Ryanodine Receptor Oxidation Causes Intracellular Calcium Leak and Muscle Weakness in Aging

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Patient-Specific Human Induced Pluripotent Stem Cell Model Assessed with Electrical Pacing Validates S107 as a Potential Therapeutic Agent for Catecholaminergic Polymorphic Ventricular Tachycardia

Sasaki, K., Makiyama, T., Yoshida, Y., Wuriyanghai, Y., Kamakura, T., Nishiuchi, S., Hayano, M., Harita, T., Yamamoto, Y., Kohjitani, H., et al. (2016) · PLoS ONE · doi:10.1371/journal.pone.0164795 · Cited by 67

Role of defective Ca2+ signaling in skeletal muscle weakness: Pharmacological implications

Agrawal, A., Suryakumar, G., & Rathor, R. (2018) · Journal of Cell Communication and Signaling · doi:10.1007/s12079-018-0477-z · Cited by 65

Mechanisms of force depression caused by different types of physical exercise studied by direct electrical stimulation of human quadriceps muscle

Skurvydas, A., Mamkus, G., Kamandulis, S., Dudonienė, V., Valančienė, D., & Westerblad, H. (2016) · European Journal of Applied Physiology · doi:10.1007/s00421-016-3473-0 · Cited by 63

Mitochondrial-Targeted Catalase

Dai, D., Chiao, Y. A., Martin, G. M., Marcinek, D. J., Basisty, N., Quarles, E. K., & Rabinovitch, P. S. (2017) · Progress in molecular biology and translational science · doi:10.1016/bs.pmbts.2016.12.015 · Cited by 65

Sleep Duration and Sarcopenia: An Updated Systematic Review and Meta-Analysis

Li, X., He, J., & Sun, Q. (2023) · Journal of the American Medical Directors Association · doi:10.1016/j.jamda.2023.04.032 · Cited by 68

Reactive oxygen species in the pathogenesis of sarcopenia

Xu, H., Brown, J. L., Bhaskaran, S., & Van Remmen, H. (2025) · Free Radical Biology and Medicine · doi:10.1016/j.freeradbiomed.2024.11.046 · Cited by 61

Mitochondrial health and muscle plasticity after spinal cord injury

Gorgey, A. S., Witt, O., O’Brien, L. C., Cardozo, C. P., Chen, Q., Lesnefsky, E. J., & Graham, Z. (2018) · European Journal of Applied Physiology · doi:10.1007/s00421-018-4039-0 · Cited by 64

Mitochondrial oxidative stress during cardiac lipid overload causes intracellular calcium leak and arrhythmia

Joseph, L. C., Subramanyam, P., Radlicz, C., Trent, C. M., Iyer, V., Colecraft, H. M., & Morrow, J. P. (2016) · Heart Rhythm · doi:10.1016/j.hrthm.2016.05.002 · Cited by 60

Intracellular calcium leak as a therapeutic target for RYR1-related myopathies

Kushnir, A., Todd, J. J., Witherspoon, J. W., Yuan, Q., Reiken, S. R., Lin, H., Munce, R. H., Wajsberg, B., Melville, Z., Clarke, O. B., et al. (2020) · Acta Neuropathologica · doi:10.1007/s00401-020-02150-w · Cited by 60

High-Throughput Screens to Discover Small-Molecule Modulators of Ryanodine Receptor Calcium Release Channels

Rebbeck, R. T., Essawy, M. M., Nitu, F. R., Grant, B. D., Gillispie, G. D., Thomas, D. D., Bers, D. M., & Cornea, R. L. (2016) · SLAS DISCOVERY · doi:10.1177/1087057116674312 · Cited by 59

S-nitrosylation of E3 ubiquitin-protein ligase RNF213 alters non-canonical Wnt/Ca+2 signaling in the P301S mouse model of tauopathy

Amal, H., Gong, G., Gjoneska, E., Lewis, S. M., Wishnok, J. S., Tsai, L., & Tannenbaum, S. R. (2019) · Translational Psychiatry · doi:10.1038/s41398-019-0388-7 · Cited by 55

Analytical approaches for the detection of emerging therapeutics and non-approved drugs in human doping controls

Thevis, M., & Schänzer, W. (2014) · Journal of Pharmaceutical and Biomedical Analysis · doi:10.1016/j.jpba.2014.05.020 · Cited by 58

Redox modulation of muscle mass and function

Gómez‐Cabrera, M. C., Arc‐Chagnaud, C., Salvador‐Pascual, A., Brioche, T., Chopard, A., González, G. O., & Viña, J. (2020) · Redox Biology · doi:10.1016/j.redox.2020.101531 · Cited by 61

Restoration of Sarcoplasmic Reticulum Ca2+ ATPase (SERCA) Activity Prevents Age-Related Muscle Atrophy and Weakness in Mice

Qaisar, R., Pharaoh, G. A., Bhaskaran, S., Xu, H., Ranjit, R., Bian, J., Ahn, B., Georgescu, C., Wren, J. D., & Remmen, H. V. (2020) · International Journal of Molecular Sciences · doi:10.3390/ijms22010037 · Cited by 57

Preventing Ryanodine Receptor 1 calcium Leak Improves Age-Dependent Muscle Dysfunction

Andersson, D. C., Betzenhauser, M. J., Reiken, S. R., Méli, A. C., Xie, W., Lacampagne, A., & Marks, A. R. (2011) · Biophysical Journal · doi:10.1016/j.bpj.2010.12.1775 · Cited by 1

The Role of Calcium Leak in Age-Dependent Loss of C. Elegans Muscle Function

Forrester, F. M., Umanskaya, A., Xie, W., Reiken, S. R., Yuan, Q., Lacampagne, A., & Marks, A. R. (2017) · Biophysical Journal · doi:10.1016/j.bpj.2016.11.1274 · Cited by 1

Role of oxidation of excitation-contraction coupling machinery in age-dependent loss of muscle function in Caenorhabditis elegans

Dridi, H., Forrester, F. M., Umanskaya, A., Xie, W., Reiken, S. R., Lacampagne, A., & Marks, A. R. (2022) · eLife · doi:10.7554/elife.75529 · Cited by 12

Ca2+ leakage out of the sarcoplasmic reticulum is increased in type I skeletal muscle fibres in aged humans

Lamboley, C. R. H., Wyckelsma, V. L., McKenna, M. J., Murphy, R. M., & Lamb, G. D. (2015) · The Journal of Physiology · doi:10.1113/jp271382 · Cited by 47

RYR Calcium Release Channels from Aging Rat EDL but not Soleus Exhibit Iimpaired Calcium Regulation

Balog, E. M., & Kampfer, A. J. (2010) · Medicine & Science in Sports & Exercise · doi:10.1249/01.mss.0000386556.64145.d5