of β cells

Dorrell, C., Schug, J., Canaday, P., Russ, H., Tarlow, B. D., Grompe, M. T., Horton, T., Hebrok, M., Streeter, P., Kaestner, K., et al. (2016) · Nature Communications · doi:10.1038/ncomms11756 · Cited by 339 · see citing works

Somatostatin Secreted by Islet δ-Cells Fulfills Multiple Roles as a Paracrine Regulator of Islet Function

Hauge-Evans, A. C., King, A. J., Carmignac, D., Richardson, C. C., Robinson, I. C. A. F., Low, M. J., Christie, M. R., Persaud, S. J., & Jones, P. M. (2009) · Diabetes · doi:10.2337/db08-0792 · Cited by 335 · see citing works

Insulin Signaling in α Cells Modulates Glucagon Secretion In Vivo

Kawamori, D., Kurpad, A. J., Hu, J., Liew, C. W., Shih, J. L., Ford, E. L., Herrera, P. L., Polonsky, K. S., McGuinness, O. P., & Kulkarni, R. N. (2009) · Cell Metabolism · doi:10.1016/j.cmet.2009.02.007 · Cited by 316 · see citing works

Macro- and Micro-Domains in the Endocrine Pancreas

Orci, L. (1982) · Diabetes · doi:10.2337/diab.31.6.538 · Cited by 309 · see citing works

Membrane potential of beta-cells in pancreatic islets

Meissner, H. P., & Schmelz, H. (1974) · Pflügers Archiv - European Journal of Physiology · doi:10.1007/bf00586918 · Cited by 299 · see citing works

Transgenic mice with green fluorescent protein-labeled pancreatic β-cells

Hara, M., Wang, X., Kawamura, T., Bindokas, V. P., Dizon, R. F., Alcoser, S. Y., Magnuson, M. A., & Bell, G. I. (2003) · American Journal of Physiology-Endocrinology and Metabolism · doi:10.1152/ajpendo.00321.2002 · Cited by 293 · see citing works

β-Cell Secretory Products Activate α-Cell ATP-Dependent Potassium Channels to Inhibit Glucagon Release

Franklin, I., Gromada, J., Gjinovci, A., Theander, S., & Wollheim, C. (2005) · Diabetes · doi:10.2337/diabetes.54.6.1808 · Cited by 291 · see citing works

Intra-islet insulin suppresses glucagon release via GABA-GABAA receptor system

Xu, E., Kumar, M., Zhang, Y., Ju, W., Obata, T., Zhang, N., Liu, S., Wendt, A., Deng, S., Ebina, Y., et al. (2006) · Cell Metabolism · doi:10.1016/j.cmet.2005.11.015 · Cited by 283 · see citing works

Glucose or Insulin, but not Zinc Ions, Inhibit Glucagon Secretion From Mouse Pancreatic α-Cells

Ravier, M. A., & Rutter, G. A. (2005) · Diabetes · doi:10.2337/diabetes.54.6.1789 · Cited by 264 · see citing works

Reversible changes in pancreatic islet structure and function produced by elevated blood glucose

Brereton, M. F., Iberl, M., Shimomura, K., Zhang, Q., Adriaenssens, A. E., Proks, P., Spiliotis, I. I., Dace, W., Mattis, K. K., Ramracheya, R., et al. (2014) · Nature Communications · doi:10.1038/ncomms5639 · Cited by 259 · see citing works

Stimulus-secretion coupling in pancreatic β cells

Ashcroft, F. M., Proks, P., Smith, P. A., Ämmälä, C., Bokvist, K., & Rorsman, P. (1994) · Journal of Cellular Biochemistry · doi:10.1002/jcb.240550007 · Cited by 255 · see citing works

A KATP Channel-Dependent Pathway within α Cells Regulates Glucagon Release from Both Rodent and Human Islets of Langerhans

MacDonald, P. E., Marinis, Y. Z. D., Ramracheya, R. D., Salehi, A. A., Ma, X., Johnson, P., Cox, R., Eliasson, L., & Rorsman, P. (2007) · PLoS Biology · doi:10.1371/journal.pbio.0050143 · Cited by 243 · see citing works

Endocrine Pancreas: Three-Dimensional Reconstruction Shows Two Types of Islets of Langerhans

Baetens, D., MALAISSE-LAGAE, F., Perrelet, A., & Orci, L. (1979) · Science · doi:10.1126/science.390711 · Cited by 237 · see citing works

Regulation of glucagon release in mouse α‐cells by K_ATP channels and inactivation of TTX‐sensitive Na⁺ channels

Göpel, S. O., Kanno, T., Barg, S., Weng, X. ‐., Gromada, J., & Rorsman, P. (2000) · The Journal of Physiology · doi:10.1111/j.1469-7793.2000.00509.x · Cited by 229 · see citing works

Voltage‐gated and resting membrane currents recorded from B‐cells in intact mouse pancreatic islets

Göpel, S., Kanno, T., Barg, S., Galvanovskis, J., & Rorsman, P. (1999) · The Journal of Physiology · doi:10.1111/j.1469-7793.1999.00717.x · Cited by 226 · see citing works

Role of KATP Channels in Glucose-Regulated Glucagon Secretion and Impaired Counterregulation in Type 2 Diabetes

Zhang, Q., Ramracheya, R., Lahmann, C., Tarasov, A., Bengtsson, M., Braha, O., Braun, M., Brereton, M., Collins, S., Galvanovskis, J., et al. (2013) · Cell Metabolism · doi:10.1016/j.cmet.2013.10.014 · Cited by 225 · see citing works

Transcriptomic profiling of pancreatic alpha, beta and delta cell populations identifies delta cells as a principal target for ghrelin in mouse islets

Adriaenssens, A. E., Svendsen, B., Lam, B. Y. H., Yeo, G. S. H., Holst, J. J., Reimann, F., & Gribble, F. M. (2016) · Diabetologia · doi:10.1007/s00125-016-4033-1 · Cited by 223 · see citing works

Glucose inhibits glucagon secretion by a direct effect on mouse pancreatic alpha cells

Vieira, E., Salehi, A., & Gylfe, E. (2007) · Diabetologia · doi:10.1007/s00125-006-0511-1 · Cited by 218 · see citing works

Standards for Standardized Logistic Regression Coefficients

Menard, S. (2011) · Social Forces · doi:10.1093/sf/89.4.1409 · Cited by 209 · see citing works

Tight coupling between electrical activity and exocytosis in mouse glucagon-secreting alpha-cells.

Barg, S., Galvanovskis, J., Göpel, S. O., Rorsman, P., & Eliasson, L. (2000) · Diabetes · doi:10.2337/diabetes.49.9.1500 · Cited by 209 · see citing works

Abnormalities in insulin secretion in type 2 diabetes mellitus

Guillausseau, P.-J., Meas, T., Virally, M., Laloi-Michelin, M., Medeau, V., & Kévorkian, J.-P. (2008) · Diabetes & Metabolism · doi:10.1016/s1262-3636(08)73394-9 · Cited by 191 · see citing works

Once daily injection of exendin-4 to diabetic mice achieves long-term beneficial effects on blood glucose concentrations

Greig, N. H., Holloway, H. W., Ore, K. A. D., Jani, D., Wang, Y., Zhou, J., Garant, M. J., & Egan, J. M. (1999) · Diabetologia · doi:10.1007/s001250051111 · Cited by 189 · see citing works

A<i>TP</i>-Sensitive <i>K</i>+ Channel–Dependent Regulation of Glucagon Release and Electrical Activity by Glucose in Wild-Type and <i>SUR1</i>−/− Mouse α-Cells

Gromada, J., Ma, X., Høy, M., Bokvist, K., Salehi, A., Berggren, P.-O., & Rorsman, P. (2004) · Diabetes · doi:10.2337/diabetes.53.suppl_3.s181 · Cited by 164 · see citing works

[5] Access resistance and space clamp problems associated with whole-cell patch clamping

Armstrong, C. M., & Gilly, W. F. (1992) · Methods in enzymology on CD-ROM/Methods in enzymology · doi:10.1016/0076-6879(92)07007-b · Cited by 160 · see citing works

Capacitance measurements of exocytosis in mouse pancreatic α‐, β‐ and δ‐cells within intact islets of Langerhans

Göpel, S., Zhang, Q., Eliasson, L., Ma, X., Galvanovskis, J., Kanno, T., Salehi, A., & Rorsman, P. (2004) · The Journal of Physiology · doi:10.1113/jphysiol.2003.059675 · Cited by 160 · see citing works

Glucose-induced electrical activities and insulin secretion in pancreatic islet β-cells are modulated by CFTR

Guo, J. H., Chen, H., Ruan, Y. C., Zhang, X. L., Zhang, X. H., Fok, K. L., Tsang, L. L., Yu, M. K., Huang, W. Q., Sun, X., et al. (2014) · Nature Communications · doi:10.1038/ncomms5420 · Cited by 157 · see citing works

Patch‐clamp characterisation of somatostatin‐secreting δ‐cells in intact mouse pancreatic islets

Göpel, S., Kanno, T., Barg, S., & Rorsman, P. (2000) · The Journal of Physiology · doi:10.1111/j.1469-7793.2000.00497.x · Cited by 143 · see citing works

Insulin secretion from human beta cells is heterogeneous and dependent on cell-to-cell contacts

Wojtusciszyn, A., Armanet, M., Morel, P., Berney, T., & Bosco, D. (2008) · Diabetologia · doi:10.1007/s00125-008-1103-z · Cited by 141 · see citing works

The voltage-dependent K+ channels Kv1.3 and Kv1.5 in human cancer

Comes, N., Bielańska, J., Vallejo-Gracia, A., Serrano-Albarrás, A., Marruecos, L., Gómez, D., Soler, C., Condom, E., y Cajal, S. R., Hernández‐Losa, J., et al. (2013) · Frontiers in Physiology · doi:10.3389/fphys.2013.00283 · Cited by 140 · see citing works

Electronic Design of the Patch Clamp

Sigworth, F. J. (1983) · Springer eBooks · doi:10.1007/978-1-4615-7858-1_1 · Cited by 139 · see citing works

Membrane Potential-Dependent Inactivation of Voltage-Gated Ion Channels in α-Cells Inhibits Glucagon Secretion From Human Islets

Ramracheya, R., Ward, C., Shigeto, M., Walker, J. N., Amisten, S., Zhang, Q., Johnson, P. R., Rorsman, P., & Braun, M. (2010) · Diabetes · doi:10.2337/db09-1505 · Cited by 136 · see citing works

An Improved Parameter Estimation Method for Hodgkin-Huxley Models

Willms, A. R., Baro, D. J., Harris‐Warrick, R. M., & Guckenheimer, J. M. (1999) · Journal of Computational Neuroscience · doi:10.1023/a:1008880518515 · Cited by 133 · see citing works

Potassium channels Kv1.1, Kv1.2 and Kv1.6 influence excitability of rat visceral sensory neurons

Glazebrook, P. A., Ramirez, A. N., Schild, J. H., Shieh, C., Doan, T. N., Wible, B. A., & Kunze, D. L. (2002) · The Journal of Physiology · doi:10.1113/jphysiol.2001.018333 · Cited by 125 · see citing works

Somatostatin inhibits exocytosis in rat pancreatic α‐cells by G _i2 ‐dependent activation of calcineurin and depriming of secretory granules

Gromada, J., Høy, M., Buschard, K., Salehi, A., & Rorsman, P. (2001) · The Journal of Physiology · doi:10.1111/j.1469-7793.2001.00519.x · Cited by 120 · see citing works

Autofluorescence-activated cell sorting of pancreatic islet cells: Purification of insulin-containing B-cells according to glucose-induced changes in cellular redox state

Winkel, M. V. D., & PIPELEERS, D. G. (1983) · Biochemical and Biophysical Research Communications · doi:10.1016/0006-291x(83)90857-4 · Cited by 113 · see citing works

Gating-dependent mechanism of 4-aminopyridine block in two related potassium channels.

Kirsch, G. E., & Drewe, J. (1993) · The Journal of General Physiology · doi:10.1085/jgp.102.5.797 · Cited by 112 · see citing works

Glucagon secretion from pancreatic α-cells

Briant, L., Salehi, A., Vergari, E., Zhang, Q., & Rorsman, P. (2016) · Upsala Journal of Medical Sciences · doi:10.3109/03009734.2016.1156789 · Cited by 109 · see citing works

Somatostatin release, electrical activity, membrane currents and exocytosis in human pancreatic delta cells

Braun, M., Ramracheya, R., Amisten, S., Bengtsson, M., Moritoh, Y., Zhang, Q., Johnson, P. R. V., & Rorsman, P. (2009) · Diabetologia · doi:10.1007/s00125-009-1382-z · Cited by 104 · see citing works

Glucose regulation of glucagon secretion

Gylfe, E., & Gilon, P. (2013) · Diabetes Research and Clinical Practice · doi:10.1016/j.diabres.2013.11.019 · Cited by 98 · see citing works

Characterization of voltage‐dependent sodium and calcium channels in mouse pancreatic A‐ and B‐cells

Vignali, S., Leiss, V., Karl, R., Hofmann, F., & Welling, A. (2006) · The Journal of Physiology · doi:10.1113/jphysiol.2005.102368 · Cited by 96 · see citing works

Na⁺ current properties in islet α‐ and β‐cells reflect cell‐specific <i>Scn3a</i> and <i>Scn9a</i> expression

Zhang, Q., Chibalina, M. V., Bengtsson, M., Groschner, L. N., Ramracheya, R., Rorsman, N. J. G., Leiss, V., Nassar, M. A., Welling, A., Gribble, F. M., et al. (2014) · The Journal of Physiology · doi:10.1113/jphysiol.2014.274209 · Cited by 90 · see citing works

Tolbutamide Controls Glucagon Release From Mouse Islets Differently Than Glucose

Cheng, R., Gómez-Ruiz, A., Antoine, N., Noël, L. A., Chae, H., Ravier, M. A., Chimienti, F., Schuit, F. C., & Gilon, P. (2013) · Diabetes · doi:10.2337/db12-0347 · Cited by 88 · see citing works

The GluCre‐ROSA26EYFP mouse: A new model for easy identification of living pancreatic α‐cells

Quoix, N., Rui, C.-X., Guiot, Y., Herrera, P., Henquin, J., & Gilon, P. (2007) · FEBS Letters · doi:10.1016/j.febslet.2007.07.068 · Cited by 87 · see citing works

Insulin Regulates Islet α-Cell Function by Reducing KATP Channel Sensitivity to Adenosine 5′-Triphosphate Inhibition

Leung, Y., Ahmed, I., Sheu, L., Gao, X., Hara, M., Tsushima, R. G., Diamant, N. E., & Gaisano, H. Y. (2006) · Endocrinology · doi:10.1210/en.2005-1249 · Cited by 83 · see citing works

Cellular function in multicellular system for hormone-secretion: electrophysiological aspect of studies on α-, β- and δ-cells of the pancreatic islet

Kanno, T., Göpel, S., Rorsman, P., & Wakui, M. (2002) · Neuroscience Research · doi:10.1016/s0168-0102(01)00318-2 · Cited by 81 · see citing works

Glucose and Pharmacological Modulators of ATP-Sensitive K+ Channels Control [Ca2+]c by Different Mechanisms in Isolated Mouse α-Cells

Quoix, N., Cheng, R., Mattart, L., Zeinoun, Z., Guiot, Y., Beauvois, M. C., Henquin, J., & Gilon, P. (2008) · Diabetes · doi:10.2337/db07-1298 · Cited by 78 · see citing works

Secretion, Fates and Actions of Insulin and Related Products

Williams, R. H., & Ensinck, J. W. (1966) · Diabetes · doi:10.2337/diab.15.9.623 · Cited by 77 · see citing works

Electrophysiological Characterization of Pancreatic Islet Cells in the Mouse Insulin Promoter-Green Fluorescent Protein Mouse

Leung, Y., Ahmed, I., Sheu, L., Tsushima, R. G., Diamant, N. E., Hara, M., & Gaisano, H. Y. (2005) · Endocrinology · doi:10.1210/en.2005-0803 · Cited by 74 · see citing works

Unperturbed islet α‐cell function examined in mouse pancreas tissue slices

Huang, Y., Rupnik, M. S., & Gaisano, H. Y. (2010) · The Journal of Physiology · doi:10.1113/jphysiol.2010.200345 · Cited by 71 · see citing works

On the mechanism of 4‐aminopyridine action on the cloned mouse brain potassium channel mKv1.1.

Stephens, G. J., Garratt, J. C., Robertson, B., & Owen, D. G. (1994) · The Journal of Physiology · doi:10.1113/jphysiol.1994.sp020183 · Cited by 69 · see citing works

Closed- and open-state binding of 4-aminopyridine to the cloned human potassium channel Kv1.5.

Bouchard, R. A., & Fedida, D. (1995) · Journal of Pharmacology and Experimental Therapeutics · doi:10.1016/s0022-3565(25)12140-x · Cited by 67 · see citing works

UCP2 Regulates the Glucagon Response to Fasting and Starvation

Allister, E. M., Doucette, C. A., Prentice, K. J., Hardy, A. B., Sultan, S., Gaisano, H. Y., Kong, D., Gilon, P., Herrera, P. L., Lowell, B. B., et al. (2013) · Diabetes · doi:10.2337/db12-0981 · Cited by 67 · see citing works

Zinc‐induced changes in ionic currents of clonal rat pancreatic β‐cells: activation of ATP‐sensitive K+ channels

Bloc, A., Cens, T., Cruz, H. G., & Dunant, Y. (2000) · The Journal of Physiology · doi:10.1111/j.1469-7793.2000.00723.x · Cited by 63 · see citing works

Islet cell plasticity and regeneration

Migliorini, A., Bader, E., & Lickert, H. (2014) · Molecular Metabolism · doi:10.1016/j.molmet.2014.01.010 · Cited by 60 · see citing works

BK channels mediate a novel ionic mechanism that regulates glucose-dependent electrical activity and insulin secretion in mouse pancreatic β-cells: BK channels in pancreatic beta cells

Houamed, K. M., Sweet, I. R., & Satin, L. S. (2010) · The Journal of Physiology · doi:10.1113/jphysiol.2009.184341 · Cited by 59 · see citing works

Electronic Design of the Patch Clamp

Sigworth, F. J. (1995) · Springer eBooks · doi:10.1007/978-1-4419-1229-9_4 · Cited by 57 · see citing works

Paracrine regulation of glucagon secretion: the β/α/δ model

Watts, M., Ha, J., Kimchi, O., & Sherman, A. (2016) · American Journal of Physiology-Endocrinology and Metabolism · doi:10.1152/ajpendo.00415.2015 · Cited by 53 · see citing works

Feedback Control of the ATP-Sensitive K+ Current by Cytosolic Ca2+ Contributes to Oscillations of the Membrane Potential in Pancreatic β-Cells

Rolland, J., Henquin, J., & Gilon, P. (2002) · Diabetes · doi:10.2337/diabetes.51.2.376 · Cited by 49 · see citing works

In Situ Electrophysiological Examination of Pancreatic α Cells in the Streptozotocin-Induced Diabetes Model, Revealing the Cellular Basis of Glucagon Hypersecretion

Huang, Y.-C., Rupnik, M., Karimian, N., Herrera, P., Gilon, P., Feng, Z.-P., & Gaisano, H. (2013) · Diabetes · doi:10.2337/db11-0786 · Cited by 49 · see citing works

Glucose-dependent docking and SNARE protein-mediated exocytosis in mouse pancreatic alpha-cell

Andersson, S. A., Pedersen, M. G., Vikman, J., & Eliasson, L. (2011) · Pflügers Archiv - European Journal of Physiology · doi:10.1007/s00424-011-0979-5 · Cited by 46 · see citing works

Modeling the pancreatic α-cell: dual mechanisms of glucose suppression of glucagon secretion

Watts, M., & Sherman, A. (2014) · Biophysical Journal · doi:10.1016/j.bpj.2013.11.4504 · Cited by 45 · see citing works

Fluorescent protein vectors for pancreatic islet cell identification in live-cell imaging

Shuai, H., Xu, Y., Yu, Q., Gylfe, E., & Tengholm, A. (2016) · Pflügers Archiv - European Journal of Physiology · doi:10.1007/s00424-016-1864-z · Cited by 45 · see citing works

Block by 4‐aminopyridine of a Kv1.2 delayed rectifier K+ current expressed in Xenopus oocytes.

Russell, S. N., Publicover, N. G., Hart, P. J., Carl, A., Hume, J. R., Sanders, K. M., & Horowitz, B. (1994) · The Journal of Physiology · doi:10.1113/jphysiol.1994.sp020464 · Cited by 44 · see citing works

TASK-1 Potassium Channels Limit Pancreatic α-Cell Calcium Influx and Glucagon Secretion

Dadi, P. K., Luo, B., Vierra, N. C., & Jacobson, D. A. (2015) · Molecular Endocrinology · doi:10.1210/me.2014-1321 · Cited by 40 · see citing works

Hyperinsulinism and Diabetes: Genetic Dissection of β Cell Metabolism-Excitation Coupling in Mice

Remedi, M. S., & Nichols, C. G. (2009) · Cell Metabolism · doi:10.1016/j.cmet.2009.10.011 · Cited by 39 · see citing works

Pancreatic alpha-cells from female mice undergo morphofunctional changes during compensatory adaptations of the endocrine pancreas to diet-induced obesity

Merino, B., Alonso‐Magdalena, P., Lluesma, M., Ñeco, P., González, A., Marroquí, L., García‐Arévalo, M., Nadal, Á., & Quesada, I. (2015) · Scientific Reports · doi:10.1038/srep11622 · Cited by 36 · see citing works

Modelling the Electrical Activity of Pancreatic α-cells Based on Experimental Data from Intact Mouse Islets

Diderichsen, P. M., & Göpel, S. (2006) · Journal of Biological Physics · doi:10.1007/s10867-006-9013-0 · Cited by 30 · see citing works

Fundamental Concepts in Biophysics

Jue, T. (2009) · Humana Press eBooks · doi:10.1007/978-1-59745-397-4 · Cited by 27 · see citing works

Glucose Control of Glucagon Secretion: There Is More to It Than KATP Channels

Gylfe, E. (2013) · Diabetes · doi:10.2337/db13-0193 · Cited by 23 · see citing works

Tolbutamide potentiates the volume-regulated anion channel current in rat pancreatic beta cells

Best, L. C., Davies, S. L., & Brown, P. (2004) · Diabetologia · doi:10.1007/s00125-004-1559-4 · Cited by 17 · see citing works

4-Aminopyridine block of the noninactivating cloned K+ channel Kv1.5 expressed in Xenopus oocytes

Yamane, T., Furukawa, T., & Hiraoka, M. (1995) · American Journal of Physiology-Heart and Circulatory Physiology · doi:10.1152/ajpheart.1995.269.2.h556 · Cited by 16 · see citing works

A computational systems analysis of factors regulating α cell glucagon secretion

Fridlyand, L. E., & Philipson, L. H. (2012) · Islets · doi:10.4161/isl.22193 · Cited by 12 · see citing works

Age-dependent changes in the exocytotic efficacy in Kir6.2 ablated mouse pancreatic β-cells

Tsiaze, E., Huang, Y.-C., Bombek, L. K., Yang, S., Jevšek, M., Seino, S., & Rupnik, M. (2012) · Open Journal of Molecular and Integrative Physiology · doi:10.4236/ojmip.2012.23008 · Cited by 3 · see citing works

Electrophysiological Measurements of Membrane Proteins

Chen, T., Lin, Y., & Zheng, J. (2009) · Humana Press eBooks · doi:10.1007/978-1-59745-397-4_5 · Cited by 2 · see citing works

Pancreatic β-Cell Electrical Activity and Insulin Secretion: Of Mice and Men

Rorsman, P., & Ashcroft, F. M. (2018) · Physiological Reviews · doi:10.1152/physrev.00008.2017 · Cited by 793 · see citing works

Patch-Seq Links Single-Cell Transcriptomes to Human Islet Dysfunction in Diabetes

Camuñas-Soler, J., Dai, X.-Q., Hang, Y., Bautista, A., Lyon, J. G., Suzuki, K., Kim, S. K., Quake, S. R., & MacDonald, P. E. (2020) · Cell Metabolism · doi:10.1016/j.cmet.2020.04.005 · Cited by 282 · see citing works

The somatostatin-secreting pancreatic δ-cell in health and disease

Rorsman, P., & Huising, M. O. (2018) · Nature Reviews Endocrinology · doi:10.1038/s41574-018-0020-6 · Cited by 259 · see citing works

Multimodal profiling of single-cell morphology, electrophysiology, and gene expression using Patch-seq

Cadwell, C. R., Scala, F., Li, S., Livrizzi, G., Shen, S., Sandberg, R., Jiang, X., & Tolias, A. S. (2017) · Nature Protocols · doi:10.1038/nprot.2017.120 · Cited by 147 · see citing works

δ‐cells and β‐cells are electrically coupled and regulate α‐cell activity via somatostatin

Briant, L. J. B., Reinbothe, T. M., Spiliotis, I., Miranda, C., Rodriguez, B., & Rorsman, P. (2018) · The Journal of Physiology · doi:10.1113/jp274581 · Cited by 155 · see citing works

The physiological role of β-cell heterogeneity in pancreatic islet function

Benninger, R. K. P., & Kravets, V. V. (2021) · Nature Reviews Endocrinology · doi:10.1038/s41574-021-00568-0 · Cited by 136 · see citing works

Integrating the inputs that shape pancreatic islet hormone release

Noguchi, G. M., & Huising, M. O. (2019) · Nature Metabolism · doi:10.1038/s42255-019-0148-2 · Cited by 130 · see citing works

GLP-1 suppresses glucagon secretion in human pancreatic alpha-cells by inhibition of P/Q-type Ca ²⁺ channels

Ramracheya, R., Chapman, C., Chibalina, M., Dou, H., Miranda, C., González, A., Moritoh, Y., Shigeto, M., Zhang, Q., Braun, M., et al. (2018) · Physiological Reports · doi:10.14814/phy2.13852 · Cited by 128 · see citing works

CPT1a-Dependent Long-Chain Fatty Acid Oxidation Contributes to Maintaining Glucagon Secretion from Pancreatic Islets

Briant, L. J. B., Dodd, M. S., Chibalina, M. V., Rorsman, N. J. G., Johnson, P., Carmeliet, P., Rorsman, P., & Knudsen, J. G. (2018) · Cell Reports · doi:10.1016/j.celrep.2018.05.035 · Cited by 97 · see citing works

A critical role of the mechanosensor PIEZO1 in glucose-induced insulin secretion in pancreatic β-cells

Ye, Y., Barghouth, M., Dou, H., Luan, C., Wang, Y., Karagiannopoulos, A., Jiang, X., Krus, U., Fex, M., Zhang, Q., et al. (2022) · Nature Communications · doi:10.1038/s41467-022-31103-y · Cited by 89 · see citing works

Heterogenous impairment of α-cell function in type 2 diabetes is linked to cell maturation state

Dai, X.-Q., Camunas-Soler, J., Briant, L., dos Santos, T., Spigelman, A., Walker, E., Drigo, R. A., Bautista, A., Jones, R. C., Avrahami, D., et al. (2022) · Cell Metabolism · doi:10.1016/j.cmet.2021.12.021 · Cited by 69 · see citing works

The Human Islet: Mini-Organ With Mega-Impact

Walker, J. T., Saunders, D. C., Briššová, M., & Powers, A. C. (2021) · Endocrine Reviews · doi:10.1210/endrev/bnab010 · Cited by 80 · see citing works

Reduced somatostatin signalling leads to hypersecretion of glucagon in mice fed a high-fat diet

Kellard, J. A., Rorsman, N. J. G., Hill, T. G., Armour, S. L., van de Bunt, M., Rorsman, P., Knudsen, J. G., & Briant, L. J. B. (2020) · Molecular Metabolism · doi:10.1016/j.molmet.2020.101021 · Cited by 62 · see citing works

Beta-cell hubs maintain Ca2+ oscillations in human and mouse islet simulations

Lei, C. L., Kellard, J. A., Hara, M., Johnson, J. D., Rodríguez, B., & Briant, L. (2018) · Islets · doi:10.1080/19382014.2018.1493316 · Cited by 56 · see citing works

Gi/o protein-coupled receptor inhibition of beta-cell electrical excitability and insulin secretion depends on Na+/K+ ATPase activation

Dickerson, M. T., Dadi, P. K., Zaborska, K. E., Nakhe, A. Y., Schaub, C. M., Dobson, J. R., Wright, N. M., Lynch, J. C., Scott, C. F., Robinson, L. D., et al. (2022) · Nature Communications · doi:10.1038/s41467-022-34166-z · Cited by 47 · see citing works

Beta‐Cell Ion Channels and Their Role in Regulating Insulin Secretion

Thompson, B. M., & Satin, L. S. (2021) · Comprehensive physiology · doi:10.1002/cphy.c210004 · Cited by 51 · see citing works

Glucose stimulates somatostatin secretion in pancreatic δ-cells by cAMP-dependent intracellular Ca2+ release

Denwood, G., Tarasov, A. I., Salehi, A. A., Vergari, E., Ramracheya, R. D., Takahashi, H., Nikolaev, V. O., Seino, S., Gribble, F. M., Reimann, F. M., et al. (2019) · The Journal of General Physiology · doi:10.1085/jgp.201912351 · Cited by 38 · see citing works

Vitamin-D-Binding Protein Contributes to the Maintenance of α Cell Function and Glucagon Secretion

Viloria, K., Nasteska, D., Briant, L. J. B., Heising, S., Larner, D. P., Fine, N. H. F., Ashford, F. B., Xavier, G. D. S., Ramos, M. J., Hasib, A., et al. (2020) · Cell Reports · doi:10.1016/j.celrep.2020.107761 · Cited by 35 · see citing works

Glucose Controls Glucagon Secretion by Regulating Fatty Acid Oxidation in Pancreatic α-Cells

Armour, S. L., Frueh, A., Chibalina, M. V., Dou, H., Argemi‐Muntadas, L., Hamilton, A., Katzilieris‐Petras, G., Carmeliet, P., Davies, B., Möritz, T., et al. (2023) · Diabetes · doi:10.2337/db23-0056 · Cited by 32 · see citing works

Loss of electrical β-cell to δ-cell coupling underlies impaired hypoglycaemia-induced glucagon secretion in type-1 diabetes

Hill, T. G., Gao, R., Benrick, A., Kothegala, L., Rorsman, N., Santos, C., Acreman, S., Briant, L. J., Dou, H., Gandasi, N. R., et al. (2024) · Nature Metabolism · doi:10.1038/s42255-024-01139-z · Cited by 30 · see citing works

‘Resistance is futile?’ – paradoxical inhibitory effects of K ATP channel closure in glucagon‐secreting α‐cells

Zhang, Q., Dou, H., & Rorsman, P. (2020) · The Journal of Physiology · doi:10.1113/jp279775 · Cited by 30 · see citing works

Mitochondrial Dysfunction in Pancreatic Alpha and Beta Cells Associated with Type 2 Diabetes Mellitus

Grubelnik, V., Zmazek, J., Markovič, R., Gosak, M., & Marhl, M. (2020) · Life · doi:10.3390/life10120348 · Cited by 28 · see citing works

Intercellular Communication in the Islet of Langerhans in Health and Disease

Ng, X. W., Chung, Y. H., & Piston, D. W. (2021) · Comprehensive physiology · doi:10.1002/cphy.c200026 · Cited by 39 · see citing works

Pathways of Glucagon Secretion and Trafficking in the Pancreatic Alpha Cell: Novel Pathways, Proteins, and Targets for Hyperglucagonemia

Asadi, F., & Dhanvantari, S. (2021) · Frontiers in Endocrinology · doi:10.3389/fendo.2021.726368 · Cited by 24 · see citing works

Neuromodulation of metabolic functions: from pharmaceuticals to bioelectronics to biocircuits

Seicol, B. J., Bejarano, S., Behnke, N., & Guo, L. (2019) · Journal of Biological Engineering · doi:10.1186/s13036-019-0194-z · Cited by 22 · see citing works

Gap junction coupling and islet delta-cell function in health and disease.

Miranda, C., Begum, M., Vergari, E., & Briant, L. (2021) · Peptides · doi:10.1016/j.peptides.2021.170704 · Cited by 18 · see citing works

HNF1A and A1CF coordinate a beta cell transcription-splicing axis that is disrupted in type 2 diabetes

Bernardo, E., Vas, M. G. D., Balboa, D., Cuenca-Ardura, M., Bonàs‐Guarch, S., Planas-Fèlix, M., Mollandin, F., Torrens-Dinarès, M., Maestro, M. A., García-Hurtado, J., et al. (2025) · Cell Metabolism · doi:10.1016/j.cmet.2025.07.007 · Cited by 17 · see citing works

Modelling of energy-driven switch for glucagon and insulin secretion

Grubelnik, V., Zmazek, J., Markovič, R., Gosak, M., & Marhl, M. (2020) · Journal of Theoretical Biology · doi:10.1016/j.jtbi.2020.110213 · Cited by 15 · see citing works

Comparative analysis of reconstructed architectures from mice and human islets

Félix-Martínez, G. J., & Godínez-Fernández, J. R. (2021) · Islets · doi:10.1080/19382014.2021.1987827 · Cited by 8 · see citing works

Beta-cell Ion Channels and Their Role in Regulating Insulin Secretion

Thompson, B. M., & Satin, L. S. (2021) · Comprehensive Physiology · doi:10.1002/j.2040-4603.2021.tb00189.x · Cited by 47 · see citing works

Heterogeneous alpha-cell population modeling of glucose-induced inhibition of electrical activity

Montefusco, F., Cortese, G., & Pedersen, M. G. (2020) · Journal of Theoretical Biology · doi:10.1016/j.jtbi.2019.110036 · Cited by 13 · see citing works

The endoplasmic reticulum plays a key role in α-cell intracellular Ca2+ dynamics and glucose-regulated glucagon secretion in mouse islets

Acreman, S., Ma, J., Denwood, G., Gao, R., Tarasov, A. I., Rorsman, P., & Zhang, Q. (2024) · iScience · doi:10.1016/j.isci.2024.109665 · Cited by 15 · see citing works

Vitamin D binding protein/GC‐globulin: a novel regulator of alpha cell function and glucagon secretion

Viloria, K., Hewison, M., & Hodson, D. (2021) · Journal of Physiology · doi:10.1113/jp280890 · Cited by 9 · see citing works

Intercellular Communication in the Islet of Langerhans in Health and Disease

Ng, X.-W., Yong, H.-C., & Piston, D. W. (2021) · Comprehensive Physiology · doi:10.1002/j.2040-4603.2021.tb00177.x · Cited by 27 · see citing works

Calcium Oscillations in Pancreatic α-cells Rely on Noise and ATP-Driven Changes in Membrane Electrical Activity

González‐Vélez, V., Piron, A., & Dupont, G. (2020) · Frontiers in Physiology · doi:10.3389/fphys.2020.602844 · Cited by 10 · see citing works

Altered immune and metabolic molecular pathways drive islet cell dysfunction in human type 1 diabetes

dos Santos, T., Dai, X.-Q., Jones, R. C., Spigelman, A. F., Mummey, H. M., Ewald, J., Ellis, C. E., Lyon, J. G., Smith, N. P., Bautista, A., et al. (2025) · Journal of Clinical Investigation · doi:10.1172/jci195267 · Cited by 9 · see citing works

The effects of beta-cell mass and function, intercellular coupling, and islet synchrony on [Formula: see text] dynamics.

Saadati, M., & Jamali, Y. (2020) · Scientific Reports · doi:10.1038/s41598-021-89333-x · Cited by 5 · see citing works

Xanthine-derived KMUP-1 reverses glucotoxicity-activated Kv channels through the cAMP/PKA signaling pathway in rat pancreatic β cells

Lee, C., Chu, C., Tsai, H.-J., Ke, L., Lee, H., Yeh, J., Chen, C., & Wu, B. (2017) · Chemico-Biological Interactions · doi:10.1016/j.cbi.2017.11.017 · Cited by 9 · see citing works

Acute and chronic effects of the organophosphate malathion on the pancreatic α and β cell viability, cell structure, and voltage-gated K+ currents.

Martins, J. R. N., Lopes, S. C., Hurtado, H. N., da Silva, F. N., Villard, D. R., Taboga, S. R., Souza, K. L. A., Quesada, I., Soriano, S., & Rafacho, A. (2022) · Environmental Toxicology and Pharmacology · doi:10.1016/j.etap.2022.104046 · Cited by 8 · see citing works

Hyperglucagonemia and glucagon hypersecretion in early type 2 diabetes result from multifaceted dysregulation of pancreatic mouse α-cells

Ruiz-Pino, A., Goncalves-Ramírez, A., Jiménez-Palomares, M., Merino, B., Castellano-Muñoz, M., Vettorazzi, J. F., Rafacho, A., Marroquí, L., Nadal, Á., Alonso‐Magdalena, P., et al. (2024) · Pflügers Archiv - European Journal of Physiology · doi:10.1007/s00424-024-03045-5 · Cited by 7 · see citing works

Nicotinic Signaling Stimulates Glucagon Secretion in Mouse and Human Pancreatic α-Cells

Hamilton, A., Zhang, Q., Gao, R., Hill, T. G., Salehi, A., Knudsen, J. G., Draper, M., Johnson, P. R. V., Rorsman, P., & Tarasov, A. (2024) · Diabetes · doi:10.2337/db23-0809 · Cited by 5 · see citing works

Random Matrix Analysis of Ca2+ Signals in β-Cell Collectives

Korošak, D., & Rupnik, M. S. (2019) · Frontiers in Physiology · doi:10.3389/fphys.2019.01194 · Cited by 6 · see citing works

Electrophysiological models of the human pancreatic δ‐cell: From single channels to the firing of action potentials

Félix-Martínez, G. J., González-Vélez, V., Godínez-Fernández, J. R., & Gil, A. (2019) · International Journal for Numerical Methods in Biomedical Engineering · doi:10.1002/cnm.3296 · Cited by 5 · see citing works

Loss of tetraspanin‐7 expression reduces pancreatic β‐cell exocytosis Ca2+ sensitivity but has limited effect on systemic metabolism

McLaughlin, K., Acreman, S., Nawaz, S., Cutteridge, J., Clark, A., Knudsen, J. G., Denwood, G., Spigelman, A., Fox, J. E. M., Singh, S. P., et al. (2022) · Diabetic Medicine · doi:10.1111/dme.14984 · Cited by 6 · see citing works

Antecedent hypoglycaemia impairs glucagon secretion by enhancing somatostatin-mediated negative feedback control

Gao, R., Acreman, S., Dou, H., Ma, J., MIRANDA, C. A., Zhao, R., Dickerson, M. T., Tarasov, A. I., Zou, Q., Gironella-Torrent, M., et al. (2026) · Nature Metabolism · doi:10.1038/s42255-025-01422-7 · Cited by 4 · see citing works

Alpha Cell Stimulus-Secretion Coupling and Intercellular Interactions in Health and Type 2 Diabetes

Pohorec, V., Zadravec, N., Turk, M., Dolenšek, J., & Stožer, A. (2023) · Acta Medico-Biotechnica · doi:10.18690/actabiomed.246 · Cited by 4 · see citing works

Metabolic and Paracrine Heterogeneity of Pancreatic Glucagon-Secreting α-Cells

Dou, H., MIRANDA, C. A., Tolö, J., dos Santos, C. P., Gao, R., Gandasi, N. R., Hill, T. G., Kothegala, L., Tarasov, A. I., Zhang, Q., et al. (2025) · Diabetes · doi:10.2337/db24-1053 · Cited by 4 · see citing works

δ-Cells Control a Subset of β-Cells in Mouse Pancreatic Islets

MIRANDA, C. A., dos Santos, C. P., Tolö, J., Gao, R., Hill, T. G., Kothegala, L., Tarasov, A. I., Zhang, Q., Rorsman, P., & Dou, H. (2025) · Diabetes · doi:10.2337/db25-0302 · Cited by 3 · see citing works

GABAA Receptor-Mediated Currents and Hormone mRNAs in Cells Expressing More Than One Hormone Transcript in Intact Human Pancreatic Islets

Korol, S., Jin, Z., & Birnir, B. (2019) · bioRxiv · doi:10.3390/ijms21020600 · Cited by 2 · see citing works

Targeting GluN2B-containing NMDA receptors to interact with stress pathways and Ca2+-regulated K+ channels in murine islets of Langerhans.

Hurtado, H. N., Hense, J., Klöpper, N., Osthues, J., Wünsch, B., & Düfer, M. (2025) · European Journal of Pharmacology · doi:10.1016/j.ejphar.2025.178223 · Cited by 1 · see citing works

Hypoglycemic conditions enhance neonatal β-cell glucose responsiveness via AMPK/mTOR-increased KATP channel density

Novichkova, E., Dou, H., Gupta, N., Kotova, P., Tolö, J., MIRANDA, C. A., Rorsman, P., Helman, A., & WALKER, M. D. (2026) · Endocrinology · doi:10.1210/endocr/bqag085 · Cited by 1 · see citing works

On the Electrophysiological Component of Pancreatic Alpha-Cell Models

Romero-Campos, H. E., Dupont, G., & González-Vélez, V. (2021) · Annual International Conference of the IEEE Engineering in Medicine and Biology Society · doi:10.1109/embc46164.2021.9630329 · Cited by 1 · see citing works

Linking molecular pathways and islet cell dysfunction in human type 1 diabetesPreprint

dos Santos, T., Dai, X. Q., Jones, R. C., Spigelman, A. F., Mummey, H. M., Ewald, J., Ellis, C. E., Lyon, J. G., Smith, N., Bautista, A., et al. (2025) · bioRxiv (Cold Spring Harbor Laboratory) · doi:10.1101/2025.02.20.639325 · Cited by 1 · see citing works

Vitamin D-binding protein is required for the maintenance of α-cell function and glucagon secretionPreprint

Viloria, K., Nasteska, D., Briant, L. J. B., Heising, S., Larner, D. P., Fine, N. H. F., Ashford, F. B., Xavier, G. D. S., Ramos, M. J., Fox, J. E. M., et al. (2019) · bioRxiv (Cold Spring Harbor Laboratory) · doi:10.1101/2019.12.19.881185

The Effects of Beta-cell Mass and Function, Intercellular Coupling, and islet Synchrony on Ca2+ Dynamics in Patients with Type 2 Diabetes MellitusPreprint

Saadati, M., & Jamali, Y. (2020) · Research Square · doi:10.21203/rs.3.rs-132280/v1

A Surge of Extracellular Succinate Ensures Glucose Supply During Systemic High Energy DemandPreprint

Wu, Y., Andersson-Hall, U. K., Dou, H., Shrestha, M. M., Komai, A. M., Tolö, J., Pettersson, S., Pedersen, A., Chanclón, B., Bauzá-Thorbrügge, M., et al. (2022) · SSRN Electronic Journal · doi:10.2139/ssrn.4099800

Effect of whole-body creatine-deficiency on secretion of insulin and glucagon from isolated mouse isletsPreprint

Zervou, S., A, S., Zhang, Q., Hill, T., McAndrew, D. J., Tarasov, A. I., Lygate, C. A., & Rorsman, P. (2025) · SSRN Electronic Journal · doi:10.2139/ssrn.5623207

Transistors Electrochimiques Organiques (OECTs) : nouveaux capteurs pour l’analyse de l’activité électrique des micro-organes pancréatiques

Abarkan, M. (2021) · theses.fr (ABES) · doi:10.70675/0f990149z612az4d86z9394z193eeae3b644

Computational modeling of the pancreas and pancreatic function

Félix‐Martínez, G. J. (2026) · Elsevier eBooks · doi:10.1016/b978-0-443-30263-3.00018-x

Electrophysiological identification of mouse islet α-cells: From isolated single α-cells to in situ assessment within pancreas slices

Huang, Y., Gaisano, H. Y., & Leung, Y. (2011) · Islets · doi:10.4161/isl.3.4.16166 · Cited by 14 · see citing works

Heterogeneous alpha-cell population modeling of glucose-induced inhibition of electrical activity

Montefusco, F., Cortese, G., & Pedersen, M. G. (2020) · Journal of Theoretical Biology · doi:10.1016/j.jtbi.2019.110036 · Cited by 13 · see citing works

Computational modelling of natural cell-to-cell heterogeneity reveals key parameters that control the diversity of human pancreatic islet β-cell excitability in response to glucosePreprint

Goswami, I., Koepke, J. P., Baghelani, M., MacDonald, P. E., Kravets, V. V., Light, P. E., & Edwards, A. G. (2026) · bioRxiv (Cold Spring Harbor Laboratory) · doi:10.64898/2026.02.27.708039

Heterogenous impairment of α-cell function in type 2 diabetes is linked to cell maturation state

Dai, X.-Q., Camunas-Soler, J., Briant, L., dos Santos, T., Spigelman, A., Walker, E., Drigo, R. A., Bautista, A., Jones, R. C., Avrahami, D., et al. (2022) · Cell Metabolism · doi:10.1016/j.cmet.2021.12.021 · Cited by 69 · see citing works

Reconstruction of a Pancreatic Beta Cell Network From Heterogeneous Functional Measurements

Shetty, R., Singh-Agarwal, R., Meier, S., Goetz, C., & Edwards, A. G. (2024) · Simula SpringerBriefs on computing · doi:10.1007/978-3-031-53145-3_5 · Cited by 1 · see citing works