The DOI matches its Crossref record; 11 of the 11 references it cites were found in a registry or an index.
Akt2 Is Required for Hepatic Lipid Accumulation in Models of Insulin Resistance
Open accessAbstract
Summary Insulin drives the global anabolic response to nutrient ingestion, regulating both carbohydrate and lipid metabolism. Previous studies have demonstrated that Akt2/protein kinase B is critical to insulin’s control of glucose metabolism, but its role in lipid metabolism has remained controversial. Here we show that Akt2 is required for hepatic lipid accumulation in obese, insulin-resistant states induced by either leptin-deficiency or high fat diet feeding. Lepob/ob mice lacking hepatic Akt2 failed to amass triglycerides in their livers, associated with and most likely due to a decrease in lipogenic gene expression and de novo lipogenesis. However, Akt2 is also required for steatotic pathways unrelated to fatty acid synthesis, as mice fed high fat diet had reduced liver triglycerides in the absence of hepatic Akt2 but did not exhibit changes in lipogenesis. These data demonstrate that Akt2 is a requisite component of the insulin-dependent regulation of lipid metabolism during insulin resistance.
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Akt/PKB regulates hepatic metabolism by directly inhibiting PGC-1α transcription coactivator
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Cited by
AKT/PKB Signaling: Navigating the Network
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Mechanisms of Insulin Action and Insulin Resistance
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Self-citationInsulin action and resistance in obesity and type 2 diabetes
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SREBP-regulated lipid metabolism: convergent physiology - divergent pathophysiology
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Metadata
- Authors
- Leavens, K. F., Easton, R. M., Shulman, G. I., Previs, S. F., & Birnbaum, M. J.
- Venue
- Cell Metabolism
- Publisher
- Elsevier BV
- Published
- 2009-11
- Volume
- 10
- Issue
- 5
- Pages
- 405-418
- ISSN
- 1550-4131 (ISSN-L)
- OpenAlex
- W2088024537
- Cited by
- 281
- References
- 11
- FWCI
- 9.65
- Type
- journal article
- Language
- en
- Open access
- bronze
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- Leavens, K. F., Easton, R. M., Shulman, G. I., Previs, S. F., & Birnbaum, M. J. (2009). Akt2 Is Required for Hepatic Lipid Accumulation in Models of Insulin Resistance. Cell Metabolism. https://doi.org/10.1016/j.cmet.2009.10.004
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Bibliographic data: Semantic Scholar, OpenAlex, Crossref.
Contains information from the Semantic Scholar Academic Graph Datasets, made available under the ODC Attribution License (ODC-BY 1.0).
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