The DOI matches its Crossref record; 58 of the 58 references it cites were found in a registry or an index.
High-Mobility Group Box 1 Is Essential for Mitochondrial Quality Control
Open accessAbstract
Mitochondria are organelles centrally important for bioenergetics as well as regulation of apoptotic death in eukaryotic cells. High mobility group box 1 (HMGB1), an evolutionarily conserved chromatin-associated protein which maintains nuclear homeostasis, is also a critical regulator of mitochondrial function and morphology. We show that heat shock protein beta-1 (HSPB1/ HSP27) is the downstream mediator of this effect. Disruption of the HSPB1 gene in embryonic fibroblasts with wild-type HMGB1 recapitulates the mitochondrial fragmentation, deficits in mitochondrial respiration, and adenosine triphosphate (ATP) synthesis observed with targeted deletion of HMGB1. Forced expression of HSPB1 reverses this phenotype in HMGB1 knockout cells. Mitochondrial effects mediated by HMGB1 regulation of HSPB1 expression, serves as a defense against mitochondrial abnormality, enabling clearance and autophagy in the setting of cellular stress. Our findings reveal a novel role for HMGB1 in autophagic surveillance with important effects on mitochondrial quality control.
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Cites
Parkin is recruited selectively to impaired mitochondria and promotes their autophagy
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Cited by
Immunogenic Cell Death in Cancer Therapy
Kroemer, G., Galluzzi, L., Kepp, O., & Zitvogel, L. (2013) · Annual Review of Immunology · doi:10.1146/annurev-immunol-032712-100008 · Cited by 3,303
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Self-citationMitophagy: mechanisms, pathophysiological roles, and analysis
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Self-citationHSPB1 as a novel regulator of ferroptotic cancer cell death
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Metadata
- Authors
- Tang, D., Kang, R., Livesey, K. M., Kroemer, G., Billiar, T. R., Van Houten, B., Zeh, H. J., & Lotze, M. T.
- Venue
- Cell Metabolism
- Publisher
- Elsevier BV
- Published
- 2011-06
- Volume
- 13
- Issue
- 6
- Pages
- 701-711
- ISSN
- 1550-4131 (ISSN-L)
- OpenAlex
- W2045316920
- Cited by
- 296
- References
- 58
- FWCI
- 7.41
- Type
- journal article
- Language
- en
- Open access
- bronze
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