Alzheimer's Disease Mechanisms and Emerging Roads to Novel Therapeutics
Open accessAbstract
Ten years of remarkable progress in understanding the fundamental biochemistry of Alzheimer's disease have been followed by ten years of remarkable and increasing clinical insight into the natural progression of the disorder. The concept of a long, intermediary, prodromal phase between the first appearance of amyloid plaques and tangles and the manifestation of dementia is now well established. The major challenge for the next decade is to chart the many cellular processes that underlie this phase and link the biochemical alterations to the clinical manifestation of Alzheimer's disease. We discuss here how genetics, new cell culture systems, and improved animal models will fuel this work. We anticipate that the resulting novel insights will provide a basis for further drug development for this terrible disease.
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Side effects associated with targeting β- and γ-secretases arise because these enzymes have a wide range of substrates vital in other physiological processes.
“However, the side effects associated with targeting β- and γ-secretases arise because these enzymes have a wide range of substrates that are vital in other physiological processes.170”
From Recent advances in Alzheimer's disease: Mechanisms, clinical trials and new drug development strategies. (2024) · cites this paper as [170]
In “The Usual Suspects and Problems in Developing Tau- or Amyloid-β-Centered Therapy” (page not provided), the review says BACE1 has multiple substrates beyond APP and that interfering with it affects brain-development mechanisms. The same section identifies γ-secretase’s many substrates as a drawback and discusses limiting side effects. It does not establish that substrate-related side effects have occurred for both targets: it calls side effects in the adult human brain from BACE1 inhibition an unresolved concern. (LLM, conf=0.84)
Experimental — accuracy not yet measuredWhen Aβ antibodies such as bapineuzumab did not yield significant therapeutic effects, research shifted towards inhibiting the formation of Aβ.
“When Aβ antibodies, such as bapineuzumab (31), did not yield significant therapeutic effects, research shifted towards inhibiting the formation of Aβ.109,170”
From Recent advances in Alzheimer's disease: Mechanisms, clinical trials and new drug development strategies. (2024) · cites this paper as [170]
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Indrigo, M. T., Morella, I., Orellana, D. I., d’Isa, R., Papale, A., Parra, R., Gurgone, A., Lecca, D., Cavaccini, A., Tigaret, C. M., et al. (2018) · bioRxiv (Cold Spring Harbor Laboratory) · doi:10.1101/496141 · Cited by 2 · see citing works
Nanotechnology Applications in Food and Nutrition Science
rizi, K. S., Rezayi, M., Aryan, E., Meshkat, Z., & Ghayour‐Mobarhan, M. (2022) · Wiley eBooks · doi:10.1002/9781119558026.ch8 · Cited by 2 · see citing works
Hurdles and Strategies in Treating Alzheimer’s Disease
Qureshi, T., Desale, S. E., Chidambaram, H., & Chinnathambi, S. (2024) · Springer eBooks · doi:10.1007/978-981-96-0259-9_6 · Cited by 1 · see citing works
- Authors
- Sala Frigerio, C., & De Strooper, B.
- Affiliations
- VIB Center for the Biology of Disease, Vlaams Instituut voor Biotechnologie, Leuven 3000, Belgium;,
- Venue
- Annual Review of Neuroscience
- Publisher
- Annual Reviews
- Published
- 2016-07-08
- Volume
- 39
- Issue
- 1
- Pages
- 57-79
- ISSN
- 0147-006X (ISSN-L)
- 1545-4126
- OpenAlex
- W2219854607
- Cited by
- 116
- References
- 163
- Citations by year
- 2025: 10 · 2024: 9 · 2023: 10 · 2022: 10 · 2021: 11 · 2020: 22 · 2019: 14 · 2018: 16 · 2017: 14
- FWCI
- 1.72
- Type
- journal article
- Language
- en
- Open access
- bronze
- doi.org
- Locations
- Annual Review of Neuroscience (publishedVersion)
- PubMed (publishedVersion)
- UCL Discovery (University College London) (submittedVersion)
- Lirias (submittedVersion)
- Funders
- Fonds Wetenschappelijk Onderzoek
- KU Leuven
- Vlaamse regering
- Topics
- Health Sciences › Medicine › Physiology › Alzheimer's disease research and treatments
- Health Sciences › Medicine › Psychiatry and Mental health › Dementia and Cognitive Impairment Research
- Life Sciences › Neuroscience › Neurology › Neuroinflammation and Neurodegeneration Mechanisms
- Keywords
- Alzheimer's disease, prodromal symptoms, amyloid plaques, neurofibrillary tangles, disease progression, genetic risk factors, cell culture model, animal models, drug development
- MeSH terms
- Alzheimer Disease, Animals, Brain, Disease Models, Animal, Humans, Amyloid beta-Peptides, tau Proteins, Plaque, Amyloid
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