CoChat
Sign Up
Cited by 95

The DOI matches its Crossref record; 5 of the 5 references it cites were found in a registry or an index.

A non‐amyloidogenic function of BACE‐2 in the secretory pathway

Fluhrer, Regina, Capell, Anja, Westmeyer, Gil, Willem, Michael, Hartung, Bianka, Condron, Margaret M., Teplow, David B., Haass, Christian, Walter, Jochen·2002·Journal of Neurochemistry
DOI 10.1046/j.1471-4159.2002.00908.x
Open this paper in CoChat — free account

Abstract

β‐Site amyloid precursor protein cleavage enzyme (BACE)‐1 and BACE‐2 are members of a novel family of membrane‐bound aspartyl proteases. While BACE‐1 is known to cleave β‐amyloid precursor protein (βAPP) at the β‐secretase site and to be required for the generation of amyloid β‐peptide (Aβ), the role of its homologue BACE‐2 in amyloidogenesis is less clear. We now demonstrate that BACE‐1 and BACE‐2 have distinct specificities in cleavage of βAPP in cultured cells. Radiosequencing of the membrane‐bound C‐terminal cleavage product revealed that BACE‐2 cleaves βAPP in the middle of the Aβ domain between phenylalanines 19 and 20, resulting in increased secretion of APPs‐α‐ and p3‐like products and reduced production of Aβ species. This cleavage can occur in the Golgi and later secretory compartments. We also demonstrate that BACE‐1‐mediated cleavage of βAPP at Asp1 of the Aβ domain can occur as early as in the endoplasmic reticulum, while cleavage at Glu11 occurs in later compartments. These data indicate that the distinct specificities of BACE‐1 and BACE‐2 in their cleavage of βAPP differentially affect the generation of Aβ.

Overview

Integrity signals

Registry

Crossref · 10.1046/j.1471-4159.2002.00908.x

Cites

5 of 5 references verified0 citation errors · 0 not checkable

Statistics

Recomputing p-values needs the paper’s full text.

Verification

Claims the paper makes

This paper’s full text isn’t openly available, so its claims and self-check weren’t run. The registry and citation checks still apply.

Claims other papers make about this one

Each is checked against this paper’s own text: does it say what the citing paper says it does?

  • High overexpression of BACE1 decreases Aβ levels in cell culture and transgenic mice by additional cleavages within Aβ.

    “High overexpression of BACE1 was also shown to decrease A␤ levels in cell culture and transgenic mice by additional cleavages within A␤ (Fluhrer et al., 2002(Fluhrer et al., , 2003;;Liu et al., 2002;Lee et al., 2005).”

    From GGA1 Is Expressed in the Human Brain and Affects the Generation of Amyloid β-Peptide (2006) · cites this paper as Fluhrer et al., 2002

Citations

Cites

Flagged first, then by citations

Research works printed but not linked: 38

  1. 10.1016/S0014-5793(00)01192-3 · DOI
  2. 10.1074/jbc.M009899200 · DOI · Paper page
  3. 10.1074/jbc.M002688200 · DOI · Paper page
  4. 10.1074/jbc.M005339200 · DOI
  5. 10.1038/85064 · DOI
  6. 10.1074/jbc.M003202200 · DOI · Paper page
  7. 10.1038/nm0997-1021 · DOI
  8. 10.1074/jbc.M006947200 · DOI · Paper page
  9. 10.1126/science.286.5443.1255a · DOI
  10. 10.1073/pnas.160115697 · DOI · Paper page
  11. 10.1046/j.1471-4159.1998.71051920.x · DOI
  12. 10.1016/S0021-9258(18)53650-4 · DOI
  13. 10.1074/jbc.M002095200 · DOI
  14. 10.1038/nm0997-1016 · DOI
  15. 10.1126/science.290.5489.150 · DOI
  16. 10.1385/MN:22:1-3:081 · DOI
  17. 10.1074/jbc.M004175200 · DOI · Paper page
  18. 10.1074/jbc.M111141200 · DOI · Paper page
  19. 10.1006/mcne.1999.0811 · DOI · Paper page
  20. 10.1006/mcne.2000.0884 · DOI
  21. 10.1073/pnas.97.4.1456 · DOI
  22. 10.1021/bi015800g · DOI · Paper page
  23. 10.1038/85059 · DOI · Paper page
  24. 10.1093/hmg/10.12.1317 · DOI · Paper page
  25. 10.1126/science.286.5443.1255a · DOI
  26. 10.1038/399a023 · DOI · Paper page
  27. 10.1038/361260a0 · DOI
  28. 10.1038/990114 · DOI · Paper page
  29. 10.1126/science.1691865 · DOI
  30. 10.1038/35043065 · DOI · Paper page
  31. 10.1016/S0896-6273(00)00051-9 · DOI
  32. 10.1016/S0959-4388(00)00253-1 · DOI
  33. 10.1074/jbc.M011116200 · DOI · Paper page
  34. 10.1074/jbc.272.26.16085 · DOI · Paper page
  35. 10.1038/990107 · DOI · Paper page
  36. 10.1074/jbc.M105583200 · DOI
  37. 10.1074/jbc.M104350200 · DOI
  38. Zhong Z., 1994, Secretion of beta‐amyloid precursor protein involves multiple cleavage sites, J. Biol. Chem., 269, 627, 10.1016/S0021-9258(17)42395-7 · DOI

Cited by

Sorted by citations

Metadata

Authors
Fluhrer, R., Capell, A., Westmeyer, G., Willem, M., Hartung, B., Condron, M. M., Teplow, D. B., Haass, C., & Walter, J.
Venue
Journal of Neurochemistry
Publisher
Wiley
Published
2002-05-21
Volume
81
Issue
5
Pages
1011-1020
ISSN
  • 0022-3042
  • 1471-4159
DOI
10.1046/j.1471-4159.2002.00908.x
Cited by
95
References
5
Language
en
Licence
onlinelibrary.wiley.com/termsAndConditions#vor (vor)

About these checks

Registry, retraction, Cites and statistics results are computed, not judged, with one exception: a printed reference that no index lists is read once by a model before it counts as a citation error. Claims are extracted by a model and kept only when their quote appears verbatim in the text; each cited source is then checked, with a model’s help, for whether it says what the claim relies on. Those verdicts can be wrong — read the claim’s quote and the cited source before relying on one.

Statistics and arithmetic are recomputed, not judged.

Confidence bands are shown only for fields calibrated on our annotated test set. None is calibrated yet, so no band is shown.

What counts as a claim ›How we measure confidence ›How we check this ›

Are you an author, or do you see a problem with this page? Request a review